Abstract
ABSTRACT: Dapsone is a sulfone antibiotic, which has
anti-inflammatory and anti-bacterial effects and used in leprosy, intractable
skin lesions, rheumatologic diseases like systemic lupus erythematosus and Pneumocystis jiroveci prophylaxis.
Aplastic anemia is an uncommon adverse hematologic effect in patients treated
with dapsone. We present a 59 years old female patient which developed aplastic
anemia, direct coombs positively and methemoglobinemia because of dapsone.
Before starting dapsone treatment, side effect profile must be discussed
thoroughly; periodic CBC must be performed before and after the treatment, even
without any patient complaints.
KEYWORDS: Dapsone, aplastic anemia, hemolysis
ÖZET: Dapsone, romatolojik hastalıklardan sistemik lupus
eritematozis ve Pneumocystis jiroveci
proflaksisi ile lepra ve inatçı cilt lezyonlarında kullanılan,
anti-inflamatuvar ve antibakteriyel özelliklere sahip bir sülfon
antibiyotiktir. Aplastik anemi, dapsonla tedavi edilen hastalarda nadir görülen
hematolojik bir yan etkidir. Bu yazıda dapsona bağlı aplastik anemi, direkt
coombs pozitifliği ve methemoglobinemi gelişen 59 yaşındaki kadın hastayı
sunduk. Dapson başlamadan önce ilacın yan etkileri dikkatli bir şekilde gözden
geçirilmeli, ilacı başlamadan önce ve başladıktan sonra periyodik olarak tam
kan sayımı yapılmalıdır.
ANAHTAR KELİMELER: Dapson, aplastik anemi, hemoliz
Keywords
References
- 1. Plotkin, J. S., Buell, J. F., Njoku, M. J., Wilson, S., Kuo, P. C., Bartlett, S. T., ... & Johnson, L. B. (1997). Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: A two‐case report and review. Liver Transplantation and Surgery, 3(2), 149-152.
- 2. Ranawaka, R. R., Mendis, S., & Weerakoon, H. S. (2008). Dapsone-induced haemolytic anaemia, hepatitis and agranulocytosis in a leprosy patient with normal glucose-6-phosphate-dehydrogenase activity. Leprosy review, 79(4), 436.
- 3. Hörnsten, P., Keisu, M., & Wiholm, B. E. (1990). The incidence of agranulocytosis during treatment of dermatitis herpetiformis with dapsone as reported in Sweden, 1972 through 1988. Archives of dermatology, 126(7), 919-922.
- 4. Meyerson, M. A., & COHEN, P. R. (1994, December). Dapsone-induced aplastic anemia in a woman with bullous systemic lupus erythematosus. In Mayo Clinic Proceedings (Vol. 69, No. 12, pp. 1159-1162). Elsevier.
- 5. Foucauld J, Uphouse W, Berenberg J. (1985). Dapsone and aplastic anemia, Ann Intern Med 102:139
- 6. Mishra, M., & Chhetia, R. (2006). Dapsone-induced agranulocytosis in a patient of leprosy. Indian Journal of Dermatology, Venereology, and Leprology, 72(6), 456.
- 7. Machet, L., Callens, A., Mercier, E., Gargot, S., Lorette, G., & Vaillant, L. (1995, December). [Agranulocytosis induced by dapsone prescribed for dermatitis herpetiformis]. In Annales de dermatologie et de venereologie (Vol. 123, No. 5, pp. 328-330).
Abstract
References
- 1. Plotkin, J. S., Buell, J. F., Njoku, M. J., Wilson, S., Kuo, P. C., Bartlett, S. T., ... & Johnson, L. B. (1997). Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: A two‐case report and review. Liver Transplantation and Surgery, 3(2), 149-152.
- 2. Ranawaka, R. R., Mendis, S., & Weerakoon, H. S. (2008). Dapsone-induced haemolytic anaemia, hepatitis and agranulocytosis in a leprosy patient with normal glucose-6-phosphate-dehydrogenase activity. Leprosy review, 79(4), 436.
- 3. Hörnsten, P., Keisu, M., & Wiholm, B. E. (1990). The incidence of agranulocytosis during treatment of dermatitis herpetiformis with dapsone as reported in Sweden, 1972 through 1988. Archives of dermatology, 126(7), 919-922.
- 4. Meyerson, M. A., & COHEN, P. R. (1994, December). Dapsone-induced aplastic anemia in a woman with bullous systemic lupus erythematosus. In Mayo Clinic Proceedings (Vol. 69, No. 12, pp. 1159-1162). Elsevier.
- 5. Foucauld J, Uphouse W, Berenberg J. (1985). Dapsone and aplastic anemia, Ann Intern Med 102:139
- 6. Mishra, M., & Chhetia, R. (2006). Dapsone-induced agranulocytosis in a patient of leprosy. Indian Journal of Dermatology, Venereology, and Leprology, 72(6), 456.
- 7. Machet, L., Callens, A., Mercier, E., Gargot, S., Lorette, G., & Vaillant, L. (1995, December). [Agranulocytosis induced by dapsone prescribed for dermatitis herpetiformis]. In Annales de dermatologie et de venereologie (Vol. 123, No. 5, pp. 328-330).
Details
| Subjects | Health Care Administration |
|---|---|
| Journal Section | OLGU SUNUMU |
| Authors | |
| Publication Date | January 7, 2017 |
| Published in Issue | Year 2017 Volume: 39 Issue: 1 |