Abstract
Keywords
Cervical lymphadenopathy; excisional biopsy; fine needle aspiration biopsy; ultrasonography Cervical lymphadenopathy excisional biopsy fine needle aspiration biopsy ultrasonography
Supporting Institution
Yok.
Project Number
Proje çalışması değil.
References
- 1. Özkan, EA, Göret CC, Özdemir ZT, Yanık S, Göret NE, Doğan M, et al. Evaluation of peripheral lymphadenopathy with excisional biopsy: six-year experience. Int J Clin Exp Pathol 2015;8(11):15234-9. google scholar
- 2. Bazemore AW, Smucker DR. Lymphadenopathy and malignancy. Am Fam Physician 2002;66(11):2103-10. google scholar
- 3. Öztürk M, Durmuş K. Boyun Kitleleri. Koç C. ed. Kulak Burun Boğaz Hastalıkları ve Baş Boyun Cerrahisi. 3. Ankara: Güneş Tıp Kitabevleri, 2019: 855-79 google scholar
- 4. Vandana M, Dambar S, Amit J. Role of Ultrasonography in Evaluation of Cervical Lymphadenopathy. Medphoenix 2019;234(1):59-63. google scholar
- 5. Chan JM, Shin LK, Jeffrey RB. Ultrasonography of abnormal neck lymph nodes. Ultrasound Q 2007;23(1):47-54. google scholar
- 6. Giacomini CP, Jeffrey RB, Shin LK. Ultrasonographic evaluation of malignant and normal cervical lymph nodes. Semin Ultrasound CT MR 2013;34(3):236-47 google scholar
- 7. Yang JR, Song Y, Jia YL, Ruan LT. Application of multimodal ultrasonography for differentiating benign and malignant cervical lymphadenopathy. Jpn J Radiol 2021;39(10):938-45. google scholar
- 8. Ahmed N, Israr S, Ashraf MS. Comparison of fine needle aspiration cytology (FNAC) and excision biopsy in the diagnosis of cervical lymphadenopathy. Pak J Surg 2009;25:72-5. google scholar
- 9. Frederiksen JK, Sharma M, Casulo C, Burack WR. Systematic review of the effectiveness of fine-needle aspiration and/or core needle biopsy for subclassifying lymphoma. Arch Pathol Lab Med 2015;139(2):245-51. google scholar
- 10. Hafez NH, Tahoun NS. Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. J Egypt Natl Canc Inst 2011;23(3):105-14. google scholar
- 11. Nolder AR. Paediatric cervical lymphadenopathy: when to biopsy? Curr Opin Otolaryngol Head Neck Surg 2013;21(6):567-70. google scholar
- 12. Hehn ST, Grogan TM, Miller TP. Utility of fine-needle aspiration as a diagnostic technique in lymphoma. J Clin Oncol 2004;22(15):3046-52. google scholar
- 13. Kim BM, Kim EK, Kim MJ, Yang WI, Park CS, Park SI. Sonographically guided core needle biopsy of cervical lymphadenopathy in patients without known malignancy. J Ultrasound Med 2007;26(5):585-91. google scholar
- 14. Darnal HK, Karim N, Kamini K, Angela K. The profile of lymphadenopathy in adults and children. Med J Malaysia 2005;60(5):590-8. google scholar
- 15. Kamat, Girish C. A ten-year histopathological study of generalised lymphadenopathy in India. South African Family Practice 2011;53(3): 267-70. google scholar
- 16. Celenk, F., Baysal, E., Aytac, I., Durucu, C., Sari, I., Mumbuc, S., et al. Incidence and predictors of malignancy in children with persistent cervical lymphadenopathy. Int J Pediatr Otorhinolaryngol 2013;77(12):2004-7. google scholar
- 17. Kartal Ö, Ataş E, Gürsel O. Differentiation of benign from malignant cervical lymphadenopathy by ultrasonography in children. Diferenciación entre linfadenopatía cervical benigna y maligna mediante ecografía en niños. Arch Argent Pediatr 2020;118(1):11-7. google scholar
- 18. Kurt A, Gunes Tatar I, Ipek A, Hekimoglu B. B-mode and elastosonographic evaluation to determine the reference elastosonography values for cervical lymph nodes. ISRN Radiol 2013;2013:895287. google scholar
- 19. Khanna R, Sharma AD, Khanna S, Kumar M, Shukla RC. Usefulness of ultrasonography for the evaluation of cervical lymphadenopathy. World J Surg Oncol 2011;9:29. google scholar
Predictive Value of Fine Needle Aspiration Biopsy and Ultrasonography in The Diagnosis of Cervical Lymphadenopathy
Abstract
Objective: Cervical lymphadenopathy (LAP) is one of the most common pathologies in adults and children. While ultrasonography (USG) and fine needle aspiration biopsy (FNAB) are the two methods used as diagnostic tests, excisional biopsy is the gold standard method for diagnosis. In this study, we aimed to show the relationship between USG findings and FNAB results with malignancy in patients with LAP. Materials and methods: Patients who visited our clinic with the complaint of cervical LAP between March 2020 and September 2022 and underwent excisional biopsy were included in this retrospective study. The number, distribution, side, size, cortical thickness, conglomeration, and necrosis characteristics of LAP were evaluated on USG. The sensitivity and specificity of the FNAB were calculated in patients in accordance with the histopathological results. Results: Of the patients included in the study, 45 were female and 42 were male. The overall mean age was 32.72 ± 20.02. The sensitivity of the FNAB was 43.5% and the specificity was 90.0%. Advanced age, presence of conglomeration, unilateral LAP, and generalized LAP were found to be statistically significant in terms of malignancy, while cortical thickness, the number and size of LAPs, and necrosis were not statistically significant. Conclusion: FNAB was not found to be a reliable test to rule out malignancy due to low sensitivity for determining malignancy and but was found to be a highly selective test, and the malignancy-suspected result detected the real patients quite successfully. The advanced age, unilateral LAP, generalized distribution, and conglomeration were the parameters supporting malignancy.
Project Number
Proje çalışması değil.
References
- 1. Özkan, EA, Göret CC, Özdemir ZT, Yanık S, Göret NE, Doğan M, et al. Evaluation of peripheral lymphadenopathy with excisional biopsy: six-year experience. Int J Clin Exp Pathol 2015;8(11):15234-9. google scholar
- 2. Bazemore AW, Smucker DR. Lymphadenopathy and malignancy. Am Fam Physician 2002;66(11):2103-10. google scholar
- 3. Öztürk M, Durmuş K. Boyun Kitleleri. Koç C. ed. Kulak Burun Boğaz Hastalıkları ve Baş Boyun Cerrahisi. 3. Ankara: Güneş Tıp Kitabevleri, 2019: 855-79 google scholar
- 4. Vandana M, Dambar S, Amit J. Role of Ultrasonography in Evaluation of Cervical Lymphadenopathy. Medphoenix 2019;234(1):59-63. google scholar
- 5. Chan JM, Shin LK, Jeffrey RB. Ultrasonography of abnormal neck lymph nodes. Ultrasound Q 2007;23(1):47-54. google scholar
- 6. Giacomini CP, Jeffrey RB, Shin LK. Ultrasonographic evaluation of malignant and normal cervical lymph nodes. Semin Ultrasound CT MR 2013;34(3):236-47 google scholar
- 7. Yang JR, Song Y, Jia YL, Ruan LT. Application of multimodal ultrasonography for differentiating benign and malignant cervical lymphadenopathy. Jpn J Radiol 2021;39(10):938-45. google scholar
- 8. Ahmed N, Israr S, Ashraf MS. Comparison of fine needle aspiration cytology (FNAC) and excision biopsy in the diagnosis of cervical lymphadenopathy. Pak J Surg 2009;25:72-5. google scholar
- 9. Frederiksen JK, Sharma M, Casulo C, Burack WR. Systematic review of the effectiveness of fine-needle aspiration and/or core needle biopsy for subclassifying lymphoma. Arch Pathol Lab Med 2015;139(2):245-51. google scholar
- 10. Hafez NH, Tahoun NS. Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. J Egypt Natl Canc Inst 2011;23(3):105-14. google scholar
- 11. Nolder AR. Paediatric cervical lymphadenopathy: when to biopsy? Curr Opin Otolaryngol Head Neck Surg 2013;21(6):567-70. google scholar
- 12. Hehn ST, Grogan TM, Miller TP. Utility of fine-needle aspiration as a diagnostic technique in lymphoma. J Clin Oncol 2004;22(15):3046-52. google scholar
- 13. Kim BM, Kim EK, Kim MJ, Yang WI, Park CS, Park SI. Sonographically guided core needle biopsy of cervical lymphadenopathy in patients without known malignancy. J Ultrasound Med 2007;26(5):585-91. google scholar
- 14. Darnal HK, Karim N, Kamini K, Angela K. The profile of lymphadenopathy in adults and children. Med J Malaysia 2005;60(5):590-8. google scholar
- 15. Kamat, Girish C. A ten-year histopathological study of generalised lymphadenopathy in India. South African Family Practice 2011;53(3): 267-70. google scholar
- 16. Celenk, F., Baysal, E., Aytac, I., Durucu, C., Sari, I., Mumbuc, S., et al. Incidence and predictors of malignancy in children with persistent cervical lymphadenopathy. Int J Pediatr Otorhinolaryngol 2013;77(12):2004-7. google scholar
- 17. Kartal Ö, Ataş E, Gürsel O. Differentiation of benign from malignant cervical lymphadenopathy by ultrasonography in children. Diferenciación entre linfadenopatía cervical benigna y maligna mediante ecografía en niños. Arch Argent Pediatr 2020;118(1):11-7. google scholar
- 18. Kurt A, Gunes Tatar I, Ipek A, Hekimoglu B. B-mode and elastosonographic evaluation to determine the reference elastosonography values for cervical lymph nodes. ISRN Radiol 2013;2013:895287. google scholar
- 19. Khanna R, Sharma AD, Khanna S, Kumar M, Shukla RC. Usefulness of ultrasonography for the evaluation of cervical lymphadenopathy. World J Surg Oncol 2011;9:29. google scholar
Details
| Primary Language | English |
|---|---|
| Subjects | Otorhinolaryngology |
| Journal Section | Research Article |
| Authors | |
| Project Number | Proje çalışması değil. |
| Publication Date | March 29, 2023 |
| Submission Date | January 1, 2023 |
| Published in Issue | Year 2023 Volume: 33 Issue: 1 |
