Abstract
Aim: Anemia is one of the major health problems in the world. In this study,
we aimed to investigate the etiology of anemia in the inpatient infants due to severe
anemia.
Material and methods: The records of the hospitalized patients aged 1 to 24
months due to severe anemia were retrospectively reviewed. Demographic data
such as age, gender, weight and socioeconomic status of the patients and
laboratory results were recorded.
Results: Twenty-five of the 34 cases (73.6%) were male and 9 (26.4%) were female.
The mean age of the patients was 11.25 ± 6.02 months. Twelve
patients (58.8%) had iron deficiency anemia (DEA), nine patients (26.5%) had
megaloblastic anemia, three patients (8.8%) had hemolytic anemia, one patient
had hereditary spherocytosis and one patient (2.9%) had thalassemia major. There were also tachycardia in 21 patients (61.7%) and
systolic murmur in mesocardiac focus in 14 patients (41.1%). Blood transfusion
was performed to 27 (79.4%) cases which detected signs of heart failure.
Conclusion: In our study, DEA was the most common cause of severe
anemia and megaloblastic anemia due to B12 deficiency in second place. Our
findings support that the correction of nutritional deficiencies and the iron
prophylaxis applied during infancy may be effective in preventing the
development of severe anemia.
References
- 10. Şimşek Ö, Büyükavcı M, Kaya MD, Akdağ R, Karakelleoğlu C. Orta derecede rakımda yaşayan Erzurum ve pediatri polikliniğine başvuran 6 ay-6 yaş arasındaki çocuklarda anemi prevalansı ve etyolojik faktörler. Zeynep Kamil Bülteni 2005;36:33-8.
- 11. Kapil U, Tyagi M. Etiology of severe anemia amongst adolescent children. Indian J Pediatr 2012;79:401-2.
- 12. Baker RD, Greer FR. Diagnosis and prevention of iron deficiency and ıron deficiency anemia in infants and young children. Pediatrics 2010;126:1040-1050.
- 13. Charles CV, Summerlee AJ, Dewey CE. Anemia in Cambodia: prevalence, etiology and research needs. Asia Pac J Clin Nutr 2012;21(2):171-81.
- 14. Reeve K, Jones H, Hatrey R. Transfüsion guidelines in children:1. Anaesth Intensive Care 2014;13:20-23.
- 15. Kılıçaslan Ö, Yıldırmak ZY, Urgancı N. Derin anemi nedeni ile çocuk kliniğine yatırılıp demir eksikliği tanısı alan olguların değerlendirilmesi. Ş.E.E.A.H. Tıp Bültesi 2014;48:234-8.
- 16. Yüksel Ş, Uslan İ, Acartürk G, Çölbay M, Karaman Ö, Maralcan M, Demir S. A Retrospective Evaluation of Patients with Vitamin B12 Deficiency. Medical Journal of Bakırköy 2006;2:126-9.
- 17. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, Peña-Rosas JP, Bhutta ZA, Ezzati M; Nutrition Impact Model Study Group (Anaemia). Global, regional, and national trends in haemoglobin concentration and prevelence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data. Lancet Glob Health 2013;1(1):16-25.
- 18. Patra S, Pemde HK, Singh V, Chandra J, Dutta A. Profile of adolescents with severe anemia admitted in a tertiary care hospital in Northern India. Indian J Pediatr 2011;78(7):863-5.
- 19. Alvarez-Uria G, Naik PK, Midde M, Yalla PS, Pakam R. Prevalence and severity of anaemia stratified by age and gender in Rural India. Anemia 2014;2014:176182.
- 1. Sullivan KM, Mei Z, Grummer-Strawn L, Parvanta I. Haemoglobin adjustments to define anaemia. Trop Med Int Health 2008;13(10):1267-71.
- 2. WHO’s Certified[ Internet]. Vitamin and Mineral Nutrition Information System [Internet] Switzerland: Hemoglobin concentrations for the diagnosis of anemia and assesment of severity. C 2000-1. Availabel from: http://www.who.int/vmnis/indicators/haemoglobin.
- 3. Hensbrock MB, Jonker F, Bates I. Severe acquired anaemia in Africa: new concepts. Br J Haematol 2011;154:690-95.
- 4. Sloniewsky D. Anemia and transfusion in critically ill pediatric patients: a review of etiology, management, and outcomes. Crit Care Clin 2013;29(2):301-17.
- 5. Özdemir N. Iron deficiency anemia from diagnosis to treatment in children. Turk Pediatri Ars 2015;50(1):11–9.
- 6. Baumgartner MR. Vitamin-responsive disorders: cobalamin, folate, biotin, vitamins B1 and E. Handb Clin Neurol 2013;113:1799-810.
- 7. Loiselle K, Lee JL, Szulczewski L, Drake S, Crosby LE, Pai AL. Systematic and Meta-Analytic Review: Medication Adherence Among Pediatric Patients With Sickle Cell Disease. J Pediatr Psychol 2016;41(4):406-18.
- 8. Pasricha SR, Drakesmith H. Iron Deficiency Anemia: Problems in Diagnosis and Prevention at the Population Level. Hematol Oncol Clin North Am 2016;30(2):309-25.
- 9. Güvenç H, Aygün AD, Soylu F, Kocabay K. Çocukluk döneminde derin anemi etyolojisinde demir eksikliğinin önemi. MN Pediatri 1994;1:149-52.
Abstract
Amaç: Anemi dünyadaki önemli sağlık
problemlerinden birisidir. Bu çalışmada derin anemi nedeniyle hastanede yatan
sütçocuğu olgularının anemi etiyolojisi açısından incelenmesini amaçladık.
Gereç
ve Yöntem: Derin
anemi nedeniyle hastanede yatan 1 ay-24 ay arasındaki hastaların dosyaları
geriye dönük olarak incelendi. Hastaların yaş, cinsiyet, ağırlık ve
sosyoekonomik durum gibi demografik verileri ile laboratuvar sonuçları
kaydedildi.
Bulgular: Çalışmaya dahil edilen 34
olgunun 25’i (%73,6) erkek, 9’u (%26,4) kız idi. Hastaların yaş ortalaması 11,25±6,02
ay idi. Yirmi hasta (% 58,8) demir eksikliği anemisi (DEA), dokuz hasta (%
26,5) megaloblastik anemi, üç hasta (% 8,8) hemolitik anemi, bir hasta (% 2,9)
herediter sferositoz ve bir hasta (% 2,9) talasemi major tanısı aldı. Ayrıca 21
hastada (% 61,7) taşikardi, 14 hastada (% 41,1) mezokardiyak odakta sistolik
üfürüm saptandı. Olguların 27’sinde (% 79,4) kalp yetmezliği bulguları
saptanması üzerine kan transfüzyonu yapıldı.
Sonuç: Çalışmamızda derin aneminin en
sık nedeni olarak DEA ve ikinci sırada B12 eksikliğine bağlı megaloblastik
anemi saptandı. Bulgularımız besinsel eksikliklerin düzeltilmesinin ve süt
çocukluğu döneminde uygulanan demir proflaksisinin derin anemi gelişimini
önlemede etkili olabileceğini desteklemektedir.
References
- 10. Şimşek Ö, Büyükavcı M, Kaya MD, Akdağ R, Karakelleoğlu C. Orta derecede rakımda yaşayan Erzurum ve pediatri polikliniğine başvuran 6 ay-6 yaş arasındaki çocuklarda anemi prevalansı ve etyolojik faktörler. Zeynep Kamil Bülteni 2005;36:33-8.
- 11. Kapil U, Tyagi M. Etiology of severe anemia amongst adolescent children. Indian J Pediatr 2012;79:401-2.
- 12. Baker RD, Greer FR. Diagnosis and prevention of iron deficiency and ıron deficiency anemia in infants and young children. Pediatrics 2010;126:1040-1050.
- 13. Charles CV, Summerlee AJ, Dewey CE. Anemia in Cambodia: prevalence, etiology and research needs. Asia Pac J Clin Nutr 2012;21(2):171-81.
- 14. Reeve K, Jones H, Hatrey R. Transfüsion guidelines in children:1. Anaesth Intensive Care 2014;13:20-23.
- 15. Kılıçaslan Ö, Yıldırmak ZY, Urgancı N. Derin anemi nedeni ile çocuk kliniğine yatırılıp demir eksikliği tanısı alan olguların değerlendirilmesi. Ş.E.E.A.H. Tıp Bültesi 2014;48:234-8.
- 16. Yüksel Ş, Uslan İ, Acartürk G, Çölbay M, Karaman Ö, Maralcan M, Demir S. A Retrospective Evaluation of Patients with Vitamin B12 Deficiency. Medical Journal of Bakırköy 2006;2:126-9.
- 17. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, Peña-Rosas JP, Bhutta ZA, Ezzati M; Nutrition Impact Model Study Group (Anaemia). Global, regional, and national trends in haemoglobin concentration and prevelence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data. Lancet Glob Health 2013;1(1):16-25.
- 18. Patra S, Pemde HK, Singh V, Chandra J, Dutta A. Profile of adolescents with severe anemia admitted in a tertiary care hospital in Northern India. Indian J Pediatr 2011;78(7):863-5.
- 19. Alvarez-Uria G, Naik PK, Midde M, Yalla PS, Pakam R. Prevalence and severity of anaemia stratified by age and gender in Rural India. Anemia 2014;2014:176182.
- 1. Sullivan KM, Mei Z, Grummer-Strawn L, Parvanta I. Haemoglobin adjustments to define anaemia. Trop Med Int Health 2008;13(10):1267-71.
- 2. WHO’s Certified[ Internet]. Vitamin and Mineral Nutrition Information System [Internet] Switzerland: Hemoglobin concentrations for the diagnosis of anemia and assesment of severity. C 2000-1. Availabel from: http://www.who.int/vmnis/indicators/haemoglobin.
- 3. Hensbrock MB, Jonker F, Bates I. Severe acquired anaemia in Africa: new concepts. Br J Haematol 2011;154:690-95.
- 4. Sloniewsky D. Anemia and transfusion in critically ill pediatric patients: a review of etiology, management, and outcomes. Crit Care Clin 2013;29(2):301-17.
- 5. Özdemir N. Iron deficiency anemia from diagnosis to treatment in children. Turk Pediatri Ars 2015;50(1):11–9.
- 6. Baumgartner MR. Vitamin-responsive disorders: cobalamin, folate, biotin, vitamins B1 and E. Handb Clin Neurol 2013;113:1799-810.
- 7. Loiselle K, Lee JL, Szulczewski L, Drake S, Crosby LE, Pai AL. Systematic and Meta-Analytic Review: Medication Adherence Among Pediatric Patients With Sickle Cell Disease. J Pediatr Psychol 2016;41(4):406-18.
- 8. Pasricha SR, Drakesmith H. Iron Deficiency Anemia: Problems in Diagnosis and Prevention at the Population Level. Hematol Oncol Clin North Am 2016;30(2):309-25.
- 9. Güvenç H, Aygün AD, Soylu F, Kocabay K. Çocukluk döneminde derin anemi etyolojisinde demir eksikliğinin önemi. MN Pediatri 1994;1:149-52.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 15, 2016 |
| Submission Date | February 2, 2018 |
| Acceptance Date | February 17, 2018 |
| Published in Issue | Year 2016 Volume: 2 Issue: 3 |
