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Ege Journal of Medicine
2005, Cilt 44, Sayı 2, Sayfa(lar) 111-115
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CORRELATION OF C-ERBB-2 OVEREXPRESSION WITH HISTOPATHOLOGIC AND IMMUNOHISTOCHEMICAL PROGNOSTIC FACTORS IN 131 INVASIVE DUCTAL CARCINOMA CASES
Ebru ARABACI1, Gülay BİLİR1, Işın PAK1, Ali E. DEMİRBAĞ2
1Ankara Onkoloji Eğitim ve Araştırma Hastanesi Patoloji Bölümü, ANKARA
2Yüksek İhtisas Hastanesi Gastroenteroloji Cerrahi Bölümü, ANKARA
Keywords: breast cancer, c-erbB-2 oncogene, prognostic factors

C-erbB-2 oncogene, encodes a transmembran glycoprotein with tyrosine kinase activity known as p185, which belongs to the family of epidermal growth factors. Its overexpression in breast cancer has been correlated with poor prognosis.

In this study, paraffin-embedded tumor sections from 131 invasive ductal carcinoma cases were analyzed . The relationship between c-erbB-2 overexpression and other prognostic markers (age, tumor size, lymph node involvement, tumor grade, lymphovascular invasion, neural invasion, extensive intraductal carcinoma, estrogen, progesteron receptor status and p53) were examined. Our results showed that, c-erbB-2 overexpression is statistically correlated with age (p=0.02), tumor grade (p=0.001), estrogen receptor (p=0.0017) and p53 (p=0.047).

This study confirmed that c-erbB-2 oncogene, related to other clinicopathological-molecular factors, is an important biologic marker in breast cancer.


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