There are few studies that investigate the relationship between iron deficiency anemia and thyroid hormones. The aim of this study is to evaluate the relationship between iron deficiency anemia, a common disease of childhood, and thyroid hormones.
Materials and Methods: A total of 102 children (70 in the study group and 32 in the control group) ranging in age from 6 months to 17 years were included in the study. Blood samples were obtained from the children to determine total blood count, blood iron, total iron binding capacity, ferritin, and thyroid hormone levels.
Results: The median age of the study group was 7.5 years and 62.9% of the subjects were female. Gender and age distribution of the groups were not different (p>0.005). The mean thyroid-stimulating hormone (TSH) level was 2.03±0.95 μIU/mL, mean free thyroxine (FT4) was 1.09±0.21 ng/dL, and mean free triiodothyronine (FT3) was 3.25±0.68 pg/dL in the study group. In the control group, mean TSH was 2.15±0.94 μIU/mL, mean FT4 was 1.14±0.16 ng/dL, and mean FT3 was 3.45±0.56 pg/dL. There was no statistically significant difference between the groups in TSH, FT4, or FT3 levels (p=0.540, p=0.255, and p=0.149, respectively). However, there was a positive correlation between FT4 and hemoglobin (p=0.031, r=0.214).
Conclusion: The main finding of our study was the positive correlation between FT4 and hemoglobin. Thus, we believe that further studies are needed to investigate the relationship between iron and thyroid hormones, which play important roles in growth and cognitive and mental development in childhood.