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Investigation of Seroprevalence of Toxoplasma, Rubella and Cytomegalovirus in Pregnant Population in Istanbul

Year 2020, Volume: 5 Issue: 3, 19 - 24, 01.12.2020

Abstract

Aim: Toxoplasma, rubella and cytomegalovirus (CMV) are among the most common intrauterine infection agents associated with congenital anomalies in the world. In this study, it was aimed to determine the seroprevalence of toxoplasma, rubella and CMV in pregnant women in Istanbul by ELISA screening tests, to evaluate them according to three different age groups and to compare them with the literature.
Material and Methods: In 5485 serum samples of pregnant women, IgM and IgG antibodies against toxoplasma, rubella and CMV were investigated and total of 16496 tests were evaluated retrospectively. Samples were tested on the Architect i2000SR (Abbott Diagnostics, USA) using kits based on the chemiluminescence microparticle enzyme immunassay principle (Architect, USA).
Results: Toxoplasma, rubella and CMV IgM positivity rates were 0.6%, 0.3% and 2.7%, respectively, and 23%, 89.1% and 98.7% for IgG, respectively. The toxoplasma IgG seropositivity rate was highest in the 36-49 age group (p =0.012). The toxoplasma IgM seropositivity rate was the lowest in the 26-35 age group (0.5%). The lowest rubella and CMV IgG seropositivity were found in 36-49 (87.8%) and 26-35 (98.4%) age groups.
Conclusion: In pregnant women, serological screening tests seem to be important for monitoring and informing high risk groups, especially seronegative, due to the low seroprevalence of toxoplasma. However, routine screening of rubella and CMV in the pregnant population should be questioned due to the high immunity rates.

References

  • Referans1 RK, Maity S, Saha S. A review on TORCH: groups of congenital infection during pregnancy. J Sci Innov Res. 2014;3(2):258–64.
  • Referans2 Akpınar O, Akpınar H. Investıgatıon of the rubella and cytomegalovırus seroprevalences by ELISA method ın pregnant women. Balikesir Saglik Bil Derg. 2017;6:11–5.
  • Referans3 Boyer SG, Boyer KM. Update on TORCH infections in the newborn infant. Newborn Infant Nurs Rev. 2004 Mar 1;4(1):70–80.
Year 2020, Volume: 5 Issue: 3, 19 - 24, 01.12.2020

Abstract

References

  • Referans1 RK, Maity S, Saha S. A review on TORCH: groups of congenital infection during pregnancy. J Sci Innov Res. 2014;3(2):258–64.
  • Referans2 Akpınar O, Akpınar H. Investıgatıon of the rubella and cytomegalovırus seroprevalences by ELISA method ın pregnant women. Balikesir Saglik Bil Derg. 2017;6:11–5.
  • Referans3 Boyer SG, Boyer KM. Update on TORCH infections in the newborn infant. Newborn Infant Nurs Rev. 2004 Mar 1;4(1):70–80.
There are 3 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Makale
Authors

Sema Alaçam 0000-0001-7957-2906

Ayfer Bakır 0000-0002-9006-5267

Aysel Karatas 0000-0001-8916-8499

Belkıs Yolburun This is me 0000-0003-1877-2757

Özlem Uzunkaya This is me 0000-0001-7238-1904

Ferda Aktaş This is me 0000-0002-4664-5213

Mehmet Canberk This is me 0000-0002-3715-3014

Publication Date December 1, 2020
Acceptance Date November 21, 2020
Published in Issue Year 2020 Volume: 5 Issue: 3

Cite

Vancouver Alaçam S, Bakır A, Karatas A, Yolburun B, Uzunkaya Ö, Aktaş F, Canberk M. Investigation of Seroprevalence of Toxoplasma, Rubella and Cytomegalovirus in Pregnant Population in Istanbul. JAMER. 2020;5(3):19-24.