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Ege Journal of Medicine
2005, Cilt 44, Sayı 2, Sayfa(lar) 081-085
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EFFECTS OF SYSTEMIC FLUORIDE INTAKE ON RAT GASTRIC MUCOSA
Çiğdem ELBEK ÇUBUKÇU
Pediatric Dental Clinic Uludag University, Faculty of Medicine Gorukle Campus 16059 BURSA-TURKEY
Keywords: Systemic Fluoride Intake, Rat Gastric Mucosa

This paper presents a study that was carried out to determine the adverse effects of graded doses of fluoride on rat gastric mucosa. Fifty Swiss Albino rats were used. Experimental groups received a solution of 0.5, 5, 50, and 500 ppm fluoride. Control group had distilled water. These solutions administered to the experimental animals during 30 days. In Group V experiment duration was 12 h. In all experimental groups, the rat stomachs were prepared for stereomicroscopic and light microscopic investigation to identify the morphologic and histologic changes. H&E and PAS stains were used for cellular detail. The most specific finding in high fluoride concentrations was mucus layer loss. The fluoride injury was limited in the luminal one-third of the mucosa. Fluoride damaged histological structure in gastric mucosa without causing any injury macroscopically.

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