Kahve ve çay tüketiminin tip 2 diyabet ve insülin direnci olan bireylerdeki etkisinin kesitsel bir çalışma ile değerlendirilmesi
Abstract
Tüm dünyada yaygın olarak tüketilen çay ve kahvenin tip 2 diyabetli bireylerde glikoz kullanımı ve metabolizmasını etkileyebileceği düşünülmüştür. Amaç: Tip 2 diyabet veya insülin dirençli bireylerde kahve ile çay tüketiminin antropometrik ve biyokimyasal değerlerle ilişkisinin saptaması amaçlanmıştır. Yöntem: Çalışma Ege Üniversitesi Endokrinoloji ve Metabolizma Hastalıkları BD polikliniğine 2015-2016 Aralık tarihleri arasında başvuran (18-65 yaş arası) tip 2 diyabetli ve insülin direnci olan bireylere veri toplama formu ile uygulanarak yürütülmüştür. Bulgular: Gönüllülerin (n=300, yaş ortalaması 45.0) %54.0’ü tip 2 diyabetiktir; %65.0’i oral antidiyabetik, %14.3’ü bazal insülin, %15.6’sı ise multipl enjektabl tedavisi kullanmaktadır. Tıbbi beslenme tedavisinin %62.7’si uygulanmamaktadır. Katılımcıların %48.3’ü Türk kahvesini, %73.0’ü çayı, %84.7’si granül kahveyi şekersiz tüketmektedir. Beden kütle indeksi (BKİ), bel çevresi, yağ oranı ortalaması sırasıyla (n=300) 33.6 kg/m2, (n=299) 108.6 cm, (n=287) %39.1 belirlenmiştir. HbA1c, total kolesterol, trigliserit, HDL kolesterol, LDL kolesterol, sistolik ve diyastolik kan basıncları ortalamaları sırasıyla (n=274) %6.3, (n=252) 207.7 mg/dL, (n=253) 166.8 mg/dL, (n=249) 50.1 mg/dL, (n=247) 126.1 mg/dL, (n=288) 123.7 mmHg, (n=288) 80.3 mmHg olarak saptanmıştır. Bireylerin günlük mL tüketim ortalaması 187.5 7 (n=70) yeşil çay, 564.7 (n=288) siyah çay, 53.0 (n=240) Türk kahvesi, 206.5 (n=115) granül kahvedir. Günlük ≥800 mL siyah çay tüketenlerde <800 mL siyah çay tüketenlere göre vücut yağ oranının normal olma durumu anlamlı olarak yüksek saptanmıştır (p<0.05). Sonuç: Kahveyle çayın etkisini saptamak amacıyla kapsamlı çalışmalara ihtiyaç vardır.
Keywords
Supporting Institution
Bu çalışma Ege Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü 16/ECZ/001 nolu proje tarafından desteklenmiştir.
Project Number
16/ECZ/001 nolu proje
Thanks
İstatistiksel analiz konusunda desteklerinden dolayı Dr. Kıvanç Yüksel’e teşekkür ederiz
References
- Kaynaklar 1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87(1): 4-14.
- 2. Evert AB, Boucher JL, Cypress M et al. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care 2014;37(1):120-143.
- 3. Ra A, Polansky MM. Tea enhances insulin activity. J Agric Food Chem 2002;50(24):7182-7186.
- 4. Higdon JV, Frei B. Tea Catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sc Nut 2003;43(1):89-143.
- 5. Lane JD, Barkauskas CE, Surwit RS, Feinglos MN. caffeine impairs glucose metabolism in type 2 diabetes. Diabetes Care 2004;27(8):2047-2048.
- 6. Kobayashi Y, Suzuki M, Satsu H et al. Green tea polyphenols ınhibit the sodium-dependent glucose transporter of ıntestinal epithelial cells by a competitive mechanism. J Agric Food Chem 2000; 48(11): 5618-5623.
- 7. Shimizu M, Kobayashi Y, Suzuki M, Satsu H, Miyamoto Y. Regulation of intestinal glucose transport by tea catechins. BioFactors 2000;13(1-4):61–65.
- 8. Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 2000;141(3):980-987.
- 9. Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 2002;277(38):34933-34940.
- 10. Kao YH, Chang HH, Lee MJ, Chen CL. Tea, obesity, and diabetes. Mol Nutr Food Res 2006;50(2):188-210.
- 11. Tuomilehto J, Hu G, Bidel S, Lindström J, Jousilahti P. Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women. JAMA 2004;291(10):1213-1219.
- 12. Arion WJ, Canfield WK, Ramos FC et al. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys 1997;339(2):315-322.
- 13. Herling AW, Burger H, Schubert G, Hemmerle H, Schaefer H, Kramer W. Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats. Eur J Pharmacol 1999;386(1):75-82.
- 14. Li Y, Kim J, Li J et al. Natural anti-diabetic compound 1,2,3,4,6-penta-O-galloyl-D-glucopyranose binds to insulin receptor and activates insulin-mediated glucose transport signaling pathway. Biochem Biophys Res Commun 2005;336(2):430-437.
- 15. Muthusamy VS, Anand S, Sangeetha KN, Sujatha S, Arun B, Lakshmi BS. Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition. Chem Biol Interact 2008;174(1):69-78.
- 16. Prabhakar PK, Doble M. Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. Phytomedicine 2009;16(12):1119-1126.
- 17. Egawa T, Hamada T, Kameda N et al. Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Metabolism 2009;58(11):1609–1617.
- 18. Vitaglione P, Morisco F, Mazzone G et al. Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins. Hepatology 2010;52(5):1652-1661.
- 19. Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 2003;26(4):1147-1152.
- 20. Belin RJ, He K. Magnesium physiology and pathogenic mechanisms that contribute to the development of the metabolic syndrome. Magnes Res 2007;20(2):107-129.
- 21. Craig CL, Marshall AL, Sjöström M et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35(8):1381–1395.
- 22. Öztürk M., Üniversitede eğitim-öğretim gören öğrencilerde uluslararası fiziksel aktivite anketinin geçerliliği ve güvenirliği ve fiziksel aktivite düzeylerinin belirlenmesi (Yüksek Lisans Tezi), Hülya Arıkan, Yayımlanmamış tezi, Ankara, 2005.
- 23. American Diabetes Association. Standards of Medical Care in Diabetes-2015. Diabetes Care 2014; 38(1):21-24.
- 24. Liu CY, Huang CJ, Huang LH, Chen IJ, Chiu JP, Hsu CH. Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial. PLoS One 2014;9(3):e91163.
- 25. Williams CJ, Fargnoli JL, Hwang JJ et al. Coffee consumption is associated with higher plasma adiponectin concentrations in women with or without type 2 diabetes: a prospective cohort study. Diabetes Care 2008;31(3):504-507.
- 26. Bhaktha G, Nayak BS, Mayya S, Shantaram M. Relationship of Caffeine with Adiponectin and Blood Sugar Levels in Subjects with and without Diabetes. J Clin Diagn Res 2015;9(1):BC01-BC3.
- 27. Hosoda K, Wang MF, Liao ML et al. Antihyperglycemic effect of oolong tea in type 2 diabetes. Diabetes Care 2003; 26(6): 1714–1718.
- 28. Sözlü S, Yılmaz B, Acar Tek N. Kahve tüketimi ve bazı hastalıklarla ilişkisi: son yıllarda yapılan insan temelli araştırmaların irdelenmesi. SDÜ Sağlık Bilimleri Dergisi. 2017;8(2): 33-39.
- 29. Shi L, Brunius C, Johansson I et al. Plasma metabolite biomarkers of boiled and filtered coffee intake and their association with type 2 diabetes risk. J Intern Med 2020;287(4):405-421.
- 30. Dincer C, T Apaydın D, Gogas Y. Endocrine Effects of Coffee Consumption. Turk J Endocrinol Metab 2020;24(1):72-86.
- 31. Saltan FZ, H Kaya. Kahve: Bir Farmakognozik Derleme. Fabad J Pharm Sci 2018;43(3):279-289.
Evaluation of effect of coffee and tea consumption on individuals with type 2 diabetes and insulin resistance: A cross-sectional study
Abstract
Tea and coffee, widely consumed around the world, were thought to affect glucose usage and metabolism in individuals with type 2 diabetes. Objective: To determine the relationship between coffee and tea consumption with anthropometric and biochemical values individuals with type 2 diabetes and insulin resistance was aimed. Method: The study was conducted with face-to-face questionnaires with individuals (ages 18-65), having type 2 diabetes or insulin resistance who applied to the Ege University Endocrinology and Metabolic Diseases Clinic between December 2015-2016. Results: Volunteers (n=300, average age 45.0) had type 2 diabetic (54.0%) uses oral antidiabetic (65.0%), basal insulin (14.3%), multiple injectable (15.6%) therapies. Medical nutrition therapy was not performed (62.7%). The participants consume Turkish coffee (48.3%) tea (73.0%) granulated coffee (84.7%) without sugar. Averages of Body Mass Index, waist circumference, fat ratio mean was determined as (n=300) 33.6 kg / m2, (n=299) 108.6 cm, (n=287) 39.1% respectively. HbA1c, total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, systolic and diastolic blood pressure averages were (n=274) 6.3%, (n=252) 207.7 mg / dL, (n=253) 166.8 mg / dL, (n=249) 50.1 mg / dL, (n=247) 126.1 mg / dL, (n=288) 123.7 mmHg, (n=288) 80.3 mmHg respectively. Individuals consumed mL/daily average of 187.5 7 (n=70) green tea, 564.7 (n=288) black tea, 53.0 (n=240) Turkish coffee, 206.5 (n=115) granulated coffee. The normal state of body fat was found to be significantly higher in those who consumed ≥800 mL of black tea daily, than those consumed <800 mL (p <0.05). Conclusion: Further studies are needed to determine effects of tea and coffee.
Keywords
Project Number
16/ECZ/001 nolu proje
References
- Kaynaklar 1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87(1): 4-14.
- 2. Evert AB, Boucher JL, Cypress M et al. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care 2014;37(1):120-143.
- 3. Ra A, Polansky MM. Tea enhances insulin activity. J Agric Food Chem 2002;50(24):7182-7186.
- 4. Higdon JV, Frei B. Tea Catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sc Nut 2003;43(1):89-143.
- 5. Lane JD, Barkauskas CE, Surwit RS, Feinglos MN. caffeine impairs glucose metabolism in type 2 diabetes. Diabetes Care 2004;27(8):2047-2048.
- 6. Kobayashi Y, Suzuki M, Satsu H et al. Green tea polyphenols ınhibit the sodium-dependent glucose transporter of ıntestinal epithelial cells by a competitive mechanism. J Agric Food Chem 2000; 48(11): 5618-5623.
- 7. Shimizu M, Kobayashi Y, Suzuki M, Satsu H, Miyamoto Y. Regulation of intestinal glucose transport by tea catechins. BioFactors 2000;13(1-4):61–65.
- 8. Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 2000;141(3):980-987.
- 9. Law ME, Wang XL, Law BK, Hall RK, Nawano M, Granner DK. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 2002;277(38):34933-34940.
- 10. Kao YH, Chang HH, Lee MJ, Chen CL. Tea, obesity, and diabetes. Mol Nutr Food Res 2006;50(2):188-210.
- 11. Tuomilehto J, Hu G, Bidel S, Lindström J, Jousilahti P. Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women. JAMA 2004;291(10):1213-1219.
- 12. Arion WJ, Canfield WK, Ramos FC et al. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys 1997;339(2):315-322.
- 13. Herling AW, Burger H, Schubert G, Hemmerle H, Schaefer H, Kramer W. Alterations of carbohydrate and lipid intermediary metabolism during inhibition of glucose-6-phosphatase in rats. Eur J Pharmacol 1999;386(1):75-82.
- 14. Li Y, Kim J, Li J et al. Natural anti-diabetic compound 1,2,3,4,6-penta-O-galloyl-D-glucopyranose binds to insulin receptor and activates insulin-mediated glucose transport signaling pathway. Biochem Biophys Res Commun 2005;336(2):430-437.
- 15. Muthusamy VS, Anand S, Sangeetha KN, Sujatha S, Arun B, Lakshmi BS. Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition. Chem Biol Interact 2008;174(1):69-78.
- 16. Prabhakar PK, Doble M. Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes. Phytomedicine 2009;16(12):1119-1126.
- 17. Egawa T, Hamada T, Kameda N et al. Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Metabolism 2009;58(11):1609–1617.
- 18. Vitaglione P, Morisco F, Mazzone G et al. Coffee reduces liver damage in a rat model of steatohepatitis: the underlying mechanisms and the role of polyphenols and melanoidins. Hepatology 2010;52(5):1652-1661.
- 19. Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care 2003;26(4):1147-1152.
- 20. Belin RJ, He K. Magnesium physiology and pathogenic mechanisms that contribute to the development of the metabolic syndrome. Magnes Res 2007;20(2):107-129.
- 21. Craig CL, Marshall AL, Sjöström M et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35(8):1381–1395.
- 22. Öztürk M., Üniversitede eğitim-öğretim gören öğrencilerde uluslararası fiziksel aktivite anketinin geçerliliği ve güvenirliği ve fiziksel aktivite düzeylerinin belirlenmesi (Yüksek Lisans Tezi), Hülya Arıkan, Yayımlanmamış tezi, Ankara, 2005.
- 23. American Diabetes Association. Standards of Medical Care in Diabetes-2015. Diabetes Care 2014; 38(1):21-24.
- 24. Liu CY, Huang CJ, Huang LH, Chen IJ, Chiu JP, Hsu CH. Effects of green tea extract on insulin resistance and glucagon-like peptide 1 in patients with type 2 diabetes and lipid abnormalities: a randomized, double-blinded, and placebo-controlled trial. PLoS One 2014;9(3):e91163.
- 25. Williams CJ, Fargnoli JL, Hwang JJ et al. Coffee consumption is associated with higher plasma adiponectin concentrations in women with or without type 2 diabetes: a prospective cohort study. Diabetes Care 2008;31(3):504-507.
- 26. Bhaktha G, Nayak BS, Mayya S, Shantaram M. Relationship of Caffeine with Adiponectin and Blood Sugar Levels in Subjects with and without Diabetes. J Clin Diagn Res 2015;9(1):BC01-BC3.
- 27. Hosoda K, Wang MF, Liao ML et al. Antihyperglycemic effect of oolong tea in type 2 diabetes. Diabetes Care 2003; 26(6): 1714–1718.
- 28. Sözlü S, Yılmaz B, Acar Tek N. Kahve tüketimi ve bazı hastalıklarla ilişkisi: son yıllarda yapılan insan temelli araştırmaların irdelenmesi. SDÜ Sağlık Bilimleri Dergisi. 2017;8(2): 33-39.
- 29. Shi L, Brunius C, Johansson I et al. Plasma metabolite biomarkers of boiled and filtered coffee intake and their association with type 2 diabetes risk. J Intern Med 2020;287(4):405-421.
- 30. Dincer C, T Apaydın D, Gogas Y. Endocrine Effects of Coffee Consumption. Turk J Endocrinol Metab 2020;24(1):72-86.
- 31. Saltan FZ, H Kaya. Kahve: Bir Farmakognozik Derleme. Fabad J Pharm Sci 2018;43(3):279-289.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Project Number | 16/ECZ/001 nolu proje |
| Publication Date | April 30, 2021 |
| Submission Date | August 13, 2020 |
| Acceptance Date | November 16, 2020 |
| Published in Issue | Year 2021 Volume: 14 Issue: 1 |
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