Yıl 2007,
Cilt: 60 Sayı: 1, 26 - 30, 01.01.2007
Öz
Anahtar Kelimeler
Kaynakça
- Cross EC, Halliwell B, Borih ET, et al. Oxygen radicals and human disease. Ann Intern Med 1987; 107:526-545.
- Nielsen F, Mikkelsen BB, Nielsen JB,Andersen HR, Grandjean P. Plasma malondialdehyde as biomarker for oxi- dative stress: reference interval and ef- fects of life-style factors. Clin Chem 1997; 43: 1209-1214.
- Bundak R, Furman A, Gunoz H, Daren- deliler F, Bas F, Neyzi O. Body mass in- dex references for Turkish children. Ac- ta Paediatr 2006; 95194-8.
- Ikatsu H, Nakajima T, Muraama N, Kore- naga T. Flow-injection analysis for ma- londialdehyde in plasma with the thi- obarbituric acid reaction. Clin Chem 1992; 38: 2061-5.
- The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20: 1183- 1197.
- Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assess- ment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for asses- sing insulin resistance among obese children and adolescents. Pediatrics 2005;115: 500-503.
- Alberti KG, Zimmet PZ. Definition, diag- nosis and classification of diabetes mel- litus and its complications. Part 1: Diag- nosis and classification of diabetes mel- litus provisional report of a WHO con- sultation. Diab Med 1998;15: 539-553.
- Erdeve O, Siklar Z, Kocatürk PA, Antioxi- dant superoxide dismutase activity in obese children. Biol Trace Elem Res 2004;98:219-228.
- Van Gaal LF, Zhang A, Steijaert MM, De Leeuw IH. Human obesity: from lipid abnormalities to lipid peroxidation. Int J Obes Relat Metab Disord 1995; 19 (Suppl 3): S21.
- Moor de Burgos A, Wartanowicz M, Zi- emlanski S. Blood vitamin and lipid le- vels in overweight and obese women. Eur J Clin Nutr 1992; 46: 803.
- Manios Y, Kolotourou M, Moschonis G, et al. Macronutrient intake, physical ac- tivity, serum lipids and increased body weight in primary school children in Is- tanbul. Pediatr Int 2005 47:159-66.
- Erdincler DS, Seven A, Inci F, et al. Lipid peroxidation and antioxidant status in experimental animals: effects of aging and hypercholesterolemic diet. Clin Chim Acta 1997; 265:77-84.
- Lewis GF, Steiner G. Acute effect s of in- sulin in the control of VLDL production in humans. Implications for insulin-re- sistant state. Diabetes Care 1996, 19: 390-393.
- Arner P. Differences in lipolysis between human subcutaneous and omental adi- pose tissues. Ann Med 1995, 27: 435- 438.
- Patsch JR, Miesenbock G, Hopferwieser T, et al. Relation of triglyceride metabo- lism and coronary artery disease. Studi- es in the postprandial state. Arterioscler Thromb 1992, 12: 1336-1345.
- Sattler W, Malle E, Kostner GM. Metho- dological approaches for assessing lipid and protein oxidation and modification in plasma and isolated lipoproteins. Methods Mol Biol 1998; 110: 167.
- Van Gaal LF, Vertommen J, De Leeuw IH. The in vitro oxidizabilitiy of lipopro- tein particals in obese and non-obese subjects. Atherosclerosis 1998; 137 (suppl): S39.
- Tack CJ, Smits P, Demacker PN, Stalen- hoef AF. Troglitazone decreases the pro- portion of small dense LDL and incre- ases the resistance of LDL to oxidation in obese subjects. Diabetes Care 1998; 21: 796.
- Prazny M, Skrha J, Hilgertova J. Plasma malondialdehyde and obesity: is there a relationship? Clin Chem Lab Med 1999; 37:1129-1130.
- Mutlu-Turkoðlu U, Oztezcan S, Telci A, et al. An increase in lipoproteinoxidati- on and endogenous lipid peroxides in serum of obese woman. Clin Exp Med 2003; 2: 171-174.
- Dandona P, Mohanty P, Ghanim H, et al. The suppressive effect of dietary restric- tion and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and pro- tein carbonylation. J Clin Endocrinol Metab 2001, 86: 355-362.
- Davi G, Guagnano MT, Ciabattoni G, et al. Platelet activation in obese women: ole of inflammation and oxidant stress. JAMA 2002, 288: 2008-2014.
Yıl 2007,
Cilt: 60 Sayı: 1, 26 - 30, 01.01.2007
Öz
Amaç: Obezite artan lipid peroksidasyonu ile ilişkilidir. Lipid peroksidasyon sürecinin birkaç
yan ürününden biri olan malondialdehid (MDA), lipid peroksidasyon düzeyini yansıtan biyolojik
bir belirteçtir. Bu çalışmada obez çocuklarda oksidan hasarın belirlenmesi amaçladı.
Gereç ve Yöntem: Otuz iki çocuk ve aynı yaş grubunda yirmi obez olmayan çocuk değerlendirildi.
Olguların hiçbiri insülin düzeyini, insülin duyarlılığını veya oksidatif stresi etkileyecek
ilaç almıyordu. Gece açlığı sonrası biyokimyasal parametreleri ve MDA düzeyini belirlemek
için kan alındı. İnsülin direnci HOMA-IR kullanılarak değerlendirildi.
Bulgular: Obez grup kontrol grubuyla karşılaştırıldığında anlamlı olarak yüksek açlık plazma
insülin, açlık plazma glukozu, plazma kolesterolü, LDL-kolesterol ve yüksek kan basıncı
değerlerine sahipti (p < 0.05). Serum MDA düzeyi kontrol grubuyla (5.43±1.096 µmol/L)
karşılaştırıldığında, obez grupta (9.856±3.705 µmol/L) anlamlı olarak yüksekti (p=0.001).
Tüm olgularda HOMA-IR değerleri ile vücut kitle indeksi (p=0.0001) ve HOMA-IR değerleri
ile MDA düzeyleri arasında (p=0.003) anlamlı pozitif korelasyon gözlendi.
Sonuç: Bu bulgular çocuklarda obezitenin, oksidatif stres artışında önemli bir faktör olduğunu göstermektedir.
Anahtar Kelimeler
çocukluk çağı obezitesi insülin direnci malondialdehid oksidatif stres
Kaynakça
- Cross EC, Halliwell B, Borih ET, et al. Oxygen radicals and human disease. Ann Intern Med 1987; 107:526-545.
- Nielsen F, Mikkelsen BB, Nielsen JB,Andersen HR, Grandjean P. Plasma malondialdehyde as biomarker for oxi- dative stress: reference interval and ef- fects of life-style factors. Clin Chem 1997; 43: 1209-1214.
- Bundak R, Furman A, Gunoz H, Daren- deliler F, Bas F, Neyzi O. Body mass in- dex references for Turkish children. Ac- ta Paediatr 2006; 95194-8.
- Ikatsu H, Nakajima T, Muraama N, Kore- naga T. Flow-injection analysis for ma- londialdehyde in plasma with the thi- obarbituric acid reaction. Clin Chem 1992; 38: 2061-5.
- The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20: 1183- 1197.
- Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homeostasis model assess- ment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for asses- sing insulin resistance among obese children and adolescents. Pediatrics 2005;115: 500-503.
- Alberti KG, Zimmet PZ. Definition, diag- nosis and classification of diabetes mel- litus and its complications. Part 1: Diag- nosis and classification of diabetes mel- litus provisional report of a WHO con- sultation. Diab Med 1998;15: 539-553.
- Erdeve O, Siklar Z, Kocatürk PA, Antioxi- dant superoxide dismutase activity in obese children. Biol Trace Elem Res 2004;98:219-228.
- Van Gaal LF, Zhang A, Steijaert MM, De Leeuw IH. Human obesity: from lipid abnormalities to lipid peroxidation. Int J Obes Relat Metab Disord 1995; 19 (Suppl 3): S21.
- Moor de Burgos A, Wartanowicz M, Zi- emlanski S. Blood vitamin and lipid le- vels in overweight and obese women. Eur J Clin Nutr 1992; 46: 803.
- Manios Y, Kolotourou M, Moschonis G, et al. Macronutrient intake, physical ac- tivity, serum lipids and increased body weight in primary school children in Is- tanbul. Pediatr Int 2005 47:159-66.
- Erdincler DS, Seven A, Inci F, et al. Lipid peroxidation and antioxidant status in experimental animals: effects of aging and hypercholesterolemic diet. Clin Chim Acta 1997; 265:77-84.
- Lewis GF, Steiner G. Acute effect s of in- sulin in the control of VLDL production in humans. Implications for insulin-re- sistant state. Diabetes Care 1996, 19: 390-393.
- Arner P. Differences in lipolysis between human subcutaneous and omental adi- pose tissues. Ann Med 1995, 27: 435- 438.
- Patsch JR, Miesenbock G, Hopferwieser T, et al. Relation of triglyceride metabo- lism and coronary artery disease. Studi- es in the postprandial state. Arterioscler Thromb 1992, 12: 1336-1345.
- Sattler W, Malle E, Kostner GM. Metho- dological approaches for assessing lipid and protein oxidation and modification in plasma and isolated lipoproteins. Methods Mol Biol 1998; 110: 167.
- Van Gaal LF, Vertommen J, De Leeuw IH. The in vitro oxidizabilitiy of lipopro- tein particals in obese and non-obese subjects. Atherosclerosis 1998; 137 (suppl): S39.
- Tack CJ, Smits P, Demacker PN, Stalen- hoef AF. Troglitazone decreases the pro- portion of small dense LDL and incre- ases the resistance of LDL to oxidation in obese subjects. Diabetes Care 1998; 21: 796.
- Prazny M, Skrha J, Hilgertova J. Plasma malondialdehyde and obesity: is there a relationship? Clin Chem Lab Med 1999; 37:1129-1130.
- Mutlu-Turkoðlu U, Oztezcan S, Telci A, et al. An increase in lipoproteinoxidati- on and endogenous lipid peroxides in serum of obese woman. Clin Exp Med 2003; 2: 171-174.
- Dandona P, Mohanty P, Ghanim H, et al. The suppressive effect of dietary restric- tion and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and pro- tein carbonylation. J Clin Endocrinol Metab 2001, 86: 355-362.
- Davi G, Guagnano MT, Ciabattoni G, et al. Platelet activation in obese women: ole of inflammation and oxidant stress. JAMA 2002, 288: 2008-2014.
Toplam 22 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Ocak 2007 |
| Yayımlandığı Sayı | Yıl 2007 Cilt: 60 Sayı: 1 |