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Non-Sebaceous Lymphadenoma: A Rare Salivary Gland Tumor

Year 2020, Ağız Kanserleri Özel Sayısı, 182 - 186, 28.09.2020

Abstract

Lymphadenomas comprise a very rare group of salivary gland tumors, the two types of which are defined as sebaceous and non-sebaceous lymphadenomas.
In the case presented here, a patient presented with swelling in the right parotid gland, and the mass seen by ultrasonography was suggestive of pleomorphic adenoma.
According to fine needle aspiration biopsy, the presence of lymphoid and epithelial cells first suggested a diagnosis of Warthin tumor. However, the presence of cystic degenerated ductal structures and the solid, benign nature of the epithelial islands intertwined with mature lymphoid cells in the biopsied specimen showed no sebaceous differentiation, and thus, the case was reported as “non-sebaceous lymphadenoma.”
We aimed to present the relevant literature and our case of non-sebaceous lymphadenoma, whose clinicopathological features and etiopathogenesis are not clearly understood, since it is considered to be underreported due to its sonographic and histomorphological similarities to pleomorphic adenoma and Warthin tumor.

References

  • REFERENCES 1) Hellquist H, Paiva-Correia A, Vander Poorten V et al. Analysis of the clinical relevance of histological classification of benign epithelial salivary gland tumours. Adv Ther 2019;36(8):1950-1974.
  • 2) Kühn U, Köhler HH, Jecker P. Rare tumors of the parotid gland. Lymphadenoma of a sebaceous gland and extracranial metastasis from glioblastoma. HNO 2003;51(5):417-420.
  • 3) McGavran MH, Bauer WC, Ackerman LV. Sebaceous lymphadenoma of the parotid salivary gland. Cancer 1960;13:1185-1187.
  • 4) Liu G, He J, Zhang C, Fu S, et al. Lymphadenoma of the salivary gland: Report of 10 cases. Oncol Lett 2014 Apr;7(4):1097-1101.
  • 5) Seethala RR, Thompson LDR, Gnepp DR et al. Lymphadenoma of the salivary gland: Clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol 2012;25(1):26-35.
  • 6) Kuzenko YV, Romanuk AM, Dyachenko OO, et al. Pathogenesis of Warthin’s tumors. Interv Med Appl Sci 2016;8(2):41-48.
  • 7) Chung YF, Khoo ML, Heng MK, et al. Epidemiology of Warthin’s tumour of the parotid gland in an Asian population. Br J Surg 1999;86(5):661-664.
  • 8) Sykara M, Ntovas P, Kalogirou EM, et al. Oral lymphoepithelial cyst: A clinicopathological study of 26 cases and review of the literature. J Clin Exp Dent 2017 Aug;9(8):e1035-e1043.
  • 9) Lewis PD, Baxter P, Paul Griffiths A, et al. Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin’s tumour. J Pathol 2000;191(3):274-281.
  • 10) Gnepp DR. My journey into the world of salivary gland sebaceous neoplasms. Head Neck Pathol 2012 Mar;6(1):101-110.
  • 11) Auclair PL. Tumor-associated lymphoid proliferation in the parotid gland. A potential diagnostic pitfall. In Oral Surg Oral Med Oral Pathol 1994;77(1):19-26.
  • 12) Kara H, Sönmez S, Bağbudar S, Güllüoğlu M, et al. Malignant transformation of parotid gland non-sebaceous lymphadenoma: Case report and review of literature. Head Neck Pathol 2020; 10.1007/s12105-020-01133-3.

Non-Sebasöz Lenfadenoma: Nadir Görülen Bir Tükrük Bezi Tümörü

Year 2020, Ağız Kanserleri Özel Sayısı, 182 - 186, 28.09.2020

Abstract

Lenfadenomalar tükrük bezi tümörleri içinde oldukça nadir görülen bir gruptur. Parotis bezinde ileri yaşlarda sıklığı artmaktadır. Sebasöz ve non-sebasöz lenfadenomalar olmak üzere iki grupta incelenmektedir.
Lenfadenomalar klinik, ultrasonografik ve morfolojik olarak birçok tükrük bezi tümörü ile benzer özellikler göstermektedir. Bizim olgumuzda sağ parotis lojunda şişlik şikayeti ile başvuran hastanın ultrasonografisinde görülen lezyon pleomorfik adenomu düşündürmüştür. İnce iğne aspirasyon biyopsisinde görülen lenfoid stroma ve epitelyal özellikler ilk olarak Warthin tümörünü akla getirmiştir. Ancak eksizyon materyalinde uniform özellikte lenfoid hücrelerin içinde sakin görünümde yer yer kistik yer yer solid epitel adalarının görülmesi, epitelde atipi, mitoz saptanmaması üzerine vaka da lenfadenoma düşünülmüştür. İncelenen kesitlerde sebasöz diferansiyasyon izlenmemesi ile de olgumuz ‘Non-sebasöz lenfadenoma’ olarak raporlandı.
Literatürde lenfadenoma vakası oldukça az görülmektedir. Bunun sebebi belki de sonografik ve histomorfolojik benzerliğinden dolayı plemorfik adenom veya Warthin tümörü olarak yanlış tanı alan vakalardır. Patogenezinin net olarak aydınlatılabilmesi ve ayırıcı tanısında belli kriterlerin kullanılabilmesi için daha geniş çalışmalara ihtiyaç duyulmaktadır. Biz de non sebasöz lenfadenoma olarak raporladığımız bir vakayı sunarak literatüre katkı sağlamayı amaçladık.

References

  • REFERENCES 1) Hellquist H, Paiva-Correia A, Vander Poorten V et al. Analysis of the clinical relevance of histological classification of benign epithelial salivary gland tumours. Adv Ther 2019;36(8):1950-1974.
  • 2) Kühn U, Köhler HH, Jecker P. Rare tumors of the parotid gland. Lymphadenoma of a sebaceous gland and extracranial metastasis from glioblastoma. HNO 2003;51(5):417-420.
  • 3) McGavran MH, Bauer WC, Ackerman LV. Sebaceous lymphadenoma of the parotid salivary gland. Cancer 1960;13:1185-1187.
  • 4) Liu G, He J, Zhang C, Fu S, et al. Lymphadenoma of the salivary gland: Report of 10 cases. Oncol Lett 2014 Apr;7(4):1097-1101.
  • 5) Seethala RR, Thompson LDR, Gnepp DR et al. Lymphadenoma of the salivary gland: Clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol 2012;25(1):26-35.
  • 6) Kuzenko YV, Romanuk AM, Dyachenko OO, et al. Pathogenesis of Warthin’s tumors. Interv Med Appl Sci 2016;8(2):41-48.
  • 7) Chung YF, Khoo ML, Heng MK, et al. Epidemiology of Warthin’s tumour of the parotid gland in an Asian population. Br J Surg 1999;86(5):661-664.
  • 8) Sykara M, Ntovas P, Kalogirou EM, et al. Oral lymphoepithelial cyst: A clinicopathological study of 26 cases and review of the literature. J Clin Exp Dent 2017 Aug;9(8):e1035-e1043.
  • 9) Lewis PD, Baxter P, Paul Griffiths A, et al. Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin’s tumour. J Pathol 2000;191(3):274-281.
  • 10) Gnepp DR. My journey into the world of salivary gland sebaceous neoplasms. Head Neck Pathol 2012 Mar;6(1):101-110.
  • 11) Auclair PL. Tumor-associated lymphoid proliferation in the parotid gland. A potential diagnostic pitfall. In Oral Surg Oral Med Oral Pathol 1994;77(1):19-26.
  • 12) Kara H, Sönmez S, Bağbudar S, Güllüoğlu M, et al. Malignant transformation of parotid gland non-sebaceous lymphadenoma: Case report and review of literature. Head Neck Pathol 2020; 10.1007/s12105-020-01133-3.
There are 12 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section OLGU SUNUMU
Authors

Mahi Balcı 0000-0001-5836-2344

Merva Aydemir Akkaya 0000-0002-2745-6177

Tuba Devrim 0000-0002-5321-2002

Publication Date September 28, 2020
Published in Issue Year 2020 Ağız Kanserleri Özel Sayısı

Cite

Vancouver Balcı M, Aydemir Akkaya M, Devrim T. Non-Sebaceous Lymphadenoma: A Rare Salivary Gland Tumor. Osmangazi Tıp Dergisi. 2020;42(5):182-6.


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