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İnflamatuvar Fibroid Polipler ve Platelet Türevli Büyüme Faktörü Reseptör Mutasyon Analizi

Year 2022, Volume: 1 Issue: 3, 158 - 162, 19.12.2022
https://doi.org/10.57221/izmirtip.1157336

Abstract

İnflamatuvar fibroid polip gastrointestinal trakta çok nadir görülen tümörlerden biridir. Klinik olarak çok farklı bulgulara neden olabileceği için tanı zorluğuna neden olur. Ayrıca, histopatolojik olarak da malign bir lezyonu taklit edebilir. İnflamatuvar fibroid poliplerde platelet-derived growth factor receptor α mutasyon varlığı ile ilgili olarak bilgilerimiz artmaktadır.
Bu sunumda histopatolojik olarak inflamatuvar fibroid polip morfolojisi bulunan ve platelet-derived growth factor receptor α mutasyonu saptanan üç olgu, bu gibi bir antitenin varlığı ve farkındalığına dikkat çekmek amacıyla literatür bilgileri eşliğinde tartışılmıştır.

References

  • 1.Lasota J, Wang ZF, Sobin LH, Miettinen M. Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps: a study of 60 cases. Mod Pathol. 2009;22:1049-56.
  • 2.Vanek J. Gastric submucosal granuloma with eosinophilic infiltration. Am J Pathol. 1949;25:397-411. 3.Helwig EB, Ranier A. Inflammatory fibroid polyps of the stomach. Surg Gynecol Obstet. 1953;96:335–67.
  • 4.Harima H, Kimura T, Hamabe K, Hisano F , Matsuzaki Y, Sanuki K et al. Invasive inflammatory fibroid polyp of the stomach: a case report and literature review. BMC Gastroenterol. 2018;31;18: 74.
  • 5.Fleres F, Mazzeo C, Ieni A, Rossitto M, Cucinotta E. Gastric inflammatory fibroid polyp tumor with acute intestinal obstruction—Vanek’s tumor can mimick a giant gastrointestinal stromal tumor or a gastric lymphoma. J Vis Surg. 2018;4:54.
  • 6.Tajima S, Koda K. Locally infiltrative inflammatory fibroid polyp of the ileum. Report of a case showing transmural proliferation. Gastroenterol Rep (Oxf). 2018; 6:144-8.
  • 7.Ricci R, Giustiniani MC, Gessi M, Lanza P, Castri F, Biondi A et al. Telocytes are the physiological counterpart of inflammatory fibroid polyps and PDGFRA-mutant GISTs. J Cell Mol Med. 2018;22:4856-62. 8.Sugawara T, Sugita S, Tateno M, Yabutani A, Segawa K, Ito Y et al. Colonic inflamatory fibroid polyp with PDGFRA expression. Pathol Int. 2018;68:205-6. 9.Calibasi G, Baskin Y, Alyuruk H, Cavas L, Oztop I, Sagol O et al. Molecular analysis of the KIT gene in GIST with novel mutations. Appl Immunohistochem Mol Morphol. 2014;22:37-45.
  • 10.Klingbeil KD, Balaban A, Fertig RM, Gamret AC, Gong Y, Torres C et al. Inflammatory fibroid polyp of the gastric antrum presenting as hypovolemic shock: Case report and literature review. Intractable Rare Dis Res. 2017;6:304-9.
  • 11.Silva M, Albuquerque A, Cardoso H, Costa J, Macedo G. Gastric inflammatory fibroid polyp mimicking a gastrointestinal stromal tumour. Rev Esp Enferm Dig. 2016;108:497-8. 12.Liu L, Wu L, Shan D, Han B. Characterization and clinical relevance of PDGFRA pathway copy number variation gains across human cancers. Molecular Genetics and Genomics. 2022;297:561-71.
  • 13.Siemion K, Reszec-Gielazyn J, Kisluk J, Roszkowiak L, Zak J, Korzynska A. What do we know about inflammatory myofibroblastic tumors? - A systematic review. Adv Med Sci. 2022;67:129-38. 14.Calderon MG, Caivano VC, Bagnaresi S Jr, de Oliveira Lira JO, Raimundo RD, de Abreu LC et al. A unique case of inflammatory fibroid polyp in the duodenum of a female adolescent: Case report and literature review. Medicine (Baltimore). 2017;96:e6131. 15.Plesec T P. Gastrointestinal mesenchymal neoplasms other than gastrointestinal stromal tumors: Focusing on their molecular aspects. Patholog Res Int. 2011;2011: 952569.

Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis

Year 2022, Volume: 1 Issue: 3, 158 - 162, 19.12.2022
https://doi.org/10.57221/izmirtip.1157336

Abstract

Aim: Inflammatory fibroid polyp is one of the most rarely seen tumors in the gastrointestinal tract. It is clinically confusing as it can cause many different findings. On the other hand, it may histopathologically mimic a malignant lesion. Our knowledge about the presence of platelet-derived growth factor receptor α (PDGFRA) mutation in inflammatory fibroid polyps are increasing. Cases: Herein, histopathological and immunohistochemical findings of three different tumors, two localized in the small intestine and one in the stomach, were interpreted as compatible with inflammatory fibroid polyp. PDGFR mutation analysis was performed in both cases and the presence of mutation was detected. Conclusion: The pathogenesis and histogenesis of inflammatory fibroid polyps are uncertain. We obtained results supporting the presence of PFGR mutations in IFPs mimicking both benign and malignant tumors.

References

  • 1.Lasota J, Wang ZF, Sobin LH, Miettinen M. Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps: a study of 60 cases. Mod Pathol. 2009;22:1049-56.
  • 2.Vanek J. Gastric submucosal granuloma with eosinophilic infiltration. Am J Pathol. 1949;25:397-411. 3.Helwig EB, Ranier A. Inflammatory fibroid polyps of the stomach. Surg Gynecol Obstet. 1953;96:335–67.
  • 4.Harima H, Kimura T, Hamabe K, Hisano F , Matsuzaki Y, Sanuki K et al. Invasive inflammatory fibroid polyp of the stomach: a case report and literature review. BMC Gastroenterol. 2018;31;18: 74.
  • 5.Fleres F, Mazzeo C, Ieni A, Rossitto M, Cucinotta E. Gastric inflammatory fibroid polyp tumor with acute intestinal obstruction—Vanek’s tumor can mimick a giant gastrointestinal stromal tumor or a gastric lymphoma. J Vis Surg. 2018;4:54.
  • 6.Tajima S, Koda K. Locally infiltrative inflammatory fibroid polyp of the ileum. Report of a case showing transmural proliferation. Gastroenterol Rep (Oxf). 2018; 6:144-8.
  • 7.Ricci R, Giustiniani MC, Gessi M, Lanza P, Castri F, Biondi A et al. Telocytes are the physiological counterpart of inflammatory fibroid polyps and PDGFRA-mutant GISTs. J Cell Mol Med. 2018;22:4856-62. 8.Sugawara T, Sugita S, Tateno M, Yabutani A, Segawa K, Ito Y et al. Colonic inflamatory fibroid polyp with PDGFRA expression. Pathol Int. 2018;68:205-6. 9.Calibasi G, Baskin Y, Alyuruk H, Cavas L, Oztop I, Sagol O et al. Molecular analysis of the KIT gene in GIST with novel mutations. Appl Immunohistochem Mol Morphol. 2014;22:37-45.
  • 10.Klingbeil KD, Balaban A, Fertig RM, Gamret AC, Gong Y, Torres C et al. Inflammatory fibroid polyp of the gastric antrum presenting as hypovolemic shock: Case report and literature review. Intractable Rare Dis Res. 2017;6:304-9.
  • 11.Silva M, Albuquerque A, Cardoso H, Costa J, Macedo G. Gastric inflammatory fibroid polyp mimicking a gastrointestinal stromal tumour. Rev Esp Enferm Dig. 2016;108:497-8. 12.Liu L, Wu L, Shan D, Han B. Characterization and clinical relevance of PDGFRA pathway copy number variation gains across human cancers. Molecular Genetics and Genomics. 2022;297:561-71.
  • 13.Siemion K, Reszec-Gielazyn J, Kisluk J, Roszkowiak L, Zak J, Korzynska A. What do we know about inflammatory myofibroblastic tumors? - A systematic review. Adv Med Sci. 2022;67:129-38. 14.Calderon MG, Caivano VC, Bagnaresi S Jr, de Oliveira Lira JO, Raimundo RD, de Abreu LC et al. A unique case of inflammatory fibroid polyp in the duodenum of a female adolescent: Case report and literature review. Medicine (Baltimore). 2017;96:e6131. 15.Plesec T P. Gastrointestinal mesenchymal neoplasms other than gastrointestinal stromal tumors: Focusing on their molecular aspects. Patholog Res Int. 2011;2011: 952569.
There are 9 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Reports
Authors

Nuket Özkavruk Eliyatkın 0000-0002-7784-5699

Özen Özden Yükselen 0000-0001-7104-8202

Seda Karaoğlu Baytekin 0000-0002-5446-8202

Yasemin Başbınar 0000-0001-9439-2217

Altay Kandemir 0000-0002-2918-3811

Publication Date December 19, 2022
Submission Date August 6, 2022
Published in Issue Year 2022 Volume: 1 Issue: 3

Cite

APA Özkavruk Eliyatkın, N., Yükselen, Ö. Ö., Karaoğlu Baytekin, S., Başbınar, Y., et al. (2022). Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis. İzmir Tıp Fakültesi Dergisi, 1(3), 158-162. https://doi.org/10.57221/izmirtip.1157336
AMA Özkavruk Eliyatkın N, Yükselen ÖÖ, Karaoğlu Baytekin S, Başbınar Y, Kandemir A. Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis. İzmir Tıp Fak. Derg. December 2022;1(3):158-162. doi:10.57221/izmirtip.1157336
Chicago Özkavruk Eliyatkın, Nuket, Özen Özden Yükselen, Seda Karaoğlu Baytekin, Yasemin Başbınar, and Altay Kandemir. “Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis”. İzmir Tıp Fakültesi Dergisi 1, no. 3 (December 2022): 158-62. https://doi.org/10.57221/izmirtip.1157336.
EndNote Özkavruk Eliyatkın N, Yükselen ÖÖ, Karaoğlu Baytekin S, Başbınar Y, Kandemir A (December 1, 2022) Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis. İzmir Tıp Fakültesi Dergisi 1 3 158–162.
IEEE N. Özkavruk Eliyatkın, Ö. Ö. Yükselen, S. Karaoğlu Baytekin, Y. Başbınar, and A. Kandemir, “Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis”, İzmir Tıp Fak. Derg., vol. 1, no. 3, pp. 158–162, 2022, doi: 10.57221/izmirtip.1157336.
ISNAD Özkavruk Eliyatkın, Nuket et al. “Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis”. İzmir Tıp Fakültesi Dergisi 1/3 (December 2022), 158-162. https://doi.org/10.57221/izmirtip.1157336.
JAMA Özkavruk Eliyatkın N, Yükselen ÖÖ, Karaoğlu Baytekin S, Başbınar Y, Kandemir A. Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis. İzmir Tıp Fak. Derg. 2022;1:158–162.
MLA Özkavruk Eliyatkın, Nuket et al. “Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis”. İzmir Tıp Fakültesi Dergisi, vol. 1, no. 3, 2022, pp. 158-62, doi:10.57221/izmirtip.1157336.
Vancouver Özkavruk Eliyatkın N, Yükselen ÖÖ, Karaoğlu Baytekin S, Başbınar Y, Kandemir A. Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis. İzmir Tıp Fak. Derg. 2022;1(3):158-62.