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Ege Journal of Medicine
2017, Cilt 56, Sayı 3, Sayfa(lar) 154-156
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A case of bilateral Sertoli cell adenoma in androgen insensitivity syndrome
Zeynep Öztürk İnal1, Nursadan Gergerlioğlu2, İlknur Küçükosmanoğlu2, Meryem İlkay Karanis2
1Konya Training and Research Hospital, Clinic of Obstetrics and Gynecology, Konya, Turkey
2Konya Training and Research Hospital, Clinic of Pathology, Konya, Turkey
Keywords: Sertoli cell adenoma, androgen insensitivity syndrome

Androgen insensitivity syndrome, previously referred to as testicular feminization syndrome, is an X-linked recessive disorder that is characterized by a mutation in the q11-q12 region of the X chromosome, which results in a deformed androgen receptor gene. Patients with androgen insensitivity syndrome may develop testicular tumors, especially seminomas after puberty. A 35-year-old female patient presented with the complaint of primary amenorrhea and had masses of approximately 4 cm size palpated in the bilateral inguinal regions. The masses were excised and the histopathological examination was reported as bilateral Sertoli cell adenoma. Although the risk of bilateral gonadal tumor development is low in patients with androgen insensitivity syndrome, such malignancies should not be disregarded.

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