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Ege Journal of Medicine
2019, Cilt 58, Sayı 1, Sayfa(lar) 021-026
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Changes in ghrelin, leptin and insulin levels after laparoscopic sleeve gastrectomy
Varlık Erol1, Cengiz Aydın2 Levent Uğurlu2 Emre Turgut2, Hülya Yalçın3, Fatma Demet İnce3
sup>Başkent University İzmir Research and Practice Center, Clinic of General Surgery, İzmir, Turkey
2Tepecik Training and Research Center, Clinic of General Surgery, İzmir, Turkey
3Tepecik Training and Research Center, Clinic of Biochemistry, İzmir, Turkey
Keywords: Morbid obesity, sleeve gastrectomy, hormonal changes

Aim: The objective of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG), performed upon patients with morbid obesity, on weight loss and recovery of comorbid diseases as well as on metabolic and hormonal mechanisms by comparing pre and postoperative hormone levels.

Materials and Methods: 38 patients having undergone LSG between May 2013 and May 2014 were included in the study. In this prospective study, patients’ demographic data and associated diseases; weight loss; pre and post-operative insulin levels in addition to pre and post-operative leptin and ghrelin levels in the eighth weeks were compared.

Results: Of 38 patients included in the study there were 32 (84.2%) females and 6 (15.8%) males. Median leptin level was 11.16 ng/mL in the preoperative blood sample, whereas postoperative hormone level in the eighth week was 4.39 ng/mL. When ghrelin levels were examined; preoperative median was 25.72 pg/mL, whereas postoperative hormone level was 14.16 pg/mL in the eighth week. Preoperative median body mass index was determined to be 44.27 and post-operative median was observed to be 36.6 in the eighth week. No mortality was observed.

Conclusion: Today LSG has become a unique surgical technique in the treatment of morbid obesity due to its efficiency in obtaining weight loss and its feasible complication rates. After reviewing the results of our study; we believe this surgical technique does not only provide continuity in weight loss by restrictive changes but at the same time by metabolic ones, too.

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