Q ATEŞİ ENFEKSİYONUN KEMİK EKLEM TUTULUMLARI

Sevil Alkan; Süleyman Kaan Öner; Süleyman Kozlu

Review

BONE JOINT INVOLVEMENTS OF Q FEVER INFECTION

Year 2023, Volume: 5 Issue: 2 - Dental and Medical Journal - Review, 12 - 20, 30.06.2023

Sevil Alkan Süleyman Kaan Öner Süleyman Kozlu

Abstract

Q fever is a zoonotic disease caused by an obligate intracellular Gram-negative bacterium called Coxiella burnetii that causes acute and chronic clinical symptoms. This disease is associated with a wide clinical spectrum, from asymptomatic or mildly symptomatic infection to fatal disease. Q fever osteomyelitis is probably an underreported and underdiagnosed disease. Q fever can cause granulomatous osteomyelitis that occurs without systemic symptoms and often results in a chronic, recurrent, multifocal clinical course. In this review, we aimed to review the literature on bone and joint involvement of Q fever and to raise awareness on this issue.

Keywords

Q Fever, Osteomyelitis, Vertebral Osteomyelitis, Coxiella Burnetii, Q Ateşi, Osteomyelit, Vertebral Osteomyelit

References

1. Angelakis E, Raoult D. Q Fever. Vet Microbiol. 2010;140(3-4):297-309. doi: 10.1016/j.vetmic.2009.07.016.
2. Ekici A, Gürbüz E, Halidi AG, Ünlü AH, Aydemir S. Kene Isırığı Şikâyetiyle Hastaneye Başvuran Hastalardan Çıkarılan Kenelerde Coxiella burnetii ve Ehrlichia canis’in Moleküler Yöntemlerle Araştırılması. Commagene Journal of Biology. 2021; 5 (2): 199-203. doi: 10.31594/commagene.1037939.
3. España PP, Uranga A, Cillóniz C, Torres A. Q Fever (Coxiella Burnetii). Semin Respir Crit Care Med. 2020;41(4):509-521. doi: 10.1055/s-0040-1710594.
4. Yessinou RE, Katja MS, Heinrich N, Farougou S. Prevalence of Coxiella-infections in ticks review and meta-analysis. Ticks Tick Borne Dis. 2022;13(3):101926. doi: 10.1016/j.ttbdis.2022.101926.
5. Roest HI, Bossers A, Rebel JM. Q fever diagnosis and control in domestic ruminants. Dev Biol (Basel). 2013;135:(183-189). doi: 10.1159/000188081.
6. Souza EAR, André MR, Labruna MB, Horta MC. Q fever and coxiellosis in Brazil: an underestimated disease? A brief review. Rev Bras Parasitol Vet. 2022;31(3): e009822. doi:10.1590/S1984-29612022051.
7. Fenollar F, Fournier PE, Carrieri MP, Habib G, Messana T, Raoult D. Risks factors and prevention of Q fever endocarditis. Clin Infect Dis. 2001;33(3):312-6. doi: 10.1086/321889.
8. Angelakis E, Edouard S, Lafranchi MA, Pham T, Lafforgue P, Raoult D. Emergence of Q fever arthritis in France. J Clin Microbiol. 2014;52(4):1064-7. doi: 10.1128/JCM.03371-13.
9. Meriglier E, Sunder A, Elsendoorn A, Canoui E, Rammaert B, Million M, et al. Osteoarticular manifestations of Q fever: a case series and literature review. Clin Microbiol Infect. 2018;24(8):912-913. doi: 10.1016/j.cmi.2018.03.005.
10. Cottalorda J, Jouve JL, Bollini G, Touzet P, Poujol A, Kelberine F, Raoult D. Osteoarticular infection due to Coxiella burnetii in children. J Pediatr Orthop B. 1995;4(2):219-21. doi: 10.1097/01202412-199504020-00018.
11. Assunção H, Prata AR, Silva J, Malcata A. Polyarthritis and fever-a clinical conundrum. Rheumatology (Oxford). 2021;60(12): e438-e440. doi: 10.1093/rheumatology/keab592.
12. Özlü A. Brucellosis: A perspective from physical therapy and rehabilitation specialist. D J Med Sci 2021;7(3):323-326.
13. Raoult D, Tissot-Dupont H, Foucault C, Gouvernet J, Fournier PE, Bernit E, et al. Q fever 1985–1998. Clinical and epidemiologic features of 1,383 infections. Medicine (Baltimore).2000; 79:109–123.
14. Acquacalda E, Montaudie H, Laffont C, Fournier PE, Pulcini C. A case of multifocal chronic Q fever osteomyelitis. Infection. 2011;39(2):167-9. doi: 10.1007/s15010-010-0076-2.
15. Neth OW, Falcon D, Peromingo E, Soledad Camacho M, Rodríguez-Gallego C, Obando I. Successful management of chronic multifocal Q fever Osteomyelitis with adjuvant interferon-gamma therapy. Pediatr Infect Dis J. 2011;30(9):810-2. doi: 10.1097/INF.0b013e31821487f5.
16. Nourse C, Allworth A, Jones A, Horvath R, McCormack J, Bartlett J, et al. Three cases of Q fever osteomyelitis in children and a review of the literature. Clin Infect Dis. 2004;39(7):e61-6. doi: 10.1086/424014.
17. Miailhes P, Conrad A, Sobas C, Laurent F, Lustig S, Ferry T; Lyon BJI study group. Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin-rifampin treatment and complex reconstruction were needed for the cure. Arthroplasty. 2021;3(1):43. doi: 10.1186/s42836-021-00097-1.
18. Landais C, Fenollar F, Constantin A, Cazorla C, Guilyardi C, Lepidi H, et al. Q fever osteoarticular infection: four new cases and a review of the literature. Eur J Clin Microbiol Infect Dis. 2007;26(5):341-7. doi: 10.1007/s10096-007-0285-5.
19. Ellis ME, Smith CC, Moffat MA. Chronic or fatal Q-fever infection: a review of 16 patients seen in North-East Scotland (1967-80). Q J Med. 1983;52(205):54-66.
20. Virk A, Mahmood M, Kalra M, Bower TC, Osmon DR, Berbari EF, et al. Coxiella burnetii Multilevel Disk Space Infection, Epidural Abscess, and Vertebral Osteomyelitis Secondary to Contiguous Spread From Infected Abdominal Aortic Aneurysm or Graft: Report of 4 Cases Acquired in the US and Review of the Literature. Open Forum Infect Dis. 2017;4(4):ofx192. doi: 10.1093/ofid/ofx192.
21. Ghanem-Zoubi N, Karram T, Kagna O, Merhav G, Keidar Z, Paul M. Q fever vertebral osteomyelitis among adults: a case series and literature review. Infect Dis (Lond). 2021;53(4):231-240. doi: 10.1080/23744235.2020.1871508.
22. Buijs SB, Weehuizen JM, Oosterheert JJ, van Roeden SE. Chronic Q fever vertebral osteomyelitis, an underrecognized clinical entity. Infect Dis (Lond). 2021;53(4):241-242. doi: 10.1080/23744235.2020.1871509.
23. Cottalorda J, Jouve JL, Bollini G, Touzet P, Poujol A, Kelberine F, Raoult D. Osteoarticular infection due to Coxiella burnetii in children. J Pediatr Orthop B. 1995;4(2):219-21. doi: 10.1097/01202412-199504020-00018.
24. Poujol A, Toesca S, Di Marco JN, Rimet Y, Tissot Dupont H, Macé L, et al. Ostéites récidivantes et Coxiella burnetti: relation avec l'ostéomyélite chronique récurrente multifocale [Recurrent osteitis and Coxiella burnetii: the relation to chronic recurrent multifocal osteomyelitis]. Arch Pediatr. 1998;5(3):291-4. doi: 10.1016/s0929-693x (97)89372-4.
25. Maurin M, Raoult D. Q fever. Clin Microbiol Rev. 1999;12(4):518-53. doi: 10.1128/CMR.12.4.518.
26. Garron E, Viehweger E, Launay F, Guillaume JM, Jouve JL, Bollini G. Nontuberculous spondylodiscitis in children. J Pediatr Orthop. 2002;22(3):321-8.
27. Francis JR, Robson J, Wong D, et al. Chronic recurrent multifocal Q fever osteomyelitis in children: an emerging clinical challenge. Pediatr Infect Dis J. 2016; 35:972–976.
28. Merhej V, Tattevin P, Revest M, Le Touvet B, Raoult D. Q fever osteomyelitis: a case report and literature review. Comp Immunol Microbiol Infect Dis. 2012;35(2):169-72. doi: 10.1016/j.cimid.2011.12.008.
29. Dabaja-Younis H, Meir M, Ilivizki A, Militianu D, Eidelman M, Kassis I, Shachor-Meyouhas Y. Q Fever Osteoarticular Infection in Children. Emerg Infect Dis. 2020;26(9):2039–45. doi: 10.3201/eid2609.191360.
30. Eldin C, Mélenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, et al. From Q fever to Coxiella burnetii infection: a paradigm change. Clin Microbiol Rev. 2017; 30:115–90.
31. Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, et al. Diagnosis and management of Q fever—United States, 2013: recommendations from CDC and the Q Fever Working Group. MMWR Recomm Rep. 2013;62(RR-03):1–30.
32. Howard-Jones AR, Isaacs D. Systematic review of duration and choice of systemic antibiotic therapy for acute haematogenous bacterial osteomyelitis in children. J Paediatr Child Health. 2013; 49:760–8.
33. Melenotte C, Million M, Raoult D. New insights in Coxiella burnetii infection: diagnosis and therapeutic update. Expert Rev Anti Infect Ther. 2020; 18:75–86.
34. Hernández-Rupérez MB, Seoane-Reula E, Villa Á, Lancharro Á, Marín Arriaza M, Saavedra-Lozano J. Chronic Q Fever as Recurrent Osteoarticular Infection in Children: Case Report and Literature Review. Pediatr Infect Dis J. 2022;41(11): e489-e494. doi: 10.1097/INF.0000000000003655.
35. Ghanem-Zoubi N, Karram T, Kagna O, Merhav G, Keidar Z, Paul M. Q fever vertebral osteomyelitis among adults: a case series and literature review. Infect Dis (Lond). 2021;53(4):231-240. doi: 10.1080/23744235.2020.1871508.
36. Dorfman K, Eran A, Ghanem-Zoubi N. Q Fever Vertebral Osteomyelitis Complicating Vertebroplasty. Rambam Maimonides Med J. 2021;12(1): e0007. doi: 10.5041/RMMJ.10430.
37. Angelakis E, Raoult D. Emergence of q fever. Iran J Public Health. 2011;40(3):1–18.
38. Million M, Bellevegue L, Labussiere AS, Dekel M, Ferry T, Deroche P, et al. Culture-negative prosthetic joint arthritis related to Coxiella burnetii. Am J Med. 2014;127(8): 786.e7-786.e10. doi: 10.1016/j.amjmed.2014.03.013.
39. Weisenberg S, Perlada D, Peatman T. Q fever prosthetic joint infection. BMJ Case Rep. 2017;2017: bcr2017220541. doi: 10.1136/bcr-2017-220541.
40. Huang, Changyu et al. “Diagnosis of Coxiella burnetii Prosthetic Joint Infection Using mNGS and ptNGS: A Case Report and Literature Review.” Orthopaedic surgery vol. 15,1 (2023): 371-376. doi:10.1111/os.13600

Q ATEŞİ ENFEKSİYONUN KEMİK EKLEM TUTULUMLARI

Year 2023, Volume: 5 Issue: 2 - Dental and Medical Journal - Review, 12 - 20, 30.06.2023

Sevil Alkan Süleyman Kaan Öner Süleyman Kozlu

Abstract

Q ateşi, akut ve kronik klinik belirtilere neden olan Coxiella burnetii adlı zorunlu hücre içi Gram negatif bir bakterinin neden olduğu zoonotik bir hastalıktır. Bu hastalık, asemptomatik veya hafif semptomatik enfeksiyondan, ölümcül hastalığa kadar geniş bir klinik spektrum ile ilişkilidir. Q ateşi osteomiyeliti muhtemelen yeterince bildirilmemiş ve tanısı atlanmış olan bir hastalıktır. Q ateşi sistemik semptomlar olmadan ortaya çıkan ve sıklıkla kronik, tekrarlayan, multifokal bir klinik seyirle sonuçlanan granülomatöz osteomiyelite neden olabilir. Bu derleme çalışmasında Q ateşi hastalığının kemik eklem tutulumları konusundaki literatürü gözden geçirmeyi ve bu konuda farkındalığı arttırmayı amaçladık.

Keywords

Q Ateşi, Osteomyelit, Vertebral Osteomyelit, Coxiella Burnetii

References

1. Angelakis E, Raoult D. Q Fever. Vet Microbiol. 2010;140(3-4):297-309. doi: 10.1016/j.vetmic.2009.07.016.
2. Ekici A, Gürbüz E, Halidi AG, Ünlü AH, Aydemir S. Kene Isırığı Şikâyetiyle Hastaneye Başvuran Hastalardan Çıkarılan Kenelerde Coxiella burnetii ve Ehrlichia canis’in Moleküler Yöntemlerle Araştırılması. Commagene Journal of Biology. 2021; 5 (2): 199-203. doi: 10.31594/commagene.1037939.
3. España PP, Uranga A, Cillóniz C, Torres A. Q Fever (Coxiella Burnetii). Semin Respir Crit Care Med. 2020;41(4):509-521. doi: 10.1055/s-0040-1710594.
4. Yessinou RE, Katja MS, Heinrich N, Farougou S. Prevalence of Coxiella-infections in ticks review and meta-analysis. Ticks Tick Borne Dis. 2022;13(3):101926. doi: 10.1016/j.ttbdis.2022.101926.
5. Roest HI, Bossers A, Rebel JM. Q fever diagnosis and control in domestic ruminants. Dev Biol (Basel). 2013;135:(183-189). doi: 10.1159/000188081.
6. Souza EAR, André MR, Labruna MB, Horta MC. Q fever and coxiellosis in Brazil: an underestimated disease? A brief review. Rev Bras Parasitol Vet. 2022;31(3): e009822. doi:10.1590/S1984-29612022051.
7. Fenollar F, Fournier PE, Carrieri MP, Habib G, Messana T, Raoult D. Risks factors and prevention of Q fever endocarditis. Clin Infect Dis. 2001;33(3):312-6. doi: 10.1086/321889.
8. Angelakis E, Edouard S, Lafranchi MA, Pham T, Lafforgue P, Raoult D. Emergence of Q fever arthritis in France. J Clin Microbiol. 2014;52(4):1064-7. doi: 10.1128/JCM.03371-13.
9. Meriglier E, Sunder A, Elsendoorn A, Canoui E, Rammaert B, Million M, et al. Osteoarticular manifestations of Q fever: a case series and literature review. Clin Microbiol Infect. 2018;24(8):912-913. doi: 10.1016/j.cmi.2018.03.005.
10. Cottalorda J, Jouve JL, Bollini G, Touzet P, Poujol A, Kelberine F, Raoult D. Osteoarticular infection due to Coxiella burnetii in children. J Pediatr Orthop B. 1995;4(2):219-21. doi: 10.1097/01202412-199504020-00018.
11. Assunção H, Prata AR, Silva J, Malcata A. Polyarthritis and fever-a clinical conundrum. Rheumatology (Oxford). 2021;60(12): e438-e440. doi: 10.1093/rheumatology/keab592.
12. Özlü A. Brucellosis: A perspective from physical therapy and rehabilitation specialist. D J Med Sci 2021;7(3):323-326.
13. Raoult D, Tissot-Dupont H, Foucault C, Gouvernet J, Fournier PE, Bernit E, et al. Q fever 1985–1998. Clinical and epidemiologic features of 1,383 infections. Medicine (Baltimore).2000; 79:109–123.
14. Acquacalda E, Montaudie H, Laffont C, Fournier PE, Pulcini C. A case of multifocal chronic Q fever osteomyelitis. Infection. 2011;39(2):167-9. doi: 10.1007/s15010-010-0076-2.
15. Neth OW, Falcon D, Peromingo E, Soledad Camacho M, Rodríguez-Gallego C, Obando I. Successful management of chronic multifocal Q fever Osteomyelitis with adjuvant interferon-gamma therapy. Pediatr Infect Dis J. 2011;30(9):810-2. doi: 10.1097/INF.0b013e31821487f5.
16. Nourse C, Allworth A, Jones A, Horvath R, McCormack J, Bartlett J, et al. Three cases of Q fever osteomyelitis in children and a review of the literature. Clin Infect Dis. 2004;39(7):e61-6. doi: 10.1086/424014.
17. Miailhes P, Conrad A, Sobas C, Laurent F, Lustig S, Ferry T; Lyon BJI study group. Coxiella burnetti prosthetic joint infection in an immunocompromised woman: iterative surgeries, prolonged ofloxacin-rifampin treatment and complex reconstruction were needed for the cure. Arthroplasty. 2021;3(1):43. doi: 10.1186/s42836-021-00097-1.
18. Landais C, Fenollar F, Constantin A, Cazorla C, Guilyardi C, Lepidi H, et al. Q fever osteoarticular infection: four new cases and a review of the literature. Eur J Clin Microbiol Infect Dis. 2007;26(5):341-7. doi: 10.1007/s10096-007-0285-5.
19. Ellis ME, Smith CC, Moffat MA. Chronic or fatal Q-fever infection: a review of 16 patients seen in North-East Scotland (1967-80). Q J Med. 1983;52(205):54-66.
20. Virk A, Mahmood M, Kalra M, Bower TC, Osmon DR, Berbari EF, et al. Coxiella burnetii Multilevel Disk Space Infection, Epidural Abscess, and Vertebral Osteomyelitis Secondary to Contiguous Spread From Infected Abdominal Aortic Aneurysm or Graft: Report of 4 Cases Acquired in the US and Review of the Literature. Open Forum Infect Dis. 2017;4(4):ofx192. doi: 10.1093/ofid/ofx192.
21. Ghanem-Zoubi N, Karram T, Kagna O, Merhav G, Keidar Z, Paul M. Q fever vertebral osteomyelitis among adults: a case series and literature review. Infect Dis (Lond). 2021;53(4):231-240. doi: 10.1080/23744235.2020.1871508.
22. Buijs SB, Weehuizen JM, Oosterheert JJ, van Roeden SE. Chronic Q fever vertebral osteomyelitis, an underrecognized clinical entity. Infect Dis (Lond). 2021;53(4):241-242. doi: 10.1080/23744235.2020.1871509.
23. Cottalorda J, Jouve JL, Bollini G, Touzet P, Poujol A, Kelberine F, Raoult D. Osteoarticular infection due to Coxiella burnetii in children. J Pediatr Orthop B. 1995;4(2):219-21. doi: 10.1097/01202412-199504020-00018.
24. Poujol A, Toesca S, Di Marco JN, Rimet Y, Tissot Dupont H, Macé L, et al. Ostéites récidivantes et Coxiella burnetti: relation avec l'ostéomyélite chronique récurrente multifocale [Recurrent osteitis and Coxiella burnetii: the relation to chronic recurrent multifocal osteomyelitis]. Arch Pediatr. 1998;5(3):291-4. doi: 10.1016/s0929-693x (97)89372-4.
25. Maurin M, Raoult D. Q fever. Clin Microbiol Rev. 1999;12(4):518-53. doi: 10.1128/CMR.12.4.518.
26. Garron E, Viehweger E, Launay F, Guillaume JM, Jouve JL, Bollini G. Nontuberculous spondylodiscitis in children. J Pediatr Orthop. 2002;22(3):321-8.
27. Francis JR, Robson J, Wong D, et al. Chronic recurrent multifocal Q fever osteomyelitis in children: an emerging clinical challenge. Pediatr Infect Dis J. 2016; 35:972–976.
28. Merhej V, Tattevin P, Revest M, Le Touvet B, Raoult D. Q fever osteomyelitis: a case report and literature review. Comp Immunol Microbiol Infect Dis. 2012;35(2):169-72. doi: 10.1016/j.cimid.2011.12.008.
29. Dabaja-Younis H, Meir M, Ilivizki A, Militianu D, Eidelman M, Kassis I, Shachor-Meyouhas Y. Q Fever Osteoarticular Infection in Children. Emerg Infect Dis. 2020;26(9):2039–45. doi: 10.3201/eid2609.191360.
30. Eldin C, Mélenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, et al. From Q fever to Coxiella burnetii infection: a paradigm change. Clin Microbiol Rev. 2017; 30:115–90.
31. Anderson A, Bijlmer H, Fournier PE, Graves S, Hartzell J, Kersh GJ, et al. Diagnosis and management of Q fever—United States, 2013: recommendations from CDC and the Q Fever Working Group. MMWR Recomm Rep. 2013;62(RR-03):1–30.
32. Howard-Jones AR, Isaacs D. Systematic review of duration and choice of systemic antibiotic therapy for acute haematogenous bacterial osteomyelitis in children. J Paediatr Child Health. 2013; 49:760–8.
33. Melenotte C, Million M, Raoult D. New insights in Coxiella burnetii infection: diagnosis and therapeutic update. Expert Rev Anti Infect Ther. 2020; 18:75–86.
34. Hernández-Rupérez MB, Seoane-Reula E, Villa Á, Lancharro Á, Marín Arriaza M, Saavedra-Lozano J. Chronic Q Fever as Recurrent Osteoarticular Infection in Children: Case Report and Literature Review. Pediatr Infect Dis J. 2022;41(11): e489-e494. doi: 10.1097/INF.0000000000003655.
35. Ghanem-Zoubi N, Karram T, Kagna O, Merhav G, Keidar Z, Paul M. Q fever vertebral osteomyelitis among adults: a case series and literature review. Infect Dis (Lond). 2021;53(4):231-240. doi: 10.1080/23744235.2020.1871508.
36. Dorfman K, Eran A, Ghanem-Zoubi N. Q Fever Vertebral Osteomyelitis Complicating Vertebroplasty. Rambam Maimonides Med J. 2021;12(1): e0007. doi: 10.5041/RMMJ.10430.
37. Angelakis E, Raoult D. Emergence of q fever. Iran J Public Health. 2011;40(3):1–18.
38. Million M, Bellevegue L, Labussiere AS, Dekel M, Ferry T, Deroche P, et al. Culture-negative prosthetic joint arthritis related to Coxiella burnetii. Am J Med. 2014;127(8): 786.e7-786.e10. doi: 10.1016/j.amjmed.2014.03.013.
39. Weisenberg S, Perlada D, Peatman T. Q fever prosthetic joint infection. BMJ Case Rep. 2017;2017: bcr2017220541. doi: 10.1136/bcr-2017-220541.
40. Huang, Changyu et al. “Diagnosis of Coxiella burnetii Prosthetic Joint Infection Using mNGS and ptNGS: A Case Report and Literature Review.” Orthopaedic surgery vol. 15,1 (2023): 371-376. doi:10.1111/os.13600

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Details

Primary Language	Turkish
Subjects	Clinical Sciences
Journal Section	Basic Sciences
Authors	Sevil Alkan 0000-0003-1944-2477 Süleyman Kaan Öner 0000-0002-4333-0582 Süleyman Kozlu 0000-0001-5175-0600
Publication Date	June 30, 2023
Submission Date	December 9, 2022
Published in Issue	Year 2023 Volume: 5 Issue: 2 - Dental and Medical Journal - Review

Cite

Vancouver	Alkan S, Öner SK, Kozlu S. Q ATEŞİ ENFEKSİYONUN KEMİK EKLEM TUTULUMLARI. Dent & Med J - R. 2023;5(2):12-20.

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"The truest guide for everything in the world, for civilization, for life, for success, is science. Seeking a guide outside of science and science is heedlessness, ignorance, and deviating from the right path. It is only necessary to understand the development of science and science in every minute we live and to follow the progress in time. To attempt to apply the rules of science and science a thousand, two thousand, and thousands of years ago, today, after so many thousand years, is, of course, not to be in science and science."

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