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Ege Üniversitesi Hastanesinde görülen melanom dışı deri kanserlerinin epidemiyolojik ve demografik özellikleri

Year 2020, Volume: 59 Suppl: 1 (Oncology), 97 - 108, 26.10.2020

Ayda Acar Banu Yaman Ayris Yanmaz Ayşe Hande Yoldaş Işıl Karaarslan Taner Akalın Fezal Özdemir Bengü Gerçeker Türk Ayşe Caner Gülşen Kandiloğlu Ayfer Haydaroğlu Can Ceylan

https://doi.org/10.19161/etd.815373

Abstract

Amaç: Bu çalışmada Ege Üniversitesi Hastanesi veri tabanındaki 1992-2017 yılları arası melanom dışı malign deri kanseri tanısı alan hastaların epidemiyolojik ve demografik özelliklerinin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezinin özel eğitimli ve sertifikalı kanser kayıt elemanları tarafından CANREG 4 programı ile kaydedilen 1992-2017 yılları arasında Ege Üniversitesinde kayıtlı 8395 melanom dışı malign deri kanseri tanılı hastanın; tanı yaşı, cinsiyeti, tümörün histopatolojik tanısı, tümör yerleşim yeri, hastalık evresi ve uygulanan tedavi yöntemleri değerlendirilmiştir. Kategorik değişkenler arası ilişki varlığı Ki-Kare yöntemiyle değerlendirilirken, gruplar arası nümerik değişkenler Kruskal Wallis ve Dunn Testi ile karşılaştırıldı. Tüm Hipotez testleri 0,05 önem seviyesinde uygulandı.

Bulgular: Ege Üniversitesi Kanser Araştırma Merkezinde 1992 ile 2017 yılları arasında kayıtlı melanom dışı deri kanseri olan 8395 hastanın 8386’sı dahil edildi. Hastaların %55,9’unda bazal hücreli karsinom, %30,3’ünde skuamoz hücreli karsinom, %3,6’sında malign kutanöz yumuşak doku tümörü, %3,4’ünde bazoskuamoz karsinom, %2,7’sinde kutanöz lenfoma, %1,4’ünde malign deri eki tümörü, %0,4’ünde Merkel hücreli karsinom, %2,3’ünde sınıflandırılamayan tümör mevcuttu. Hastaların %57,3’ü erkek, %42,7’si kadındı. Yaş ortalaması 63,3±14,3 idi.

Sonuçlar: Olguların çoğunu epitelyal karsinomlar oluşturmakta idi. Çalışmada en sık görülen kanser tipi bazal hücreli karsinomdu ve bunu ikinci sırada skuamoz hücreli karsinom izlemekteydi. En az görülen Merkel hücreli karsinomdu. Merkel hücreli karsinom dışında erkek cinsiyet daha baskındı. Yaş ortalaması en genç olan grup kutanöz lenfomalarken, en ileri yaş gruplu tümör skuamoz hücreli karsinomdu.

Keywords

Melanom dışı deri kanserleri bazal hücreli karsinom skuamoz hücreli karsinom bazoskuamoz karsinom kutanöz lenfoma

References

  • Apalla Z, Lallas A, Sotiriou E, Lazaridou E, Ioannides D. Epidemiological trends in skin cancer. Dermatol Pract Concept. 2017;7(2):1-6.
  • Motaparthi K, Kapil JP, Velazquez EF. Cutaneous Squamous Cell Carcinoma: Review of the Eighth Edition of the American Joint Committee on Cancer Staging Guidelines, Prognostic Factors, and Histopathologic Variants. Adv Anat Pathol. 2017;24(4):171-94.
  • Ünal İ, Acar A. Skuamoz Hücreli Karsinom.Özkan AŞ, Akyol M, Editör. Dermatoonkoloji. 1. Baskı. İzmir: O’xxTIP Kitabevi; 2019:78-92.
  • Kallini JR, Hamed N, Khachemoune A. Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends. Int J Dermatol. 2015;54(2):130-40.
  • Parekh V, Seykora JT. Cutaneous Squamous Cell Carcinoma. Clin Lab Med. 2017;37(3):503-25.
  • Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P. Guidelines of care for the management of cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2018;78(3):560-578.
  • Tanese K. Diagnosis and Management of Basal Cell Carcinoma. Curr Treat Options Oncol. 2019;20(2):13.
  • Rubin AI, Chen EH, Ratner D. Basal-cell carcinoma. N Engl J Med. 2005;353(21):2262-9.
  • Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol. 1994; 30:774-8.
  • Zanetti R, Rosso S, Martinez C, Nieto A, Miranda A, Mercier M, et al. Comparison of risk patterns in carcinoma and melanoma of the skin in men: a multiCentre case-case-control study. Br J Cancer. 2006;94:743–51
  • Boonchai W, Green A, Ng J, Dicker A, Chenevix-Trench G. Basal cell carcinoma in chronic arsenicism occurring in Queensland, Australia, after ingestion of an asthma medication. J Am Acad Dermatol. 2000;43:664–9.
  • Watt TC, Inskip PD, Stratton K, Smith SA, Kry SF, Sigurdson AJ, et al. Radiation-related risk of basal cell carcinoma: a report from the childhood cancer survivor study. J Natl Cancer Inst. 2012;104:1240–50.
  • Silverberg MJ, Leyden W, Warton EM, Quesenberry CP Jr, Engels EA, Asgari MM. HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer. J Natl Cancer Inst. 2013;105:350–60.
  • Walling HW, Fosko SW, Geraminejad PA, Whitaker DC, Arpey CJ. Aggressive basal cell carcinoma: presentation, pathogenesis, and management. Cancer Metastasis Rev 2004;23:389-402.
  • NCCN.org [homepage on the internet]. Pennsylvania: National Comprehensive Cancer Network. Basal cell skin cancer [Version 1.2020-October 24,2019]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/nmsc.pdf.
  • Tan CZ, Rieger KE, Sarin KY. Basosquamous Carcinoma: Controversy, Advances, and Future Directions. Dermatol Surg. 2017;43(1):23-31.
  • Shukla S, Khachemoune A. Reappraising basosquamous carcinoma: a summary of histologic features, diagnosis, and treatment. Arch Dermatol Res. 2020 Mar 12.
  • Güler Şimşek G, Yalçın GŞ. Deri Eki Tümörlerin Dünya Sağlık Örgütü Sınıflandırması. Güncel Patoloji Dergisi. 2019; 3(1):15-20.
  • Craig PJ. An Overview of Uncommon Cutaneous Malignancies, Including Skin Appendageal (Adnexal) Tumours and Sarcomas. Clin Oncol (R Coll Radiol). 2019;31(11):769‐78.
  • Harms PW. Update on Merkel Cell Carcinoma. Clin Lab Med. 2017;37(3):485-501.
  • Yazıcı S, Bülbül Başkan E. Merkel hücreli karsinom. Özkan AŞ, Akyol M, Editör. Dermatoonkoloji. 1. Baskı. İzmir: O’xxTIP Kitabevi; 2019:301-6.
  • Becker JC, Stang A, DeCaprio JA, et al. Merkel cell carcinoma. Nat Rev Dis Primers. 2017;3:17077.
  • Willemze R, Cerroni L, Kempf W, et al. (2019) The 2018 update of the WHOEORTC classification for primary cutaneous lymphomas. Blood. blood‐2018‐11‐881268
  • Elder DE, Massi D, Scolyer RA, Willemze R.WHO Classification of Skin Tumours. 4th ed. Lyon, France: IARC Press; 2018.
  • Foss, F. M., & Girardi, M. (2017). Mycosis Fungoides and Sezary Syndrome. Hematology/Oncology Clinics of North America, 31(2), 297–315.
  • Morales Suárez-Varela, M. M., Llopis González, A., Marquina Vila, A., & Bell, J. (2000). Mycosis fungoides: Review of Epidemiological Observations. Dermatology, 201(1), 21–8.
  • Whittaker S, Child F. Cutaneous Lymphomas. In: Griffiths C, Barker J, Bleiker T, Chalmers R, Creamer D (ed). Rook’s Textbook of Dermatology. 9th ed. Oxford, UK: Wiley-Blackwell; 2016:140.1-140.50.
  • Talpur, R., Singh, L., Daulat, S., Liu, P., Seyfer, S., Trynosky, T., Duvic, M. (2012). Long-term Outcomes of 1,263 Patients with Mycosis Fungoides and Sezary Syndrome from 1982 to 2009. Clinical Cancer Research, 18(18), 5051–60.
  • Kempf, W., Zimmermann, A., & Mitteldorf, C. (2019). Cutaneous lymphomas—An update 2019. Hematological Oncology, 37(S1), 43–7.
  • Garcia del Muro X, de Alava E, Artigas V, et al. Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma by the Spanish group for research in sarcomas (GEIS). Cancer Chemother Pharmacol. 2016;77(1):133‐46.
  • Acar A, Karaarslan I, Ozturk G, Yaman B, Ozdemir F. Reflectance confocal microscopic findings in a case of huge dermatofibrosarcoma protuberans. Wien Med Wochenschr. 2020 Mar 13.
  • 32. Acosta AE, Vélez CS. Dermatofibrosarcoma Protuberans. Curr Treat Options Oncol. 2017;18(9):56.
  • Allen A, Ahn C, Sangüeza OP. Dermatofibrosarcoma Protuberans. Dermatol Clin. 2019;37(4):483-88.
  • Etemad SA, Dewan AK. Kaposi Sarcoma Updates. Dermatol Clin. 2019;37(4):505‐17.
  • Gündüz K. Vasküler Tümörler. Özkan AŞ, Akyol M, Editör. Dermatoonkoloji. 1. Baskı. İzmir: O’xxTIP Kitabevi; 2019:261-81.
  • Ceylan C, Ozturk G, Alper S. Non-melanoma skin cancers between the years of 1990 and 1999 in Izmir, Turkey: Demographic and clinicopathological characteristics. J Dermatol 2003;30 (2):123-131.
  • Özkan A.Ş., Bazal hücreli karsinom. Özkan AŞ, Akyol M, Editör. Dermatoonkoloji. 1. Baskı. İzmir: O’xxTIP Kitabevi; 2019:48-77.
  • Wermker K, Roknic N, Goessling K, Klein M, Schulze HJ, Hallermann C. Basosquamous carcinoma of the head and neck: clinical and histologic characteristics and their impact on disease progression. Neoplasia. 2015;17(3):301-5.
  • Kohlmeyer J, Steimle-Grauer SA, Hein R. Cutaneous sarcomas. J Dtsch Dermatol Ges. 2017;15(6):630‐48.
  • Wollina U, Koch A, Hansel G, et al. A 10-year analysis of cutaneous mesenchymal tumors (sarcomas and related entities) in a skin cancer center. Int J Dermatol. 2013;52(10):1189-97.

Epidemiological and demographic characteristics of non-melanoma skin cancers in Ege University Hospital

Year 2020, Volume: 59 Suppl: 1 (Oncology), 97 - 108, 26.10.2020

Ayda Acar Banu Yaman Ayris Yanmaz Ayşe Hande Yoldaş Işıl Karaarslan Taner Akalın Fezal Özdemir Bengü Gerçeker Türk Ayşe Caner Gülşen Kandiloğlu Ayfer Haydaroğlu Can Ceylan

https://doi.org/10.19161/etd.815373

Abstract

Aim: We aimed to evaluate the epidemiological characteristics of patients diagnosed as non-melanoma skin cancer in the database of Ege University Hospital between 1992-2017

Materials and Methods: The data of 8395 patients diagnosed with non-melanoma skin cancer enrolled at Ege University between 1992-2017, recorded by the CANREG 4 program by specially trained and certified cancer registry staff of the Ege University Cancer Control Research and Application Center, were collected and evaluated in terms of age, sex, histopathological diagnosis of the tumor, tumor location, disease stage and treatment methods. While the existence of the relationship between categorical variables was evaluated with the Chi-Square method, the numerical variables between the groups were compared with the Kruskal Wallis and Dunn Test. All Hypothesis tests were applied at 0.05 significance level.


Results: 8386 of 8395 patients with non-melanoma skin cancer registered between 1992 and 2017 at the Cancer Research Center of Ege University were included. Of 55.9% patients had basal cell carcinoma, 30.3% had squamous cell carcinoma, 3.6% had malignant cutaneous soft tissue tumor , 3.4% had basosquamous carcinoma, 2.7% had cutaneous lymphoma, 1.4% had malignant cutaneous adnexal tumors, 0.4% had Merkel cell carcinoma and 2.3% had unclassified tumor. Of 57.3% patients were male and 42.7% were female. The average age was 63.3 ± 14.3.

Conclusions: In our study most of the cases were epithelial carcinomas. The most common cancer was basal cell carcinoma, followed by squamous cell carcinoma. The least common tumor was the Merkel cell carcinoma. Except Merkel cell carcinoma, the male sex was more dominant. The group with the youngest mean age was cutaneous lymphomas, while the older age group was squamous cell carcinoma.

Keywords

non-melanoma malignant skin cancer basal cell carcinoma squamous cell carcinoma basosquamous carcinoma cutaneous lymphoma survival

References

  • Apalla Z, Lallas A, Sotiriou E, Lazaridou E, Ioannides D. Epidemiological trends in skin cancer. Dermatol Pract Concept. 2017;7(2):1-6.
  • Motaparthi K, Kapil JP, Velazquez EF. Cutaneous Squamous Cell Carcinoma: Review of the Eighth Edition of the American Joint Committee on Cancer Staging Guidelines, Prognostic Factors, and Histopathologic Variants. Adv Anat Pathol. 2017;24(4):171-94.
  • Ünal İ, Acar A. Skuamoz Hücreli Karsinom.Özkan AŞ, Akyol M, Editör. Dermatoonkoloji. 1. Baskı. İzmir: O’xxTIP Kitabevi; 2019:78-92.
  • Kallini JR, Hamed N, Khachemoune A. Squamous cell carcinoma of the skin: epidemiology, classification, management, and novel trends. Int J Dermatol. 2015;54(2):130-40.
  • Parekh V, Seykora JT. Cutaneous Squamous Cell Carcinoma. Clin Lab Med. 2017;37(3):503-25.
  • Work Group; Invited Reviewers, Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P. Guidelines of care for the management of cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2018;78(3):560-578.
  • Tanese K. Diagnosis and Management of Basal Cell Carcinoma. Curr Treat Options Oncol. 2019;20(2):13.
  • Rubin AI, Chen EH, Ratner D. Basal-cell carcinoma. N Engl J Med. 2005;353(21):2262-9.
  • Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol. 1994; 30:774-8.
  • Zanetti R, Rosso S, Martinez C, Nieto A, Miranda A, Mercier M, et al. Comparison of risk patterns in carcinoma and melanoma of the skin in men: a multiCentre case-case-control study. Br J Cancer. 2006;94:743–51
  • Boonchai W, Green A, Ng J, Dicker A, Chenevix-Trench G. Basal cell carcinoma in chronic arsenicism occurring in Queensland, Australia, after ingestion of an asthma medication. J Am Acad Dermatol. 2000;43:664–9.
  • Watt TC, Inskip PD, Stratton K, Smith SA, Kry SF, Sigurdson AJ, et al. Radiation-related risk of basal cell carcinoma: a report from the childhood cancer survivor study. J Natl Cancer Inst. 2012;104:1240–50.
  • Silverberg MJ, Leyden W, Warton EM, Quesenberry CP Jr, Engels EA, Asgari MM. HIV infection status, immunodeficiency, and the incidence of non-melanoma skin cancer. J Natl Cancer Inst. 2013;105:350–60.
  • Walling HW, Fosko SW, Geraminejad PA, Whitaker DC, Arpey CJ. Aggressive basal cell carcinoma: presentation, pathogenesis, and management. Cancer Metastasis Rev 2004;23:389-402.
  • NCCN.org [homepage on the internet]. Pennsylvania: National Comprehensive Cancer Network. Basal cell skin cancer [Version 1.2020-October 24,2019]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/nmsc.pdf.
  • Tan CZ, Rieger KE, Sarin KY. Basosquamous Carcinoma: Controversy, Advances, and Future Directions. Dermatol Surg. 2017;43(1):23-31.
  • Shukla S, Khachemoune A. Reappraising basosquamous carcinoma: a summary of histologic features, diagnosis, and treatment. Arch Dermatol Res. 2020 Mar 12.
  • Güler Şimşek G, Yalçın GŞ. Deri Eki Tümörlerin Dünya Sağlık Örgütü Sınıflandırması. Güncel Patoloji Dergisi. 2019; 3(1):15-20.
  • Craig PJ. An Overview of Uncommon Cutaneous Malignancies, Including Skin Appendageal (Adnexal) Tumours and Sarcomas. Clin Oncol (R Coll Radiol). 2019;31(11):769‐78.
  • Harms PW. Update on Merkel Cell Carcinoma. Clin Lab Med. 2017;37(3):485-501.
  • Yazıcı S, Bülbül Başkan E. Merkel hücreli karsinom. Özkan AŞ, Akyol M, Editör. Dermatoonkoloji. 1. Baskı. İzmir: O’xxTIP Kitabevi; 2019:301-6.
  • Becker JC, Stang A, DeCaprio JA, et al. Merkel cell carcinoma. Nat Rev Dis Primers. 2017;3:17077.
  • Willemze R, Cerroni L, Kempf W, et al. (2019) The 2018 update of the WHOEORTC classification for primary cutaneous lymphomas. Blood. blood‐2018‐11‐881268
  • Elder DE, Massi D, Scolyer RA, Willemze R.WHO Classification of Skin Tumours. 4th ed. Lyon, France: IARC Press; 2018.
  • Foss, F. M., & Girardi, M. (2017). Mycosis Fungoides and Sezary Syndrome. Hematology/Oncology Clinics of North America, 31(2), 297–315.
  • Morales Suárez-Varela, M. M., Llopis González, A., Marquina Vila, A., & Bell, J. (2000). Mycosis fungoides: Review of Epidemiological Observations. Dermatology, 201(1), 21–8.
  • Whittaker S, Child F. Cutaneous Lymphomas. In: Griffiths C, Barker J, Bleiker T, Chalmers R, Creamer D (ed). Rook’s Textbook of Dermatology. 9th ed. Oxford, UK: Wiley-Blackwell; 2016:140.1-140.50.
  • Talpur, R., Singh, L., Daulat, S., Liu, P., Seyfer, S., Trynosky, T., Duvic, M. (2012). Long-term Outcomes of 1,263 Patients with Mycosis Fungoides and Sezary Syndrome from 1982 to 2009. Clinical Cancer Research, 18(18), 5051–60.
  • Kempf, W., Zimmermann, A., & Mitteldorf, C. (2019). Cutaneous lymphomas—An update 2019. Hematological Oncology, 37(S1), 43–7.
  • Garcia del Muro X, de Alava E, Artigas V, et al. Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma by the Spanish group for research in sarcomas (GEIS). Cancer Chemother Pharmacol. 2016;77(1):133‐46.
  • Acar A, Karaarslan I, Ozturk G, Yaman B, Ozdemir F. Reflectance confocal microscopic findings in a case of huge dermatofibrosarcoma protuberans. Wien Med Wochenschr. 2020 Mar 13.
  • 32. Acosta AE, Vélez CS. Dermatofibrosarcoma Protuberans. Curr Treat Options Oncol. 2017;18(9):56.
  • Allen A, Ahn C, Sangüeza OP. Dermatofibrosarcoma Protuberans. Dermatol Clin. 2019;37(4):483-88.
  • Etemad SA, Dewan AK. Kaposi Sarcoma Updates. Dermatol Clin. 2019;37(4):505‐17.
  • Gündüz K. Vasküler Tümörler. Özkan AŞ, Akyol M, Editör. Dermatoonkoloji. 1. Baskı. İzmir: O’xxTIP Kitabevi; 2019:261-81.
  • Ceylan C, Ozturk G, Alper S. Non-melanoma skin cancers between the years of 1990 and 1999 in Izmir, Turkey: Demographic and clinicopathological characteristics. J Dermatol 2003;30 (2):123-131.
  • Özkan A.Ş., Bazal hücreli karsinom. Özkan AŞ, Akyol M, Editör. Dermatoonkoloji. 1. Baskı. İzmir: O’xxTIP Kitabevi; 2019:48-77.
  • Wermker K, Roknic N, Goessling K, Klein M, Schulze HJ, Hallermann C. Basosquamous carcinoma of the head and neck: clinical and histologic characteristics and their impact on disease progression. Neoplasia. 2015;17(3):301-5.
  • Kohlmeyer J, Steimle-Grauer SA, Hein R. Cutaneous sarcomas. J Dtsch Dermatol Ges. 2017;15(6):630‐48.
  • Wollina U, Koch A, Hansel G, et al. A 10-year analysis of cutaneous mesenchymal tumors (sarcomas and related entities) in a skin cancer center. Int J Dermatol. 2013;52(10):1189-97.
There are 40 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Articles
Authors

Ayda Acar 0000-0001-7507-6999

Banu Yaman 0000-0002-2915-0788

Ayris Yanmaz 0000-0003-0760-9292

Ayşe Hande Yoldaş 0000-0002-2219-5422

Işıl Karaarslan 0000-0001-5348-027X

Taner Akalın 0000-0003-0785-0430

Fezal Özdemir 0000-0001-8511-4565

Bengü Gerçeker Türk 0000-0002-3926-4199

Ayşe Caner 0000-0003-3058-9971

Gülşen Kandiloğlu 0000-0003-1861-1240

Ayfer Haydaroğlu 0000-0001-5709-0981

Can Ceylan 0000-0001-6528-0566

Publication Date October 26, 2020
Submission Date August 28, 2020
Published in Issue Year 2020Volume: 59 Suppl: 1 (Oncology)

Cite

Vancouver Acar A, Yaman B, Yanmaz A, Yoldaş AH, Karaarslan I, Akalın T, Özdemir F, Gerçeker Türk B, Caner A, Kandiloğlu G, Haydaroğlu A, Ceylan C. Ege Üniversitesi Hastanesinde görülen melanom dışı deri kanserlerinin epidemiyolojik ve demografik özellikleri. EJM. 2020:97-108.
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