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INH Direnç Mekanizmaları

Year 2017, Volume: 44 Issue: 3, 287 - 292, 20.09.2017

Tanseli Gönlügür Ugur Gönlügür

https://doi.org/10.5798/dicletip.339020

Abstract



Her ne kadar izoniazid (INH) ‘ın Mycobacterium tuberculosis üzerindeki etki mekanizması tam anlaşılamamış olsa da öncü ilaç olan INH sitoplazmaya
pasif difüzyon ile girmektedir. KatG geni tarafından kodlanan katalaz/peroksidaz
enzimi ile aktiflenmektedir.
INH
‘ın aktiflenmesi ile serbest metabolik radikaller oluşmakta, bunlar da mikolik asit
sentezi gibi pek çok hücresel fonksiyonu bozmaktadırlar.
KatG mutasyonları INH direncinin ana sebebidir. INH 'a dirençli klinik izolatların % 50 'den fazlasında katG 315. pozisyonda serin yerine treonin 'in değiştiği bir mutasyon vardır. İnhA, ndh ve pompa genleri gibi genler de INH direncine katkıda bulunabilirler. Bu derleme yazısı
Mycobacterium tuberculosis 'de INH etki mekanizmasını ve ilaç direncinin moleküler temellerini özetlemektedir.

Keywords

İzoniazid direnç mekanizma tüberküloz

References

  • 1. Unissa AN, Subbian S, Hanna LE, Selvakumar N. Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis. Infect Genet Evol. 2016; 45:474-92.
  • 2. Ramaswamy S, Musser JM. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis. 1998; 79:3-29.
  • 3. Heym B, Saint-Joanis B, Cole ST. The molecular basis of isoniazid resistance in Mycobacterium tuberculosis. Tuber Lung Dis. 1999; 79:267-71.
  • 4. Nasiri MJ, Haeili M, Ghazi M, et al. New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria. Front Microbiol. 2017;8:681.
  • 5. Zhang Y, Yew WW. Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015. Int J Tuberc Lung Dis. 2015; 19:1276-89.
  • 6. Timmins GS, Deretic V. Mechanisms of action of isoniazid. Mol Microbiol. 2006; 62:1220-7.
  • 7. Musser JM. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin Microbiol Rev. 1995; 8:496–514.
  • 8. Cohn ML, Kovitz C, Oda U, Middlebrook G. Studies on isoniazid and tubercle bacilli. II. The growth requirements, catalase activities, and pathogenic properties of isoniazid-resistant mutants. Am Rev Tuberc. 1954; 70:641-64.
  • 9. Almeida Da Silva PE, Palomino JC. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs. J Antimicrob Chemother. 2011; 66:1417-30.
  • 10. Cade CE, Dlouhy AC, Medzihradszky KF, et al. Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities. Protein Sci.2010; 19:458-74.
  • 11. Rahim Z, Nakajima C, Raqib R, Zaman K, Endtz HP, van der Zanden AG, Suzuki Y. Molecular mechanism of rifampicin and isoniazid resistance in Mycobacterium tuberculosis from Bangladesh. Tuberculosis (Edinb). 2012; 92:529-34.
  • 12. Aslan G, Tezcan S, Serin MS, Emekdas G. Genotypic analysis of isoniazid and rifampin resistance in drug- resistant clinical Mycobacterium tuberculosis complex isolates in southern Turkey. Jpn J Infect Dis. 2008; 61:255-60.
  • 13. Barry CE 3rd, Slayden RA, Mdluli K. Mechanisms of isoniazid resistance in Mycobacterium tuberculosis. Drug Resist Updat. 1998;1: 128-34. 14. Slayden RA, Barry CE 3rd. The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis. Microbes Infect. 2000;2: 659-69.
  • 15. Pinheiro M, Silva AS, Pisco S, Reis S. Interactions of isoniazid with membrane models: implications for drug mechanism of action. Chem Phys Lipids. 2014;183:184-90.
  • 16. Wayne LG, Hayes LG. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun. 1996; 64:2062-9.
  • 17. Betts JC, Lukey PT, Robb LC, et al. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol Microbiol. 2002; 43:717-31.
  • 18. Voskuil MI, Schnappinger D, Visconti KC, et al. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J Exp Med. 2003; 198:705-13.
  • 19. Lavollay M, Arthur M, Fourgeaud M, et al. The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation. J Bacteriol. 2008;190:4360-6.
  • 20. Ramos RM, Perez JM, Baptista LA, de Amorim HL. Interaction of wild type, G68R and L125M isoforms of the arylamine-N-acetyltransferase from Myco- bacterium tuberculosis with isoniazid: a computational study on a new possible mechanism ofresistance. J Mol Model. 2012;18:4013-24.
  • 21. Zhang M, Yue J, Yang YP, et al. Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China. J Clin Microbiol. 2005;43:5477-82.
  • 22. Nandakumar M, Nathan C, Rhee KY. Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nat Commun. 2014; 5:4306.

Year 2017, Volume: 44 Issue: 3, 287 - 292, 20.09.2017

Tanseli Gönlügür Ugur Gönlügür

https://doi.org/10.5798/dicletip.339020

Abstract

References

  • 1. Unissa AN, Subbian S, Hanna LE, Selvakumar N. Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis. Infect Genet Evol. 2016; 45:474-92.
  • 2. Ramaswamy S, Musser JM. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber Lung Dis. 1998; 79:3-29.
  • 3. Heym B, Saint-Joanis B, Cole ST. The molecular basis of isoniazid resistance in Mycobacterium tuberculosis. Tuber Lung Dis. 1999; 79:267-71.
  • 4. Nasiri MJ, Haeili M, Ghazi M, et al. New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria. Front Microbiol. 2017;8:681.
  • 5. Zhang Y, Yew WW. Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015. Int J Tuberc Lung Dis. 2015; 19:1276-89.
  • 6. Timmins GS, Deretic V. Mechanisms of action of isoniazid. Mol Microbiol. 2006; 62:1220-7.
  • 7. Musser JM. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin Microbiol Rev. 1995; 8:496–514.
  • 8. Cohn ML, Kovitz C, Oda U, Middlebrook G. Studies on isoniazid and tubercle bacilli. II. The growth requirements, catalase activities, and pathogenic properties of isoniazid-resistant mutants. Am Rev Tuberc. 1954; 70:641-64.
  • 9. Almeida Da Silva PE, Palomino JC. Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs. J Antimicrob Chemother. 2011; 66:1417-30.
  • 10. Cade CE, Dlouhy AC, Medzihradszky KF, et al. Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities. Protein Sci.2010; 19:458-74.
  • 11. Rahim Z, Nakajima C, Raqib R, Zaman K, Endtz HP, van der Zanden AG, Suzuki Y. Molecular mechanism of rifampicin and isoniazid resistance in Mycobacterium tuberculosis from Bangladesh. Tuberculosis (Edinb). 2012; 92:529-34.
  • 12. Aslan G, Tezcan S, Serin MS, Emekdas G. Genotypic analysis of isoniazid and rifampin resistance in drug- resistant clinical Mycobacterium tuberculosis complex isolates in southern Turkey. Jpn J Infect Dis. 2008; 61:255-60.
  • 13. Barry CE 3rd, Slayden RA, Mdluli K. Mechanisms of isoniazid resistance in Mycobacterium tuberculosis. Drug Resist Updat. 1998;1: 128-34. 14. Slayden RA, Barry CE 3rd. The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis. Microbes Infect. 2000;2: 659-69.
  • 15. Pinheiro M, Silva AS, Pisco S, Reis S. Interactions of isoniazid with membrane models: implications for drug mechanism of action. Chem Phys Lipids. 2014;183:184-90.
  • 16. Wayne LG, Hayes LG. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun. 1996; 64:2062-9.
  • 17. Betts JC, Lukey PT, Robb LC, et al. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol Microbiol. 2002; 43:717-31.
  • 18. Voskuil MI, Schnappinger D, Visconti KC, et al. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J Exp Med. 2003; 198:705-13.
  • 19. Lavollay M, Arthur M, Fourgeaud M, et al. The peptidoglycan of stationary-phase Mycobacterium tuberculosis predominantly contains cross-links generated by L,D-transpeptidation. J Bacteriol. 2008;190:4360-6.
  • 20. Ramos RM, Perez JM, Baptista LA, de Amorim HL. Interaction of wild type, G68R and L125M isoforms of the arylamine-N-acetyltransferase from Myco- bacterium tuberculosis with isoniazid: a computational study on a new possible mechanism ofresistance. J Mol Model. 2012;18:4013-24.
  • 21. Zhang M, Yue J, Yang YP, et al. Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China. J Clin Microbiol. 2005;43:5477-82.
  • 22. Nandakumar M, Nathan C, Rhee KY. Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nat Commun. 2014; 5:4306.
There are 21 citations in total.

Details

Journal Section Collection
Authors

Tanseli Gönlügür This is me 0000-0003-0751-6184

Ugur Gönlügür 0000-0001-8720-2788

Publication Date September 20, 2017
Submission Date September 20, 2017
Published in Issue Year 2017 Volume: 44 Issue: 3

Cite

APA Gönlügür, T., & Gönlügür, U. (2017). INH Direnç Mekanizmaları. Dicle Tıp Dergisi, 44(3), 287-292. https://doi.org/10.5798/dicletip.339020
AMA Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. diclemedj. September 2017;44(3):287-292. doi:10.5798/dicletip.339020
Chicago Gönlügür, Tanseli, and Ugur Gönlügür. “INH Direnç Mekanizmaları”. Dicle Tıp Dergisi 44, no. 3 (September 2017): 287-92. https://doi.org/10.5798/dicletip.339020.
EndNote Gönlügür T, Gönlügür U (September 1, 2017) INH Direnç Mekanizmaları. Dicle Tıp Dergisi 44 3 287–292.
IEEE T. Gönlügür and U. Gönlügür, “INH Direnç Mekanizmaları”, diclemedj, vol. 44, no. 3, pp. 287–292, 2017, doi: 10.5798/dicletip.339020.
ISNAD Gönlügür, Tanseli - Gönlügür, Ugur. “INH Direnç Mekanizmaları”. Dicle Tıp Dergisi 44/3 (September 2017), 287-292. https://doi.org/10.5798/dicletip.339020.
JAMA Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. diclemedj. 2017;44:287–292.
MLA Gönlügür, Tanseli and Ugur Gönlügür. “INH Direnç Mekanizmaları”. Dicle Tıp Dergisi, vol. 44, no. 3, 2017, pp. 287-92, doi:10.5798/dicletip.339020.
Vancouver Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. diclemedj. 2017;44(3):287-92.