Abstract
Aim: Histamine is a common anhydrous
substance in the organism. Histamine responses of the cells were found in the
cytoplasm of H1 and it is provided by H2 receptors. In the IBU study, it was
aimed to investigate the effect of drug-blocking of histamine receptors
commonly found in organism on blood gas, which is maintained in a very narrow
range with kidney lung and hemoglobin.
Material and
Method: Between
1988-1989, 25 female and 20 male patients who were hospitalized in Ankara
Numune Hospital 1st Internal Medicine Clinic were included in this study. H1
and peptic ulcer patients received H2 receptor antagonists intravenously at the
usual treatment dose and blood gas samples were taken before and 1 hour after
administration. Blood gas evaluation was performed in the control group at 1
hour interval without drug administration.
Result: The change of pH, pO2,
HCO3, BEB, BEcf of H1 receptor antagonists was statistically
insignificant (p>0.05) while pCO2 value was statistically
significant (36.01+4.023 before treatment, 34.42+3.72 p<0.05 after
treatment). H2 receptor antagonist administration showed statistically
insignificant change in pCO2 and pO2 levels but
statistically significant increase in pH (<0.05), HCO3 (p<0.001),
BEB (p<0.01) and BEcf (p<0.01).
Conclusion: Histamine receptor antagonist
drugs may cause changes to the blood gas parameters that are not pathological
depending on the receptors to which they are antagonized. However, there is a
need for more extensive work to comment on whether or not they will cause
serious problems in clinical situations that cause change in blood gas.
Keywords
References
- 1. Flynn SB, Gristwood RW, Owen DAA. Differantion of the roles of Histamine H1 and H2 receptors in the mediation of the effects Histamine in the isolated working heart of the qunea pig. Br.J. Pharmacol 1977; 65; 127-37.
- 2. Ash AS, Schild HO. Receptors mediating some actions of histamine. Br J Pharmacol Chemother 1966: 27: 427-39
- 3. Carpenter DO, Gaubatz GL. H1 and H2 histamine receptors on aplasia neurons. Nature 1973: 254: 343.
- 4. Borchard D, Hafner D. Electrophysiological charactersation of histamine receptors subtypes in mammalian heart preparation. Naunyn-Schmiedberg’s Arch Pharmacol 1986: 334; 294-302.
- 5. Black JW, Duncan WAM, Durant CJ, Ganellin CR, Parsons ME. Definition and antagonism of histamine H1 receptors. Nature1972: 236: 385-90.
- 6. El-Acked TM, Brody MJ. Evidence for mast cell histamine in the vascular wall. Blood Vessels 1975: 12: 181.
- 7. Anton AH, Sayre DF. A modified fluorimetric procedure for tissue Histadine and its distrubition in various animals. J Pharmacol Exp Ther 1969: 166: 285.
- 8. Reinhardt D, Borchard UH. H1 receptor antogonists: comperative pharmacology and clinical use. Clin Wochenschr 1982: 60: 983-90.
- 9. Levi R, Capurro N, Lee CH. Pharmacological caracterization of cardiac histamin receptors: sensitivity to H1 and H2 receptors agonists antagonists. Eur J Pharmacol 1975; 30: 328-35.
- 10. Corbic M, Munoz C, Dumont M, Erlinger S. Effect of systemic pH, pCO and bikarbonate concentration biliary bicarbonate on secretion in the rat. Hepatology 1985; 5: 594-9.
- 11. Dale HH. Conditions which are conducive to the production of shock by histamine. British J Experimental Pathol 1920; 1: 103-14.
- 12. Wallace GB, Pellini EJ. Proc Sot Exp Biol Med; 1920- 21; xviii: 115.
- 13. Underhill FP, Ringer MJ. Biol Chem 1921; xlviii, 533.
- 14. Hiller A. The effect of histamine on the asid-base balance. J Biol Chem 1927: 3: 833-46.
- 15. Best CH, Dale HH, Dudley HW, Thprpe WV. The nature of the vaso-dilator constituents of certain tissues. J Physiol 1927; 62: 397.
- 16. Chand N. Distrubution and classification of airway histamine receptors: the physsiological significance of histamine H1 receptörs. Adv Pharmacol Chemother 1980: 17: 103.
- 17. Lindgren BR, Grunström N, Anderssson RGG. Compration of the effects of clonidine and quanfacine on the histamine liberation from human mast cells and basophils and on th human bronchial smooth muscle activity. Arzneim Forsch Drug Resp 1987: 37: 551-3.
Abstract
Amaç: Histamin organizmada yaygın
olarak bulunan bir amindir. Hücrelerin histamine yanıtları sitoplazmada bulunan
H1 ve H2 reseptörleri ile sağlanır. Bu çalışmada organizmada yaygın
olarak bulunan histamin reseptörlerinin ilaçlarla bloke edilmesinin böbrek
akciğer ve hemoglobin aracılığı ile çok dar aralıkta dengede tutulan kan gazı
üzerine etkisinin araştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışma 1988-1989 yılları
arasında Ankara Numune Hastanesi 1. Dahiliye Kliniği’ne yatarak tedavi gören 25
peptik ülser, 10 alerji, 10 kan gazını etkilemeyen farklı hastalık nedeniyle
yatan 25 kadın 20 erkek olgu alındı. Alerji nedeniyle yatan hastalara H1 ve
peptik ülser hastalarına H2 reseptör antagonistleri olağan tedavi dozunda intravenöz
uygulandı. Uygulamadan önce ve uygulamadan 1 saat sonra kan gazı örnekleri
alınarak değerlendirme yapıldı. Kontrol grubuna ilaç verilmeksizin 1 saat ara
ile kan gazı değerlendirmesi yapıldı.
Bulgular: H1 reseptör antagonistlerinin pH,
pO2, HCO3, BEB,
BEcf değişimi istatistiksel olarak anlamsız bulunurken (p>0.05), pCO2
değerinde ise istatisksel olarak anlamlı düşme (ilaç öncesi 36,01+4,023; ilaç
sonrası ortalama pCO2 34,42+3,72 p<0.05) saptandı. H2 reseptör
antagonisti uygulamasında ise pCO2 ve pO2 değişiminde
istatistiksel olarak anlamlı değişiklik bulunmazken, pH (<0.05), HCO3
(p<0.001), BEB (p<0.01) ve BEecf (p<0.01)
değerlerinde istatistiksel olarak anlamlı artma bulundu
Sonuç: Histamin reseptör antagonisti
ilaçlar kan gazı parametrelerinde antagonize ettikleri reseptörlere bağlı olarak patolojik
sınırlarda olmayan değişimlere neden olabilirler. Ancak kan gazında değişime
neden olan klinik durumlarda ciddi problem yaratıp yaratmayacakları hakkında
yorum yapabilmek için daha kapsamlı çalışmalara gereksinim vardır.
Keywords
References
- 1. Flynn SB, Gristwood RW, Owen DAA. Differantion of the roles of Histamine H1 and H2 receptors in the mediation of the effects Histamine in the isolated working heart of the qunea pig. Br.J. Pharmacol 1977; 65; 127-37.
- 2. Ash AS, Schild HO. Receptors mediating some actions of histamine. Br J Pharmacol Chemother 1966: 27: 427-39
- 3. Carpenter DO, Gaubatz GL. H1 and H2 histamine receptors on aplasia neurons. Nature 1973: 254: 343.
- 4. Borchard D, Hafner D. Electrophysiological charactersation of histamine receptors subtypes in mammalian heart preparation. Naunyn-Schmiedberg’s Arch Pharmacol 1986: 334; 294-302.
- 5. Black JW, Duncan WAM, Durant CJ, Ganellin CR, Parsons ME. Definition and antagonism of histamine H1 receptors. Nature1972: 236: 385-90.
- 6. El-Acked TM, Brody MJ. Evidence for mast cell histamine in the vascular wall. Blood Vessels 1975: 12: 181.
- 7. Anton AH, Sayre DF. A modified fluorimetric procedure for tissue Histadine and its distrubition in various animals. J Pharmacol Exp Ther 1969: 166: 285.
- 8. Reinhardt D, Borchard UH. H1 receptor antogonists: comperative pharmacology and clinical use. Clin Wochenschr 1982: 60: 983-90.
- 9. Levi R, Capurro N, Lee CH. Pharmacological caracterization of cardiac histamin receptors: sensitivity to H1 and H2 receptors agonists antagonists. Eur J Pharmacol 1975; 30: 328-35.
- 10. Corbic M, Munoz C, Dumont M, Erlinger S. Effect of systemic pH, pCO and bikarbonate concentration biliary bicarbonate on secretion in the rat. Hepatology 1985; 5: 594-9.
- 11. Dale HH. Conditions which are conducive to the production of shock by histamine. British J Experimental Pathol 1920; 1: 103-14.
- 12. Wallace GB, Pellini EJ. Proc Sot Exp Biol Med; 1920- 21; xviii: 115.
- 13. Underhill FP, Ringer MJ. Biol Chem 1921; xlviii, 533.
- 14. Hiller A. The effect of histamine on the asid-base balance. J Biol Chem 1927: 3: 833-46.
- 15. Best CH, Dale HH, Dudley HW, Thprpe WV. The nature of the vaso-dilator constituents of certain tissues. J Physiol 1927; 62: 397.
- 16. Chand N. Distrubution and classification of airway histamine receptors: the physsiological significance of histamine H1 receptörs. Adv Pharmacol Chemother 1980: 17: 103.
- 17. Lindgren BR, Grunström N, Anderssson RGG. Compration of the effects of clonidine and quanfacine on the histamine liberation from human mast cells and basophils and on th human bronchial smooth muscle activity. Arzneim Forsch Drug Resp 1987: 37: 551-3.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original article |
| Authors | |
| Publication Date | September 30, 2018 |
| Published in Issue | Year 2018 Volume: 10 Issue: 3 |
e-ISSN: 2548-0251
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