Year 2019, Volume 58 , Issue 2, Pages 154 - 160 2019-06-28

Temas tipi yanıklarda Hypericum perforatum (sarı kantaron) ile tedavi: Deneysel bir çalışma
Treatment of contact burn injury with hypericum perforatum: An experimental study

Derya Cabbaroğlu [1] , Meltem Songür Kodik [2] , Yiğit Uyanıkgil [3] , Emel Öykü Çetin Uyanıkgil [4] , Fatih Karabey [5] , Selahattin Kıyan [6]


Amaç: Yanık insanların karşılaştığı en zor fiziksel ve psikolojik travmalardan biridir. Genellikle yanıktan koruma ve önleme stratejileri uygulanmaktadır. Yaşlılar ve gençler yanıktan en trajik olarak etkilenen popülasyondur. Bu çalışmada, metanol ekstraksiyonu yöntemiyle elde edilen Hypericum perforatum (sarı kantaron) jelinin uzun süreli olumlu etkilerinin araştırılması amaçlandı.

Gereç ve Yöntem: Kırk adet Sprague-Dawley cinsi erkek sıçanlar 100°C de 15 saniye kaynamış suda ısıtılmış metalle dağlanarak yakılıp 5 gruba ayrıldı. Kontrol grubuna hiçbir işlem ve tedavi uygulanmadı (Grup 1). Salin grubuna (Grup 2), yanık uygulaması yapılıp % 0, 9' luk NaCl solüsyonu ile irrigasyon yapıldı. Ticari bir ürün olan Silverdin® kremi (Grup 3), metanol ekstrasyonu ile elde eldilmiş Hypericum perforatum jeli (Grup 4) ve plasebo jel (Grup 5), aynı gün topikal olarak 4 kez uygulandı. Yanık alanı ve histopatolojik analizler 4., 8. ve 24. saatte biyopsi alınıp değerlendirildi.

Bulgular: Metanol ekstrasyonu ile elde eldilmiş Hypericum perforatum jelinin deneysel yanık modeli sonrası topikal uygulaması; kollajen diskolorizasyonunu, vasküler hasar, kıl folikülü ve sebasöz bezlerde meydana gelen hasarı düşürürken ayrıca tüm damarların epidermal kalınlığının Silverdin®’e göre daha tedavi edici özellikte olduğu gözlemlendi.

Sonuç: Deneysel yanıklar üzerinde Hypericum perforatum jelinin olumlu etkilerinin olduğu ve kullanımının akut yanıklar üzerinde yararlı etkileri olabileceği görüldü.

Aim: Burns are one of the most difficult physical and psychological traumas that people face. Generally, protection and prevention strategies from burns are practiced. The young and the elderly are most likely to be affected tragically. The aim of the present study is to investigate the effect of Hypericum perforatum methanol extractcontaining gel on the healing of burn wounds.

Materials and Methods: Forty male rats of the Sprague-Dawley strain were divided into four groups after a 4x4 area of their back was shaved, and an experimental burn was created with the direct contact of an aluminum metal stamp heated in boiling water for 15 seconds. There was no implementation on or treatment of the control group (Group 1). Burn wounds were irrigated with saline solution (Saline group, Group 2), and silver sulphadiazine 1% (Silverdin®) cream (Group 3), Hypericum perforatum methanol extract-containing gel (Group 4), and a placebo gel (Group 5) were applied topically 4 times a day after the contact burn. Histopathological analyses of the burned area were made at 4, 8, and 24 hours.

Results: The topical use of Hypericum perforatum methanol extract-containing gel in the experimental contact burns, histologically; resulted in the reduction of collagen discoloration, vascular damage and hair follicle and glandula sebaceous damage while preserving total number of hair follicles, number of vessels and epidermal thickness compared to Silver Sulphadiazine 1% (Silverdin®) cream treatment.

Conclusion: Positive effects of topical Hypericum perforatum gel were detected on experimental burns and its use might have beneficial effects on acute burn wounds.

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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Orcid: 0000-0002-2165-6936
Author: Derya Cabbaroğlu
Institution: Private Medifema Hospital, Emergency Service,
Country: Turkey


Orcid: 0000-0003-4565-3374
Author: Meltem Songür Kodik (Primary Author)
Institution: Ege University Faculty of Medicine, Department of Emergency Medicine
Country: Turkey


Orcid: 0000-0002-4016-0522
Author: Yiğit Uyanıkgil
Institution: Ege University Faculty of Medicine, Department Histology and Embryology
Country: Turkey


Orcid: 0000-0001-8822-9130
Author: Emel Öykü Çetin Uyanıkgil
Institution: Ege University Faculty of Pharmacy, Department of Pharmaceutical Technology
Country: Turkey


Orcid: 0000-0003-0305-6192
Author: Fatih Karabey
Institution: Ege University Faculty of Science, Department of Botanics,
Country: Turkey


Orcid: 0000-0001-8431-7387
Author: Selahattin Kıyan
Institution: Ege University Faculty of Medicine, Department of Emergency Medicine
Country: Turkey


Dates

Publication Date : June 28, 2019

Bibtex @research article { etd512502, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege University}, year = {2019}, volume = {58}, pages = {154 - 160}, doi = {10.19161/etd.512502}, title = {Treatment of contact burn injury with hypericum perforatum: An experimental study}, key = {cite}, author = {Cabbaroğlu, Derya and Songür Kodik, Meltem and Uyanıkgil, Yiğit and Çetin Uyanıkgil, Emel Öykü and Karabey, Fatih and Kıyan, Selahattin} }
APA Cabbaroğlu, D , Songür Kodik, M , Uyanıkgil, Y , Çetin Uyanıkgil, E , Karabey, F , Kıyan, S . (2019). Treatment of contact burn injury with hypericum perforatum: An experimental study. Ege Tıp Dergisi , 58 (2) , 154-160 . DOI: 10.19161/etd.512502
MLA Cabbaroğlu, D , Songür Kodik, M , Uyanıkgil, Y , Çetin Uyanıkgil, E , Karabey, F , Kıyan, S . "Treatment of contact burn injury with hypericum perforatum: An experimental study". Ege Tıp Dergisi 58 (2019 ): 154-160 <http://egetipdergisi.com.tr/en/issue/44438/512502>
Chicago Cabbaroğlu, D , Songür Kodik, M , Uyanıkgil, Y , Çetin Uyanıkgil, E , Karabey, F , Kıyan, S . "Treatment of contact burn injury with hypericum perforatum: An experimental study". Ege Tıp Dergisi 58 (2019 ): 154-160
RIS TY - JOUR T1 - Treatment of contact burn injury with hypericum perforatum: An experimental study AU - Derya Cabbaroğlu , Meltem Songür Kodik , Yiğit Uyanıkgil , Emel Öykü Çetin Uyanıkgil , Fatih Karabey , Selahattin Kıyan Y1 - 2019 PY - 2019 N1 - doi: 10.19161/etd.512502 DO - 10.19161/etd.512502 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 154 EP - 160 VL - 58 IS - 2 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.512502 UR - https://doi.org/10.19161/etd.512502 Y2 - 2018 ER -
EndNote %0 Ege Tıp Dergisi Treatment of contact burn injury with hypericum perforatum: An experimental study %A Derya Cabbaroğlu , Meltem Songür Kodik , Yiğit Uyanıkgil , Emel Öykü Çetin Uyanıkgil , Fatih Karabey , Selahattin Kıyan %T Treatment of contact burn injury with hypericum perforatum: An experimental study %D 2019 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 58 %N 2 %R doi: 10.19161/etd.512502 %U 10.19161/etd.512502
ISNAD Cabbaroğlu, Derya , Songür Kodik, Meltem , Uyanıkgil, Yiğit , Çetin Uyanıkgil, Emel Öykü , Karabey, Fatih , Kıyan, Selahattin . "Treatment of contact burn injury with hypericum perforatum: An experimental study". Ege Tıp Dergisi 58 / 2 (June 2019): 154-160 . https://doi.org/10.19161/etd.512502
AMA Cabbaroğlu D , Songür Kodik M , Uyanıkgil Y , Çetin Uyanıkgil E , Karabey F , Kıyan S . Treatment of contact burn injury with hypericum perforatum: An experimental study. Ege Tıp Dergisi. 2019; 58(2): 154-160.
Vancouver Cabbaroğlu D , Songür Kodik M , Uyanıkgil Y , Çetin Uyanıkgil E , Karabey F , Kıyan S . Treatment of contact burn injury with hypericum perforatum: An experimental study. Ege Tıp Dergisi. 2019; 58(2): 160-154.