Postoperative nausea and vomiting (PONV) is one of the complications in a prolonged length of stay in postoperative care unit and hospital and thus, affects postoperative morbidity. We aimed to compare the effects of intraoperative midazolam and ondansetron on PONV.
Materials and Methods: Upon obtaining ethical committee consent, 60 patients (ASA I-II) agreed to participate in the randomized, prospective and double-blinded study for elective thyroid and parathyroid surgery were enrolled. Following removal of thyroid / parathyroid tissue the patients in Group M were administered midazolam IV 2 mg, and the patients in Group O were administered ondansetron IV 4 mg. Thirty minutes before the end of surgery the patients were given paracetamol. The duration of anesthesia and surgery, wake-up time, time until Aldrete score reached 10, nausea and vomiting frequency, OAS/S and VAS scores additional antiemetic need were recorded for 24 hours.
Results: There were no differences between the two groups with respect to demographic parameters. However, the operation time for Group O was longer. The total amount of fentanyl used, wake-up time, and the need for additional antiemetics in the two groups were not significantly different. The time until Aldrete score reached was significantly longer in Group M than in Group O. (p<0.05). The vomiting frequency was higher in Group M than in Group O at the 24th hour (p=0.005).
Conclusion: In this study where the effects of midazolam and ondansetron on PONV were compared, it was determined that sedation achieved with midalozam may be effective in the early postoperative period.