Year 2020, Volume 59 , Issue 2, Pages 83 - 90 2020-06-30

The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman
Adıyaman ilinde guatrla başvuran çocuk hastalarda etiyolojik dağılım ile klinik ve laboratuvar özellikler

Semih BOLU [1] , Fatih İŞLEYEN [2] , Mehmet TURĞUT [3]


Aim: The most common cause of goiter in developed countries is autoimmune diseases, while the most common cause in developing countries is iodine deficiency. We aimed to evaluate the clinical and laboratory results and etiological and demographic characteristics of cases presenting with goiter. Materials and Methods: Seventy-five patients aged between 5 and 17 years presenting with goiter between October 2016 and January 2019 were included in the study. Results: 90.7% (68) of children with goiter were female and 9.3% (7) male, the rate of goiter being 9.7-fold higher among girls. In terms of etiology, 43 patients (57.3%) were diagnosed with iodine deficiency, 25 (33.3%) with Hashimoto’s thyroiditis (HT), five with Graves’ disease (6.7%), and two (2.7%) with thyroid hormone resistance (THR). Mean ages were 13.7±2.1 years in the iodine deficient cases, 13.7±2.7 in the HT group, 14.3±1.4 in the Graves’ disease patients, and 8.2±2.3 in the patients with THR. The highest mean urinary iodine level among iodine deficient patients was 45±27.1 (12.10-84.13) μg/L in Adıyaman center, while the lowest value was determined in Gerger district at 16.8±3.1 (14.27-20.25) μg/L, and 11 patients were diagnosed with mild iodine deficiency, 20 with moderate deficiency, and 12 with severe deficiency. Conclusion: Iodine deficiency was the most common cause of goiter in children in the province of Adıyaman, followed by autoimmune thyroid gland diseases such as Graves’ disease and HT. This study shows that iodine deficiency remains still as a problem in our province.
Amaç: Gelişmiş ülkelerde guatrın en sık sebebi otoimmün hastalıklar iken gelişmekte olan ülkelerde en yaygın neden iyot eksikliğidir. Guatr ile başvuran olguların klinik ve laboratuvar sonuçları ile etiyolojik ve demografik özelliklerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmaya Ekim 2016 ile Ocak 2019 tarihleri arasında guatr ile başvuran 5-17 yaş arasındaki 75 hasta dahil edildi. Bulgular: Guatrlı çocukların % 90,7'si (68) kız, % 9,3'ü (7) erkek idi ve guatr oranı kızlarda 9,7 kat daha yüksek bulundu. Etiyoloji açısından 43 hastaya (% 57,3) iyot eksikliği, 25 hastaya (% 33,3) Hashimoto tiroiditi (HT), 5 hastaya Graves hastalığı (% 6,7) ve 2 hastaya (% 2,7) Tiroid hormon direnci (THD) tanısı konuldu. İyot eksikliği olan olgularda ortalama yaş 13,7 ± 2,1 yıl, HT grubunda 13,7 ± 2,7 yıl, Graves hastalarında 14,3 ± 1,4 yıl ve THD'li hastalarda 8,2 ± 2,3 yıl idi. İyot eksikliği olan hastalarda ortalama idrar iyot düzeyi en yüksek Adıyaman merkezde 45 ± 27,1 (12,10-84,13) μg/L olarak saptanırken, en düşük değer Gerger bölgesinde 16,8 ± 3,1 (14,27-20,25) μg/L idi. Sonuç: İyot eksikliği Adıyaman ilindeki çocuklarda guatrın en sık sebebi olup bunu Graves hastalığı ve HT gibi otoimmün tiroid bezi hastalıkları izliyordu. Bu çalışma iyot eksikliğinin ilimiz genelinde yaygın bir sorun olarak devam ettiğini göstermektedir.
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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Orcid: 0000-0002-8183-2188
Author: Semih BOLU
Institution: Adıyaman University School of Medicine, Department of Pediatric Endocrinology, Adıyaman
Country: Turkey


Orcid: 0000-0002-5015-621X
Author: Fatih İŞLEYEN (Primary Author)
Institution: Şanlıurfa Balıklıgöl State Hospital, Pediatrics, Şanlıurfa
Country: Turkey


Orcid: 0000-0002-2155-8113
Author: Mehmet TURĞUT
Institution: Adıyaman University School of Medicine, Department of Pediatrics, Adıyaman
Country: Turkey


Dates

Application Date : June 7, 2019
Acceptance Date : October 7, 2019
Publication Date : June 30, 2020

Bibtex @research article { etd756171, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege University}, year = {2020}, volume = {59}, pages = {83 - 90}, doi = {10.19161/etd.756171}, title = {The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman}, key = {cite}, author = {Bolu, Semih and İşleyen, Fatih and Turğut, Mehmet} }
APA Bolu, S , İşleyen, F , Turğut, M . (2020). The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman . Ege Tıp Dergisi , 59 (2) , 83-90 . DOI: 10.19161/etd.756171
MLA Bolu, S , İşleyen, F , Turğut, M . "The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman" . Ege Tıp Dergisi 59 (2020 ): 83-90 <http://egetipdergisi.com.tr/en/pub/issue/55079/756171>
Chicago Bolu, S , İşleyen, F , Turğut, M . "The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman". Ege Tıp Dergisi 59 (2020 ): 83-90
RIS TY - JOUR T1 - The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman AU - Semih Bolu , Fatih İşleyen , Mehmet Turğut Y1 - 2020 PY - 2020 N1 - doi: 10.19161/etd.756171 DO - 10.19161/etd.756171 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 83 EP - 90 VL - 59 IS - 2 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.756171 UR - https://doi.org/10.19161/etd.756171 Y2 - 2019 ER -
EndNote %0 Ege Tıp Dergisi The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman %A Semih Bolu , Fatih İşleyen , Mehmet Turğut %T The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman %D 2020 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 59 %N 2 %R doi: 10.19161/etd.756171 %U 10.19161/etd.756171
ISNAD Bolu, Semih , İşleyen, Fatih , Turğut, Mehmet . "The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman". Ege Tıp Dergisi 59 / 2 (June 2020): 83-90 . https://doi.org/10.19161/etd.756171
AMA Bolu S , İşleyen F , Turğut M . The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. ETD. 2020; 59(2): 83-90.
Vancouver Bolu S , İşleyen F , Turğut M . The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. Ege Tıp Dergisi. 2020; 59(2): 83-90.