Tip 1 diyabetes mellituslu çocuklarda büyümenin değerlendirilmesi ve metabolik kontrolün büyüme hızına etkisi
Abstract
Amaç: Tip 1 diyabetes mellitus hastalığının komplikasyonlarından biri de büyümenin bozulmasıdır. Bu çalışmada tip 1 diabetes mellitusta büyümenin değerlendirilmesi ve metabolik kontrolün büyüme hızına etkisinin değerlendirilmesi amaçlanmıştır.
Gereç ve yöntem: Tip 1 diyabetli 100 olgu çalışmaya dahil edildi ve olguların yıllık büyüme hızları, metabolik kontrol durumları ve puberte evreleri değerlendirildi.
Bulgular: Tanı anındaki boy SDS ile son boy SDS arasında anlamlı fark yoktu. Çocukların yüzde 43'ünün boyu genetik boy potansiyelinden daha düşüktü. Büyüme Hızı SDS ile HbA1c değerleri arasındaki ilişkinin yıllara göre değerlendirilmesinde üçüncü yılda negatif korelasyon görüldü. Final boya ulaşan 23 hastanın değerlendirilmesinde; tanıdaki boy SDS ile finaldeki boy SDS arasında anlamlı farklılık yoktu. Genetiğe göre değerlendirildiğinde ise %78 hastanın hedef boyu ile uyumlu, %22 hastanın hedef boyunun altında final boya ulaştığı görüldü. Metabolik kontroller arasında fark yoktu.
Sonuçlar: Bu çalışmada iyi ve orta metabolik kontrollü olgularda büyüme hızı ve final boyların etkilenmediği, kötü metabolik kontrollü olgularda ise olumsuz yönde etkilendiği sonucuna varıldı.
Anahtar kelimeler: Çocuklarda tip 1 diabetes mellitus, büyüme hızı, son boy.
Supporting Institution
Yok
References
- REFERRENCE1. Sperling M.A. Diabetes Mellitus. In: Sperling M.A (eds). Pediatric Endocrinology. 2nd edition. Pennsylvania (USA): Saunders Elseiver Science; 2002. p.323-66
- REFERRENCE2. Dunger DB & Cheetham TD. Growth hormone–insulin-like growth factor-I axis in insulin-dependent diabetes mellitus. Hormone Research 1996 46 2–6.
- REFERRENCE3. Anju Virmani. Growth disorders in type 1 diabetes: an Indian experience. Indian J Endocrinol Metab. 2015 Apr; 19(Suppl 1): S64–S67.
- REFERRENCE4. Greulich, W. W., Pyle, S. I., Radiographic Atlas Of Skeletal Development of the Hand and Wrist, Stanford University Press, Stanford, California, 1971
- REFERRENCE5. Olcay N, Hülya G, Andrzej F. ve ark. Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri. Çocuk Sağlığı ve Hastalıkları Dergisi 2008; 51: 1-14.
- REFERRENCE6. Galera Martínez R, García García E, Gámez Gómez MD, Gómez Llorente JL, Garrido Fernández P, Bonillo Perales AAn Pediatr (Barc). Final size attained in type 1 diabetes children. An Pediatr (Barc). 2009;70:235-40.
- REFERRENCE7. Timóteo C, Castanhinha S, Constant C, Robalo B, Pereira C, Sampaio L. Growth and puberty in type 1 diabetes mellitus - experience from a pediatric endocrinology unit. Acta Med Port. 2012 Jul-Aug;25(4):213-8.
- REFERRENCE8. Holl RW, Grabert M, Heinze E, Sorgo W, Debatin KM. Age at onset and long-term metabolic control affect height in type-1 diabetes mellitus. Eur J Pediatr. 1998 Dec;157(12):972-7.
- REFERRENCE9. ISPAD. Consensus Guidelines for the Management of Insulin dependent Diabetes in Childhood and Adolescence. 2000; 23:216-228
- REFERRENCE10. Çakır S. Tip 1 Diyabetli Çocuklarda Glisemik Kontrolü Etkileyen Faktörler-Özgün Araştırma. Güncel Pediatri 2010 Yıl 2010, Cilt 8 ,Sayı 2, Sayfalar 7 - 19
- REFERRENCE11. Hoey H. Psychosocial factors are associated with metabolic control in adolescents: research from the Hvidoere Study Group on Childhood Diabetes. Pediatric Diabetes 2009 Dec;10 Suppl 13:9-14
- REFERRENCE12. Donaghue K.C, Kordonouri O, Chan A, Silink M, Secular trends in growth in diabetes: are we winning? Arch Dis Child 2003;88:151–154
- REFERRENCE13. Salerno M, Argenziano A, Di Maio S et al. Pubertal growth, sexual maturation, and final height in children with IDDM. Effects of age at onset and metabolic control. Diabetes Care. 1997 May;20(5):721-4
- REFERRENCE14. Huang CY, Lee YJ, Huang FY, Hsu CH, Kao HA. Final height of children with type 1 diabetes: the effects of age at diagnosis, metabolic control, and parental height. Acta Paediatr Taiwan. 2001 Jan-Feb;42(1):33-8.
- REFERRENCE15. Demir K, Altıncık A, Abacı A, Büyükgebiz A, Böber E. Growth of children with type 1 diabetes mellitus. J Clin Res Pediatr Endocrinol. 2010;2(2):72-7.
- REFERRENCE16. Scheffer-Marinus PD, Links TP, Reitsma WD, Drayer NM. Increased height in diabetes mellitus corresponds to the predicted and the adult height. Acta Paediatr. 1999 Apr;88(4):384
Evaluation of growth and effect of metabolic control on growth velocity in children with type 1 diabetes mellitus
Abstract
Purpose: One of the complications of diabetes mellitus is the disruption of growth. Evaluation of growth in type1 diabetes mellitus and the effect of metabolic control on growth velocity is aimed in this study.
Materials and methods: One hundred cases with Type1 diabetes mellitus are included and annual growth velocity, the status of metabolic control, and stage of puberties of cases are evaluated.
Results: There was no significant difference in height SDSs between at the time of diagnosis and current. Forty-three percent of the children had lower height than the genetic height potential. Evaluation of the relationship between Growthvelocity SDS and HbA1c values according to years showed a negative correlation in the third year. Evaluation of 23 cases that had attained final height presented no significant difference between height SDS at the time of diagnosis and final height SDS. Seventy-seven and a half percent of 18 cases satisfied the target height; 22.2% of cases attained a shorter final height than the target height based on evaluation with the reference to genetics. There was no difference between the metabolic controls.
Conclusions: Final height and growth velocity didn’t appear to be affected in cases with good and intermediate metabolic controls; final height and growth velocity are negatively affected in cases with poor metabolic controls.
References
- REFERRENCE1. Sperling M.A. Diabetes Mellitus. In: Sperling M.A (eds). Pediatric Endocrinology. 2nd edition. Pennsylvania (USA): Saunders Elseiver Science; 2002. p.323-66
- REFERRENCE2. Dunger DB & Cheetham TD. Growth hormone–insulin-like growth factor-I axis in insulin-dependent diabetes mellitus. Hormone Research 1996 46 2–6.
- REFERRENCE3. Anju Virmani. Growth disorders in type 1 diabetes: an Indian experience. Indian J Endocrinol Metab. 2015 Apr; 19(Suppl 1): S64–S67.
- REFERRENCE4. Greulich, W. W., Pyle, S. I., Radiographic Atlas Of Skeletal Development of the Hand and Wrist, Stanford University Press, Stanford, California, 1971
- REFERRENCE5. Olcay N, Hülya G, Andrzej F. ve ark. Türk çocuklarında vücut ağırlığı, boy uzunluğu, baş çevresi ve vücut kitle indeksi referans değerleri. Çocuk Sağlığı ve Hastalıkları Dergisi 2008; 51: 1-14.
- REFERRENCE6. Galera Martínez R, García García E, Gámez Gómez MD, Gómez Llorente JL, Garrido Fernández P, Bonillo Perales AAn Pediatr (Barc). Final size attained in type 1 diabetes children. An Pediatr (Barc). 2009;70:235-40.
- REFERRENCE7. Timóteo C, Castanhinha S, Constant C, Robalo B, Pereira C, Sampaio L. Growth and puberty in type 1 diabetes mellitus - experience from a pediatric endocrinology unit. Acta Med Port. 2012 Jul-Aug;25(4):213-8.
- REFERRENCE8. Holl RW, Grabert M, Heinze E, Sorgo W, Debatin KM. Age at onset and long-term metabolic control affect height in type-1 diabetes mellitus. Eur J Pediatr. 1998 Dec;157(12):972-7.
- REFERRENCE9. ISPAD. Consensus Guidelines for the Management of Insulin dependent Diabetes in Childhood and Adolescence. 2000; 23:216-228
- REFERRENCE10. Çakır S. Tip 1 Diyabetli Çocuklarda Glisemik Kontrolü Etkileyen Faktörler-Özgün Araştırma. Güncel Pediatri 2010 Yıl 2010, Cilt 8 ,Sayı 2, Sayfalar 7 - 19
- REFERRENCE11. Hoey H. Psychosocial factors are associated with metabolic control in adolescents: research from the Hvidoere Study Group on Childhood Diabetes. Pediatric Diabetes 2009 Dec;10 Suppl 13:9-14
- REFERRENCE12. Donaghue K.C, Kordonouri O, Chan A, Silink M, Secular trends in growth in diabetes: are we winning? Arch Dis Child 2003;88:151–154
- REFERRENCE13. Salerno M, Argenziano A, Di Maio S et al. Pubertal growth, sexual maturation, and final height in children with IDDM. Effects of age at onset and metabolic control. Diabetes Care. 1997 May;20(5):721-4
- REFERRENCE14. Huang CY, Lee YJ, Huang FY, Hsu CH, Kao HA. Final height of children with type 1 diabetes: the effects of age at diagnosis, metabolic control, and parental height. Acta Paediatr Taiwan. 2001 Jan-Feb;42(1):33-8.
- REFERRENCE15. Demir K, Altıncık A, Abacı A, Büyükgebiz A, Böber E. Growth of children with type 1 diabetes mellitus. J Clin Res Pediatr Endocrinol. 2010;2(2):72-7.
- REFERRENCE16. Scheffer-Marinus PD, Links TP, Reitsma WD, Drayer NM. Increased height in diabetes mellitus corresponds to the predicted and the adult height. Acta Paediatr. 1999 Apr;88(4):384
Details
| Primary Language | English |
|---|---|
| Subjects | Paediatrics |
| Journal Section | Research Article |
| Authors | |
| Publication Date | October 1, 2022 |
| Submission Date | January 23, 2022 |
| Acceptance Date | July 8, 2022 |
| Published in Issue | Year 2022 Volume: 15 Issue: 4 |
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