Lung cancer remains the leading cause of cancer-related mortality in all over the world. Non-small cell lung cancer (NSCLC) is the most frequent type of lung carcinoma. In the current study, the effects of tumor-associated macrophages (TAM) on tumor progression and metastasis in NSCLC were investigated.
Materials and Methods: Eighty NSCLC cases, which were diagnosed in Başkent University Medical School, Department of Pathology between January 2011 and May 2016 were included into the study. Clinical follow-up findings of the patients were recorded and CD68 immunohistochemistry was performed to all of them.
Results: Histologically, 36 cases (45%) were squamous cell carcinoma, 36 cases (45%) were adenocarcinoma, 6 cases (7.5%) were large cell carcinoma, and 2 cases were adenosquamous carcinoma (2.5%). The density of TAM in tumor tissue was 1+ in 28 cases (35%), 2+ in 21 cases (26.3%) and 3+ in 31 (38.8%) cases by immunohistochemistry. In addition, the density of TAM was 3+ in only 1 (3.1%) of 32 stage 1 patients, 17 (53.1%) of 32 stage 2 and 13 (81.3%) of 16 stage 3 and 4 patients had 3+ TAM density. The average survival was 39.7±17.4 months, 36.6±17.1 months and 27.3±18.4 months respectively (p<0.05), in the the patients who had 1+, 2+ and 3+ TAM density.
Conclusion: In the current study, we detected that the number of TAM is higher in NSCLC patients who had higher pathological T and TNM stage. Also, an average survival of the patients who had a higher number of TAM was shorter than the patients who had a lower number of TAM.