Derleme
Yıl 2019,
Cilt: 28 Sayı: 3, 242 - 248, 30.09.2019
Öz
Nazal
ve paranasal mukozanın kronik inflamatuar hastalığı olan nazal polipozis,
çoğunlukla ön etmoid bölgeden ödemli mukozanın sarkması ve gri renkli polipoid
kitleler oluşturması ile karakterize bir hastalıktır. Nazal poliplerin toplumda
görülme oranı %1-4 dür. Hastalarda burun
tıkanıklığı, rinore, geniz akıntısı, koku kaybı ve daha az sıklıkta yüz ağrısı
şikayetlerine yol açabilir. Nazal polip tedavisi bu belirtilerin ortadan
kaldırılmasına yönelik medikal ve cerrahi tadavileri içerir fakat genel kabul
görmüş bir tedavi protokolü yoktur. Altta yatan nedene yönelik olarak birçok hipotez
ortaya atılsa da etyolojisi halen tam olarak bilinmemektedir. Bu makalede nazal
polipozis tanı ve tedavisindeki güncel gelişmeler literatür gözden geçirilerek
sunulmuştur.
Anahtar Kelimeler
Kaynakça
- Referans1. Larsen K, Tos M. The estimated incidence of symptomatic nasal polyps. Acta Otolaryngol 2002; 122:179–82.
- Referans2. Tan BK, Chandra RK, Pollak J et al. Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis. J Allergy Clin Immunol 2013; 131:1350–60.
- Referans3. Hulse KE, Stevens WW, Tan BK, Schleimer RP. Pathogenesis of nasal polyposis. Clin Exp.Allergy. 2015 Feb;45(2):328-46.
- Referans4. Kim YS, Kim NH, Seong SY, Kim KR, Lee GB, Kim KS. Prevalence and risk factors of chronic rhinosinusitis in Korea. Am J Rhinol Allergy. 2011; 25:117–21.Referans5. Johansson L, Akerlund A, Holmberg K, Melen I, Bende M. Prevalence of nasal polyps in adults: the Skovde population-based study. Ann Otol Rhinol Laryngol. 2003; 112:625–9.
- Referans6. Tos M. The pathogenic theories on the formation of nasal polyps. Am J Rhinol. 1990;4:51-6.
- Referans7. İsmi O, Özcan C, Polat G, Kul S, Görür K, Pütürgeli T. TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis. Turk Arch Otorhinolaryngol. 2017 Jun;55(2):51-56.
- Referans8. Dar SA, Rai G, Ansari MA, Akhter N, Gupta N, Sharma S, Haque S, Ramachandran VG, Wahid M, Rudramurthy SM, Chakrabarti A, Das S. FcɛR1α gene polymorphism shows association with high IgE and anti-FcɛR1α in Chronic Rhinosinusitis with Nasal Polyposis. J Cell Biochem. 2018 May;119(5):4142-4149.
- Referans9. Bachert C, Zhang N, Patou J, van Zele T, Gevaert P. Role of staphylococcal superantigens in upper airway disease. Curr Opin Allergy Clin Immunol 2008; 8:34–8 Referans10. Bernstein JM, Ballow M, Schlievert PM, Rich G, Allen C, Dryja D. A superantigen hypothesis for the patho- genesis of chronic hyperplastic sinusitis with massive nasal polyposis. Am J Rhinol 2003; 17:321–6. Referans11. Sasama J, Sherris DA, Shin SH, Kep- hart GM, Kern EB, Ponikau JU. New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 2005; 13:2–8.
- Referans12. Fokkens WJ, Lund VJ, Mullol J et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl 2012; 23:1–298
- Referans13. Bavbek S, Dursun B, Dursun E, et al. The prevalence of aspirin hypersensitivity in patients with nasal polyposis and contributing factors. Am J Rhinol Allergy 25:411–415, 2011
- Referans14. Pearlman AN, Chandra RK, Chang D, et al. Relationships between severity of chronic rhinosinusitis and nasal polyposis, asthma, and atopy. Am J Rhinol Allergy 23:145–148, 2009.
- Referans15. Settipane GA. Epidemiology of nasal polyps. In Nasal Polyps: Epidemiology, Pathogenesis and Treatment. Settipane GA, Lund VJ, Bernstein JM, and Tos M (Eds). Providence, RI: OceanSide Pubications, 17-24, 1997.
- Referans16. Schäper C, Noga O, Koch B, et al: Anti- inflammatory properties of montelu- kast, a leukotriene receptor antagonist in patients with asthma and nasal pol- yposis. J Investig Allergol Clin Immunol 2011;21:51-58
- Referans17. Pauli C, Fintelmann R, Klemens C, et al: [Polyposis nasi improvement in quality of life by the influence of leukotrien receptor antagonists]. Laryngorhinootologie 2007;86:282–286.
- Referans18. Mostafa BE, Abdel Hay H, Mohammed HE, Yamani M: Role of leukotriene inhibitors in the postoperative management of nasal polyps. ORL J Otorhino- laryngol Relat Spec 2005;67:148–153.
- Referans19. Stevenson DD, Hankammer MA, Mathison DA, Christiansen SC, Simon RA: Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: long-term outcomes. J Allergy Clin Immunol 1996;98:751-758
- Referans20. Van Zele T, Gevaert P, Holtappels G, et al: Oral steroids and doxycycline: two different approaches to treat nasal pol- yps. J Allergy Clin Immunol 2010;125: 1069-1076.e4.
- Referans21. Kennedy DW, Kuhn FA, Hamilos DL, et al: Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope 2005;115:1793–1799
- Referans22. Chan KO, Genoway KA, Javer AR: Effectiveness of itraconazole in the management of refractory allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg 2008;37:870-874.
- Referans23. Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H: Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 2004;113: 1122–1128.
- Referans24. Duffy SM, Lawley WJ, Kaur D, Yang W, Bradding P. Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation. J Allergy Clin Immunol 2003;112:965-972.
- Referans25. Pletcher SD, Goldberg AN. Treatment of recurrent sinonasal polyposis with steroid infused carboxymethylcellulose foam. Am J Rhinol Allergy 2010;24(6):451–453.
- Referans26. Wynn R, Har-El G. Recurrence rates after endoscopic sinus surgery for massive sinus polyposis. Laryngoscope 2007;114:811-813.
- Referans27. Lund VJ, Mackay IS. Outcome assessment of endoscopic surgery. J R Soc Med 1994;87:70-2.
- Referans28. Moriyama H. Postoperative care and long term results. In: Okuda M, editor. Proceedings of the 1991 International Congress of Rhinology. Rhinology 1992;14 (Suppl.):156-9.
Yıl 2019,
Cilt: 28 Sayı: 3, 242 - 248, 30.09.2019
Öz
Nasal polyposis is a chronic inflammatory disease of the nasal and paranasal sinuses mucosa, characterized by prolapse of edematous mucosa as grey polypoid masses, most commonly from the anterior ethmoid region. Nasal polyps are common, affecting up to 1-4 percent of the population. They present with nasal obstruction, rhinorrhoea, post nasal drip, loss of sense of smell, and less commonly facial pain. The management of nasal polyps, aimed at improving these symptoms, includes both surgical and medical treatments, but there is no universally accepted management protocol. Several hypotheses have been put forward regarding the underlying mechanisms but the aetiology is still unknown. In this article, we present the recent advances in the diagnosis and treatment of nasal polyposis by reviewing new guidelines and meta-analysis studies.
Anahtar Kelimeler
Kaynakça
- Referans1. Larsen K, Tos M. The estimated incidence of symptomatic nasal polyps. Acta Otolaryngol 2002; 122:179–82.
- Referans2. Tan BK, Chandra RK, Pollak J et al. Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis. J Allergy Clin Immunol 2013; 131:1350–60.
- Referans3. Hulse KE, Stevens WW, Tan BK, Schleimer RP. Pathogenesis of nasal polyposis. Clin Exp.Allergy. 2015 Feb;45(2):328-46.
- Referans4. Kim YS, Kim NH, Seong SY, Kim KR, Lee GB, Kim KS. Prevalence and risk factors of chronic rhinosinusitis in Korea. Am J Rhinol Allergy. 2011; 25:117–21.Referans5. Johansson L, Akerlund A, Holmberg K, Melen I, Bende M. Prevalence of nasal polyps in adults: the Skovde population-based study. Ann Otol Rhinol Laryngol. 2003; 112:625–9.
- Referans6. Tos M. The pathogenic theories on the formation of nasal polyps. Am J Rhinol. 1990;4:51-6.
- Referans7. İsmi O, Özcan C, Polat G, Kul S, Görür K, Pütürgeli T. TNF-α and IL-1 β Cytokine Gene Polymorphism in Patients with Nasal Polyposis. Turk Arch Otorhinolaryngol. 2017 Jun;55(2):51-56.
- Referans8. Dar SA, Rai G, Ansari MA, Akhter N, Gupta N, Sharma S, Haque S, Ramachandran VG, Wahid M, Rudramurthy SM, Chakrabarti A, Das S. FcɛR1α gene polymorphism shows association with high IgE and anti-FcɛR1α in Chronic Rhinosinusitis with Nasal Polyposis. J Cell Biochem. 2018 May;119(5):4142-4149.
- Referans9. Bachert C, Zhang N, Patou J, van Zele T, Gevaert P. Role of staphylococcal superantigens in upper airway disease. Curr Opin Allergy Clin Immunol 2008; 8:34–8 Referans10. Bernstein JM, Ballow M, Schlievert PM, Rich G, Allen C, Dryja D. A superantigen hypothesis for the patho- genesis of chronic hyperplastic sinusitis with massive nasal polyposis. Am J Rhinol 2003; 17:321–6. Referans11. Sasama J, Sherris DA, Shin SH, Kep- hart GM, Kern EB, Ponikau JU. New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 2005; 13:2–8.
- Referans12. Fokkens WJ, Lund VJ, Mullol J et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl 2012; 23:1–298
- Referans13. Bavbek S, Dursun B, Dursun E, et al. The prevalence of aspirin hypersensitivity in patients with nasal polyposis and contributing factors. Am J Rhinol Allergy 25:411–415, 2011
- Referans14. Pearlman AN, Chandra RK, Chang D, et al. Relationships between severity of chronic rhinosinusitis and nasal polyposis, asthma, and atopy. Am J Rhinol Allergy 23:145–148, 2009.
- Referans15. Settipane GA. Epidemiology of nasal polyps. In Nasal Polyps: Epidemiology, Pathogenesis and Treatment. Settipane GA, Lund VJ, Bernstein JM, and Tos M (Eds). Providence, RI: OceanSide Pubications, 17-24, 1997.
- Referans16. Schäper C, Noga O, Koch B, et al: Anti- inflammatory properties of montelu- kast, a leukotriene receptor antagonist in patients with asthma and nasal pol- yposis. J Investig Allergol Clin Immunol 2011;21:51-58
- Referans17. Pauli C, Fintelmann R, Klemens C, et al: [Polyposis nasi improvement in quality of life by the influence of leukotrien receptor antagonists]. Laryngorhinootologie 2007;86:282–286.
- Referans18. Mostafa BE, Abdel Hay H, Mohammed HE, Yamani M: Role of leukotriene inhibitors in the postoperative management of nasal polyps. ORL J Otorhino- laryngol Relat Spec 2005;67:148–153.
- Referans19. Stevenson DD, Hankammer MA, Mathison DA, Christiansen SC, Simon RA: Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: long-term outcomes. J Allergy Clin Immunol 1996;98:751-758
- Referans20. Van Zele T, Gevaert P, Holtappels G, et al: Oral steroids and doxycycline: two different approaches to treat nasal pol- yps. J Allergy Clin Immunol 2010;125: 1069-1076.e4.
- Referans21. Kennedy DW, Kuhn FA, Hamilos DL, et al: Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope 2005;115:1793–1799
- Referans22. Chan KO, Genoway KA, Javer AR: Effectiveness of itraconazole in the management of refractory allergic fungal rhinosinusitis. J Otolaryngol Head Neck Surg 2008;37:870-874.
- Referans23. Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H: Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 2004;113: 1122–1128.
- Referans24. Duffy SM, Lawley WJ, Kaur D, Yang W, Bradding P. Inhibition of human mast cell proliferation and survival by tamoxifen in association with ion channel modulation. J Allergy Clin Immunol 2003;112:965-972.
- Referans25. Pletcher SD, Goldberg AN. Treatment of recurrent sinonasal polyposis with steroid infused carboxymethylcellulose foam. Am J Rhinol Allergy 2010;24(6):451–453.
- Referans26. Wynn R, Har-El G. Recurrence rates after endoscopic sinus surgery for massive sinus polyposis. Laryngoscope 2007;114:811-813.
- Referans27. Lund VJ, Mackay IS. Outcome assessment of endoscopic surgery. J R Soc Med 1994;87:70-2.
- Referans28. Moriyama H. Postoperative care and long term results. In: Okuda M, editor. Proceedings of the 1991 International Congress of Rhinology. Rhinology 1992;14 (Suppl.):156-9.
Toplam 25 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Eylül 2019 |
| Kabul Tarihi | 23 Haziran 2018 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 28 Sayı: 3 |
