Abstract
References
- Broderick JP, Adams Jr HP, Barsan W, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council. Am Heart Assoc Stroke 1999; 30: 905-15.
- Tao C, Hu X, Wang J, et al. Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage. Biomarkers Med 2017; 11: 33-42.
- Ünal Y, Barlas AM. Role of increased immature granulocyte percentage in the early prediction of acute necrotizing pancreatitis. Turk J Trauma Emerg Surg 2019; 25: 177-82.
- Bedel C, Korkut M, Aksoy F, Kuş G. Usefulness of immature granulocytes to predict high coronary SYNTAX score in acute coronary syndrome; a cross-sectional study. Arch Acad Emerg Med 2020: 8.
- Korkut M, Bedel C, Zortuk Ö, Selvi F. Can immature granulocytes indicate mortality in patients with acute ischemic stroke? Neurol Asia 2021; 26: 665-70.
- Bedel C, Korkut M, Selvi F, Zortuk Ö. The immature granulocyte count is a new predictor of the 30-day mortality in intracerebral haemorrhage patients: preliminary study. Indian J Neurosurg 2021; 10: 114-20.
- Korkut M, Bedel C, Sivil R, et al. Usefulness of immature granulocytes as a prognostic factor in st-elevation myocardial ınfarction. Brazilian J Cardiovasc Surg 2022; 37: 6.
- Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-lymphocyte ratio predicts the outcome of acute intracerebral hemorrhage. Stroke 2016; 47: 1654-7.
- Al-Mufti F, Amuluru K, Damodara N, et al. Admission neutrophil–lymphocyte ratio predicts delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. J Neurointerventional Surg 2019; 11: 1135-40.
- Walsh KB, Sekar P, Langefeld CD, et al. Monocyte count and 30-day case fatality in intracerebral hemorrhage. Stroke 2015; 46: 2302-4.
- Zhang W, Shen Y. Platelet-to-lymphocyte ratio as a new predictive index of neurological outcomes in patients with acute intracranial hemorrhage: a retrospective study. Medical Science Monitor: Int Med J Experiment Clin Res 2018; 24: 4413.
- Bhatia R, Singh H, Singh S, et al. A prospective study of in-hospital mortality and discharge outcome in spontaneous intracerebral hemorrhage. Neurol India 2013; 61: 244.
- Iso H, Jacobs Jr DR, Wentworth D, et al. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. New Engl J Med 1989; 320: 904-10.
- Takahashi O, Cook EF, Nakamura T, et al. Risk stratification for in-hospital mortality in spontaneous intracerebral haemorrhage: a Classification and Regression Tree analysis. J Assoc Physicians 2006; 99: 743-50.
- Hwang BY, Bruce SS, Appelboom G, et al. Evaluation of intraventricular hemorrhage assessment methods for predicting outcome following intracerebral hemorrhage. J Neurosurg 2012; 116: 185-92.
- Godoy DA, Pinero G, Di Napoli M. Predicting mortality in spontaneous intracerebral hemorrhage: can modification to original score improve the prediction? Stroke 2006; 37: 1038-44.
- Lima LR, Cunha GS, Nogueira KS, Comar SR. Automated immature granulocyte count in patients of the intensive care unit with suspected infection. J Brasileiro de Patologia e Medicina Laboratorial 2019; 55: 267-80.
- Ünal Y. A new and early marker in the diagnosis of acute complicated appendicitis: immature granulocytes. Ulus Travma Acil Cerrahi Derg 2018; 24: 434-9.
- Daix T, Guérin E, Tavernier E, et al. Immature granulocytes: a risk factor of infection after cardiac surgery. Cytometry Part B: Clinical Cytometry 2018; 94: 887-94.
- Karakulak S, Narcı H, Ayrık C, Erdoğan S, Üçbilek, E. The prognostic value of immature granulocyte in patients with acute pancreatitis. Am J Emerg Med 2021; 44: 203-7.
- Monteiro Júnior JGDM, de Oliveira Cipriano Torres D. Hematological parameters as prognostic biomarkers in patients with cardiovascular diseases. Curr Cardiol Rev 2019; 15: 274-82.
Immature granulocyte and other markers in prediction of mortality in spontaneous intracerebral hemorrhage
Abstract
Aim: This study aims to evaluate immature granulocyte count (IG#) and percentage (IG%) in the prediction of mortality in spontaneous intracerebral hemorrhage (SICH).
Material and Method: Demographic characteristics and laboratory test results of patients diagnosed with SICH and admitted to the neurology clinic in a tertiary hospital between January 1, 2020, and January 1, 2022, were recorded. One hundred ten patients were included in the study. While 80 of these patients constituted the group that recovered after treatment, 30 of them formed the group that died despite treatment. IG and other laboratory and clinic parameters were statistically compared in both groups.
Results: Of 110 patients, 45 (42.7%) were female, and 65 (57.3%) were male. IG counts were higher in the non-survival group than in the survival group (p=0.001). When the patients were divided according to low IG% (<0.6) and high IG% (>=0.6), 30 patients were in the high IG# group, and 80 patients were in the low IG% group. White blood cell (WBC), neutrophil count (NEUT#), monocyte count (MONO#), IG#, neutrophil-lymphocyte ratio (NLR), and hemorrhage volume (HV) values were statistically significantly higher in the high IG% group than in the low IG% group; Glasgow coma score (GCS) and percentage of lymphocytes (LYMPH%) values were significantly lower too. In addition, the mortality rate in the high IG# group was significantly higher than the mortality rate in the low IG% group (53.23% vs. 17.5%).
Conclusion: IG is a new, easily accessible, inexpensive, and promising marker for predicting in-hospital mortality in patients with SICH.
References
- Broderick JP, Adams Jr HP, Barsan W, et al. Guidelines for the management of spontaneous intracerebral hemorrhage: a statement for healthcare professionals from a special writing group of the Stroke Council. Am Heart Assoc Stroke 1999; 30: 905-15.
- Tao C, Hu X, Wang J, et al. Admission neutrophil count and neutrophil to lymphocyte ratio predict 90-day outcome in intracerebral hemorrhage. Biomarkers Med 2017; 11: 33-42.
- Ünal Y, Barlas AM. Role of increased immature granulocyte percentage in the early prediction of acute necrotizing pancreatitis. Turk J Trauma Emerg Surg 2019; 25: 177-82.
- Bedel C, Korkut M, Aksoy F, Kuş G. Usefulness of immature granulocytes to predict high coronary SYNTAX score in acute coronary syndrome; a cross-sectional study. Arch Acad Emerg Med 2020: 8.
- Korkut M, Bedel C, Zortuk Ö, Selvi F. Can immature granulocytes indicate mortality in patients with acute ischemic stroke? Neurol Asia 2021; 26: 665-70.
- Bedel C, Korkut M, Selvi F, Zortuk Ö. The immature granulocyte count is a new predictor of the 30-day mortality in intracerebral haemorrhage patients: preliminary study. Indian J Neurosurg 2021; 10: 114-20.
- Korkut M, Bedel C, Sivil R, et al. Usefulness of immature granulocytes as a prognostic factor in st-elevation myocardial ınfarction. Brazilian J Cardiovasc Surg 2022; 37: 6.
- Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-lymphocyte ratio predicts the outcome of acute intracerebral hemorrhage. Stroke 2016; 47: 1654-7.
- Al-Mufti F, Amuluru K, Damodara N, et al. Admission neutrophil–lymphocyte ratio predicts delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. J Neurointerventional Surg 2019; 11: 1135-40.
- Walsh KB, Sekar P, Langefeld CD, et al. Monocyte count and 30-day case fatality in intracerebral hemorrhage. Stroke 2015; 46: 2302-4.
- Zhang W, Shen Y. Platelet-to-lymphocyte ratio as a new predictive index of neurological outcomes in patients with acute intracranial hemorrhage: a retrospective study. Medical Science Monitor: Int Med J Experiment Clin Res 2018; 24: 4413.
- Bhatia R, Singh H, Singh S, et al. A prospective study of in-hospital mortality and discharge outcome in spontaneous intracerebral hemorrhage. Neurol India 2013; 61: 244.
- Iso H, Jacobs Jr DR, Wentworth D, et al. Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial. New Engl J Med 1989; 320: 904-10.
- Takahashi O, Cook EF, Nakamura T, et al. Risk stratification for in-hospital mortality in spontaneous intracerebral haemorrhage: a Classification and Regression Tree analysis. J Assoc Physicians 2006; 99: 743-50.
- Hwang BY, Bruce SS, Appelboom G, et al. Evaluation of intraventricular hemorrhage assessment methods for predicting outcome following intracerebral hemorrhage. J Neurosurg 2012; 116: 185-92.
- Godoy DA, Pinero G, Di Napoli M. Predicting mortality in spontaneous intracerebral hemorrhage: can modification to original score improve the prediction? Stroke 2006; 37: 1038-44.
- Lima LR, Cunha GS, Nogueira KS, Comar SR. Automated immature granulocyte count in patients of the intensive care unit with suspected infection. J Brasileiro de Patologia e Medicina Laboratorial 2019; 55: 267-80.
- Ünal Y. A new and early marker in the diagnosis of acute complicated appendicitis: immature granulocytes. Ulus Travma Acil Cerrahi Derg 2018; 24: 434-9.
- Daix T, Guérin E, Tavernier E, et al. Immature granulocytes: a risk factor of infection after cardiac surgery. Cytometry Part B: Clinical Cytometry 2018; 94: 887-94.
- Karakulak S, Narcı H, Ayrık C, Erdoğan S, Üçbilek, E. The prognostic value of immature granulocyte in patients with acute pancreatitis. Am J Emerg Med 2021; 44: 203-7.
- Monteiro Júnior JGDM, de Oliveira Cipriano Torres D. Hematological parameters as prognostic biomarkers in patients with cardiovascular diseases. Curr Cardiol Rev 2019; 15: 274-82.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Article |
| Authors | |
| Publication Date | March 27, 2023 |
| Published in Issue | Year 2023 Volume: 6 Issue: 2 |
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