Outcomes of the ocular surface squamous neoplasia following primary excision with narrow margins and cryotherapy

Demet Yolcu

Research Article

Outcomes of the ocular surface squamous neoplasia following primary excision with narrow margins and cryotherapy

Year 2023, Volume: 40 Issue: 4, 729 - 733, 03.01.2024

Abstract

The aim of the current study was to evaluate the outcomes of the surgical excision of the ocular surface squamous neoplasia (OSSN) with 2 mm margins and adjuvant cryotherapy.The medical records of the subjects who were diagnosed with OSSN and treated with surgical excision with 2 mm margins and adjuvant cryotherapy at the University of Health Sciences, Abdurrahman Yurtaslan Oncology Training and Research Hospital, Department of Ophthalmology, between May 2016 and April 2022 were analyzed. According to the margin status, subjects were divided into two groups (margin positive/indeterminate or negative), and, recurrence rate, treatment methods and complications were analyzed. Out of the 26 OSSN cases, 12 were margin positive/indeterminate and 14 were negative, and, 7 showed recurrence. Of the 14 margin negative cases, 4 showed recurrences, and, of the 12 margin positive/indeterminate cases 3 showed recurrence. Of the 12 margin positive/indeterminate cases, 9 received adjuvant treatment and 1 showed recurrence. Treatments were performed by either INF alfa 2-b or recurrent cryotherapy. There was no significant difference in histopathological diagnosis, follow up period or recurrence rate between the groups (p  0.05). Complications were mild and slightly higher in cases who were treated with recurrent cryotherapy when compared with INF alfa 2-b.Adjuvant therapies reduced the recurrence rate in margin positive/indeterminate cases after excision of the OSSN with narrow margins, and margin negative cases had similar recurrence rate with margin positive/indeterminate cases. After removal of the OSSN with narrow margins, subjects should receive adjuvant therapies if the surgical margins are not negative, and, if the surgical margins were negative, then subject should be monitored closely because of the high recurrence risk of this group.

Keywords

Ocular surface squamous neoplasia, cryotherapy, INF alfa-2b, surgical margin

References

1. Nanji AA, Moon CS, Galor A, Sein J, Oellers P, Karp CL. Surgical versus medical treatment of ocular surface squamous neoplasia: a comparison of recurrences and complications. Ophthalmology. 2014;121(5):994-1000.
2. Alvarez OP, Zein M, Galor A, Karp CL. Management of ocular surface squamous neoplasia: Bowman Club Lecture 2021. BMJ Open Ophthalmol. 2021;6(1):e000842.
3. Bowen RC, Soto H, Raval V, Bellerive C, Yeaney G, Singh AD. Ocular surface squamous neoplasia: outcomes following primary excision with 2 mm margin and cryotherapy. Eye (Lond). 2021;35(11):3102-9.
4. Shields CL, Paulose SA, Yaghy A, Dalvin LA, Constantinescu AB, Lally SE, et al. Ocular Surface Squamous Neoplasia Managed With Primary Interferon alpha2b: A Comparative Analysis of 212 Tumors in Smokers Versus Nonsmokers. Cornea. 2021;40(11):1387-94.
5. Vilaltella M, Huerva V. The regression time of ocular surface squamous neoplasia using topical interferon alfa-2b does not depend on the initial tumor size. Arq Bras Oftalmol. 2021;85(2):109-14.
6. Mejia LF, Zapata M, Gil JC. An Unexpected Incidence of Ocular Surface Neoplasia on Pterygium Surgery. A Retrospective Clinical and Histopathological Report. Cornea. 2021;40(8):1002-6.
7. Sun Y, Hua R. Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia. Drug Des Devel Ther. 2020;14:5659-65.
8. Mirzayev I, Gunduz AK, Ozalp Ates FS, Ozcan G, Isik MU. Factors affecting recurrence after surgical treatment in cases with ocular surface squamous neoplasia. Int J Ophthalmol. 2019;12(9):1426-31.
9. Rahal A, Meller D, Manthey A, Pfortner R, Lang S, Bechrakis N, et al. Midterm results of conjunctival reconstruction with buccal mucosa and amniotic membrane after resecting ocular surface squamous neoplasia of the fornix. Can J Ophthalmol. 2022.
10. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology. 1997;104(3):485-92.
11. Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, et al. Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. Ophthalmology. 2012;119(10):1974-81.
12. Shields CL, Shields JA. Tumors of the conjunctiva and cornea. Indian J Ophthalmol. 2019;67(12):1930-48.
13. Huerva V, Mangues I. Treatment of conjunctival squamous neoplasias with interferon alpha 2ab. J Fr Ophtalmol. 2008;31(3):317-25.

Year 2023, Volume: 40 Issue: 4, 729 - 733, 03.01.2024

Demet Yolcu

Abstract

References

1. Nanji AA, Moon CS, Galor A, Sein J, Oellers P, Karp CL. Surgical versus medical treatment of ocular surface squamous neoplasia: a comparison of recurrences and complications. Ophthalmology. 2014;121(5):994-1000.
2. Alvarez OP, Zein M, Galor A, Karp CL. Management of ocular surface squamous neoplasia: Bowman Club Lecture 2021. BMJ Open Ophthalmol. 2021;6(1):e000842.
3. Bowen RC, Soto H, Raval V, Bellerive C, Yeaney G, Singh AD. Ocular surface squamous neoplasia: outcomes following primary excision with 2 mm margin and cryotherapy. Eye (Lond). 2021;35(11):3102-9.
4. Shields CL, Paulose SA, Yaghy A, Dalvin LA, Constantinescu AB, Lally SE, et al. Ocular Surface Squamous Neoplasia Managed With Primary Interferon alpha2b: A Comparative Analysis of 212 Tumors in Smokers Versus Nonsmokers. Cornea. 2021;40(11):1387-94.
5. Vilaltella M, Huerva V. The regression time of ocular surface squamous neoplasia using topical interferon alfa-2b does not depend on the initial tumor size. Arq Bras Oftalmol. 2021;85(2):109-14.
6. Mejia LF, Zapata M, Gil JC. An Unexpected Incidence of Ocular Surface Neoplasia on Pterygium Surgery. A Retrospective Clinical and Histopathological Report. Cornea. 2021;40(8):1002-6.
7. Sun Y, Hua R. Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia. Drug Des Devel Ther. 2020;14:5659-65.
8. Mirzayev I, Gunduz AK, Ozalp Ates FS, Ozcan G, Isik MU. Factors affecting recurrence after surgical treatment in cases with ocular surface squamous neoplasia. Int J Ophthalmol. 2019;12(9):1426-31.
9. Rahal A, Meller D, Manthey A, Pfortner R, Lang S, Bechrakis N, et al. Midterm results of conjunctival reconstruction with buccal mucosa and amniotic membrane after resecting ocular surface squamous neoplasia of the fornix. Can J Ophthalmol. 2022.
10. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology. 1997;104(3):485-92.
11. Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, et al. Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. Ophthalmology. 2012;119(10):1974-81.
12. Shields CL, Shields JA. Tumors of the conjunctiva and cornea. Indian J Ophthalmol. 2019;67(12):1930-48.
13. Huerva V, Mangues I. Treatment of conjunctival squamous neoplasias with interferon alpha 2ab. J Fr Ophtalmol. 2008;31(3):317-25.

There are 13 citations in total.

Details

Primary Language	English
Subjects	Optometry
Journal Section	Research Article
Authors	Demet Yolcu 0000-0002-3114-0116
Publication Date	January 3, 2024
Submission Date	July 11, 2023
Acceptance Date	October 3, 2023
Published in Issue	Year 2023 Volume: 40 Issue: 4

Cite

APA	Yolcu, D. (2024). Outcomes of the ocular surface squamous neoplasia following primary excision with narrow margins and cryotherapy. Journal of Experimental and Clinical Medicine, 40(4), 729-733.
AMA	Yolcu D. Outcomes of the ocular surface squamous neoplasia following primary excision with narrow margins and cryotherapy. J. Exp. Clin. Med. January 2024;40(4):729-733.
Chicago	Yolcu, Demet. “Outcomes of the Ocular Surface Squamous Neoplasia Following Primary Excision With Narrow Margins and Cryotherapy”. Journal of Experimental and Clinical Medicine 40, no. 4 (January 2024): 729-33.
EndNote	Yolcu D (January 1, 2024) Outcomes of the ocular surface squamous neoplasia following primary excision with narrow margins and cryotherapy. Journal of Experimental and Clinical Medicine 40 4 729–733.
IEEE	D. Yolcu, “Outcomes of the ocular surface squamous neoplasia following primary excision with narrow margins and cryotherapy”, J. Exp. Clin. Med., vol. 40, no. 4, pp. 729–733, 2024.
ISNAD	Yolcu, Demet. “Outcomes of the Ocular Surface Squamous Neoplasia Following Primary Excision With Narrow Margins and Cryotherapy”. Journal of Experimental and Clinical Medicine 40/4 (January 2024), 729-733.
JAMA	Yolcu D. Outcomes of the ocular surface squamous neoplasia following primary excision with narrow margins and cryotherapy. J. Exp. Clin. Med. 2024;40:729–733.
MLA	Yolcu, Demet. “Outcomes of the Ocular Surface Squamous Neoplasia Following Primary Excision With Narrow Margins and Cryotherapy”. Journal of Experimental and Clinical Medicine, vol. 40, no. 4, 2024, pp. 729-33.
Vancouver	Yolcu D. Outcomes of the ocular surface squamous neoplasia following primary excision with narrow margins and cryotherapy. J. Exp. Clin. Med. 2024;40(4):729-33.