Case Report
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Kedi tırmığı hastalığında F18 FDG PET/BT bulguları: olgu sunumu

Year 2021, Volume 60, Issue 3, 296 - 298, 13.09.2021
https://doi.org/10.19161/etd.990268

Abstract

Kedi tırmığı hastalığı, Bartonella Henselae isimli bakterinin neden olduğu ve inokülasyon sahasını direne eden lenf nodlarının etkilendiği bir enfeksiyondur. Kedi tırmığı hastalığında en sık olarak aksiller, servikal ve inguinal yerleşimli lenf nodları etkilenmektedir. Doğasındaki granulomatozis nedeni ile bu hastalık FDG-avid kabul edilebilir. Ultrasonografik incelemesinde multipl abdominal lenfadenopati saptanan 49 yaşındaki kadın olgunun FDG-PET/BT bulgularını sunmaktayız. Olgunun F18 FDG PET/BT tetkikinde, bilateral aksiller ve abdominopelvik yerleşimli hipermetabolik lenf nodları yanısıra (SUVmax:6.2-18.5), dalakta hipermetabolik hipodens bir lezyon saptandı (SUVmax:11.3). Uygulanan aksiller lenf nodu eksizyonu sonrası patolojik olarak süpüratif gralülomatöz lenfadenit saptanmasına, yakın zamanda kedi tırmalaması öyküsünün eşlik ediyor oluşu ile, olguya Kedi Tırmığı Hastalığı tanısı konuldu. Sonuç olarak onkolojik PET/BT tetkikinde yalancı pozitiflik sebepleri arasında Kedi tırmığı hastalığı da akılda tutulmalıdır. Ek olarak, Kedi tırmığı hastalığında PET/BT’nin uygun biyopsi alanını göstermede ve diğer hastalık alanlarının saptanmasında rol oynayabileceği düşünülmektedir

References

  • Bergman AM, Groothedde JW, Schellekens JFP, van Embden JD, Ossewaarde JM, Schouls LM. Etiology of catscratch disease: a comparison of polymerase chain reaction detection of Bartonella and Afipia felis DNA with serology and skin tests. J Infect Dis. 1995; 171 (4): 916-23.
  • Mosbacher ME, Klotz S, Klotz J, Pinnas JL. Bartonella henselae and the potential for arthropod vector-borne transmission. Vector Borne Zoonotic Dis. May 2011; 11 (5): 471-7.
  • Markaki S, Sotiropoulou M, Papaspirou P, Lazaris D. Cat-scratch disease presenting as a solitary tumour in the breast: report of three cases. Eur J Obstet Gynecol Reprod Biol. 2003; 106 (2): 175-8.
  • Spach DH, Kaplan SL. Microbiology, epidemiology, clinical manifestations, and diagnosis of cat scratch disease. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on May 28, 2020).
  • Vaidyanathan S, Patel CN, Scarsbrook AF, Chowdhury FU. FDG PET/CT in infection and inflammation--current and emerging clinical applications. Clin Radiol. 2015; 70 (7): 787-800.
  • Asano S. Granulomatous lymphadenitis. J Clin Exp Hematop 2012; 52 (1): 1–16.
  • Sander A, Berner R, Ruess M. Serodiagnosis of cat scratch disease; response to Bartonella henselae in children and review of diagnostic methods. Eur J Clin Microbiol Infect Dis. 2001; 20 (6): 392-401.
  • Lin E, Alavi A. PET and PET/CT A clinical guide, Second edition. Thieme Medical Publishers, Inc.2009. P:25.
  • Nwawka OK, Nadgir R, Fujita A, Sakai O. Granulomatous disease in the head and neck: developing a differential diagnosis. Radiographics. 2014; 34 (5): 1240-56.
  • Rappaport DC, Cumming WA, Ros PR. Disseminated hepatic and splenic lesions in cat-scratch disease: imaging features. AJR Am J Roentgenol. 1991; 156 (6): 1227-8.
  • Jeong W, Seiter K, Strauchen J. et al. PET scan-positive cat scratch disease in a patient with T cell lymphoblastic lymphoma. Leuk Res. 2005; 29 (5): 591–4.
  • Imperiale A, Blondet C, Ben-Sellem D. Et al. Unusual Abdominal Localization of Cat Scratch Disease Mimicking Malignancy on F-18 FDG PET/CT Examination. Clin Nucl Med 2008; 33 (9): 621–3.

F18 FDG PET/CT findings in cat-scratch disease: a case report

Year 2021, Volume 60, Issue 3, 296 - 298, 13.09.2021
https://doi.org/10.19161/etd.990268

Abstract

Cat-scratch disease is a bacterial infection caused by Bartonella Henselae which affects lymph nodes that drain the sites of inoculation. Axillary, cervical and inguinal lymph nodes are the most common regions being involved. The disease can be considered as an FDG-avid disease, given the granulomatous nature of the infection. We herein report F18 FDG PET/CT findings of a 49-year-old woman, who has abdominal lymphadenopathy revealed on ultrasonography (USG). PET/CT scan demonstrated bilateral axillary and abdominopelvic hypermetabolic enlarged lymph nodes with SUVmax value of 6.2 to 18.5. Moreover, a hypermetabolic hypodense lesion in the spleen with SUVmax value of 11.3 was detected. Excisional biopsy of the axillary lymph node performed. Based on clinical-histopathological findings and the history of being scratched by a cat recently, the patient was diagnosed with cat-scratch disease. In conclusion, cat-scratch disease represents a cause of false-positive results in oncological PET/CT scans. Furthermore, PET/CT may have a role in revealing the applicable biopsy area and showing the additional involvement sites. Keywords: Cat-Scratch Disease, PET-CT, Lymphadenopathy.

References

  • Bergman AM, Groothedde JW, Schellekens JFP, van Embden JD, Ossewaarde JM, Schouls LM. Etiology of catscratch disease: a comparison of polymerase chain reaction detection of Bartonella and Afipia felis DNA with serology and skin tests. J Infect Dis. 1995; 171 (4): 916-23.
  • Mosbacher ME, Klotz S, Klotz J, Pinnas JL. Bartonella henselae and the potential for arthropod vector-borne transmission. Vector Borne Zoonotic Dis. May 2011; 11 (5): 471-7.
  • Markaki S, Sotiropoulou M, Papaspirou P, Lazaris D. Cat-scratch disease presenting as a solitary tumour in the breast: report of three cases. Eur J Obstet Gynecol Reprod Biol. 2003; 106 (2): 175-8.
  • Spach DH, Kaplan SL. Microbiology, epidemiology, clinical manifestations, and diagnosis of cat scratch disease. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on May 28, 2020).
  • Vaidyanathan S, Patel CN, Scarsbrook AF, Chowdhury FU. FDG PET/CT in infection and inflammation--current and emerging clinical applications. Clin Radiol. 2015; 70 (7): 787-800.
  • Asano S. Granulomatous lymphadenitis. J Clin Exp Hematop 2012; 52 (1): 1–16.
  • Sander A, Berner R, Ruess M. Serodiagnosis of cat scratch disease; response to Bartonella henselae in children and review of diagnostic methods. Eur J Clin Microbiol Infect Dis. 2001; 20 (6): 392-401.
  • Lin E, Alavi A. PET and PET/CT A clinical guide, Second edition. Thieme Medical Publishers, Inc.2009. P:25.
  • Nwawka OK, Nadgir R, Fujita A, Sakai O. Granulomatous disease in the head and neck: developing a differential diagnosis. Radiographics. 2014; 34 (5): 1240-56.
  • Rappaport DC, Cumming WA, Ros PR. Disseminated hepatic and splenic lesions in cat-scratch disease: imaging features. AJR Am J Roentgenol. 1991; 156 (6): 1227-8.
  • Jeong W, Seiter K, Strauchen J. et al. PET scan-positive cat scratch disease in a patient with T cell lymphoblastic lymphoma. Leuk Res. 2005; 29 (5): 591–4.
  • Imperiale A, Blondet C, Ben-Sellem D. Et al. Unusual Abdominal Localization of Cat Scratch Disease Mimicking Malignancy on F-18 FDG PET/CT Examination. Clin Nucl Med 2008; 33 (9): 621–3.

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Case Reports
Authors

Neslihan ÇETİN AVCI This is me (Primary Author)
Department of Nuclear Medicine, Umraniye Training and Research Hospital, Istanbul
0000-0003-2517-2274
Türkiye


Mehmet Taha AVCI This is me
Department of Radiology, Umraniye Training and Research Hospital, Istanbul
0000-0002-0216-5592
Türkiye


Aysegül AKGÜN This is me
Department of Nuclear Medicine, Ege University, Izmir
0000-0001-8922-8762
Türkiye

Publication Date September 13, 2021
Application Date June 1, 2020
Acceptance Date September 8, 2020
Published in Issue Year 2021, Volume 60, Issue 3

Cite

Bibtex @case report { etd990268, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege University}, year = {2021}, volume = {60}, pages = {296 - 298}, doi = {10.19161/etd.990268}, title = {F18 FDG PET/CT findings in cat-scratch disease: a case report}, key = {cite}, author = {Avcı, Mehmet Taha and Akgün, Aysegül} }
APA Çetin Avcı, N. , Avcı, M. T. & Akgün, A. (2021). F18 FDG PET/CT findings in cat-scratch disease: a case report . Ege Tıp Dergisi , 60 (3) , 296-298 . DOI: 10.19161/etd.990268
MLA Çetin Avcı, N. , Avcı, M. T. , Akgün, A. "F18 FDG PET/CT findings in cat-scratch disease: a case report" . Ege Tıp Dergisi 60 (2021 ): 296-298 <http://egetipdergisi.com.tr/en/pub/issue/64760/990268>
Chicago Çetin Avcı, N. , Avcı, M. T. , Akgün, A. "F18 FDG PET/CT findings in cat-scratch disease: a case report". Ege Tıp Dergisi 60 (2021 ): 296-298
RIS TY - JOUR T1 - F18 FDG PET/CT findings in cat-scratch disease: a case report AU - Neslihan Çetin Avcı , Mehmet Taha Avcı , Aysegül Akgün Y1 - 2021 PY - 2021 N1 - doi: 10.19161/etd.990268 DO - 10.19161/etd.990268 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 296 EP - 298 VL - 60 IS - 3 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.990268 UR - https://doi.org/10.19161/etd.990268 Y2 - 2020 ER -
EndNote %0 Ege Journal of Medicine F18 FDG PET/CT findings in cat-scratch disease: a case report %A Neslihan Çetin Avcı , Mehmet Taha Avcı , Aysegül Akgün %T F18 FDG PET/CT findings in cat-scratch disease: a case report %D 2021 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 60 %N 3 %R doi: 10.19161/etd.990268 %U 10.19161/etd.990268
ISNAD Çetin Avcı, Neslihan , Avcı, Mehmet Taha , Akgün, Aysegül . "F18 FDG PET/CT findings in cat-scratch disease: a case report". Ege Tıp Dergisi 60 / 3 (September 2021): 296-298 . https://doi.org/10.19161/etd.990268
AMA Çetin Avcı N. , Avcı M. T. , Akgün A. F18 FDG PET/CT findings in cat-scratch disease: a case report. EJM. 2021; 60(3): 296-298.
Vancouver Çetin Avcı N. , Avcı M. T. , Akgün A. F18 FDG PET/CT findings in cat-scratch disease: a case report. Ege Tıp Dergisi. 2021; 60(3): 296-298.
IEEE N. Çetin Avcı , M. T. Avcı and A. Akgün , "F18 FDG PET/CT findings in cat-scratch disease: a case report", Ege Tıp Dergisi, vol. 60, no. 3, pp. 296-298, Sep. 2021, doi:10.19161/etd.990268