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Ege Journal of Medicine
2017, Cilt 56, Sayı 3, Sayfa(lar) 160-161
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A case of medullary thyroid carcinoma presenting with diarrhea: MEN 2B syndrome
Elvina Almuradova, Ilgın Yıldırım Şimşir, Mehmet Erdoğan, Şevki Çetinkalp, Füsun Saygılı, Ahmet Gökhan Özgen
Ege Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İzmir, Türkiye
Keywords: Multiple endocrine neoplasia type 2B, meduller thyroid carcinom

Multiple endocrine neoplasia type 2B (MEN 2B) is a rare autosomal dominant process characterized by medullary thyroid carcinoma, pheochromocytoma, physical features such as presence of marfanoid habitus and mucosal neuromas. Clinical features are hypertension, episodic sweating, diarrhea, pruritic skin lesions or compressive symptoms from a neck mass. Patients with hypercalcemia may present with constipation, polyuria, polydipsia, memory problems, depression, nephrolithiasis, glucose intolerance, gastroesophageal reflux and fatigue, or they may have no symptoms. Herein we present a case of a patient who was hospitalised several times due to diarrhea but did not diagnosed, but when he referred to our clinic diagnosed as MEN 2B, on the basis of bilateral pheochromocytoma, medullary thyroid carcinoma, multiple paragangliomas located along the spine, marfanoid features of body habitus and mucosal neuromas.

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