Abstract
Introduction: Asthma is a chronic respiratory disease associated with airway inflammation. In some diseases such as vascular diseases and diabetes mellitus, the role of diet in the control of the disease is emphasized, but it is not defined as a similar causal factor in asthma. This study was planned to evaluate the relationship between vitamin D status and asthma-related respiratory results.
Methods: This single-center retrospective cohort study examined a total of 87 patients diagnosed with asthma. Vitamin D levels that were checked for any reason in the past 1 month were included in the present study. The asthma control status of the patients was determined by the Asthma Control Test (ACT). The statistical relationship between asthma control and vitamin D levels of the patients was examined.
Results: According to ACT results, 43 of the patients had controlled asthma and 44 had uncontrolled asthma. The median vitamin D level of all cases was found to be 12.80 (8.83-10.66). When vitamin D levels were compared between the controlled and uncontrolled asthma groups, they were statistically significant (p<0.001).
Conclusion: The present study showed that there is an association between low vitamin D levels and uncontrolled asthma and the researchers focused on the effect of diet on asthma-related respiratory outcomes and asthma control. Considering the cost- effectiveness, it is thought that monitoring vitamin D levels in asthma control and vitamin D replacement when necessary will contribute to the clinicians.
Keywords
Project Number
Yok
References
- 1. The Global Asthma Network. The Global Asthma Report; 2022.
- 2. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention (Update 2020). Avaliable from: https://ginasthma.org/gina-reports/.
- 3. Öngen B, Kabaroğlu C, Parıldar Z. D vitamininin biokimyasal ve laboratuvar değerlendirmesi Türk Klinik Biyokimya Derg 2008;6:23-31.
- 4. Glerup H, Mikkelsen K, Poulsen L, et al. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. Journal of Internal Medicine 2000;247:260-68.
- 5. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96:1911–30.
- 6. Wacker M, Holick MF. Vitamin D-Effects on Skeletal and Extraskeletal Health and the Need for Supplementation. Nutrients 2013;5:111-48.
- 7. Spiro A, Buttriss JL. Vitamin D: An overview of vitamin D status and intake in Europe. Nutr Bull 2014;39:322-50.
- 8. DeLuca HF. Vitamin D: Historical Overview. Vitam Horm 2016;100:1-20.
- 9. Provvedini DM, Tsoukas CD, Deftos L J, et al. 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 1983;221:1181–3.
- 10. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 2000;374:334-8.
- 11. Yawn J, Lawrence LA, Carroll WW, et al. Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning? J Steroid Biochem Mol Biol 2015;148:326–37.
- 12. Bozzetto S, Carraro S, Giordano G, et al. Asthma, allergy and respiratory infections: The vitamin D hypothesis. Allergy 2012;67:10–7.
- 13. Mahon BD, Wittke A, Weaver V, et al. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 2003;89:922–32.
- 14. Tang J, Zhou R, Luger D, et al.Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol 2009;182:4624–32.
- 15. Topilski I, Flaishon L, Naveh Y, et al. The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing. Eur J Immunol 2004;34:1068–76.
- 16. Han JC, Du J, Zhang YJ, et al. Vitamin D receptor polymorphisms may contribute to asthma risk. J Asthma 2016;53:790–800.
- 17. Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 2006;354:697–708.
- 18. Mora JR, Iwata M, von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 2008;8:685–98.
- 19. Korn S, Hubner M, Jung M, et al. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res 2013;14(1):25.
- 20. Niruban SJ, Alagiakrishnan K, Beach J, et al. Association between vitamin D and respiratory outcomes in canadian adolescents and adults. J Asthma 2015;52(7):653–61.
- 21. Wang Q, Ying Q, Zhu W, et al. Vitamin D and asthma occurrence in children: A systematic review and meta-analysis. J Pediatr Nurs 2022;62:e60-8.
- 22. Tamašauskienė L, Gasiūnienė E, Lavinskienė S, et al. Evaluation of vitamin D levels in allergic and non-allergic asthma. Medicina (Kaunas) 2015;51:321-7.
- 23. Kavitha TK, Gupta N, Kabra SK, et al. Association of Serum Vitamin D Levels with Level of Control of Childhood Asthma. Indian Pediatr 2017;54:29-32.
- 24. Sarıoglu N, Yalcın AD, Sahin F, et al. Does vitamin D deficiency in asthma affect clinical and functional parameters? A Turkish multicenter study. Allergy Asthma Proc 2021;42:e152-8.
- 25. Searing DA, Zhang Y, Murphy JR, et al. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol 2010;125:995-1000.
- 26. Jat KR, Goel N, Gupta N, et al. Efficacy of vitamin D supplementation in asthmatic children with vitamin D deficiency: a randomized controlled trial (ESDAC trial) Pediatric Allergy and Immunology 2021;32:479–488.
- 27. Katrinaki M, Kampa M, Margioris A, et al. Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values. Hormones (Athens) 2016;15:205-223.
Abstract
Giriş: Astım, hava yolu inflamasyonu ile ilişkili kronik solunum yolu hastalığıdır. Vasküler hastalıklar ve diabetes mellitus gibi bazı hastalıklarda, diyetin hastalığın kontrolündeki rolü vurgulanırken, astımda benzer bir nedensel faktör olarak tanımlanmamaktadır. Bu çalışmada, D vitamini düzeyi ile astım ilişkili solunum parametreleri arasındaki ilişkiyi değerlendirmek amaçlanmıştır.
Yöntemler: Bu çalışmada, astım tanısı konan toplam 87 hasta, tek merkezli retrospektif kohort olarak incelendi. Son 1 ay içinde herhangi bir nedenle D vitamini düzeyleri kontrol edilen hastalar çalışmaya dahil edildi. Hastaların astım kontrol durumu, Astım Kontrol Testi (AKT) ile belirlendi. Hastaların astım kontrolü ile D vitamini düzeyleri arasındaki istatistiksel ilişki incelendi.
Bulgular: AKT sonuçlarına göre, hastaların 43'ü kontrollü astım, 44'ü ise kontrolsüz astımdı. Tüm olguların medyan D vitamini düzeyi 12.80 (8.83-10.66) olduğu bulundu. D vitamini düzeyleri, kontrollü ve kontrolsüz astım gruplarında karşılaştırıldığında, aradaki fark istatistiksel olarak anlamlı bulundu (p<0.001).
Sonuç: Çalışmada diyetin astım ilişkili solunum parametreleri ve astım kontrolü üzerindeki etkisine odaklanılmıştır ve düşük D vitamini düzeyleri ile kontrolsüz astım arasında bir ilişki olduğunu gösterilmiştir. Maliyet-etkinlik göz önünde bulundurulduğunda astım kontrolünde, D vitamini düzeylerinin takibinin ve gerektiğinde D vitamini replasmanının yapılması, astım kontrolünün sağlanmasında, klinisyenlere katkı sağlayacağı düşünülmektedir.
Keywords
Supporting Institution
Yok
Project Number
Yok
Thanks
yok
References
- 1. The Global Asthma Network. The Global Asthma Report; 2022.
- 2. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention (Update 2020). Avaliable from: https://ginasthma.org/gina-reports/.
- 3. Öngen B, Kabaroğlu C, Parıldar Z. D vitamininin biokimyasal ve laboratuvar değerlendirmesi Türk Klinik Biyokimya Derg 2008;6:23-31.
- 4. Glerup H, Mikkelsen K, Poulsen L, et al. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. Journal of Internal Medicine 2000;247:260-68.
- 5. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96:1911–30.
- 6. Wacker M, Holick MF. Vitamin D-Effects on Skeletal and Extraskeletal Health and the Need for Supplementation. Nutrients 2013;5:111-48.
- 7. Spiro A, Buttriss JL. Vitamin D: An overview of vitamin D status and intake in Europe. Nutr Bull 2014;39:322-50.
- 8. DeLuca HF. Vitamin D: Historical Overview. Vitam Horm 2016;100:1-20.
- 9. Provvedini DM, Tsoukas CD, Deftos L J, et al. 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 1983;221:1181–3.
- 10. Veldman CM, Cantorna MT, DeLuca HF. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys 2000;374:334-8.
- 11. Yawn J, Lawrence LA, Carroll WW, et al. Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning? J Steroid Biochem Mol Biol 2015;148:326–37.
- 12. Bozzetto S, Carraro S, Giordano G, et al. Asthma, allergy and respiratory infections: The vitamin D hypothesis. Allergy 2012;67:10–7.
- 13. Mahon BD, Wittke A, Weaver V, et al. The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells. J Cell Biochem 2003;89:922–32.
- 14. Tang J, Zhou R, Luger D, et al.Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol 2009;182:4624–32.
- 15. Topilski I, Flaishon L, Naveh Y, et al. The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing. Eur J Immunol 2004;34:1068–76.
- 16. Han JC, Du J, Zhang YJ, et al. Vitamin D receptor polymorphisms may contribute to asthma risk. J Asthma 2016;53:790–800.
- 17. Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 2006;354:697–708.
- 18. Mora JR, Iwata M, von Andrian UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol 2008;8:685–98.
- 19. Korn S, Hubner M, Jung M, et al. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res 2013;14(1):25.
- 20. Niruban SJ, Alagiakrishnan K, Beach J, et al. Association between vitamin D and respiratory outcomes in canadian adolescents and adults. J Asthma 2015;52(7):653–61.
- 21. Wang Q, Ying Q, Zhu W, et al. Vitamin D and asthma occurrence in children: A systematic review and meta-analysis. J Pediatr Nurs 2022;62:e60-8.
- 22. Tamašauskienė L, Gasiūnienė E, Lavinskienė S, et al. Evaluation of vitamin D levels in allergic and non-allergic asthma. Medicina (Kaunas) 2015;51:321-7.
- 23. Kavitha TK, Gupta N, Kabra SK, et al. Association of Serum Vitamin D Levels with Level of Control of Childhood Asthma. Indian Pediatr 2017;54:29-32.
- 24. Sarıoglu N, Yalcın AD, Sahin F, et al. Does vitamin D deficiency in asthma affect clinical and functional parameters? A Turkish multicenter study. Allergy Asthma Proc 2021;42:e152-8.
- 25. Searing DA, Zhang Y, Murphy JR, et al. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol 2010;125:995-1000.
- 26. Jat KR, Goel N, Gupta N, et al. Efficacy of vitamin D supplementation in asthmatic children with vitamin D deficiency: a randomized controlled trial (ESDAC trial) Pediatric Allergy and Immunology 2021;32:479–488.
- 27. Katrinaki M, Kampa M, Margioris A, et al. Vitamin D levels in a large Mediterranean cohort: reconsidering normal cut-off values. Hormones (Athens) 2016;15:205-223.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Research Articles |
| Authors | |
| Project Number | Yok |
| Early Pub Date | October 16, 2023 |
| Publication Date | October 16, 2023 |
| Published in Issue | Year 2023 Volume: 4 Issue: Ek Sayı |
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