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Ege Journal of Medicine
2019, Cilt 58, Sayı 1, Sayfa(lar) 092-102
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Do metallic implants make allergies?
Fatma Düşünür Günsen1, Aytül Zerrin Sin1, Semih Aydoğdu2
1Ege Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Alerji ve İmmünoloji Bilim Dalı, İzmir, Türkiye
2Ege Üniversitesi Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, İzmir, Türkiye
Keywords: Metalic implants, allergy, patch test

Sensitivity to metals is very common, especially to nickel. Implanted metals corrode when in contact with biological fluids and release iron, chromium, nickel, aluminium, molybdenum etc. metallic ions. These metal ions may cause local or systemic effects and induce hypersensitivity reactions. Cutaneous reactions over the implanted device are primarily T-cell mediated type 4 delayed-type reactions. Patch test evaluation is the gold standard for searching metal hypersensitivity. Routine pre-implant patch testing is not recommended; if the patient has a personal metal allergy history, it should be performed before operation. Currently available testing methods cannot predict which patients will develop hypersensitivity reactions following insertion of metalic implants. Metal hypersensitivity is an important problem in orthopedics, because of its potential role in formation of pseudotumors, ,chronic pain, joint effusion and also prosthetic joint failure and revision need.

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