Research Article
Year 2022,
Volume: 9 Issue: 3, 263 - 265, 30.12.2022
Abstract
Multipl sklerozda (MS) santral sinir sistemi tutulması ön planda olduğu için perferik sinir iletimi çalışmalarında herhangi bir anormallik beklenmez. Ancak literatürde MS'li hastalarda periferik sinir iletim çalışmaları anormallikleri destekleyen çalışmalarda vardır. Bizim bu çalışmadaki amacımız Relapsing-Remitting formdaki MS'li (RRMS) hastalarda periferik sinir tutulumunun olup olmadığını, periferik sinir iletim çalışmaları ile ortaya koymaktır. 2001 yılında revize edilen McDonalds kriterlerine göre kesin RRMS tanısı alan 20 kişilik hasta grubu ile 15 kişilik kontrol grubu arasında yapılan elektromiyografi (EMG) ile median, peroneal, tibial ve sural sinirlerde ileti hızı, distal latans (DL) ve aksiyon potansiyeli amplitüt değerleri karşılaştırılması yapıldı. Hasta ve kontrol grubunda arasında yapılan EMG çalışmalarının karşılaştırılmasında ileti hızı, DL, aksiyon potansiyeli amplitütleri arasında istatiksel olarak anlamlı fark bulunamamıştır. Bizim yaptığımız sinir ileti çalışmalarında MS’li hastalarla, kontrol gurubu arasında istatiksel olarak anlamlı fark bulunamamış olmasına rağmen, çeşitli çalışmalarda MS’li hasta alt gruplarında yaklaşık %5 ile %14 arasında periferik sinir tutulumu gözlenmiştir. Bu konuda daha geniş örneklem büyüklüğüyle ve daha kapsamlı yapılacak çalışmalara ihtiyaç vardır.
Supporting Institution
yok
Project Number
yok
Thanks
Bu çalışmanın gerçekleştirilmesi aşamasında desteğini her zaman hissettiren sayın hocam Prof. Dr Ayhan Öztürk'e ve Düzce Üniversitesine teşekkür ederim.
References
- 1. Burrell AM, Handel AE, Ramagopalan SV, et al. Epigenetic mechanisms in multiple scleriosis and the major histocompatibility complex. (MHC) Discov Med. 2011;11(58):187-96.
- 2. Vogt J, Paul F, Aktas O, et al. Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalitis. Ann Neurol. 2009;66(3):310-22.
- 3. Miglietta O, Lowenthal M. A study of peripheral nerve involvement in fifty-four patients with multiplesclerosis. Arch Phys Med Rehabil. 1961;42:573-8.
- 4. Falcone M, Scalise A, Minisci C, et al. Spreading of autoimmunity from central to peripheral myelin: two cases of clinical association between multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. Neurol Sci. 2006;27(1):58-62.
- 5. Gartzen K, Katzarava Z, Diener HC, et al. Peripheral nervous system involvement in multiple sclerosis. Eur J Neurol. 2011;18(5):789-91.
- 6. Pender MP. The pathophysiology of acute experimental allergic encephalomyelitis induced by whole spinal cord in the Lewis rat. J Neurol Sci. 1988;84(2-3):209-22.
- 7. Waxman SG. Peripheral nerve abnormalities in multiple sclerosis. Muscle Nerve. 1993;16(1):1-5.
- 8. Emad MR, Zeinali L, Nikseresht A, et al. Peripheral Neuropathy in Multiple Sclerosis: An Electrophysiologic Study in Iranian Patients. Acta Med Iran. 2017;55(8):496-501.
- 9. Ayromlou H, Mohammad-Khanli H, Yazdchi-Marandi M, et al. Electrodiagnostic evaluation of peripheral nervous system changes in patients with multiple sclerosis. Malays J Med Sci. 2013;20(4):32-8.
Year 2022,
Volume: 9 Issue: 3, 263 - 265, 30.12.2022
Abstract
Since central nervous system involvement is prominent in multiple sclerosis (MS), no abnormality is expected in peripheral nerve conduction studies. However, there are studies in the literature supporting the abnormalities in peripheral nerve conduction studies in patients with MS. Our aim in this study is to determine whether there is peripheral nerve involvement in patients with Relapsing-Remitting MS (RRMS) with peripheral nerve conduction studies. Conduction velocity, distal latency (DL) and action potential amplitude in median, peroneal, tibial and sural nerves were compared by electromyography (EMG) between 20 patients who were diagnosed with definite RRMS according to McDonalds criteria revised in 2001 and 15 control group. In the comparison of EMG studies performed between the patient and control groups, no statistically significant difference was found between conduction velocity, DL, and action potential amplitudes. Although no statistically significant difference was found between the patients with MS and the control group in our nerve conduction studies, peripheral nerve involvement was observed between 5% and 14% in the subgroups of patients with MS in various studies. There is a need for more comprehensive studies with a larger sample size on this subject.
Project Number
yok
References
- 1. Burrell AM, Handel AE, Ramagopalan SV, et al. Epigenetic mechanisms in multiple scleriosis and the major histocompatibility complex. (MHC) Discov Med. 2011;11(58):187-96.
- 2. Vogt J, Paul F, Aktas O, et al. Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalitis. Ann Neurol. 2009;66(3):310-22.
- 3. Miglietta O, Lowenthal M. A study of peripheral nerve involvement in fifty-four patients with multiplesclerosis. Arch Phys Med Rehabil. 1961;42:573-8.
- 4. Falcone M, Scalise A, Minisci C, et al. Spreading of autoimmunity from central to peripheral myelin: two cases of clinical association between multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. Neurol Sci. 2006;27(1):58-62.
- 5. Gartzen K, Katzarava Z, Diener HC, et al. Peripheral nervous system involvement in multiple sclerosis. Eur J Neurol. 2011;18(5):789-91.
- 6. Pender MP. The pathophysiology of acute experimental allergic encephalomyelitis induced by whole spinal cord in the Lewis rat. J Neurol Sci. 1988;84(2-3):209-22.
- 7. Waxman SG. Peripheral nerve abnormalities in multiple sclerosis. Muscle Nerve. 1993;16(1):1-5.
- 8. Emad MR, Zeinali L, Nikseresht A, et al. Peripheral Neuropathy in Multiple Sclerosis: An Electrophysiologic Study in Iranian Patients. Acta Med Iran. 2017;55(8):496-501.
- 9. Ayromlou H, Mohammad-Khanli H, Yazdchi-Marandi M, et al. Electrodiagnostic evaluation of peripheral nervous system changes in patients with multiple sclerosis. Malays J Med Sci. 2013;20(4):32-8.
There are 9 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Internal Diseases |
| Journal Section | Original Article |
| Authors | |
| Project Number | yok |
| Publication Date | December 30, 2022 |
| Submission Date | September 16, 2021 |
| Published in Issue | Year 2022 Volume: 9 Issue: 3 |
