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Ege Journal of Medicine
2018, Cilt 57, Sayı 3, Sayfa(lar) 136-141
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Five-year experience on early type drug reactions in Çukurova University Clinic of Pediatric Allergy
Aylin Kont Özhan, Dilek Doğruel, Derya Ufuk Altıntaş, Mustafa Yılmaz
Çukurova Üniversitesi Tıp Fakültesi, Çocuk İmmünoloji ve Alerji Bilim Dalı, Adana, Türkiye
Keywords: Drug allergy, early type reaction, diagnostic tests, drug provocation tests

Aim: The aim of our study is to determine the demographic characteristics of the patients who admitted to our clinic, the frequency of the drugs used and the contribution of diagnostic tests on drug allergy.

Materials and Methods: Seventy-four patients, who admitted to the Çukurova University Clinic of Pediatric Allergy and Immunology between January 2010 – December 2015 with the suspicion of early type drug allergy, were included in the study. The medical records of the patients were reviewed and their age, gender, suspected drug(s), drug’s reaction, the method which was used to apply the drug(s), atopy and accompanying diseases, family history, the treatment method and the diagnostic tests were evaluated retrospectively.

Results: The 119 early type drug hypersensitivity reactions reported in the 74 patients who were included in the study were evaluated. The most common reactions were determined as urticaria (40.2%) followed by urticaria/angioedema (29.8%) and anaphylaxis (10.3%). The drug reactions were respectively beta-lactam antibiotics (39.8%) and nonsteroidal anti-inflammatory drugs (29.3%) and there was also allergic reactions history. Thirty-six patients (48.6%) had multiple drug allergy history.

Conclusion: In our study beta-lactam antibiotics were the most commonly described drugs to show reaction, and this frequency was confirmed through diagnostic tests. It has been determined that drug provocation tests should also be performed in order to confirm the diagnosis even in cases where sensitivity is not detected by skin and/or specific IgE measurement.


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