C-erbB-2 oncogene, encodes a transmembran glycoprotein with tyrosine kinase activity known as p185, which belongs
to the family of epidermal growth factors. Its overexpression in breast cancer has been correlated with poor prognosis.
In this study, paraffin-embedded tumor sections from 131 invasive ductal carcinoma cases were analyzed . The
relationship between c-erbB-2 overexpression and other prognostic markers (age, tumor size, lymph node involvement,
tumor grade, lymphovascular invasion, neural invasion, extensive intraductal carcinoma, estrogen, progesteron receptor
status and p53) were examined. Our results showed that, c-erbB-2 overexpression is statistically correlated with age
(p=0.02), tumor grade (p=0.001), estrogen receptor (p=0.0017) and p53 (p=0.047).
This study confirmed that c-erbB-2 oncogene, related to other clinicopathological-molecular factors, is an important
biologic marker in breast cancer.