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Ege Journal of Medicine
2018, Cilt 57, Sayı 1, Sayfa(lar) 008-013
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A novel predictor in acute kidney injury: Neutrophil to lymphocyte count
Devrim Bozkurt1, Aslı Kılavuz1, Mehmet Berktaş2, Fehmi Akçiçek1
1Ege University Faculty of Medicine, Department of Internal Medicine, Intensive Care Unit, İzmir, Turkey
2Yeditepe University Faculty of Medicine, Department of Biostatistics, İstanbul, Turkey
Keywords: Acute renal failure, mortality

Aim: Acute Kidney injury (AKI) represents a clinical condition reflecting systemic inflammation. Neutrophil-to-lymphocyte ratio (NLR) is novel prognostic marker in various inflammatory conditions. In this retrospective cohort we evaluated two hundred and thirteen AKI patients.

Materials and Methods: The patients’ baseline values on admission, final values at discharge and after discharging during follow-up period in outpatient clinic until six months to one year were recorded. NLR change during follow-up period after hospitalization was also examined.

Results: It has been shown that, final NLR and timely changed NLR during hospital course are significant mortality predictors in AKI patients both in univariate and mutually adjusted multivariate logistic regression analysis. To predict mortality, we showed that, level of 9.90 point for final NLR has 73% sensitivity and 87% specifity as compared to value below in ROC analysis (HR: 7.31, CI 3.36-15.91; p<0.001).

Conclusion: NLR may be a novel screening tool on patiens' mortality for AKI patients during their hospital course.


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