Year 2019, Volume 58 , Issue 3, Pages 246 - 250 2019-09-20

Primer biliyer sirozda çölyak hastalığı birlikteliği
Coexisting of coeliac disease in primary biliary cirrhosis

Sezgin Vatansever [1] , Zehra Betül Paköz [2] , Belkıs Ünsal [3]


Amaç: Otoimmun hastalıklar genel olarak birliktelik gösterme eğilimindedirler. Primer biliyer siroza (PBS) da diğer otoimmun hastalıkların yanı sıra çölyak hastalığı (ÇH) eşlik edebilmektedir. Bu çalışmada PBS’li hastalarda ÇH’nin prevalansı değerlendirildi.

Gereç ve Yöntem: Çalışmada Nisan 2006-Aralık 2017 tarihleri arasında tanı alan ve takipli olan 238 PBS’li hasta, kontrol grubu olarak alınan 205 sağlıklı gönüllü ile prospektif olarak karşılaştırıldı. Hastalarda Anti Gliadin IgA ve IgG (AGA), Anti Endomisyum IgA ve IgG (EMA) antikorları immunofloresans yöntemi ile bakıldı. Antikorları pozitif saptanan hastalardan duodenum ikinci kısmından biyopsi alındı.

Bulgular: Çalışmaya alınan 238 hastanın yaş ortalaması 54,2±12 olup 16’sı erkekti. Kontrol grubundaki 205 kişinin 115’i kadın (%56,1), 90’ı erkek ve yaş ortalaması 43,8±14,4’tü. PBS’li 4 hastada AGA ve EMA pozitifliği (%1,7) saptandı. PBS’li hastaların hiçbirinde ÇH semptomları yoktu. On üç (%5,46) hastada ise düşük titrede AGA pozitifliği saptandı. Kontrol grubundaki bir (%0,4) hastada EMA, AGA IgA ve IgG yüksek titrede pozitif saptandı ve PBS’li grup ile istatistiksel fark saptanmadı (p=0,379). PBS tanısı olan ve EMA, AGA pozitif saptanan dört hastanın biyopsisinde, bir hastada Marsh 1, bir hastada Marsh 2 ve iki hastada Marsh 3 ile uyumlu duodenum biyopsi bulguları saptandı. EMA ve AGA’sı pozitif olan kontrol grubundaki bir hastanın ince barsak biyopsisi ise Marsh 3 ile uyumluydu. 

Sonuç: PBS ve ÇH, birbiri ile ilişkili olabilen hastalıklardır. PBS tanılı hastalarda, ÇH açısından seropozitif olan hastaların takibinin ÇH ve komplikasyonlarına de yönelik olması ve tanı konulan hastalara glutensiz diyetin başlanması gerekmektedir.

Aim: Autoimmune disorders tend to show co-occurrence. Coeliac disease (CD) may accompany primary biliary cirrhosis (PBC) like other autoimmune diseases. In this study, we aimed to evaluate the prevalance of CD in PBC patients.

Materials and Methods: Two hundred and thirty-eight patients whom diagnosed as PBC between April 2006-December 2017 and 205 healthy volunteers as control group compared prospectively. AGA IgG, AGA IgA, EMA IgG and EMA IgA results evaluated. Duodenum biopsies were obtained in patients who had positive AGA an EMA results.

Results: Median age was 54.2+12 in PBC patients and 43.8+14.4 in control group. Sixteen of 238 PBC patients and 90 of 205 control were male. Four (1.7%) PBC patients had AGA and EMA positivity. None of PBC patients had symptoms for CD. Thirteen (5.46%) patients had AGA positivity with low titration. One (0.4%) healthy control had EMA and AGA positivity and there was no statistical difference between two groups (p=0.379). According to Marsh classification of duodenal biopsies we found one Marsh 1, one Marsh 2 and two Marsh 3 in PBS group. one control who had positive EMA and AGA results showed Marsh 3 in duodenal biopsies

Conclusion: PBC and CD may be associated. PBC patients who are seropositive for CD must be followed according to complications of CD. Gluten-free diet is required for these patients.


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Primary Language tr
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Orcid: 0000-0002-8413-5353
Author: Sezgin Vatansever
Institution: İzmir Katip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, İzmir,
Country: Turkey


Orcid: 0000-0001-5918-6178
Author: Zehra Betül Paköz (Primary Author)
Institution: Tepecik Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, İzmir
Country: Turkey


Orcid: 0000-0003-2816-9214
Author: Belkıs Ünsal
Institution: İzmir Katip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, İzmir
Country: Turkey


Dates

Publication Date : September 20, 2019

Bibtex @research article { etd455438, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege University}, year = {2019}, volume = {58}, pages = {246 - 250}, doi = {10.19161/etd.455438}, title = {Primer biliyer sirozda çölyak hastalığı birlikteliği}, key = {cite}, author = {Vatansever, Sezgin and Paköz, Zehra Betül and Ünsal, Belkıs} }
APA Vatansever, S , Paköz, Z , Ünsal, B . (2019). Primer biliyer sirozda çölyak hastalığı birlikteliği. Ege Tıp Dergisi , 58 (3) , 246-250 . DOI: 10.19161/etd.455438
MLA Vatansever, S , Paköz, Z , Ünsal, B . "Primer biliyer sirozda çölyak hastalığı birlikteliği". Ege Tıp Dergisi 58 (2019 ): 246-250 <http://egetipdergisi.com.tr/en/issue/47742/455438>
Chicago Vatansever, S , Paköz, Z , Ünsal, B . "Primer biliyer sirozda çölyak hastalığı birlikteliği". Ege Tıp Dergisi 58 (2019 ): 246-250
RIS TY - JOUR T1 - Primer biliyer sirozda çölyak hastalığı birlikteliği AU - Sezgin Vatansever , Zehra Betül Paköz , Belkıs Ünsal Y1 - 2019 PY - 2019 N1 - doi: 10.19161/etd.455438 DO - 10.19161/etd.455438 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 246 EP - 250 VL - 58 IS - 3 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.455438 UR - https://doi.org/10.19161/etd.455438 Y2 - 2018 ER -
EndNote %0 Ege Tıp Dergisi Primer biliyer sirozda çölyak hastalığı birlikteliği %A Sezgin Vatansever , Zehra Betül Paköz , Belkıs Ünsal %T Primer biliyer sirozda çölyak hastalığı birlikteliği %D 2019 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 58 %N 3 %R doi: 10.19161/etd.455438 %U 10.19161/etd.455438
ISNAD Vatansever, Sezgin , Paköz, Zehra Betül , Ünsal, Belkıs . "Primer biliyer sirozda çölyak hastalığı birlikteliği". Ege Tıp Dergisi 58 / 3 (September 2019): 246-250 . https://doi.org/10.19161/etd.455438
AMA Vatansever S , Paköz Z , Ünsal B . Primer biliyer sirozda çölyak hastalığı birlikteliği. Ege Tıp Dergisi. 2019; 58(3): 246-250.
Vancouver Vatansever S , Paköz Z , Ünsal B . Primer biliyer sirozda çölyak hastalığı birlikteliği. Ege Tıp Dergisi. 2019; 58(3): 250-246.