Research Article
Year 2023,
Volume: 40 Issue: 4, 721 - 724, 03.01.2024
Abstract
Hydatidiform mole (HM) is a gestational trophoblastic disease. Potential risk factors are advanced maternal age, reproductive factors, oral contraceptive use, history of gestational trophoblastic disease, oxidative stress, and other environmental factors. Serum amyloid A (SAA) protein has an important role in acute phase response but also associated with pathologic fibril formation in chronic inflammation. The aim of the current study is to determine the relationship between maternal SAA levels in patients with both complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM), and to examine possible role in the disease in pathogenesis. Fifty healthy pregnant women in the first trimester of pregnancy with completely normal pregnancy follow-up, and 50 patients who were diagnosed with HM, who were also in the first trimester of pregnancy included to the study. There was no difference between patients and control group according to body mass index (BMI), gravidity, parity, number of living children, number of miscarriage, level of blood TSH, and hemoglobin level between two groups. SAA levels in patients with HM were significantly higher than those in healthy controls. This may be an important underexplored pathway mediating the relationship between oxidative stress and abnormal placental proliferation.
References
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Year 2023,
Volume: 40 Issue: 4, 721 - 724, 03.01.2024
Abstract
Keywords
References
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- 2. Szulman AE, Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morpho- logic correlations. Am J Obstet Gynecol. 1978;131:665–671.
- 3. Newlands ES, Paradinas FJ, Fisher RA . Recent advances in gestational trophoblastic disease. Hematol Oncol Clin North Am. 1999 Feb;13(1):225-44, x.
- 4. Altieri A, Franceschi S, Ferlay J, Smith J, La Vecchia C. Epidemiology and aetiology of gestational trophoblastic diseases. Lancet Oncol 2003;4:670–678.
- 5. Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 2005;3:28.
- 6. Gupta S, Agarwal A, Banerjee J, Alvarez JG. The role of oxidative stress in spontaneous abortion and recurrent pregnancy loss: a systematic review. Obstet Gynecol Surv. 2007 May;62(5):335-47; quiz 353-4.
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- 9. Urieli-Shoval S, Linke RP, Matzner Y. Expression and function of serum amyloid A, a major acute phase protein, in normal and disease states. Curr Opin Hematol. 2000 Jan; 7:64–69.
- 10. Kovacevic A, Hammer A, Sundl M, Pfister B, Hrzenjak A, et al. Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells. FEBS Lett. 2006;580:161–167.
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- 17. Lash GE, Quenby S, Burton GJ, Nakashima A, Kamat BR, Ray J, et al. Gestational diseases – a workshop report. Placenta 2008;29 (Suppl. A):S92–4.
- 18. Sharp AN, Heazell AE, Crocker IP, Mor G. Placental apoptosis in health and disease. Am J Reprod Immunol. 2010;64:159–69.
- 19. Ferraz L, Ramos CAB, Braga A, Velarde LGC, Elias KM, Horowitz NS, et al. Association between antioxidant vitamins and oxidative stress among patients with a complete hydatidiform mole. Clinics (Sao Paulo). 2020;75:e1724.
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- 21. Koseoglu SB, Guzel AI, Deveer R, et al. Maternal serum amyloid A levels in pregnancies complicated with preterm prelabour rupture of membranes. Ginekol Pol 2014;85:516-520.
- 22. Sandri S, Urban BA, Fernandes I, et al. Serum amyloid A in the placenta and its role in trophoblast invasion. PLoS ONE. 2014;9:e90881.
- 23. Michaeli A, Finci Yeheskel Z, Dishon S, Linke RP, Levin M, Urieli-Shoval S. Serum amyloid A enhances plasminogen activation: implication for a role in colon cancer. Biochem Biophys Res Commun. 2008 Apr 4;368(2):368–373.
- 24. Verit FF, Hilali NG. Increased insulin resistance and C-reactive protein in women with complete hydatidiform mole. Gynecol Endocrinol. 2011 Oct;27(10):840-3.
- 25. Rossi L, Martin BM, Hortin GL, et al: Inflammatory protein profile during systemic high dose interleukin-2 administration. Proteomics 6:709-720, 2006.
- 26. Yamada T. Serum amyloid A (SAA): A concise review of biology, assay methods and clinical usefulness. Clin Chem Lab Med 37:381-388, 1999.
There are 26 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Article |
| Authors | |
| Publication Date | January 3, 2024 |
| Submission Date | February 15, 2023 |
| Acceptance Date | October 2, 2023 |
| Published in Issue | Year 2023 Volume: 40 Issue: 4 |
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