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Ege Journal of Medicine
2018, Cilt 57, Sayı 4, Sayfa(lar) 185-190
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Assessment of subclinical atherosclerosis in glucose metabolism disorders
Elçin Aydın1, Cihan Altın2, Sinan Emre3, Muhteşem Ağıldere4, Mustafa Agah Tekindal5
1Başkent Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, İzmir, Türkiye
2Başkent Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İzmir, Türkiye
3Başkent Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, İzmir, Türkiye
4Başkent Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, Ankara, Türkiye
5İstatistik Uzmanı, Ankara, Türkiye
Keywords: Prediabetes, diabetes mellitus, atherosclerosis, carotis intima media thickness, epicardial fat thickness, optical coherence tomography angiography

Aim: It is a well-known complication that diabetes (DM) and prediabetes (PD) affectsvascular structures and eye. In our study we aim to find out the atherosclerotic changes in patients with PD and DM by using carotis intima-media thickness (CIMT), epicardial fat thickness (EFT) and rusing optical coherence tomography angiography (OCTA).

Materials and Methods: Between May 2017- June 2017 consecutive 19 patients with PD and 12 patients with D were enrolled into the study. They compared with age sex matched control (C) group consisted of 31 individuals who have normal blood glucose levels. Patients with coronary artery disease was excluded. Measurements of CIMT, EFT and retinal and choroidal vascular changes by using OCTA technique obtained from our study group were recorded and compared with each other.

Results: Twelve patients with D (5 male,7 female, mean age 54.2±6.2), 19 patients with PD (8 male, 11 female, mean age 51±8.6) and 31 C group (13 male, 18 female, mean age 50.9±11.2) were included in the study. The highest value of CIMT was found in patients wih D following by patients with PD and control group had the lowest values. There was no difference between groups in EFT. The most common findings in OCTA were non-perfussion, FAZ (foveal avascular zone) erosion and venous pooling. Similarly these findings were more frequent in patient DM following by patients with PD.

Conclusion: Non invasive measurement of CIMT, EFT and retinal vascular changes detected by OCTA are useful and feasible tools for the assessment of subclinical atheroscleoris in patients with glucose metabolism disorders.


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