Diabetes mellitus tanısı olan hastalarda hiperlipidemi ve HbA1c’deki değişimin MPV ve RDW üzerine etkisi
Abstract
Amaç: Diabetes mellitus (DM) subklinik, sistemik, düşük dereceli inflamatuvar bir endotel hastalığı olarak kabul görmektedir. Ortalama trombosit hacmi (MPV) ve eritrosit dağılım aralığı (RDW) birçok çalışmada inflamasyon ile ilişkisi araştırılmış olan hematolojik parametrelerdir. Çalışmamızda amacımız DM tanılı hastalarda HbA1c ve lipid profili ile hematolojik parametrelerden MPV ve RDW ilişkisini incelemek olmuştur.
Gereç ve Yöntem: Retrospektif olarak planlanan çalışmaya tip 2 DM tanılı 100 hasta alındı. Diyabet tanı tarihleri, kan şekeri regülasyonu için aldıkları tedavi, diyabet ilişkili mikro ve makrovasküler komplikasyonları, HbA1c’nin yüksek olduğu dönemde ve tedavi sonrasında HbA1c’nin düştüğü dönemde açlık ve tokluk kan glukozu, lipid profili, hematolojik parametreleri retrospektif olarak incelendi.
Bulgular: Çalışmaya 58 kadın ve 42 erkek hasta dahil edildi. Ortalama DM tanı süresi 3 yıl 3 ay olarak bulundu. Hastaların ilk başvuru anındaki ortalama HbA1c %9,4 iken aynı hasta grubunun kontrol muayenesi başvurusunda ortalama HbA1c %7,4 olarak saptandı. Her iki grup karşılaştırıldığında RDW (p:0,009) için anlamlı farklılık tespit edilmesine rağmen MPV (p:0,902) için anlamlı farklılık tespit edilmemiştir.
Sonuç: Bu çalışmada HbA1c değerindeki düşüş sonrası RDW değerinde artış olduğu sonucuna varılmıştır. MPV için DM tanılı hastalarda istatistiksel anlamlılık saptanmamıştır. HbA1c değerine alternatif olarak RDW değerinin de takipte kullanılabileceği, MPV için daha fazla hasta sayısı ile çok merkezli çalışmalara ihtiyaç olduğu düşünülmektedir.
Keywords
References
- Aguiree F, Brown A, Cho NH, et al. IDF Diabetes Atlas. 2013
- Satman İ, Alagöl F, Ömer B ve ark. Türkiye Diyabet, Hipertansiyon, Obezite ve Endokrinolojik Hastalıklar Prevalans Çalışması-II (TURDEP-II Çalışması). 2010.
- Hsueh WA. In diabetes,treat hidden heart disease. Cleve Clin J Med 2000; 67: 807-13.
- Beckman JA, Creager MA, Libby P: Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 2002; 287: 2570-81.
- Marso SP. Optimizing the diabetic formulary: Beyond aspirin and insulin. J Am Coll Cardiol 2002; 40: 652-61.
- Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
- Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract 2014; 105: 141-50.
- Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. Journal of Clinical Investigation 2006; 116: 1793.
- Dandona P, Aljada A and Bandyopadhyay A, Inflammation: the link between insulin resistance, obesity and diabetes. Trends in Immunology 2004; 25: 4–7.
- Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assistdevice. Perfusion 2005; 20: 83–90.
- Weiss G, Goodnough LT. Anemia of chronicdisease. N Engl J Med 2005; 352: 1011-23.
- Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrison İç Hastalıkları Prensipleri Nobel Tıp Kitabevleri 15. Baskı 2004: 1382-86, 2109-43.
- Zhang MZ, Li S, Zou X, et al. Effect of Tongguan capsule on blood lipid and coagulation in patients with CHD after PCI. J Guangzhou Univ Tradit Chin Med 2004; 21: 93–7.
- Karakilcik AZ, Halat R, Zerin M, Nazligul Y. Effect of vitamin C and exercise on lipid profile, platelet and erythrocyte indices in young soccerplayers. J Sport Med Physical Fitness 2014; 54: 665-71.
- Lippi G, Sanchis-Gomar F, Danese E, Montagnana M. Associated of red blood cell distribution width with plasma lipids in a general population of unselected outpatients. Kardiol Pol 2013; 71: 931-6.
Abstract
Aim: Diabetes mellitus (DM) is accepted as a subclinical, systemic, low-grade inflammatory endothelial disease. Mean platelet volume (MPV) and erythrocyte distribution range (RDW) are hematological parameters whose relationship with inflammation has been investigated in many studies. In our study, our aim was to examine the relationship between HbA1c and lipid profile and hematological parameters, MPV and RDW, in patients with DM.
Material and Method: 100 patients with type 2 DM were included in the study, which was planned retrospectively. Diabetes diagnosis dates, treatment for blood sugar regulation, diabetes-related micro and macrovascular complications, fasting and postprandial blood glucose, lipid profile, hematological parameters during the period when HbA1c was high and after treatment when HbA1c decreased were analyzed retrospectively.
Results: 58 female and 42 male patients were included in the study. The mean duration of DM diagnosis was 3 years and 3 months. While the mean HbA1c at the time of first admission was9.4%, the mean HbA1c was found to be 7.4% in the control examination application of the same patient group. When the two groups were compared, although a significant difference was found for RDW (p:0.009), no significant difference was found for MPV (p:0.902).
Conclusion:In this study, it was concluded that there was an increase in RDW value after the decrease in HbA1c value. No statistical significance was found for MPV in patients with DM. It is thought that RDW value can also be used in follow-up as an alternative to HbA1c value, and multicenter studies with larger number of patients are needed for MPV.
Keywords
References
- Aguiree F, Brown A, Cho NH, et al. IDF Diabetes Atlas. 2013
- Satman İ, Alagöl F, Ömer B ve ark. Türkiye Diyabet, Hipertansiyon, Obezite ve Endokrinolojik Hastalıklar Prevalans Çalışması-II (TURDEP-II Çalışması). 2010.
- Hsueh WA. In diabetes,treat hidden heart disease. Cleve Clin J Med 2000; 67: 807-13.
- Beckman JA, Creager MA, Libby P: Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 2002; 287: 2570-81.
- Marso SP. Optimizing the diabetic formulary: Beyond aspirin and insulin. J Am Coll Cardiol 2002; 40: 652-61.
- Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
- Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract 2014; 105: 141-50.
- Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. Journal of Clinical Investigation 2006; 116: 1793.
- Dandona P, Aljada A and Bandyopadhyay A, Inflammation: the link between insulin resistance, obesity and diabetes. Trends in Immunology 2004; 25: 4–7.
- Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assistdevice. Perfusion 2005; 20: 83–90.
- Weiss G, Goodnough LT. Anemia of chronicdisease. N Engl J Med 2005; 352: 1011-23.
- Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL. Harrison İç Hastalıkları Prensipleri Nobel Tıp Kitabevleri 15. Baskı 2004: 1382-86, 2109-43.
- Zhang MZ, Li S, Zou X, et al. Effect of Tongguan capsule on blood lipid and coagulation in patients with CHD after PCI. J Guangzhou Univ Tradit Chin Med 2004; 21: 93–7.
- Karakilcik AZ, Halat R, Zerin M, Nazligul Y. Effect of vitamin C and exercise on lipid profile, platelet and erythrocyte indices in young soccerplayers. J Sport Med Physical Fitness 2014; 54: 665-71.
- Lippi G, Sanchis-Gomar F, Danese E, Montagnana M. Associated of red blood cell distribution width with plasma lipids in a general population of unselected outpatients. Kardiol Pol 2013; 71: 931-6.
Details
| Primary Language | Turkish |
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| Subjects | Health Care Administration |
| Journal Section | Research Articles [en] Araştırma Makaleleri [tr] |
| Authors | |
| Publication Date | September 8, 2021 |
| Published in Issue | Year 2021 Volume: 2 Issue: 3 |
TR DİZİN ULAKBİM and International Indexes (1d)
Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]
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