Human papilloma virus infections (HPV) which involve skin and mucous membranes are widespread all over the world. These infections are important because they can lead to benign and malign tumors.
49-year-old woman with persistant warty skin lesions was admitted to our clinic with thirty years history. Her past medical history and family history was unremarkable. On dermatological examination, verrucous plana papules and plaques were observed on the ankles, dorsal surfaces of hands, face and anogenital areas. Also there were verrucous papules on buccal mucosa and tongue. Some lesions had been treated by surgery and cryotherapy without any response. Treatment with interferon alpha-2a was initiated with the dose of subcutaneously 3 million IU , 3 times per week for 12 weeks.
Despite the lesions on the ankles and dorsal surfaces of the hands responded to the therapy partially, no response was observed in the other lesions.
Systemic interferons can be used to treat condyloma accuminatum, anogenital cancer, laryngeal papilloma and skin warts which are related HPV infection. In this article, a case of generalized verru that was treated with interferon alpha-2a is presented and discussed in the view of the literature.