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Year 2023, Volume: 2 Issue: 1, 52 - 64, 30.06.2023

Sedat Gökmen Burcu Gül

Abstract

Supporting Institution

Yok

Project Number

Yok

Thanks

Yok

References

  • Abu-Taweel, G.M., Ajarem, J.S., & Ahmad, M. (2012). Neurobehavioral toxic effects of perinatal oral exposure to aluminum on the developmental motor reflexes, learning, memory and brain neurotransmitters of mice offspring. Pharmacology Biochemistry and Behavior, 101(1), 49-56. https://doi:10.1016/j.pbb.2011.11.003
  • Bakir, A., & Darbre, P.D. (2015). Effect of aluminium on migration of oestrogen unresponsive MDA-MB-231 human breast cancer cells in culture. Journal of Inorganic Biochemistry, 152, 180-185. https://doi: 10.1016/j.jinorgbio.2015.09.001
  • Balasubramanyam, A., Sailaja, N., Mahboob, M., Rahman, M.F., Hussain, S.M., & Grover, P. (2009). In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test. Mutagenesis, 24(3), 245-251. https://doi: 10.1093/mutage/gep003
  • Bernuzzi, V., Desor, D., & Lehr, P.R. (1989). Developmental alternations in offspring of female rats orally intoxicated by aluminum chloride or lactate during gestation. Teratology, 40(1), 21-27. https://doi:10.1002/tera.1420400104
  • Bjerregaard, P., Christian, B.I., & Andersen, O.A. (2015). Ecotoxicology of metals-sources, transport, and effects on the ecosystem. In: G.F. Nordberg, & M. Nordberg (Ed.), Handbook on the toxicology of metals (4th ed., pp. 425-459), Academic Press.
  • Boothe, D.M. (2001). The analgesic, antipyretic, anti-inflammatory drugs. In: R. Adams. (Ed.), Veterinary pharmacology and therapeutics (8th ed., pp. 433-451). Iowa State University Press.
  • Burakova, Y., Madera, R., McVey, S., Schlup, J. R., & Shi, J. (2018). Adjuvants for animal vaccines. Viral Immunology, 31(1), 11-22. https://doi:10.1089/vim.2017.0049
  • Cheng, D., Zhang, X., Tang, J., Kong, Y., Wang, X., & Wang, S. (2019). Chlorogenic acid protects against aluminum toxicity via MAPK/Akt signaling pathway in murine RAW264.7 macrophages. Journal of Inorganic Biochemistry, 190, 113-120. https://doi: 10.1016/j.jinorgbio.2018.11.001
  • Cranmer, J.M., Wilkins, J.D., & Cannon, D.J. (1986). Fetal-placentalmaternal uptake of aluminum in mice following gestational exposure: effect of dose and route of administration. Neurotoxicology, 7, 601-608.
  • Darbre, P.D. (2016). Aluminium and the human breast. Morphologie, 100, 65-74. https://doi: 10.1016/j.morpho.2016.02.001
  • Darbre, P.D., Bakir, A., & Iskakova, E. (2013a). Effect of aluminium on migratory and invasive properties of MCF-7 human breast cancer cells in culture. Journal of Inorganic Biochemistry, 128, 245-249. https://doi: 10.1016/j.jinorgbio.2013.07.004
  • Darbre, P.D., Mannello, F., & Exley, C. (2013b). Aluminium and breast cancer: sources of exposure, tissue measurmenets and mechanisms of toxicological actions of breast of breast biology. Journal of Inorganic Biochemistry, 128, 257-261. https://doi: 10.1016/j.jinorgbio.2013.07.005
  • Darbre, P.D., Pugazhendhi, D., & Mannello, F. (2011). Aluminium and human breast diseases. Journal of Inorganic Biochemistry, 105(11), 1484-1488. https://doi: 10.1016/j.jinorgbio.2011.07.017
  • Dey, M. & Singh, R.K. (2022). Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer's disease. Toxicology Mechanisms and Methods, 32(8), 616-627. https://doi:10.1080/15376516.2022.2058898
  • Elkhadrawey, B, El-Bialy, B., Shimaa, A.Z., Nermeen, E.B., & Hesham, E. (2021). Potential toxic effects of aluminum nanoparticles: An overview. Journal of Current Veterinary Research, 3(2), 94-106. https://doi: 10.21608/JCVR.2021.199440
  • Frank, A.A., Hedstrom, O.R., Braselton, W.E., Huckfeldt, R.E., & Snyder, S.P. (1992). Multifocal polioencephalomyelomalacia in Simmental calves with elevated tissue aluminum and decreased tissue copper and manganese. Journal of Veterinary Diagnostic Investigation, 4, 353-355. https://doi:10.1177/104063879200400326
  • Golub, M.S., Gershwin, M.E., & Donald, J.M. (1987). Maternal and developmental toxicity of chronic aluminum exposure in mice. Fundamental and Applied Toxicology, 8, 346-357. https://doi:10.1016/0272-0590(87)90084-4
  • Golub, M.S., Keen, C.L., & Gershwin, M.E. (1992). Neurodevelopmental effect of aluminum in mice: fostering studies. Neurotoxicology and Teratology, 14(3), 177-182. https://doi:10.1016/0892-0362(92)90013-z
  • Gomez, M., Domingo, J.L., & Llobet, J.M. (1991). Developmental toxicity evaluation of oral aluminum in rats: influence of citrate. Neurotoxicology and Teratology, 13(3), 323-328. https://doi:10.1016/0892-0362(91)90078-b
  • Gorgogietas, V.A., Tsialtas, I., Sotiriou, N., Laschou, V.C., Karra, A.G., Leonidas, D.D., Chrousos, G.P., Protopapa, E., & Psarra, A.G. (2018). Potential interference of aluminum chlorohydrate with estrogen receptor signaling in breast cancer cells. Journal of Molecular Biochemistry, 7(1), 1-13.
  • Gul, B., Yerebasan, U., Korkak, F.A., Yuce, H., Baykalir, Y., Parlak Ak, T., Gul, H.F. (2022). The effect of aloe vera on interleukin-6 levels in rats given aluminium chloride. International Asian Congress On Contemporary Sciences-VII. December 9-11, 414, Olongapo City, Philippines.
  • Gupta, N., Gaurav, S.S., & Kumar, A. (2013). Molecular basis of aluminium toxicity in plants: a review. American Journal of Plant Sciences, 4(12), 21-37. https://doi: 10.4236/ajps.2013.412A3004
  • Gupta, R. C. (2012a). Aluminum. In: R. C. Gupta. (Ed.), Veterinary Toxocology Basic and Clinical Principle (2nd ed., pp. 493-498). Academic Press.
  • Gupta, R.C. (2012b). Placental toxicity. In: R.C. Gupta. (Ed.), Veterinary Toxocology Basic and Clinical Principle (2nd ed., pp. 319-336). Academic Press.
  • Herndon, J.M. (2015). Aluminum poisoning of humanity and Earth’s biota by clandestine geoengineering activity: implications for India. Current Science, 108(12), 2173-2177.
  • Igbokwe, I.O., Igwenagu, E., & Igbokwe, N.A. (2019). Aluminium toxicosis: a review of toxic actions and effects. Interdisciplinary Toxicology, 12(2), 45-70. https://doi:10.2478/intox-2019-0007.
  • Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B.B., & Beeregowda, K.N. (2014). Toxicity, mechanism and health effects of some heavy metals. Interdisciplinary Toxicology, 7(2), 60-72. https://doi:10.2478/intox-2014-0009
  • Jensen-Jarolim, E. (2015). Aluminium in allergies and allergen immunotherapy. World Allergy Organization Journal, 8(1), 1-7. https://doi:10.1186/s40413-015-0060-5
  • Krause, B.C., Kriegel, F.L., Rosenkranz, D., Dreiack, N., Tentschert, J., Jungnickel, H., Jalili, P., Fessard, V., Laux, P., & Luch, A. (2020). Aluminum and aluminum oxide nanomaterials uptake after oral exposure-a comparative study. Scientific Reports, 10(1), 1-10. https://doi: 10.1038/s41598-020-59710-z
  • Lindblad, E.B. (2004) Aluminium compounds for use in vaccines. Immunology Cell Biology, 82(5), 497-505. https://doi:10.1111/j.0818-9641.2004.01286.x
  • Liu, J, Robert, A., & Waalkes, M.P. (2008). Toxic effect of metal. In: C.D. Klaassen. (Ed.), Casarett and Doull’s toxicology the basic science of poisons (8th ed., pp. 931-980). McGraw-Hill.
  • Ogoshi, K., Yanagi, S., Moriyama, T., & Arachi, H. (1994). Accumulation of aluminum in cancers of the liver, stomach, duodenum and mammary glands of rats. Journal of trace elements and electrolytes in health and disease, 8(1), 27-31.
  • Papich, G.P. (2018). Drugs for Treating Gastrointestinal Diseases. In: J.E. Riviere & M.G. Papich (Ed.), Veterinary Pharmacology and Therapeutics (10th ed., pp.1245-1277). Wiley.
  • Patermain, J.L., Domingo, J.L., & Llobet, J.M. (1988). Embryotoxic and teratogenic effects of aluminum nitrate in rats upon oral administration. Teratology, 38, 253-257. https://doi:10.1002/tera.1420380309
  • Pineau, A., Fauconneau, B., Sappino, A.P., Deloncle, R., & Guillard, O. (2014). If exposure to aluminium in antiperspirants presents health risk, its content should be reduced. Journal of Trace Elements in Medicine and Biology, 28(2), 147-150. https://doi: 10.1016/j.jtemb.2013.12.002
  • Reinke, C.M., Breitkreutz, J., & Leuenberger, H. (2003). Aluminum in over the-counter drugs: risks outweigh benefits. Drug Safety, 26, 1011-1025. https://doi:10.2165/00002018-200326140-00003
  • Segev, G., Bandt, C., Francey, T., & Cowgill, L.D. (2008). Aluminum toxicity following administration of aluminum-based phosphate binders in 2 dogs with renal failure. Journal of Veterinary Internal Medicine, 22, 1432-1435. https://doi:10.1111/j.1939-1676.2008.0206.x
  • Soni, M.G., White, S.M., Flamm, W.G., & Burdock, G.A. (2001). Safety evaluation of dietary aluminum. Regulatory Toxicology and Pharmacology, 33(1), 66-79. https://doi:10.1006/rtph.2000.1441
  • Spickler, A.R., & Roth, J.A. (2003). Adjuvants in veterinary vaccines: modes of action and adverse effects. Journal of Veterinary Internal Medicine, 17(3), 273-281. https://doi:10.1111/j.1939-1676.2003.tb02448.x. PMID: 12774966
  • Turkez, H., Yousef, M.I., & Geyikoglu, F. (2010). Propolis prevents aluminium-induced genetic and hepatic damages in rat liver. Food and Chemical Toxicology, 48(10), 2741-2746. https://doi: 10.1016/j.fct.2010.06.049.
  • Varner, J.A., Huie, C., & Horvath, W. (1993). Chronic AlF3 administration. II. Selected histological observations. Neuroscience Research Communications, 13, 99-104.
  • Varner, J.A., Jensen, K.F., & Horvath, W. (1998). Chronic administration of aluminum fluoride or sodium fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Research, 784, 284-298. https://doi: 10.1016/s0006-8993(97)01336-x
  • Wilson, R.W. (2011). Aluminum. In: C.M. Wood, A.P. Farrell, & C.J. Brauner (Ed.), Fish Physiology (1 st ed., pp. 67-123). Academic Press.
  • Yokel, R.A. (1984). Toxicity of aluminum exposure during lactation to the maternal and suckling rabbit. Toxicology and Applied Pharmacology, 75(1), 35-43. https://doi:10.1016/0041-008x(84)90073-5
  • Yokel, R.A. (1985). Toxicity of gestational aluminum exposure to the maternal rabbit and offspring. Toxicology and Applied Pharmacology, 79(1), 121-133. https://doi:10.1016/0041-008x(85)90374-6. PMID: 404939
  • Yumoto, S., Nagai, H., Matsuzaki, H., Matsumura, H., Tada, W., Nagatsuma, E., & Kobayashi, K. (2001). Aluminium incorporation into the brain of rat fetuses and sucklings. Brain Research Bulletin, 55(2), 229-234. https://doi:10.1016/s0361-9230(01)00509-3

Aluminum and toxicity

Year 2023, Volume: 2 Issue: 1, 52 - 64, 30.06.2023

Sedat Gökmen Burcu Gül

Abstract

Aluminum (Al) is the third most prevalent element on earth after oxygen and silicon. Al compounds are used in the production of many different products including pots, pans, paints, varnishes, lubricants, cosmetics, vaccinations, pharmaceuticals, and nano-carrier systems, in the field of veterinary medicine and industry. The toxicity in animals can occur through various routes, including ingestion (food, drinking water), inhalation (air, pharmaceutical, agrochemical), and injection (pharmaceutical, vaccine). Acute poisoning in animals is rare and usually occurs following exposure. Numerous pathological effects have been associated with Al accumulation in mammalian tissues. The accumulation in tissues can Al accumulation in mammalian tissues causes various pathological disorders affecting nervous, immune, skeletal, reproductive system, lungs and breast health. The toxic effects of Al cause oxidative stress, immunological changes, genotoxicity, proinflammatory, peptide denaturation or transformation, enzymatic dysfunction, metabolic dysregulation, amyloidogenesis, membrane disruption, iron dyshomeostasis, apoptosis, necrosis and dysplasia. Al is neurotoxic, increases the permeability of the blood brain barrier and inhibits many important enzymes in the brain. This study aimed to reveal the toxicity of Al, its mechanism of action and its relationship with conditions such as vaccines, cancer, etc. in animals.

Keywords

Aluminum effects toxicity veterinary medicine

Project Number

Yok

References

  • Abu-Taweel, G.M., Ajarem, J.S., & Ahmad, M. (2012). Neurobehavioral toxic effects of perinatal oral exposure to aluminum on the developmental motor reflexes, learning, memory and brain neurotransmitters of mice offspring. Pharmacology Biochemistry and Behavior, 101(1), 49-56. https://doi:10.1016/j.pbb.2011.11.003
  • Bakir, A., & Darbre, P.D. (2015). Effect of aluminium on migration of oestrogen unresponsive MDA-MB-231 human breast cancer cells in culture. Journal of Inorganic Biochemistry, 152, 180-185. https://doi: 10.1016/j.jinorgbio.2015.09.001
  • Balasubramanyam, A., Sailaja, N., Mahboob, M., Rahman, M.F., Hussain, S.M., & Grover, P. (2009). In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test. Mutagenesis, 24(3), 245-251. https://doi: 10.1093/mutage/gep003
  • Bernuzzi, V., Desor, D., & Lehr, P.R. (1989). Developmental alternations in offspring of female rats orally intoxicated by aluminum chloride or lactate during gestation. Teratology, 40(1), 21-27. https://doi:10.1002/tera.1420400104
  • Bjerregaard, P., Christian, B.I., & Andersen, O.A. (2015). Ecotoxicology of metals-sources, transport, and effects on the ecosystem. In: G.F. Nordberg, & M. Nordberg (Ed.), Handbook on the toxicology of metals (4th ed., pp. 425-459), Academic Press.
  • Boothe, D.M. (2001). The analgesic, antipyretic, anti-inflammatory drugs. In: R. Adams. (Ed.), Veterinary pharmacology and therapeutics (8th ed., pp. 433-451). Iowa State University Press.
  • Burakova, Y., Madera, R., McVey, S., Schlup, J. R., & Shi, J. (2018). Adjuvants for animal vaccines. Viral Immunology, 31(1), 11-22. https://doi:10.1089/vim.2017.0049
  • Cheng, D., Zhang, X., Tang, J., Kong, Y., Wang, X., & Wang, S. (2019). Chlorogenic acid protects against aluminum toxicity via MAPK/Akt signaling pathway in murine RAW264.7 macrophages. Journal of Inorganic Biochemistry, 190, 113-120. https://doi: 10.1016/j.jinorgbio.2018.11.001
  • Cranmer, J.M., Wilkins, J.D., & Cannon, D.J. (1986). Fetal-placentalmaternal uptake of aluminum in mice following gestational exposure: effect of dose and route of administration. Neurotoxicology, 7, 601-608.
  • Darbre, P.D. (2016). Aluminium and the human breast. Morphologie, 100, 65-74. https://doi: 10.1016/j.morpho.2016.02.001
  • Darbre, P.D., Bakir, A., & Iskakova, E. (2013a). Effect of aluminium on migratory and invasive properties of MCF-7 human breast cancer cells in culture. Journal of Inorganic Biochemistry, 128, 245-249. https://doi: 10.1016/j.jinorgbio.2013.07.004
  • Darbre, P.D., Mannello, F., & Exley, C. (2013b). Aluminium and breast cancer: sources of exposure, tissue measurmenets and mechanisms of toxicological actions of breast of breast biology. Journal of Inorganic Biochemistry, 128, 257-261. https://doi: 10.1016/j.jinorgbio.2013.07.005
  • Darbre, P.D., Pugazhendhi, D., & Mannello, F. (2011). Aluminium and human breast diseases. Journal of Inorganic Biochemistry, 105(11), 1484-1488. https://doi: 10.1016/j.jinorgbio.2011.07.017
  • Dey, M. & Singh, R.K. (2022). Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer's disease. Toxicology Mechanisms and Methods, 32(8), 616-627. https://doi:10.1080/15376516.2022.2058898
  • Elkhadrawey, B, El-Bialy, B., Shimaa, A.Z., Nermeen, E.B., & Hesham, E. (2021). Potential toxic effects of aluminum nanoparticles: An overview. Journal of Current Veterinary Research, 3(2), 94-106. https://doi: 10.21608/JCVR.2021.199440
  • Frank, A.A., Hedstrom, O.R., Braselton, W.E., Huckfeldt, R.E., & Snyder, S.P. (1992). Multifocal polioencephalomyelomalacia in Simmental calves with elevated tissue aluminum and decreased tissue copper and manganese. Journal of Veterinary Diagnostic Investigation, 4, 353-355. https://doi:10.1177/104063879200400326
  • Golub, M.S., Gershwin, M.E., & Donald, J.M. (1987). Maternal and developmental toxicity of chronic aluminum exposure in mice. Fundamental and Applied Toxicology, 8, 346-357. https://doi:10.1016/0272-0590(87)90084-4
  • Golub, M.S., Keen, C.L., & Gershwin, M.E. (1992). Neurodevelopmental effect of aluminum in mice: fostering studies. Neurotoxicology and Teratology, 14(3), 177-182. https://doi:10.1016/0892-0362(92)90013-z
  • Gomez, M., Domingo, J.L., & Llobet, J.M. (1991). Developmental toxicity evaluation of oral aluminum in rats: influence of citrate. Neurotoxicology and Teratology, 13(3), 323-328. https://doi:10.1016/0892-0362(91)90078-b
  • Gorgogietas, V.A., Tsialtas, I., Sotiriou, N., Laschou, V.C., Karra, A.G., Leonidas, D.D., Chrousos, G.P., Protopapa, E., & Psarra, A.G. (2018). Potential interference of aluminum chlorohydrate with estrogen receptor signaling in breast cancer cells. Journal of Molecular Biochemistry, 7(1), 1-13.
  • Gul, B., Yerebasan, U., Korkak, F.A., Yuce, H., Baykalir, Y., Parlak Ak, T., Gul, H.F. (2022). The effect of aloe vera on interleukin-6 levels in rats given aluminium chloride. International Asian Congress On Contemporary Sciences-VII. December 9-11, 414, Olongapo City, Philippines.
  • Gupta, N., Gaurav, S.S., & Kumar, A. (2013). Molecular basis of aluminium toxicity in plants: a review. American Journal of Plant Sciences, 4(12), 21-37. https://doi: 10.4236/ajps.2013.412A3004
  • Gupta, R. C. (2012a). Aluminum. In: R. C. Gupta. (Ed.), Veterinary Toxocology Basic and Clinical Principle (2nd ed., pp. 493-498). Academic Press.
  • Gupta, R.C. (2012b). Placental toxicity. In: R.C. Gupta. (Ed.), Veterinary Toxocology Basic and Clinical Principle (2nd ed., pp. 319-336). Academic Press.
  • Herndon, J.M. (2015). Aluminum poisoning of humanity and Earth’s biota by clandestine geoengineering activity: implications for India. Current Science, 108(12), 2173-2177.
  • Igbokwe, I.O., Igwenagu, E., & Igbokwe, N.A. (2019). Aluminium toxicosis: a review of toxic actions and effects. Interdisciplinary Toxicology, 12(2), 45-70. https://doi:10.2478/intox-2019-0007.
  • Jaishankar, M., Tseten, T., Anbalagan, N., Mathew, B.B., & Beeregowda, K.N. (2014). Toxicity, mechanism and health effects of some heavy metals. Interdisciplinary Toxicology, 7(2), 60-72. https://doi:10.2478/intox-2014-0009
  • Jensen-Jarolim, E. (2015). Aluminium in allergies and allergen immunotherapy. World Allergy Organization Journal, 8(1), 1-7. https://doi:10.1186/s40413-015-0060-5
  • Krause, B.C., Kriegel, F.L., Rosenkranz, D., Dreiack, N., Tentschert, J., Jungnickel, H., Jalili, P., Fessard, V., Laux, P., & Luch, A. (2020). Aluminum and aluminum oxide nanomaterials uptake after oral exposure-a comparative study. Scientific Reports, 10(1), 1-10. https://doi: 10.1038/s41598-020-59710-z
  • Lindblad, E.B. (2004) Aluminium compounds for use in vaccines. Immunology Cell Biology, 82(5), 497-505. https://doi:10.1111/j.0818-9641.2004.01286.x
  • Liu, J, Robert, A., & Waalkes, M.P. (2008). Toxic effect of metal. In: C.D. Klaassen. (Ed.), Casarett and Doull’s toxicology the basic science of poisons (8th ed., pp. 931-980). McGraw-Hill.
  • Ogoshi, K., Yanagi, S., Moriyama, T., & Arachi, H. (1994). Accumulation of aluminum in cancers of the liver, stomach, duodenum and mammary glands of rats. Journal of trace elements and electrolytes in health and disease, 8(1), 27-31.
  • Papich, G.P. (2018). Drugs for Treating Gastrointestinal Diseases. In: J.E. Riviere & M.G. Papich (Ed.), Veterinary Pharmacology and Therapeutics (10th ed., pp.1245-1277). Wiley.
  • Patermain, J.L., Domingo, J.L., & Llobet, J.M. (1988). Embryotoxic and teratogenic effects of aluminum nitrate in rats upon oral administration. Teratology, 38, 253-257. https://doi:10.1002/tera.1420380309
  • Pineau, A., Fauconneau, B., Sappino, A.P., Deloncle, R., & Guillard, O. (2014). If exposure to aluminium in antiperspirants presents health risk, its content should be reduced. Journal of Trace Elements in Medicine and Biology, 28(2), 147-150. https://doi: 10.1016/j.jtemb.2013.12.002
  • Reinke, C.M., Breitkreutz, J., & Leuenberger, H. (2003). Aluminum in over the-counter drugs: risks outweigh benefits. Drug Safety, 26, 1011-1025. https://doi:10.2165/00002018-200326140-00003
  • Segev, G., Bandt, C., Francey, T., & Cowgill, L.D. (2008). Aluminum toxicity following administration of aluminum-based phosphate binders in 2 dogs with renal failure. Journal of Veterinary Internal Medicine, 22, 1432-1435. https://doi:10.1111/j.1939-1676.2008.0206.x
  • Soni, M.G., White, S.M., Flamm, W.G., & Burdock, G.A. (2001). Safety evaluation of dietary aluminum. Regulatory Toxicology and Pharmacology, 33(1), 66-79. https://doi:10.1006/rtph.2000.1441
  • Spickler, A.R., & Roth, J.A. (2003). Adjuvants in veterinary vaccines: modes of action and adverse effects. Journal of Veterinary Internal Medicine, 17(3), 273-281. https://doi:10.1111/j.1939-1676.2003.tb02448.x. PMID: 12774966
  • Turkez, H., Yousef, M.I., & Geyikoglu, F. (2010). Propolis prevents aluminium-induced genetic and hepatic damages in rat liver. Food and Chemical Toxicology, 48(10), 2741-2746. https://doi: 10.1016/j.fct.2010.06.049.
  • Varner, J.A., Huie, C., & Horvath, W. (1993). Chronic AlF3 administration. II. Selected histological observations. Neuroscience Research Communications, 13, 99-104.
  • Varner, J.A., Jensen, K.F., & Horvath, W. (1998). Chronic administration of aluminum fluoride or sodium fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Research, 784, 284-298. https://doi: 10.1016/s0006-8993(97)01336-x
  • Wilson, R.W. (2011). Aluminum. In: C.M. Wood, A.P. Farrell, & C.J. Brauner (Ed.), Fish Physiology (1 st ed., pp. 67-123). Academic Press.
  • Yokel, R.A. (1984). Toxicity of aluminum exposure during lactation to the maternal and suckling rabbit. Toxicology and Applied Pharmacology, 75(1), 35-43. https://doi:10.1016/0041-008x(84)90073-5
  • Yokel, R.A. (1985). Toxicity of gestational aluminum exposure to the maternal rabbit and offspring. Toxicology and Applied Pharmacology, 79(1), 121-133. https://doi:10.1016/0041-008x(85)90374-6. PMID: 404939
  • Yumoto, S., Nagai, H., Matsuzaki, H., Matsumura, H., Tada, W., Nagatsuma, E., & Kobayashi, K. (2001). Aluminium incorporation into the brain of rat fetuses and sucklings. Brain Research Bulletin, 55(2), 229-234. https://doi:10.1016/s0361-9230(01)00509-3
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Details

Primary Language English
Subjects Veterinary Surgery, Veterinary Pharmacology
Journal Section Reviews
Authors

Sedat Gökmen 0000-0002-4793-3030

Burcu Gül 0000-0002-9122-8953

Project Number Yok
Publication Date June 30, 2023
Submission Date May 9, 2023
Published in Issue Year 2023 Volume: 2 Issue: 1

Cite

APA Gökmen, S., & Gül, B. (2023). Aluminum and toxicity. Veterinary Journal of Kastamonu University, 2(1), 52-64.
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