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BİPERİDEN İNTOKSİKASYONUNDA FİZOSTİGMİN KULLANIMI: OLGU SUNUMU

Year 2016, Volume: 11 Issue: 1, 0 - 0, 08.11.2016

Abstract

Özet

Biperiden santral sinir sistemi üzerine etki gösteren antikolinerjik bir ajandır. Atropin benzeri etki göstererek parkinsonizim ve ekstrapiramidal semptomların tedavisinde kullanılır. Biperiden zehirlenmelerinde antikolinerjik sendrom gelişmektedir. Fizostigmin santral etkili asetilkolinesteraz inhibitörüdür. Bu yazıda ciddi Biperiden intoksikasyonuyla başvuran hastada Fizostigmin’le olan tedavi deneyimimizi paylaşmayı amaçladık.

Anahtar Kelimeler: Biperiden, Fizostigmin, İntoksikasyon

 

PHYSOSTIGMINE USE IN BIPERIDEN INTOXICATION: CASE REPORT

Abstract:

Biperiden is an anticholinergic agent that effects on central nervous system. It is used in the treatments of parkinsonism and extrapyramidal symptoms by showing Atropine -like effects. Physostigmine is a central acting cholinesterase inhibitor. In this case, we aim to share our experience with Physostigmine treatment in patient presenting with severe biperiden intoxication.

Keywords: Biperiden, Physostigmine, Intoxication

References

  • Dose M, Tempel HD. Abuse potential of anticholinergics. Pharmacopsychiatry, 2000; 33: (Sup. 1) 43-46.
  • Grace RF. Benztropine abuse and overdose--case report and review. Adverse Drug React Toxicol Rev. 1997;16(2):103-12.
  • Katsanoulas K, Papaioannou A, Fraidakis O, Michaloudis D. Undiagnosed central anticholinergic syndrome may lead to dangerous complications. Eur J Anaesthesiol 2000; 17(7):466-7.
  • Hewer W, Biedert S. [Delirium syndrome in biperiden poisoning]. Fortschr Neurol Psychiatr. 1988 Apr;56(4):133-6.
  • Demir C, Dülger C, Mete R, Arslan Ş, Dilek İ. Atropa belladonna ile zehirlenme: Bir olgu sunumu. Van Tıp Dergisi 2006; 13: 61-3.
  • Demirhan A, Tekelioğlu ÜY, Yıldız İ, ve ark. Atropa Belladonna (Güzel Avrat Otu) Meyvesi ile İlişkili Antikolinerjik Toksik Sendrom: Bir Olgu Sunumu. Turk J Anaesth Reanim 2013; 41: 226-8
  • Lester DB, Rogers TD, Blaha CD. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci Ther. 2010;16(3):137-62.
  • Köse R, Şahin ÖÖ, Abay E. Datura stramonium zehirlenmesine bağlı deliryum: Bir olgu. Anatolian Journal of Psychiatry 2008;9(1):54-7
  • Kesici S, Türkmen A, Altan A, Gündüz U, Kesici U, Sarı K. Geriatrik Bir Hastada, Postoperatif Dönemde Karşılaşılan Santral Antikolinerjik Sendrom. Okmeydanı Tıp Dergisi 2011; 27(2):101-104.
  • Falletta JM, Stasney CR, Mintz AA. Amitriptyline poisoning treated with physostigmine. South Med J 1970;63:1492–14935.
  • Watkins JW, Schwarz ES, Arroyo-Plasencia AM, Mullins ME; on behalf of the Toxicology Investigators Consortium investigators. The Use of Physostigmine by Toxicologists in Anticholinergic Toxicity. J Med Toxicol. 2014 Dec 16. DOI 10.1007/s13181-014-0452-x
  • Espi Martinez F, Espi Forcen F, Shapov A, Martinez Moya A. Biperiden dependence: case report and literature review. Case Rep Psychiatry. 2012;2012:949256.
Year 2016, Volume: 11 Issue: 1, 0 - 0, 08.11.2016

Abstract

References

  • Dose M, Tempel HD. Abuse potential of anticholinergics. Pharmacopsychiatry, 2000; 33: (Sup. 1) 43-46.
  • Grace RF. Benztropine abuse and overdose--case report and review. Adverse Drug React Toxicol Rev. 1997;16(2):103-12.
  • Katsanoulas K, Papaioannou A, Fraidakis O, Michaloudis D. Undiagnosed central anticholinergic syndrome may lead to dangerous complications. Eur J Anaesthesiol 2000; 17(7):466-7.
  • Hewer W, Biedert S. [Delirium syndrome in biperiden poisoning]. Fortschr Neurol Psychiatr. 1988 Apr;56(4):133-6.
  • Demir C, Dülger C, Mete R, Arslan Ş, Dilek İ. Atropa belladonna ile zehirlenme: Bir olgu sunumu. Van Tıp Dergisi 2006; 13: 61-3.
  • Demirhan A, Tekelioğlu ÜY, Yıldız İ, ve ark. Atropa Belladonna (Güzel Avrat Otu) Meyvesi ile İlişkili Antikolinerjik Toksik Sendrom: Bir Olgu Sunumu. Turk J Anaesth Reanim 2013; 41: 226-8
  • Lester DB, Rogers TD, Blaha CD. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci Ther. 2010;16(3):137-62.
  • Köse R, Şahin ÖÖ, Abay E. Datura stramonium zehirlenmesine bağlı deliryum: Bir olgu. Anatolian Journal of Psychiatry 2008;9(1):54-7
  • Kesici S, Türkmen A, Altan A, Gündüz U, Kesici U, Sarı K. Geriatrik Bir Hastada, Postoperatif Dönemde Karşılaşılan Santral Antikolinerjik Sendrom. Okmeydanı Tıp Dergisi 2011; 27(2):101-104.
  • Falletta JM, Stasney CR, Mintz AA. Amitriptyline poisoning treated with physostigmine. South Med J 1970;63:1492–14935.
  • Watkins JW, Schwarz ES, Arroyo-Plasencia AM, Mullins ME; on behalf of the Toxicology Investigators Consortium investigators. The Use of Physostigmine by Toxicologists in Anticholinergic Toxicity. J Med Toxicol. 2014 Dec 16. DOI 10.1007/s13181-014-0452-x
  • Espi Martinez F, Espi Forcen F, Shapov A, Martinez Moya A. Biperiden dependence: case report and literature review. Case Rep Psychiatry. 2012;2012:949256.
There are 12 citations in total.

Details

Journal Section Makaleler
Authors

Ömer Faruk Boran

Evren Büyükfırat

Ferida Esma Elibol This is me

Hasan Dolu This is me

Mustafa Azmi Dalyan This is me

Süheyla Karadağ This is me

Publication Date November 8, 2016
Submission Date January 12, 2015
Published in Issue Year 2016 Volume: 11 Issue: 1

Cite

AMA Boran ÖF, Büyükfırat E, Elibol FE, Dolu H, Dalyan MA, Karadağ S. BİPERİDEN İNTOKSİKASYONUNDA FİZOSTİGMİN KULLANIMI: OLGU SUNUMU. KSU Medical Journal. November 2016;11(1).