To determine differences in anterior segment measurements between pediatric and adult keratoconus groups using Scheimpflug imaging system.
Materials and Methods: This retrospective study included 133 patients with keratoconus and 101 healthy controls. Subjects were grouped as pediatric and adult. Differences in anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), pachymetry, corneal volume (CV) and maximum keratometry (Kmax) were sought between the age-based subgroups.
Results: Right eyes of the 133 keratoconus patients (56 pediatrics and 77 adults) and 101 healthy controls (41 pediatrics and 60 adults) were reviewed. Pediatric subgroups had significantly higher ACD and ACV compared to those of the adult subgroups in both groups (p<0.05). On the other hand, pediatric and adult keratoconus patients had significantly higher ACD than in the age (subgroup) matched controls (p< 0.05). In the pediatric keratoconus subgroup, eyes with stage 3 keratoconus had significantly deeper ACD than in the eyes with stage 2 keratoconus (p<0.05). However, in the adult group, only corneal parameters were significantly lower in eyes with stage 3 keratoconus compared to those of the eyes with stage 2 keratoconus (p<0.05).
Conclusion: Anterior chamber measurements appear to be altered by aging in both keratoconus and control groups, whereas eyes with keratoconus in all age subgroups appear to have a deeper AC than in the age-matched normals. Moreover, an increase in ACD in pediatric keratoconus might be indicative of progression. However, in the adult keratoconus, corneal parameters appear to decrease with keratoconus progression.