Research Article
BibTex RIS Cite

Konjenital Üriner Sistem Anomalileri ile Ebeveyn Yaşı Arasındaki İlişkinin Değerlendirilmesi

Year 2024, Volume: 8 Issue: 1, 1 - 13, 30.04.2024

Dilek Orbatu Alper Soylu Salih Kavukçu

https://doi.org/10.33716/bmedj.1385852

Abstract

Amaç: Böbrek ve idrar yollarının konjenital anomalileri (BİYKA) yenidoğanlarda en sık görülen doğum defektlerindendir. Bu çalışma ile çocukluk çağında önemli bir morbidite nedeni olan ve ilerleyen dönemde kronik böbrek hastalığına yol açabileceği düşünülen BİYKA tanısı için ebeveyn yaşının etkisi araştırıldı. Gereç- Yöntem: Bu retrospektif vaka kontrol çalışması Mart 2013-Şubat 2018 tarihleri arasında Dokuz Eylül Üniversitesi Tıp Fakültesi Çocuk Nefroloji Kliniği ile Sağlık Bilimleri Üniversitesi Tepecik Eğitim ve Araştırma Hastanesi Çocuk Kliniği’ne başvuran antenatal böbrek ve idrar yollarının konjenital anomalileri tanısı almış 714 hastanın bilgisayar tabanlı medikal kayıtları incelenerek yapılmıştır. Böbrek ve idrar yollarının konjenital anomalileri tipi (hidronefroz, ektopi, agenezi, multikistik displastik böbrek, çift toplayıcı sistem, üreteropelvik darlık, hipoplazi) ile doğum esnasındaki anne ve baba yaşları kaydedilmiştir. Kontrol grubunu ise aynı tarih aralığında doğan ve herhangi bir anomalisi olmayan sağlıklı infantlar oluşturmaktadır. Bulgular: Çalışmaya dahil edilen toplam 2178 olgunun 714’ü böbrek ve idrar yollarının konjenital anomalileri tanısı alan 1464’ü ise sağlıklı infantlardan oluşmaktaydı. Böbrek ve idrar yollarının konjenital anomalileri tanısı alan infantların anne ve baba yaş ortalamaları kontrol grubuna göre daha düşük saptandı. En sık tanı alan böbrek ve idrar yollarının konjenital anomalileri tipi hidronefrozdu (627 hasta, %87,8). Anne yaşı ile herhangi bir böbrek ve idrar yollarının konjenital anomalileri tipi arasında ilişki saptanmazken, hidronefroz ile baba yaşı arasında pozitif yönlü çok düşük düzeyde istatistiksel olarak önemli bir ilişki saptanmıştır (rho=0,08; p=0,032). Sonuç: Paternal yaş ve hidronefroz arasında düşük düzeyde istatistiksel anlamlılık saptanmıştır.

Keywords

Ebeveyn yaşı Çocukluk çağı Konjenital böbrek hastalığı

References

  • Amri, K., Freund, N., Vilar, J., Merlet-Bénichou, C., & Lelièvre-Pégorier, M. (1999). Adverse effects of hyperglycemia on kidney development in rats: in vivo and in vitro studies. Diabetes, 48(11), 2240–2245. https://doi.org/10.2337/diabetes.48.11.2240
  • Andrés-Jensen, L., Jørgensen, F. S., Thorup, J., Flachs, J., Madsen, J. L., Maroun, L. L., Nørgaard, P., Vinicoff, P. G., Olsen, B. H., & Cortes, D. (2016). The outcome of antenatal ultrasound diagnosed anomalies of the kidney and urinary tract in a large Danish birth cohort. Archives of disease in childhood, 101(9), 819–824. https://doi.org/10.1136/archdischild-2015-309784
  • Bondagji, N. S. Antenatal diagnosis, prevalence and outcome of congenital anomalies of the kidney and urinary tract in Saudi Arabia. Urology Annals, 6(1), 36-40. https://doi.org/10.4103/0974-7796.127021
  • Brown, T., Mandell, J., & Lebowitz, R. L. (1987). Neonatal hydronephrosis in the era of sonography. AJR. American journal of roentgenology, 148(5), 959–963. https://doi.org/10.2214/ajr.148.5.959
  • European Surveillance of Congenital Anomalies. 2013. Prevalence tables 2008–2012. Ispra, Italy: EUROCAT.
  • Fall, C. H., Sachdev, H. S., Osmond, C., Restrepo-Mendez, M. C., Victora, C., Martorell, R., Stein, A. D., Sinha, S., Tandon, N., Adair, L., Bas, I., Norris, S., Richter, L. M., & COHORTS investigators (2015). Association between maternal age at childbirth and child and adult outcomes in the offspring: a prospective study in five low-income and middle-income countries (COHORTS collaboration). The Lancet. Global health, 3(7), e366–e377. https://doi.org/10.1016/S2214-109X(15)00038-8
  • Garne, E., Loane, M., Wellesley, D., Barisic, I., & Eurocat Working Group (2009). Congenital hydronephrosis: prenatal diagnosis and epidemiology in Europe. Journal of pediatric urology, 5(1), 47–52. https://doi.org/10.1016/j.jpurol.2008.08.010
  • Groen In 't Woud, S., Renkema, K. Y., Schreuder, M. F., Wijers, C. H., van der Zanden, L. F., Knoers, N. V., Feitz, W. F., Bongers, E. M., Roeleveld, N., & van Rooij, I. A. (2016). Maternal risk factors involved in specific congenital anomalies of the kidney and urinary tract: A case-control study. Birth defects research. Part A, Clinical and molecular teratology, 106(7), 596–603. https://doi.org/10.1002/bdra.23500
  • Jacobsson, B., Ladfors, L., & Milsom, I. (2004). Advanced maternal age and adverse perinatal outcome. Obstetrics and gynecology, 104(4), 727–733. https://doi.org/10.1097/01.AOG.0000140682.63746.be
  • Khandwala, Y. S., Zhang, C. A., Lu, Y., & Eisenberg, M. L. (2017). The age of fathers in the USA is rising: an analysis of 168 867 480 births from 1972 to 2015. Human reproduction (Oxford, England), 32(10), 2110–2116. https://doi.org/10.1093/humrep/dex267
  • Kovac, J. R., Addai, J., Smith, R. P., Coward, R. M., Lamb, D. J., & Lipshultz, L. I. (2013). The effects of advanced paternal age on fertility. Asian Journal of Andrology, 15(6), 723-728. https://doi.org/10.1038/aja.2013.92
  • Laurichesse Delmas, H., Kohler, M., Doray, B., Lémery, D., Francannet, C., Quistrebert, J., Marie, C., & Perthus, I. (2017). Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries. Birth defects research, 109(15), 1204–1211. https://doi.org/10.1002/bdr2.1065
  • Liang, J., Guo, Y., Dai, M., Xiao, Q., Cai, W., Wei, Y., Amakye, W. K., Jing, J., & Zhang, Z. (2018). Differences in relationships of maternal and paternal age at childbirth with body fat distribution in offspring. American journal of human biology: the official journal of the Human Biology Council, 30(6), e23143. https://doi.org/10.1002/ajhb.23143
  • Macumber, I., Schwartz, S., & Leca, N. (2017). Maternal obesity is associated with congenital anomalies of the kidney and urinary tract in offspring. Pediatric nephrology (Berlin, Germany), 32(4), 635–642. https://doi.org/10.1007/s00467-016-3543-x
  • Nicolaou, N., Renkema, K. Y., Bongers, E. M., Giles, R. H., & Knoers, N. V. (2015). Genetic, environmental, and epigenetic factors involved in CAKUT. Nature reviews. Nephrology, 11(12), 720–731. https://doi.org/10.1038/nrneph.2015.140
  • Oldereid, N. B., Wennerholm, U. B., Pinborg, A., Loft, A., Laivuori, H., Petzold, M., Romundstad, L. B., Söderström-Anttila, V., & Bergh, C. (2018). The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis. Human reproduction update, 24(3), 320–389. https://doi.org/10.1093/humupd/dmy005
  • Parikh, C. R., McCall, D., Engelman, C., & Schrier, R. W. (2002). Congenital renal agenesis: case-control analysis of birth characteristics. American journal of kidney diseases: the official journal of the National Kidney Foundation, 39(4), 689–694. https://doi.org/10.1053/ajkd.2002.31982
  • Pope, J. C., 4th, Brock, J. W., 3rd, Adams, M. C., Stephens, F. D., & Ichikawa, I. (1999). How they begin and how they end: classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract, CAKUT. Journal of the American Society of Nephrology: JASN, 10(9), 2018–2028. https://doi.org/10.1681/ASN.V1092018
  • Postoev, V. A., Grjibovski, A. M., Kovalenko, A. A., Anda, E. E., Nieboer, E., & Odland, J. Ø. (2016). Congenital anomalies of the kidney and the urinary tract: A murmansk county birth registry study. Birth defects research. Part A, Clinical and molecular teratology, 106(3), 185–193. https://doi.org/10.1002/bdra.23475
  • Sanna-Cherchi, S., Caridi, G., Weng, P. L., Scolari, F., Perfumo, F., Gharavi, A. G., & Ghiggeri, G. M. (2007). Genetic approaches to human renal agenesis/hypoplasia and dysplasia. Pediatric Nephrology (Berlin, Germany), 22(10), 1675-1684. https://doi.org/10.1007/s00467-007-0479-1
  • Tain, Y. L., Luh, H., Lin, C. Y., & Hsu, C. N. (2016). Incidence and Risks of Congenital Anomalies of Kidney and Urinary Tract in Newborns: A Population-Based Case-Control Study in Taiwan. Medicine, 95(5), e2659. https://doi.org/10.1097/MD.0000000000002659
  • Troisi, R., Potischman, N., Roberts, J. M., Ness, R., Crombleholme, W., Lykins, D., Siiteri, P., & Hoover, R. N. (2003). Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies. International journal of epidemiology, 32(3), 455–460. https://doi.org/10.1093/ije/dyg094
  • Woroniecki, R., Gaikwad, A. B., & Susztak, K. (2011). Fetal environment, epigenetics, and pediatric renal disease. Pediatric Nephrology (Berlin, Germany), 26(5), 705. https://doi.org/10.1007/s00467-010-1714-8
  • Wennberg, A. L., Opdahl, S., Bergh, C., Aaris Henningsen, A. K., Gissler, M., Romundstad, L. B., Pinborg, A., Tiitinen, A., Skjærven, R., & Wennerholm, U. B. (2016). Effect of maternal age on maternal and neonatal outcomes after assisted reproductive technology. Fertility and sterility, 106(5), 1142–1149.e14. https://doi.org/10.1016/j.fertnstert.2016.06.021

Year 2024, Volume: 8 Issue: 1, 1 - 13, 30.04.2024

Dilek Orbatu Alper Soylu Salih Kavukçu

https://doi.org/10.33716/bmedj.1385852

Abstract

References

  • Amri, K., Freund, N., Vilar, J., Merlet-Bénichou, C., & Lelièvre-Pégorier, M. (1999). Adverse effects of hyperglycemia on kidney development in rats: in vivo and in vitro studies. Diabetes, 48(11), 2240–2245. https://doi.org/10.2337/diabetes.48.11.2240
  • Andrés-Jensen, L., Jørgensen, F. S., Thorup, J., Flachs, J., Madsen, J. L., Maroun, L. L., Nørgaard, P., Vinicoff, P. G., Olsen, B. H., & Cortes, D. (2016). The outcome of antenatal ultrasound diagnosed anomalies of the kidney and urinary tract in a large Danish birth cohort. Archives of disease in childhood, 101(9), 819–824. https://doi.org/10.1136/archdischild-2015-309784
  • Bondagji, N. S. Antenatal diagnosis, prevalence and outcome of congenital anomalies of the kidney and urinary tract in Saudi Arabia. Urology Annals, 6(1), 36-40. https://doi.org/10.4103/0974-7796.127021
  • Brown, T., Mandell, J., & Lebowitz, R. L. (1987). Neonatal hydronephrosis in the era of sonography. AJR. American journal of roentgenology, 148(5), 959–963. https://doi.org/10.2214/ajr.148.5.959
  • European Surveillance of Congenital Anomalies. 2013. Prevalence tables 2008–2012. Ispra, Italy: EUROCAT.
  • Fall, C. H., Sachdev, H. S., Osmond, C., Restrepo-Mendez, M. C., Victora, C., Martorell, R., Stein, A. D., Sinha, S., Tandon, N., Adair, L., Bas, I., Norris, S., Richter, L. M., & COHORTS investigators (2015). Association between maternal age at childbirth and child and adult outcomes in the offspring: a prospective study in five low-income and middle-income countries (COHORTS collaboration). The Lancet. Global health, 3(7), e366–e377. https://doi.org/10.1016/S2214-109X(15)00038-8
  • Garne, E., Loane, M., Wellesley, D., Barisic, I., & Eurocat Working Group (2009). Congenital hydronephrosis: prenatal diagnosis and epidemiology in Europe. Journal of pediatric urology, 5(1), 47–52. https://doi.org/10.1016/j.jpurol.2008.08.010
  • Groen In 't Woud, S., Renkema, K. Y., Schreuder, M. F., Wijers, C. H., van der Zanden, L. F., Knoers, N. V., Feitz, W. F., Bongers, E. M., Roeleveld, N., & van Rooij, I. A. (2016). Maternal risk factors involved in specific congenital anomalies of the kidney and urinary tract: A case-control study. Birth defects research. Part A, Clinical and molecular teratology, 106(7), 596–603. https://doi.org/10.1002/bdra.23500
  • Jacobsson, B., Ladfors, L., & Milsom, I. (2004). Advanced maternal age and adverse perinatal outcome. Obstetrics and gynecology, 104(4), 727–733. https://doi.org/10.1097/01.AOG.0000140682.63746.be
  • Khandwala, Y. S., Zhang, C. A., Lu, Y., & Eisenberg, M. L. (2017). The age of fathers in the USA is rising: an analysis of 168 867 480 births from 1972 to 2015. Human reproduction (Oxford, England), 32(10), 2110–2116. https://doi.org/10.1093/humrep/dex267
  • Kovac, J. R., Addai, J., Smith, R. P., Coward, R. M., Lamb, D. J., & Lipshultz, L. I. (2013). The effects of advanced paternal age on fertility. Asian Journal of Andrology, 15(6), 723-728. https://doi.org/10.1038/aja.2013.92
  • Laurichesse Delmas, H., Kohler, M., Doray, B., Lémery, D., Francannet, C., Quistrebert, J., Marie, C., & Perthus, I. (2017). Congenital unilateral renal agenesis: Prevalence, prenatal diagnosis, associated anomalies. Data from two birth-defect registries. Birth defects research, 109(15), 1204–1211. https://doi.org/10.1002/bdr2.1065
  • Liang, J., Guo, Y., Dai, M., Xiao, Q., Cai, W., Wei, Y., Amakye, W. K., Jing, J., & Zhang, Z. (2018). Differences in relationships of maternal and paternal age at childbirth with body fat distribution in offspring. American journal of human biology: the official journal of the Human Biology Council, 30(6), e23143. https://doi.org/10.1002/ajhb.23143
  • Macumber, I., Schwartz, S., & Leca, N. (2017). Maternal obesity is associated with congenital anomalies of the kidney and urinary tract in offspring. Pediatric nephrology (Berlin, Germany), 32(4), 635–642. https://doi.org/10.1007/s00467-016-3543-x
  • Nicolaou, N., Renkema, K. Y., Bongers, E. M., Giles, R. H., & Knoers, N. V. (2015). Genetic, environmental, and epigenetic factors involved in CAKUT. Nature reviews. Nephrology, 11(12), 720–731. https://doi.org/10.1038/nrneph.2015.140
  • Oldereid, N. B., Wennerholm, U. B., Pinborg, A., Loft, A., Laivuori, H., Petzold, M., Romundstad, L. B., Söderström-Anttila, V., & Bergh, C. (2018). The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis. Human reproduction update, 24(3), 320–389. https://doi.org/10.1093/humupd/dmy005
  • Parikh, C. R., McCall, D., Engelman, C., & Schrier, R. W. (2002). Congenital renal agenesis: case-control analysis of birth characteristics. American journal of kidney diseases: the official journal of the National Kidney Foundation, 39(4), 689–694. https://doi.org/10.1053/ajkd.2002.31982
  • Pope, J. C., 4th, Brock, J. W., 3rd, Adams, M. C., Stephens, F. D., & Ichikawa, I. (1999). How they begin and how they end: classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract, CAKUT. Journal of the American Society of Nephrology: JASN, 10(9), 2018–2028. https://doi.org/10.1681/ASN.V1092018
  • Postoev, V. A., Grjibovski, A. M., Kovalenko, A. A., Anda, E. E., Nieboer, E., & Odland, J. Ø. (2016). Congenital anomalies of the kidney and the urinary tract: A murmansk county birth registry study. Birth defects research. Part A, Clinical and molecular teratology, 106(3), 185–193. https://doi.org/10.1002/bdra.23475
  • Sanna-Cherchi, S., Caridi, G., Weng, P. L., Scolari, F., Perfumo, F., Gharavi, A. G., & Ghiggeri, G. M. (2007). Genetic approaches to human renal agenesis/hypoplasia and dysplasia. Pediatric Nephrology (Berlin, Germany), 22(10), 1675-1684. https://doi.org/10.1007/s00467-007-0479-1
  • Tain, Y. L., Luh, H., Lin, C. Y., & Hsu, C. N. (2016). Incidence and Risks of Congenital Anomalies of Kidney and Urinary Tract in Newborns: A Population-Based Case-Control Study in Taiwan. Medicine, 95(5), e2659. https://doi.org/10.1097/MD.0000000000002659
  • Troisi, R., Potischman, N., Roberts, J. M., Ness, R., Crombleholme, W., Lykins, D., Siiteri, P., & Hoover, R. N. (2003). Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies. International journal of epidemiology, 32(3), 455–460. https://doi.org/10.1093/ije/dyg094
  • Woroniecki, R., Gaikwad, A. B., & Susztak, K. (2011). Fetal environment, epigenetics, and pediatric renal disease. Pediatric Nephrology (Berlin, Germany), 26(5), 705. https://doi.org/10.1007/s00467-010-1714-8
  • Wennberg, A. L., Opdahl, S., Bergh, C., Aaris Henningsen, A. K., Gissler, M., Romundstad, L. B., Pinborg, A., Tiitinen, A., Skjærven, R., & Wennerholm, U. B. (2016). Effect of maternal age on maternal and neonatal outcomes after assisted reproductive technology. Fertility and sterility, 106(5), 1142–1149.e14. https://doi.org/10.1016/j.fertnstert.2016.06.021
There are 24 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences (Other)
Journal Section MAKALELER
Authors

Dilek Orbatu 0000-0002-5716-2938

Alper Soylu 0000-0002-5901-7398

Salih Kavukçu 0000-0002-9959-881X

Publication Date April 30, 2024
Submission Date November 18, 2023
Acceptance Date March 22, 2024
Published in Issue Year 2024 Volume: 8 Issue: 1

Cite

APA Orbatu, D., Soylu, A., & Kavukçu, S. (2024). Konjenital Üriner Sistem Anomalileri ile Ebeveyn Yaşı Arasındaki İlişkinin Değerlendirilmesi. Balıkesir Medical Journal, 8(1), 1-13. https://doi.org/10.33716/bmedj.1385852
 Download Cover Image

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.