[ Ana Sayfa | Amaç ve Kapsam | Yayın Kurulu | İçindekiler | Arşiv | Yayın Arama | Yazım Kuralları | İletişim ]
2007, Cilt 46, Sayı 3, Sayfa(lar) 135-140
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Evaluation of angiogenesis in urothelial carcinoma of bladder and its relation with prognostic factors
Sarı A1, Ermete M1, Dağ F1, Çallı A1, Bölükbaşı A2, Girgin C3
1Department of Pathology, İzmir Atatürk Training and Research Hospital, MD.
2Chief of Department of 2nd Urology, İzmir Atatürk Traning and Research Hospital, MD.
3Associated Chief of Department of 1st Urology, İzmir Ataturk Traning and Research Hospital, MD.
Keywords: Bladder; Bladder Neoplasm; Carcinoma, Transitional Cell; Neovascularization
Abstract
Introduction: The aim of this study was to evaluate the relationship between the established prognostic indicators and angiogenesis in urothelial carcinoma of the bladder.

Materials and Methods: Archival samples from a total of 51 radical cystectomy specimens (seven pTa, eight pT1, eleven pT2, seventeen pT3 and eight pT4) were analysed. For each case clinicopathologic parameters such as, age, sex, grade, pathologic stage, lymph node metastasis, vascular/lymphatic invasion, perineural invasion and the presence of carcinoma-in-situ were detected. To evaluate angiogenesis, vessels were immunohistochemically highlighted using CD34 antibody. Vascular surface density (VSD) and number of vessels per square millimetre of stroma (NVES) values were analysed.

Results: As a result no relation between angiogenesis and the prognostic factors studied other than the presence of carcinoma in situ could be established.

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