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Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi

Year 2017, Volume: 8 Issue: 3, 134 - 138, 01.06.2017
https://doi.org/10.18663/tjcl.285075

Abstract

Papiller tiroid karsinomu, tiroid maligniteleri
arasında en sık görülen tiptir ve tüm malignitelerin %1’ini oluşturur. Klasik
papiller tiroid karsinomu oldukça iyi prognoza sahip olmakla beraber hastaların
%10’unda rekürrens, lenf nodu metastazı, uzak organ metastazı ya da mortalite
gelişebilmektedir. Bu agresiv klinik davranış çoğunlukla difüz sklerozan, uzun
hücreli ve kolumnar hücreli gibi varyantlarda görülmektedir. 
Hobnail/mikropapiller varyant papiller tiroid
karsinomu, papiller tiroid karsinomunun oldukça nadir görülen, yeni tarif
edilen bir varyantıdır. Literatürde benzer şekilde çok az sayıda yayın mevcut
olup, genellikle agresiv seyrettiği ve metastaz yapma potansiyelinin klasik
papiller tiroid karsinomundan fazla olduğu bildirilmiştir. Ancak sitolojik
özellikleri ve moleküler alt yapısı tam olarak anlaşılamamıştır. Bu yazıda; hobnail/mikropapiller
varyant papiller tiroid karsinomlu bir hasta sunulmuş olup, tanı problemleri ve
malignite kriterleri literatür bilgileri gözden geçirilerek tartışılmıştır. 

References

  • 1. Aschebrook KB, Ward MH, Sabra MM, Devesa SS. Thyroid cancer incidence patterns in the United States by histologic type 1992–2006. 2011; 21: 125-34.
  • 2. Howlader N. SEER cancer statistics review 1975–2010. Noone AM, Krapcho M, Garshell J, Nwebeyman N, Altekruse SF et al (eds). 2013, August 20.
  • 3. National Cancer Institute 2013 Fast stats: An interactive tool for access to SEER cancer statistics. 2013, September18.
  • 4. Grogan RH, Kaplan SP, Cao H, Weiss RE et al. A study of recurrence and death from papillary thyroid cancer with 27 years of median follow up. Surgery 2013; 154: 1436–46.
  • 5. Ortiz S, Rodriguez JM, Parrilla P, Perez D, Moreno-Gallego A, Rios A, Soria T. Recurrent papillary thyroid cancer: Analysis of prognostic factors including the histological variant. Eur J Surg 2011; 167: 406–12.
  • 6. Cooper DS, Doherty GM, Haugen BR et al. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009; 19: 1167–1214.
  • 7. Malloy MK, Cunnane FM. Pathology and cytologic features of thyroid neoplasms. Surg Oncol Clin N Am 2008;17: 57-70.
  • 8. Lino-Silva LS, Dominguez-Malagon HR, Caro-Sanchez CH, Salcedo-Hernandez RA. Thyroid gland papillary carcinomas with “micropapillary pattern,” a recently recognized poor prognostic finding: Clinicopathologic and survival analysis of 7 cases. Hum Pathol 2012; 43: 1596–1600.
  • 9. Nassar H, Pansare V, Zhang H et al. Pathogenesis of invasive micropapillary carcinoma: Role of MUC-1 glycoprotein. Mod Pathol 2004; 17: 1045-50.
  • 10. Ushiku T, Matsusaka K, Iwasaki Y et al. Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis. Histopathology 2011; 59: 1081-9.
  • 11. Travis WD, Brambilla E, Noguchi M et al. International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011; 6: 244-85.
  • 12. Peterse JL. Breast carcinoma with an unexpected inside out pattern. Rotation of polarization associated with angioinvasion. Path Res Pract 1993;189:780.
  • 13. Verdu M, Roman R, Calvo M et al. Clinicopathological and molecular characterization of colorectal micropapillary carcinoma. Mod Pathol 2011; 24: 729-38.
  • 14. Tang W, Nakamura Y, Zuo H et al. Differantation proliferation and retinoid receptör status of papillary carcinoma of the thyroid. Pathol Int 2003;53: 204-213.
  • 15. Bai Y, Kakudo K, Nakamura M et al. Loss of cellular polarity/cohesivness in the invaziv front of papillary thyroid carsinoma and periostin expression. Canser Lett. 2009; 281: 188-195.
  • 16. Motosugi U, Murata S, Nagata K, et al. Thyroid papillary carcinoma with micropapillary and hobnail growth pattern: A histological variant with intermediate malignancy? Thyroid. 2009; 19: 535-537.
  • 17. Bellevicine C, Cozzolino I, Malapelle U, Zeppa P, Troncone G. Cytological and molecular features of papillary thyroid carcinoma with prominent hobnail features: A case report. Acta Cytol 2012; 56: 560-564.
  • 18. Asioli S,Erickson LA, Sebo TJ, et al. Papillary thyroid carcinoma with prominent hobnail features: A new agressive variant of moderately differantiated papillary carcinoma. A clinicopathologic, immunohistochemical and molecular study of eight cases. Am J Surg Pathol. 2010; 34: 44-52.
  • 19. Morris LG, Shaha AR, Tuttle RM, Sikora AG. Tall-cell variant of papillary thyroid carcinoma: A matched pair analysis of survival. Thyroid 2010; 20: 153–158.
  • 20. Sheu SY, Schwertheim S, Worm K et al. Diffuse sclerosing variant of papillary thyroid carsinoma: Lack of BRAF mutation but occurrence of RET/PTC rearrangement. Mod Pathol. 2007; 20: 779-787.
  • 21. Gaertner EM, Davidson M, Weing M. The columnar cell variant of thyroid papillary carcinoma. Case report and discussion of an unusually aggressive thyroid papillary carcinoma. Am J Surg Pathol. 1995; 19(8): 940-47.
  • 22. Nassar H. Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol 2004; 11: 297-303.
  • 23. Wreesmann VB, Sieczka EM, Socci ND, et al. Genomewide profiling of papillary thyroid cancer identifies MUC-1 as an independent prognostic marker. Cancer Res 2004; 64: 3780-9.
  • 24. Kebebew E, Weng J, Bauer J et al. The prevalence and prognostic value of BRAF mutation in thyroid cancer. AnnSurg 2007; 246: 466-70.
  • 25. Lupi C, Giannini R, Ugolini C, et al. Association of BRAF mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma. J Clin Endocrinol Metab 2007; 92: 4085-90.

Hobnail/micropapillary variant papillary thyroid carcinoma: is it a variant or a pattern

Year 2017, Volume: 8 Issue: 3, 134 - 138, 01.06.2017
https://doi.org/10.18663/tjcl.285075

Abstract

Papillary thyroid carcinoma is the most common type of
thyroid malignancies and constitutes 1% of all malignancies. Classical
papillary thyroid carcinoma is very good prognosis; but recurrence, lymph node
metastasis, distant organ metastasis or mortality can develop in 10% of
patients. This aggressive clinical behavior is more often seen in variants such
as diffuse sclerosis, tall cell and columnar cell. Hobnail/micropapillary
variant papillary thyroid carcinoma is a relatively rare, newly described variant
of papillary thyroid carcinoma. There are very few publications in the
literature and it is reported that the aggressive course and metastasizing
potential is greater than the classic papillary thyroid carcinoma. However,
their cytological properties and molecular backround are not fully understood.
In this article; a patient with hobnail/micropapillary variant papillary
thyroid carcinoma has been presented, and diagnostic problems and malignancy
criteria have been discussed by reviewing the literature.

References

  • 1. Aschebrook KB, Ward MH, Sabra MM, Devesa SS. Thyroid cancer incidence patterns in the United States by histologic type 1992–2006. 2011; 21: 125-34.
  • 2. Howlader N. SEER cancer statistics review 1975–2010. Noone AM, Krapcho M, Garshell J, Nwebeyman N, Altekruse SF et al (eds). 2013, August 20.
  • 3. National Cancer Institute 2013 Fast stats: An interactive tool for access to SEER cancer statistics. 2013, September18.
  • 4. Grogan RH, Kaplan SP, Cao H, Weiss RE et al. A study of recurrence and death from papillary thyroid cancer with 27 years of median follow up. Surgery 2013; 154: 1436–46.
  • 5. Ortiz S, Rodriguez JM, Parrilla P, Perez D, Moreno-Gallego A, Rios A, Soria T. Recurrent papillary thyroid cancer: Analysis of prognostic factors including the histological variant. Eur J Surg 2011; 167: 406–12.
  • 6. Cooper DS, Doherty GM, Haugen BR et al. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009; 19: 1167–1214.
  • 7. Malloy MK, Cunnane FM. Pathology and cytologic features of thyroid neoplasms. Surg Oncol Clin N Am 2008;17: 57-70.
  • 8. Lino-Silva LS, Dominguez-Malagon HR, Caro-Sanchez CH, Salcedo-Hernandez RA. Thyroid gland papillary carcinomas with “micropapillary pattern,” a recently recognized poor prognostic finding: Clinicopathologic and survival analysis of 7 cases. Hum Pathol 2012; 43: 1596–1600.
  • 9. Nassar H, Pansare V, Zhang H et al. Pathogenesis of invasive micropapillary carcinoma: Role of MUC-1 glycoprotein. Mod Pathol 2004; 17: 1045-50.
  • 10. Ushiku T, Matsusaka K, Iwasaki Y et al. Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis. Histopathology 2011; 59: 1081-9.
  • 11. Travis WD, Brambilla E, Noguchi M et al. International association for the study of lung cancer/American thoracic society/European respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011; 6: 244-85.
  • 12. Peterse JL. Breast carcinoma with an unexpected inside out pattern. Rotation of polarization associated with angioinvasion. Path Res Pract 1993;189:780.
  • 13. Verdu M, Roman R, Calvo M et al. Clinicopathological and molecular characterization of colorectal micropapillary carcinoma. Mod Pathol 2011; 24: 729-38.
  • 14. Tang W, Nakamura Y, Zuo H et al. Differantation proliferation and retinoid receptör status of papillary carcinoma of the thyroid. Pathol Int 2003;53: 204-213.
  • 15. Bai Y, Kakudo K, Nakamura M et al. Loss of cellular polarity/cohesivness in the invaziv front of papillary thyroid carsinoma and periostin expression. Canser Lett. 2009; 281: 188-195.
  • 16. Motosugi U, Murata S, Nagata K, et al. Thyroid papillary carcinoma with micropapillary and hobnail growth pattern: A histological variant with intermediate malignancy? Thyroid. 2009; 19: 535-537.
  • 17. Bellevicine C, Cozzolino I, Malapelle U, Zeppa P, Troncone G. Cytological and molecular features of papillary thyroid carcinoma with prominent hobnail features: A case report. Acta Cytol 2012; 56: 560-564.
  • 18. Asioli S,Erickson LA, Sebo TJ, et al. Papillary thyroid carcinoma with prominent hobnail features: A new agressive variant of moderately differantiated papillary carcinoma. A clinicopathologic, immunohistochemical and molecular study of eight cases. Am J Surg Pathol. 2010; 34: 44-52.
  • 19. Morris LG, Shaha AR, Tuttle RM, Sikora AG. Tall-cell variant of papillary thyroid carcinoma: A matched pair analysis of survival. Thyroid 2010; 20: 153–158.
  • 20. Sheu SY, Schwertheim S, Worm K et al. Diffuse sclerosing variant of papillary thyroid carsinoma: Lack of BRAF mutation but occurrence of RET/PTC rearrangement. Mod Pathol. 2007; 20: 779-787.
  • 21. Gaertner EM, Davidson M, Weing M. The columnar cell variant of thyroid papillary carcinoma. Case report and discussion of an unusually aggressive thyroid papillary carcinoma. Am J Surg Pathol. 1995; 19(8): 940-47.
  • 22. Nassar H. Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol 2004; 11: 297-303.
  • 23. Wreesmann VB, Sieczka EM, Socci ND, et al. Genomewide profiling of papillary thyroid cancer identifies MUC-1 as an independent prognostic marker. Cancer Res 2004; 64: 3780-9.
  • 24. Kebebew E, Weng J, Bauer J et al. The prevalence and prognostic value of BRAF mutation in thyroid cancer. AnnSurg 2007; 246: 466-70.
  • 25. Lupi C, Giannini R, Ugolini C, et al. Association of BRAF mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma. J Clin Endocrinol Metab 2007; 92: 4085-90.
There are 25 citations in total.

Details

Subjects Health Care Administration
Journal Section Case Report
Authors

Mehmet Zengin

Feray Günver This is me

Nevra Dursun

Publication Date June 1, 2017
Published in Issue Year 2017 Volume: 8 Issue: 3

Cite

APA Zengin, M., Günver, F., & Dursun, N. (2017). Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi. Turkish Journal of Clinics and Laboratory, 8(3), 134-138. https://doi.org/10.18663/tjcl.285075
AMA Zengin M, Günver F, Dursun N. Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi. TJCL. October 2017;8(3):134-138. doi:10.18663/tjcl.285075
Chicago Zengin, Mehmet, Feray Günver, and Nevra Dursun. “Hobnail/mikropapiller Varyant Papiller Tiroid Karsinomu: Varyant mı, Patern Mi”. Turkish Journal of Clinics and Laboratory 8, no. 3 (October 2017): 134-38. https://doi.org/10.18663/tjcl.285075.
EndNote Zengin M, Günver F, Dursun N (October 1, 2017) Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi. Turkish Journal of Clinics and Laboratory 8 3 134–138.
IEEE M. Zengin, F. Günver, and N. Dursun, “Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi”, TJCL, vol. 8, no. 3, pp. 134–138, 2017, doi: 10.18663/tjcl.285075.
ISNAD Zengin, Mehmet et al. “Hobnail/mikropapiller Varyant Papiller Tiroid Karsinomu: Varyant mı, Patern Mi”. Turkish Journal of Clinics and Laboratory 8/3 (October 2017), 134-138. https://doi.org/10.18663/tjcl.285075.
JAMA Zengin M, Günver F, Dursun N. Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi. TJCL. 2017;8:134–138.
MLA Zengin, Mehmet et al. “Hobnail/mikropapiller Varyant Papiller Tiroid Karsinomu: Varyant mı, Patern Mi”. Turkish Journal of Clinics and Laboratory, vol. 8, no. 3, 2017, pp. 134-8, doi:10.18663/tjcl.285075.
Vancouver Zengin M, Günver F, Dursun N. Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi. TJCL. 2017;8(3):134-8.


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