Abstract
Adenomyoepithelioma is rare benign breast neoplasia characterized by the proliferation of both epithelial and myoepithelial cells of the mammary lobules and ducts. This tumour, which does not have specific risk factors and radiological findings, is mostly seen in advanced ages. This tumour, which occurs with the biphasic proliferation of epithelial and myoepithelial cells, also contains normal breast lobules and ducts. This tumour is very difficult to diagnose and includes many radiological and pathological pitfalls. Although malignant degeneration has been reported in the literature, it is a rare condition. In this study, we present a rare case with radiologically suspicious findings and pathologically reported as adenomyoepithelioma.
Keywords
Project Number
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References
- Antonelli MS, Mallel G, Pecoraro A, et al. Adenomyoepithelioma of the breast: case report and literature review. G Chir 2018; 39: 255-7.
- Smith Iorfido SM, Shah M, Iorfido SB, et al. Adenomyoepithelioma of the breast. Breast J 2017; 23: 755-6.
- Foschini Mp, Reis-Filho JS, Eusebi V, et al. Salivary gland-like tumours of the breast: surgical and molecular pathology. J Clin Pathol 2003; 56: 497-506.
- Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad 2003; 100: 8418–23.
- Gudjonsson T, Adriance MC, Sternlicht MD, et al. Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia 2005; 10: 261-72.
- McLaren BK, Smith J, Schuyler PA, et al. Adenomyoepithelioma: clinical, histologic, and immunohistologic evaluation of a series of related lesions Am J Surg Pathol 2005; 29: 1294-9.
- Gusterson BA, Warburton MJ, Mitchell D, et al. Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases. Cancer Res 1982; 42: 763-70.
- Hikino H, Nagaoka S, Miura H, et al. Benign myoepithelioma of the breast: origin and development. Pathol Int 2009; 59: 422‐6.
- Adejolu M, Wu Y, Santiago L, et al. Adenomyoepithelial tumors of the breast: imaging findings with histopathologic correlation. AJR Am J Roentgenol 2011; 197: W184-90.
- Chang A, Bassett L, Bose S. Adenomyoepithelioma of the breast. A cytologic dilemma. Report of a case and review of the literature. Diagn Cytopathol 2002; 26: 191-6.
- Reis Filho JS, Schmitt FC. Taking advantage of basic research: p63 is a reliable myoepithelial and stem cell marker. Adv Anat Pathol 2002; 9: 280–9.
- Díaz Del Arco C, Estrada Muñoz L, Pascual Martín A, et al. Adenomyoepithelioma of the breast: Report of four cases and literature review. Rev Esp Patol 2018; 51: 55-60.
- Zhu J, Ni G, Wang D, He Q, et al. Lobulated adenomyoepithelioma: a case report showing immunohistochemical profiles. Int J Clin Exp Pathol 2015; 8: 15407-11.
- Korolczuk A, Amarowicz M, Bak K, et al. Adenomyoepithelioma of the breast with late pulmonary metastases - case report and review of the literature. J Cardiothorac Surg 2016; 11: 121.
- Kim MJ, Kim CS, Ju MJ, et al. Malignant adenomyoepithelioma of the breast: a rare case report. Int J Surg Case Rep 2019; 59: 111–4.
- Moro K, Sakata E, Nakahara A, et al. Malignant adenomyoepithelioma of the breast. Surg Case Rep 2020; 6: 118.
- Lee S, Oh SY, Kim SH, et al. Malignant adenomyoepithelioma of the breast and responsiveness to eribulin. J Breast Cancer 2015; 18: 400-3
Abstract
Adenomiyoepitelyoma, meme lobül ve kanallarının hem epitel hem de miyoepitelyal hücrelerin proliferasyonu ile karakterize, nadir görülen benign bir meme neoplazisidir. Kendine özgü risk faktörleri ve radyolojik bulguları olmayan bu tümör çoğunlukla ileri yaşlarda görülür. Epitelyal ve miyoepitelyal hücrelerin bifazik proliferasyonu ile meydana gelir ve içerisinde normal meme lobülleri ve duktuslarını da barındırır. Bu tümör tanı açısından oldukça zordur ve radyolojik ve patolojik olarak birçok tuzakları içerir. Malign dejenerasyon literatürde bildirilmekle beraber nadir bir durumdur. Bu çalışmada radyolojik olarak şüpheli bulgular gösteren ve patolojik olarak adenomiyoepitelyoma olarak raporlanan nadir bir olgu sunduk.
Keywords
Supporting Institution
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Project Number
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Thanks
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References
- Antonelli MS, Mallel G, Pecoraro A, et al. Adenomyoepithelioma of the breast: case report and literature review. G Chir 2018; 39: 255-7.
- Smith Iorfido SM, Shah M, Iorfido SB, et al. Adenomyoepithelioma of the breast. Breast J 2017; 23: 755-6.
- Foschini Mp, Reis-Filho JS, Eusebi V, et al. Salivary gland-like tumours of the breast: surgical and molecular pathology. J Clin Pathol 2003; 56: 497-506.
- Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad 2003; 100: 8418–23.
- Gudjonsson T, Adriance MC, Sternlicht MD, et al. Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia 2005; 10: 261-72.
- McLaren BK, Smith J, Schuyler PA, et al. Adenomyoepithelioma: clinical, histologic, and immunohistologic evaluation of a series of related lesions Am J Surg Pathol 2005; 29: 1294-9.
- Gusterson BA, Warburton MJ, Mitchell D, et al. Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases. Cancer Res 1982; 42: 763-70.
- Hikino H, Nagaoka S, Miura H, et al. Benign myoepithelioma of the breast: origin and development. Pathol Int 2009; 59: 422‐6.
- Adejolu M, Wu Y, Santiago L, et al. Adenomyoepithelial tumors of the breast: imaging findings with histopathologic correlation. AJR Am J Roentgenol 2011; 197: W184-90.
- Chang A, Bassett L, Bose S. Adenomyoepithelioma of the breast. A cytologic dilemma. Report of a case and review of the literature. Diagn Cytopathol 2002; 26: 191-6.
- Reis Filho JS, Schmitt FC. Taking advantage of basic research: p63 is a reliable myoepithelial and stem cell marker. Adv Anat Pathol 2002; 9: 280–9.
- Díaz Del Arco C, Estrada Muñoz L, Pascual Martín A, et al. Adenomyoepithelioma of the breast: Report of four cases and literature review. Rev Esp Patol 2018; 51: 55-60.
- Zhu J, Ni G, Wang D, He Q, et al. Lobulated adenomyoepithelioma: a case report showing immunohistochemical profiles. Int J Clin Exp Pathol 2015; 8: 15407-11.
- Korolczuk A, Amarowicz M, Bak K, et al. Adenomyoepithelioma of the breast with late pulmonary metastases - case report and review of the literature. J Cardiothorac Surg 2016; 11: 121.
- Kim MJ, Kim CS, Ju MJ, et al. Malignant adenomyoepithelioma of the breast: a rare case report. Int J Surg Case Rep 2019; 59: 111–4.
- Moro K, Sakata E, Nakahara A, et al. Malignant adenomyoepithelioma of the breast. Surg Case Rep 2020; 6: 118.
- Lee S, Oh SY, Kim SH, et al. Malignant adenomyoepithelioma of the breast and responsiveness to eribulin. J Breast Cancer 2015; 18: 400-3
Details
| Primary Language | Turkish |
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| Subjects | Health Care Administration |
| Journal Section | Case Report [en] Olgu Sunumu [tr] |
| Authors | |
| Project Number | - |
| Publication Date | June 28, 2022 |
| Published in Issue | Year 2022 Volume: 3 Issue: 2 |
TR DİZİN ULAKBİM and International Indexes (1d)
Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS]
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