Research Article
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Year 2023, Volume: 15 Issue: 1, 26 - 32, 30.06.2023

Sedat Yaşin Erman Altunışık

https://doi.org/10.56484/iamr.1217558

Abstract

Keywords

Migraine magnesium headache measurement level pathogenesis

References

  • 1. Panconesi A, Bartolozzi ML, Guidi L. Migraine pain: reflections against vasodilatation. J Headache Pain 2009; 10: 317–325.
  • 2. Altunisik E, Oren B. Retinal Neurovascular Structural Changes in Optical Coherence Tomography and the Relationship between These Changes and White Matter Hyperintensities in Patients with Migraine. Eur Neurol. 2021; 84(6): 460-471
  • 3. Chiristiaopher J, David J, Capobian co. Headache and facial pain. In: Walter G, Bradly, Robert Daroff. Neurology in clinical practice, Vol. 2, Fifth edition, Philadelphia, Elsevier, 2008; 2011-2063
  • 4. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 2013; 33(9): 629-808
  • 5. Grober, U.; Schmidt, J.; Kisters, K. Magnesium in prevention and therapy. Nutrients 2015; 7: 8199–8226
  • 6. Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients. 2018; 10(6): 730.
  • 7. Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses 2011; 77:147–151
  • 8. Stewart WF, Lipton RB, Downson AJ, et al. Development and testing of the migraine disability assessment (MIDAS) questionnaire to assess headache related disability. Neurology 2001; 56: 20–28.
  • 9. Modyl, Lambert JDC, Heinemann B: Low extra cellular magnesium induce epileptiform activity and spreading depression in rate hypocampal slices. J Neurophysical 1987; 57: 869-888.
  • 10. Samsam M. Central nervous system acting drugs in treatment of migraine headache. Cent Nerv Syst Agents Med Chem 2012; 12:158–172.
  • 11. Dolati S, Rikhtegar R, Mehdizadeh A, Yousefi M. The Role of Magnesium in Pathophysiology and Migraine Treatment. Biol Trace Elem Res. 2020; 196: 375-383.
  • 12. Bussone G. Pathophysiology of migraine. Neurol Sci. 2004; 25: 239-241.
  • 13. Tepper SJ, Rapoport A, Sheftell F. The pathophysiology of migraine. Neurologist. 2001 ;7(5): 279-286.
  • 14. Samaie A, Asghari N, Ghorbani R, Arda J. Blood Magnesium levels in migraineurs within and between the headache attacks: a case control study. Pan Afr Med J. 2012; 11: 46.
  • 15. Mauskop A, Altura BT, Altura BM. Serum ionized magnesium levels and serum ionized calcium/ionized magnesium ratios in women with menstrual migraine. Headache 2002; 42(4): 242-248
  • 16. Trauninger A, Pfund Z, Koszegi T, Czopf J. Oral magnesium load test in patients with migraine. Headache 2002; 42(2): 114-9.
  • 17. Assarzadegan F, Asadollahi M, Derakhshanfar H, Kashefizadeh A, Aryani O, Khorshidi M. Measuring Serum Level of Ionized Magnesium in Patients with Migraine. Iran J Child Neurol. 2015; 9(3): 13-16.
  • 18. Masoud A. A study on relation between attacks of migraine headache and serum-magnesium level. Iranian J Publ Health 2003; 32: 27–30.
  • 19. Miller AC, K Pfeffer B, Lawson MR, et al. Intravenous magnesium sulfate to treat acute headaches in the emergency department: A systematic review. Headache. 2019; 59: 1674-686.
  • 20. Khani S, Hejazi SA, Yaghoubi M, Sharifipour E. Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: A randomized controlled double-blind trial. J Headache Pain. 2021; 22: 21.
  • 21. Christina Sun-Edelstein, Alexander Mauskop. Role of magnesium in the pathogenesis and treatment of migraine. Expert Review of Neurotherapeutic 2009; 9(3): 369-379.

Decreased serum magnesium levels patients with migraine: a case control study

Year 2023, Volume: 15 Issue: 1, 26 - 32, 30.06.2023

Sedat Yaşin Erman Altunışık

https://doi.org/10.56484/iamr.1217558

Abstract

Objective: Migraine is a common neurological syndrome that affects 15% of the population. The pathogenesis of migraines is not fully understood. In the nervous system; magnesium plays critical roles such as nerve conduction, neuromuscular coordination and protection against excitotoxicity.
Method: In this retrospective study, patients were diagnosed with migraine according to the International Classification of Headache Disorders-3 beta criteria were included. Patients were divided into three groups as migraine with aura, migraine without aura and chronic migraine.
Results: A total of 168 participant, 71 patients and 97 controls, were included in the study. Serum Mg values were measured as 1.98 mg/dl in the patient group and 2.04 mg/dl in the control group and were found to be significantly lower in the patient group (p=0.021). No significant difference was found in terms of mean serum Mg values in migraine subgroups.
Conclusion: We found that serum Mg levels are low in migraine patients and we think that this vital cation may be one of the factors playing a role in the pathogenesis of migraine. Evaluation of serum Mg level in migraine patients may help in predicting migraine attacks and symptoms, as well as in appropriate therapeutic planning for patients.

Keywords

Migraine magnesium headache measurement level pathogenesis

References

  • 1. Panconesi A, Bartolozzi ML, Guidi L. Migraine pain: reflections against vasodilatation. J Headache Pain 2009; 10: 317–325.
  • 2. Altunisik E, Oren B. Retinal Neurovascular Structural Changes in Optical Coherence Tomography and the Relationship between These Changes and White Matter Hyperintensities in Patients with Migraine. Eur Neurol. 2021; 84(6): 460-471
  • 3. Chiristiaopher J, David J, Capobian co. Headache and facial pain. In: Walter G, Bradly, Robert Daroff. Neurology in clinical practice, Vol. 2, Fifth edition, Philadelphia, Elsevier, 2008; 2011-2063
  • 4. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 2013; 33(9): 629-808
  • 5. Grober, U.; Schmidt, J.; Kisters, K. Magnesium in prevention and therapy. Nutrients 2015; 7: 8199–8226
  • 6. Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients. 2018; 10(6): 730.
  • 7. Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses 2011; 77:147–151
  • 8. Stewart WF, Lipton RB, Downson AJ, et al. Development and testing of the migraine disability assessment (MIDAS) questionnaire to assess headache related disability. Neurology 2001; 56: 20–28.
  • 9. Modyl, Lambert JDC, Heinemann B: Low extra cellular magnesium induce epileptiform activity and spreading depression in rate hypocampal slices. J Neurophysical 1987; 57: 869-888.
  • 10. Samsam M. Central nervous system acting drugs in treatment of migraine headache. Cent Nerv Syst Agents Med Chem 2012; 12:158–172.
  • 11. Dolati S, Rikhtegar R, Mehdizadeh A, Yousefi M. The Role of Magnesium in Pathophysiology and Migraine Treatment. Biol Trace Elem Res. 2020; 196: 375-383.
  • 12. Bussone G. Pathophysiology of migraine. Neurol Sci. 2004; 25: 239-241.
  • 13. Tepper SJ, Rapoport A, Sheftell F. The pathophysiology of migraine. Neurologist. 2001 ;7(5): 279-286.
  • 14. Samaie A, Asghari N, Ghorbani R, Arda J. Blood Magnesium levels in migraineurs within and between the headache attacks: a case control study. Pan Afr Med J. 2012; 11: 46.
  • 15. Mauskop A, Altura BT, Altura BM. Serum ionized magnesium levels and serum ionized calcium/ionized magnesium ratios in women with menstrual migraine. Headache 2002; 42(4): 242-248
  • 16. Trauninger A, Pfund Z, Koszegi T, Czopf J. Oral magnesium load test in patients with migraine. Headache 2002; 42(2): 114-9.
  • 17. Assarzadegan F, Asadollahi M, Derakhshanfar H, Kashefizadeh A, Aryani O, Khorshidi M. Measuring Serum Level of Ionized Magnesium in Patients with Migraine. Iran J Child Neurol. 2015; 9(3): 13-16.
  • 18. Masoud A. A study on relation between attacks of migraine headache and serum-magnesium level. Iranian J Publ Health 2003; 32: 27–30.
  • 19. Miller AC, K Pfeffer B, Lawson MR, et al. Intravenous magnesium sulfate to treat acute headaches in the emergency department: A systematic review. Headache. 2019; 59: 1674-686.
  • 20. Khani S, Hejazi SA, Yaghoubi M, Sharifipour E. Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: A randomized controlled double-blind trial. J Headache Pain. 2021; 22: 21.
  • 21. Christina Sun-Edelstein, Alexander Mauskop. Role of magnesium in the pathogenesis and treatment of migraine. Expert Review of Neurotherapeutic 2009; 9(3): 369-379.
There are 21 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Research Paper
Authors

Sedat Yaşin 0000-0001-8067-8388

Erman Altunışık 0000-0002-5996-2090

Publication Date June 30, 2023
Published in Issue Year 2023 Volume: 15 Issue: 1

Cite

APA Yaşin, S., & Altunışık, E. (2023). Decreased serum magnesium levels patients with migraine: a case control study. International Archives of Medical Research, 15(1), 26-32. https://doi.org/10.56484/iamr.1217558
AMA Yaşin S, Altunışık E. Decreased serum magnesium levels patients with migraine: a case control study. IAMR. June 2023;15(1):26-32. doi:10.56484/iamr.1217558
Chicago Yaşin, Sedat, and Erman Altunışık. “Decreased Serum Magnesium Levels Patients With Migraine: a Case Control Study”. International Archives of Medical Research 15, no. 1 (June 2023): 26-32. https://doi.org/10.56484/iamr.1217558.
EndNote Yaşin S, Altunışık E (June 1, 2023) Decreased serum magnesium levels patients with migraine: a case control study. International Archives of Medical Research 15 1 26–32.
IEEE S. Yaşin and E. Altunışık, “Decreased serum magnesium levels patients with migraine: a case control study”, IAMR, vol. 15, no. 1, pp. 26–32, 2023, doi: 10.56484/iamr.1217558.
ISNAD Yaşin, Sedat - Altunışık, Erman. “Decreased Serum Magnesium Levels Patients With Migraine: a Case Control Study”. International Archives of Medical Research 15/1 (June 2023), 26-32. https://doi.org/10.56484/iamr.1217558.
JAMA Yaşin S, Altunışık E. Decreased serum magnesium levels patients with migraine: a case control study. IAMR. 2023;15:26–32.
MLA Yaşin, Sedat and Erman Altunışık. “Decreased Serum Magnesium Levels Patients With Migraine: a Case Control Study”. International Archives of Medical Research, vol. 15, no. 1, 2023, pp. 26-32, doi:10.56484/iamr.1217558.
Vancouver Yaşin S, Altunışık E. Decreased serum magnesium levels patients with migraine: a case control study. IAMR. 2023;15(1):26-32.
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