Abstract
Diffuse alveolar hemorrhage (DAH) is accumulation of erythrocytes into the alveoli and is often caused
by pulmonary microcirculation resulting in systemic vasculitis. Immune and non-immune causes are
responsible for DAH etiology. Hemoptysis and dyspnea are the most common clinical symptoms.
Bilateral ground-glass opacity is seen at chest x-ray. Hemogram, renal function tests and
immunological markers are diagnostic laboratory tests. Diagnosis is made by macroscopic and
microscopic findings of bronco-alveolar lavage fluid. Treatments of the underlying disease as well as
immunosuppressive therapy especially high-dose corticosteroids are important in treatment of DAH
Keywords
References
- Taşbakan MS, Özdemir Ö, Yıldız BS, Özerkan F, Bacakoğlu F. Varfarin toksisitesi ve amiodaron tedavisi ile ilişkili iki alveoler hemoraji sendromu olgusu. Yoğun Bakım Dergisi 2010; 9 (1): 57-63.
- Krause ML, Cartin-Ceba R, Specks U, Peikert T. Update on diffuse alveolar hemorrhage and pulmonary vasculitis. Immunol Allergy Clin North Am 2012; 32 (4): 587-600.
- Quadrelli S, Diana D, Solis M, et al. Immune diffuse alveolar hemorrhage: clinical presentation and outcome. Respiratory Medicine 2017; 129: 59-62.
- Gürgün A, Köşker P, Susur A, et al. Diffüz alveoler hemoraji sendromlarında mortaliteyi etkileyen faktörler. Türkiye Klinikleri Arch Lung 2009; 10 (2): 39-44.
- Picard C, Cadranel J, Porcher R, et al. Alveolar haemorrhage in the immunocompetent host: a scale for early diagnosis of an immune cause. Respiration 2010; 80: 313-20.
- Lichtenberger JP, Digumarthy SR, Abbott GF, Shepard JA, Sharma A. Diffuse pulmonary hemorrhage: clues to the diagnosis. Curr Probl Diagn Radiol 2014; 43: 128-39.
- Ednalino C, Yip J, Carsons SE. Systematic review of diffuse alveolar hemorrhage in systemic lupus erythematosus: focus on outcome and therapy. J Clin Rheumatol 2015; 21: 305-10.
Abstract
Diffüz alveoler hemoraj (DAH) pulmoner mikro-sirkülasyondan kaynaklanan, sıklıkla sistemik bir
vaskülitin neden olduğu, alveol içine eritrosit birikmesidir. DAH etiyolojisinde immün ve non-immün
nedenler sorumludur. Hemoptizi ve nefes darlığı en sık karşılaşılan klinik semptomlardır. Akciğer
grafisinde bilateral buzlu cam dansiteleri izlenir. Hemogram, böbrek fonksiyon testleri ve immünolojik
belirteçler tanıya yardımcı laboratuvar testleridir. Bronko-alveoler lavaj sıvısının makroskopik ve
mikroskobik bulguları ile tanı konulur. Tedavisinde altta yatan hastalığın tedavisi yanı sıra, yüksek doz
kortikosteroid başta olmak üzere immünsupresif tedavi önem taşır.
Keywords
References
- Taşbakan MS, Özdemir Ö, Yıldız BS, Özerkan F, Bacakoğlu F. Varfarin toksisitesi ve amiodaron tedavisi ile ilişkili iki alveoler hemoraji sendromu olgusu. Yoğun Bakım Dergisi 2010; 9 (1): 57-63.
- Krause ML, Cartin-Ceba R, Specks U, Peikert T. Update on diffuse alveolar hemorrhage and pulmonary vasculitis. Immunol Allergy Clin North Am 2012; 32 (4): 587-600.
- Quadrelli S, Diana D, Solis M, et al. Immune diffuse alveolar hemorrhage: clinical presentation and outcome. Respiratory Medicine 2017; 129: 59-62.
- Gürgün A, Köşker P, Susur A, et al. Diffüz alveoler hemoraji sendromlarında mortaliteyi etkileyen faktörler. Türkiye Klinikleri Arch Lung 2009; 10 (2): 39-44.
- Picard C, Cadranel J, Porcher R, et al. Alveolar haemorrhage in the immunocompetent host: a scale for early diagnosis of an immune cause. Respiration 2010; 80: 313-20.
- Lichtenberger JP, Digumarthy SR, Abbott GF, Shepard JA, Sharma A. Diffuse pulmonary hemorrhage: clues to the diagnosis. Curr Probl Diagn Radiol 2014; 43: 128-39.
- Ednalino C, Yip J, Carsons SE. Systematic review of diffuse alveolar hemorrhage in systemic lupus erythematosus: focus on outcome and therapy. J Clin Rheumatol 2015; 21: 305-10.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | January 20, 2021 |
| Submission Date | April 6, 2020 |
| Published in Issue | Year 2021Volume: 60 Suppl:1 (Rheumatology) |
