Mean platelet volume (MPV) is a marker that indicates platelet volume and activation as well as inflammatory conditions such as osteoarthritis with synovitis, rheumatoid arthritis and ankylosing spondylitis. The aim of the present study was to investigate the relationship between MPV level and the variables of physical examination, laboratory tests, and radiographic measurements in patients with knee osteoarthritis (OA).
Material and Methods: In this cross-sectional study, 160 patients with knee OA admitted to the Physical Medicine and Rehabilitation Department between January 2013 and November 2015 were included. MPV levels, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of patients were obtained from electronic database of the hospital. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate patients symptoms and disability. Also, patients pain was scored by visual analog scale (VAS). Knee OA was graded according to the Kellgren-Lawrence (KL) classification system on plain anteroposterior knee radiographs.
Results: No correlation was found between MPV and the parameters including ESR, CRP, visual analog scale score and WOMAC score. MPV was negatively correlated with platelet count (r=-0.374). When MPV level was analyzed with regard to the KL grades, no difference was found among groups (p=0.090). When patients were divided into two groups as mild OA (KL grade 1-2) and moderate-severe OA (KL grade 3-4), there was no difference between the groups in terms of MPV level (p=0.066).
Conclusion: No association was detected between MPV level and the parameters. Further studies are needed to evaluate the role of MPV level in disease activity among patients with knee osteoarthritis.