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Protective Effects of Ethanol Extract from Hippophae rhamnoides L. Leaves against Indomethacin-Induced Gastric Ulcer in Rats

Yıl 2023, Cilt: 6 Sayı: 4, 697 - 704, 15.10.2023

Lale Duysak Mine Gülaboğlu Tuğba Nurcan Yüksel Zekai Halıcı Doğukan Canayakın Galip Mesut Demir

https://doi.org/10.19127/bshealthscience.1336015
Cited By: 1

Öz

We aimed to determine the effects of ethanol extract of Hippophae rhamnoides L. leaves on indomethacin-induced gastric ulcer in rats. 35 male Sprague Dawley rats were divided into 7 groups (n=5) at random: healthy; Hippophae rhamnoides L. leaves ethanol extract (HR) III; indomethacin; indomethacin+famotidine; indomethacin+HRI (100 mg/kg); indomethacin +HRII (250 mg/kg) and indomethacin +HRIII (500 mg/kg). All rats except the healthy group fasted for 24 hours. At the end of this period, HR and famotidine (20 mg/kg) were administered by oral gavage to the corresponding rat groups. Five minutes after the HR treatments, 25 mg/kg of indomethacin was applied by oral gavage to all groups except the Healthy and HR III groups. Six hours after indomethacin administration, stomach tissues were removed for investigation macroscopic and biochemically (Superoxide dismutase activity, Glutathione, and Malondialdehyde levels). HR administration improved ulcerative injury in stomach tissues caused by the indomethacin-induced gastric ulcer. HR administration reduced indomethacin-induced ulcer areas. Moreover, HR treatment significantly decreased malondialdehyde levels, increased glutathione levels, and elevated superoxide dismutase activity. HR significantly improved gastric ulcer by alleviating oxidative stress that could be important in ulcer. HR may be a new potential treatment option for ulcer treatment with an antioxidant effect. These findings may provide a mechanistic basis for using HR leaves to treat gastric ulcer.

Anahtar Kelimeler

Antioxidant Antiulcerogenic effect Ethanol extract Gastric ulcer Hippophae rhamnoides L. Indomethacin

Destekleyen Kurum

Atatürk Üniversitesi Bilimsel Araştırma Projeleri Birimi

Proje Numarası

2013/58

Kaynakça

  • Adinortey MB, Ansah C, Galyuon I Nyarko A. 2013. In vivo models used for evaluation of potential antigastroduodenal ulcer agents. Ulcers, 2013.
  • Antonisamy P, Arasu MV, Dhanasekaran M, Choi K. C, Aravinthan A, Kim N. S, . . . Kim JH. 2016. Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms. Food Function, 7(1): 398-408.
  • Balmus IM, Ciobica A, Trifan A Stanciu C. 2016. The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models. Saudi J Gastroenterol, 22(1): 3-17. doi:10.4103/1319-3767.173753.
  • Barboza KRM, Coco LZ, Alves GM, Peters B, Vasquez EC, Pereira TMC, . . . Campagnaro B. P. 2018. Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress. Life Sci, 209 370-376. doi:10.1016/j.lfs.2018.08.035
  • Bhattacharyya A, Chattopadhyay R, Mitra S Crowe S. E. 2014. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev, 94(2): 329-354. doi:10.1152/physrev.00040.2012.
  • Bonciu E, Olaru AL, Rosculete E Rosculete C. A. 2020. Cytogenetic study on the biostimulation potential of the aqueous fruit extract of Hippophaë rhamnoides for a sustainable agricultural ecosystem. Plants, 9(7): 843.
  • Bostanci MS, Bakacak M, Inanc F, Yaylali A, Serin S, Attar R, . . . Yildirim G. 2016. The protective effect of G-CSF on experimental ischemia/reperfusion injury in rat ovary. Arch Gynecol Obstet, 293(4): 789-795. doi:10.1007/s00404-015-3878-8.
  • Calik I, Yayla M, Cinar I, Cadirci E, Albayrak A, Sirin B, . . . Halici Z. 2020. LP44 (4-[2-(methylthio):phenyl]-N-(1234-tetrahydronaphthalen-1-yl):-1-piperazinehexanamide): exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats. Inflammopharmacol, 28(4): 893-902. doi:10.1007/s10787-020-00725-3.
  • Cho C. H, Jang H, Lee M, Kang H, Heo H. J Kim D. O. 2017. Sea Buckthorn (Hippophae rhamnoides L.): Leaf Extracts Protect Neuronal PC-12 Cells from Oxidative Stress. J Microbiol Biotechnol, 27(7): 1257-1265. doi:10.4014/jmb.1704.04033.
  • Ding W, Hong L. 2013. Progress research on relationship between oxidative stress and collagen metabolism diseases. J Jilin University, (Medicine Edition): 39(06): 1302-1306.
  • Dogra R, Tyagi SP, Kumar A. 2013. Efficacy of Seabuckthorn (Hippophae rhamnoides): Oil vis-a-vis Other Standard Drugs for Management of Gastric Ulceration and Erosions in Dogs. Vet Med Int, 2013: 176848. doi:10.1155/2013/176848.
  • Dubey S, Deep P, Singh AK. 2016. Phytochemical characterization and evaluation of anticataract potential of seabuckthorn leaf extract. Vet Ophthalmol, 19(2): 144-148. doi:10.1111/vop.12271.
  • Eraslan E, Tanyeli A, Guler MC, Kurt N, Yetim Z. 2020. Agomelatine prevents indomethacin-induced gastric ulcer in rats. Pharmacol Rep, 72(4): 984-991. doi:10.1007/s43440-019-00049-2.
  • Ermis A, Aritici Colak G, Acikel-Elmas M, Arbak S Kolgazi M. 2023. Ferulic acid treats gastric ulcer via suppressing oxidative stress and inflammation. Life (Basel), 13(2). doi:10.3390/life13020388.
  • Gatlan AM, Gutt G. 2021. Sea Buckthorn in Plant Based Diets. An Analytical Approach of Sea Buckthorn Fruits Composition: Nutritional Value Applications and Health Benefits. Int J Environ Res Public Health, 18(17). doi:10.3390/ijerph18178986.
  • Geetha S, Sai Ram M, Mongia SS, Singh V, Ilavazhagan G, Sawhney RC. 2003. Evaluation of antioxidant activity of leaf extract of Seabuckthorn (Hippophae rhamnoides L.): on chromium(VI): induced oxidative stress in albino rats. J Ethnopharmacol, 87(2-3): 247-251. doi:10.1016/s0378-8741(03):00154-5.
  • Guzman-Gomez O, Garcia-Rodriguez RV, Perez-Gutierrez S, Rivero-Ramirez NL, Garcia-Martinez Y, Pablo-Perez SS, . . . Chamorro-Cevallos G. 2023. Protective Effect of the Phycobiliproteins from Arthrospira maxima on Indomethacin-Induced Gastric Ulcer in a Rat Model. Plants (Basel), 12(8). doi:10.3390/plants12081586.
  • Halici Z, Polat B, Cadirci E, Topcu A, Karakus E, Kose D, . . . Bayir Y. 2016. Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. Chem Biol Interact, 258: 266-275. doi:10.1016/j.cbi.2016.09.011.
  • Harakeh S, Saber SH, Akefe IO, Shaker S, Barkaat Hussain M, Saad Almasaudi A, . . . Almasaudi S. 2022. Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats. Saudi J Biol Sci, 29(4): 3040-3050. doi:10.1016/j.sjbs.2022.01.031.
  • Isnain FS, Liao NC, Tsai HY, Zhao YJ, Huang CH, Hsu JL, . . . Chen YK. 2022. Freshwater Clam Extract Attenuates Indomethacin-Induced Gastric Damage In Vitro and In Vivo. Foods, 12(1). doi:10.3390/foods12010156.
  • Jafari A, Andishfar N, Esmaeilzadeh Z, Khezri MR Ghasemnejad-Berenji M. 2022. Gastroprotective effect of topiramate on indomethacin-induced peptic ulcer in rats: Biochemical and histological analyses. Basic Clin Pharmacol Toxicol, 130(5): 559-568. doi:10.1111/bcpt.13718.
  • Jia DR, Abbott RJ, Liu TL, Mao K. S, Bartish IV, Liu JQ. 2012. Out of the Qinghai–Tibet Plateau: evidence for the origin and dispersal of Eurasian temperate plants from a phylogeographic study of Hippophaë rhamnoides (Elaeagnaceae). New Phytologist, 194(4): 1123-1133.
  • Kubczak M, Khassenova AB, Skalski B, Michlewska S, Wielanek M, Sklodowska M, . . . Ionov M. 2022. Hippophae rhamnoides L. leaf and twig extracts as rich sources of nutrients and bioactive compounds with antioxidant activity. Sci Rep, 12(1): 1095. doi:10.1038/s41598-022-05104-2.
  • Lee HI, Kim MS, Lee KM, Park SK, Seo KI, Kim H. J, . . . Lee MK. 2011. Anti-visceral obesity and antioxidant effects of powdered sea buckthorn (Hippophae rhamnoides L.): leaf tea in diet-induced obese mice. Food Chem Toxicol, 49(9): 2370-2376. doi:10.1016/j.fct.2011.06.049.
  • Li W, Wang X, Zhi W, Zhang H, He Z, Wang Y, . . . Zhang X. 2017. The gastroprotective effect of nobiletin against ethanol-induced acute gastric lesions in mice: impact on oxidative stress and inflammation. Immunopharmacol Immunotoxicol, 39(6): 354-363. doi:10.1080/08923973.2017.1379088.
  • Li Y, Xu C, Zhang Q, Liu JY, Tan R.X. 2005. In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J Ethnopharmacol, 98(3): 329-333. doi:10.1016/j.jep.2005.01.020.
  • Maheshwari DT, Yogendra Kumar MS, Verma SK, Singh VK, Singh SN. 2011. Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.): leaves. Food Chem Toxicol, 49(9): 2422-2428. doi:10.1016/j.fct.2011.06.061.
  • Mahmoud MF, Nabil M, Abdo W, Abdelfattah MAO, El-Shazly AM, El Kharrassi Y, Sobeh M. 2021. Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-kappaB signaling pathway in rats. Biomed Pharmacother, 139: 111675. doi:10.1016/j.biopha.2021.111675.
  • Pineda-Pena EA, Orona-Ortiz A, Velazquez-Moyado JA, Tavares-Carvalho JC, Chavez-Pina AE, Balderas-Lopez JL, Navarrete A. 2020. Anti-inflammatory antioxidant and gaso-protective mechanism of 3alpha-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage. Naunyn Schmiedebergs Arch Pharmacol, 393(8): 1501-1513. doi:10.1007/s00210-020-01857-7.
  • Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, . . . Bitto A. 2017. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev 2017 8416763. doi:10.1155/2017/8416763.
  • Pundir S, Garg P, Dviwedi A, Ali A, Kapoor V, Kapoor D, . . . Negi P. 2021. Ethnomedicinal uses phytochemistry and dermatological effects of Hippophae rhamnoides L.: A review. J Ethnopharmacology, 26: 113434.
  • Purushothaman J, Suryakumar G, Shukla D, Jayamurthy H, Kasiganesan H, Kumar R Sawhney R. C. 2011. Modulation of Hypoxia-Induced Pulmonary Vascular Leakage in Rats by Seabuckthorn (Hippophae rhamnoides L.). Evid Based Complement Alternat Med, 2011: 574524. doi:10.1093/ecam/nep199.
  • Purushothaman J, Suryakumar G, Shukla D, Malhotra AS, Kasiganesan H, Kumar R, . . . Chami A. 2008. Modulatory effects of seabuckthorn (Hippophae rhamnoides L.): in hypobaric hypoxia induced cerebral vascular injury. Brain Res Bull 77(5): 246-252. doi:10.1016/j.brainresbull.2008.08.026.
  • Ran B, Guo CE, Li W, Li W, Wang Q, Qian J, Li H. 2021. Sea buckthorn (Hippophae rhamnoides L.): fermentation liquid protects against alcoholic liver disease linked to regulation of liver metabolome and the abundance of gut microbiota. J Sci Food Agric, 101(7): 2846-2854. doi:10.1002/jsfa.10915.
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  • Shivapriya S, Ilango K Dubey G. P. 2015. Evaluation of antioxidant and neuroprotective effect of Hippophae rhamnoides (L.): on oxidative stress induced cytotoxicity in human neural cell line IMR32. Saudi J Biol Sci, 22(5): 645-650. doi:10.1016/j.sjbs.2015.04.011.
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Protective Effects of Ethanol Extract from Hippophae rhamnoides L. Leaves against Indomethacin-Induced Gastric Ulcer in Rats

Yıl 2023, Cilt: 6 Sayı: 4, 697 - 704, 15.10.2023

Lale Duysak Mine Gülaboğlu Tuğba Nurcan Yüksel Zekai Halıcı Doğukan Canayakın Galip Mesut Demir

https://doi.org/10.19127/bshealthscience.1336015
Cited By: 1

Öz

We aimed to determine the effects of ethanol extract of Hippophae rhamnoides L. leaves on indomethacin-induced gastric ulcer in rats. 35 male Sprague Dawley rats were divided into 7 groups (n=5) at random: healthy; Hippophae rhamnoides L. leaves ethanol extract (HR) III; indomethacin; indomethacin+famotidine; indomethacin+HRI (100 mg/kg); indomethacin +HRII (250 mg/kg) and indomethacin +HRIII (500 mg/kg). All rats except the healthy group fasted for 24 hours. At the end of this period, HR and famotidine (20 mg/kg) were administered by oral gavage to the corresponding rat groups. Five minutes after the HR treatments, 25 mg/kg of indomethacin was applied by oral gavage to all groups except the Healthy and HR III groups. Six hours after indomethacin administration, stomach tissues were removed for investigation macroscopic and biochemically (Superoxide dismutase activity, Glutathione, and Malondialdehyde levels). HR administration improved ulcerative injury in stomach tissues caused by the indomethacin-induced gastric ulcer. HR administration reduced indomethacin-induced ulcer areas. Moreover, HR treatment significantly decreased malondialdehyde levels, increased glutathione levels, and elevated superoxide dismutase activity. HR significantly improved gastric ulcer by alleviating oxidative stress that could be important in ulcer. HR may be a new potential treatment option for ulcer treatment with an antioxidant effect. These findings may provide a mechanistic basis for using HR leaves to treat gastric ulcer.

Anahtar Kelimeler

Antioxidant Antiulcerogenic effect Ethanol extract Gastric ulcer Hippophae rhamnoides L. Indomethacin

Proje Numarası

2013/58

Kaynakça

  • Adinortey MB, Ansah C, Galyuon I Nyarko A. 2013. In vivo models used for evaluation of potential antigastroduodenal ulcer agents. Ulcers, 2013.
  • Antonisamy P, Arasu MV, Dhanasekaran M, Choi K. C, Aravinthan A, Kim N. S, . . . Kim JH. 2016. Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms. Food Function, 7(1): 398-408.
  • Balmus IM, Ciobica A, Trifan A Stanciu C. 2016. The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models. Saudi J Gastroenterol, 22(1): 3-17. doi:10.4103/1319-3767.173753.
  • Barboza KRM, Coco LZ, Alves GM, Peters B, Vasquez EC, Pereira TMC, . . . Campagnaro B. P. 2018. Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress. Life Sci, 209 370-376. doi:10.1016/j.lfs.2018.08.035
  • Bhattacharyya A, Chattopadhyay R, Mitra S Crowe S. E. 2014. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev, 94(2): 329-354. doi:10.1152/physrev.00040.2012.
  • Bonciu E, Olaru AL, Rosculete E Rosculete C. A. 2020. Cytogenetic study on the biostimulation potential of the aqueous fruit extract of Hippophaë rhamnoides for a sustainable agricultural ecosystem. Plants, 9(7): 843.
  • Bostanci MS, Bakacak M, Inanc F, Yaylali A, Serin S, Attar R, . . . Yildirim G. 2016. The protective effect of G-CSF on experimental ischemia/reperfusion injury in rat ovary. Arch Gynecol Obstet, 293(4): 789-795. doi:10.1007/s00404-015-3878-8.
  • Calik I, Yayla M, Cinar I, Cadirci E, Albayrak A, Sirin B, . . . Halici Z. 2020. LP44 (4-[2-(methylthio):phenyl]-N-(1234-tetrahydronaphthalen-1-yl):-1-piperazinehexanamide): exerts anti-ulcer effects via 5-hydroxytryptamine receptor 7 activation on indomethacin-induced gastric ulcers in rats. Inflammopharmacol, 28(4): 893-902. doi:10.1007/s10787-020-00725-3.
  • Cho C. H, Jang H, Lee M, Kang H, Heo H. J Kim D. O. 2017. Sea Buckthorn (Hippophae rhamnoides L.): Leaf Extracts Protect Neuronal PC-12 Cells from Oxidative Stress. J Microbiol Biotechnol, 27(7): 1257-1265. doi:10.4014/jmb.1704.04033.
  • Ding W, Hong L. 2013. Progress research on relationship between oxidative stress and collagen metabolism diseases. J Jilin University, (Medicine Edition): 39(06): 1302-1306.
  • Dogra R, Tyagi SP, Kumar A. 2013. Efficacy of Seabuckthorn (Hippophae rhamnoides): Oil vis-a-vis Other Standard Drugs for Management of Gastric Ulceration and Erosions in Dogs. Vet Med Int, 2013: 176848. doi:10.1155/2013/176848.
  • Dubey S, Deep P, Singh AK. 2016. Phytochemical characterization and evaluation of anticataract potential of seabuckthorn leaf extract. Vet Ophthalmol, 19(2): 144-148. doi:10.1111/vop.12271.
  • Eraslan E, Tanyeli A, Guler MC, Kurt N, Yetim Z. 2020. Agomelatine prevents indomethacin-induced gastric ulcer in rats. Pharmacol Rep, 72(4): 984-991. doi:10.1007/s43440-019-00049-2.
  • Ermis A, Aritici Colak G, Acikel-Elmas M, Arbak S Kolgazi M. 2023. Ferulic acid treats gastric ulcer via suppressing oxidative stress and inflammation. Life (Basel), 13(2). doi:10.3390/life13020388.
  • Gatlan AM, Gutt G. 2021. Sea Buckthorn in Plant Based Diets. An Analytical Approach of Sea Buckthorn Fruits Composition: Nutritional Value Applications and Health Benefits. Int J Environ Res Public Health, 18(17). doi:10.3390/ijerph18178986.
  • Geetha S, Sai Ram M, Mongia SS, Singh V, Ilavazhagan G, Sawhney RC. 2003. Evaluation of antioxidant activity of leaf extract of Seabuckthorn (Hippophae rhamnoides L.): on chromium(VI): induced oxidative stress in albino rats. J Ethnopharmacol, 87(2-3): 247-251. doi:10.1016/s0378-8741(03):00154-5.
  • Guzman-Gomez O, Garcia-Rodriguez RV, Perez-Gutierrez S, Rivero-Ramirez NL, Garcia-Martinez Y, Pablo-Perez SS, . . . Chamorro-Cevallos G. 2023. Protective Effect of the Phycobiliproteins from Arthrospira maxima on Indomethacin-Induced Gastric Ulcer in a Rat Model. Plants (Basel), 12(8). doi:10.3390/plants12081586.
  • Halici Z, Polat B, Cadirci E, Topcu A, Karakus E, Kose D, . . . Bayir Y. 2016. Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. Chem Biol Interact, 258: 266-275. doi:10.1016/j.cbi.2016.09.011.
  • Harakeh S, Saber SH, Akefe IO, Shaker S, Barkaat Hussain M, Saad Almasaudi A, . . . Almasaudi S. 2022. Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats. Saudi J Biol Sci, 29(4): 3040-3050. doi:10.1016/j.sjbs.2022.01.031.
  • Isnain FS, Liao NC, Tsai HY, Zhao YJ, Huang CH, Hsu JL, . . . Chen YK. 2022. Freshwater Clam Extract Attenuates Indomethacin-Induced Gastric Damage In Vitro and In Vivo. Foods, 12(1). doi:10.3390/foods12010156.
  • Jafari A, Andishfar N, Esmaeilzadeh Z, Khezri MR Ghasemnejad-Berenji M. 2022. Gastroprotective effect of topiramate on indomethacin-induced peptic ulcer in rats: Biochemical and histological analyses. Basic Clin Pharmacol Toxicol, 130(5): 559-568. doi:10.1111/bcpt.13718.
  • Jia DR, Abbott RJ, Liu TL, Mao K. S, Bartish IV, Liu JQ. 2012. Out of the Qinghai–Tibet Plateau: evidence for the origin and dispersal of Eurasian temperate plants from a phylogeographic study of Hippophaë rhamnoides (Elaeagnaceae). New Phytologist, 194(4): 1123-1133.
  • Kubczak M, Khassenova AB, Skalski B, Michlewska S, Wielanek M, Sklodowska M, . . . Ionov M. 2022. Hippophae rhamnoides L. leaf and twig extracts as rich sources of nutrients and bioactive compounds with antioxidant activity. Sci Rep, 12(1): 1095. doi:10.1038/s41598-022-05104-2.
  • Lee HI, Kim MS, Lee KM, Park SK, Seo KI, Kim H. J, . . . Lee MK. 2011. Anti-visceral obesity and antioxidant effects of powdered sea buckthorn (Hippophae rhamnoides L.): leaf tea in diet-induced obese mice. Food Chem Toxicol, 49(9): 2370-2376. doi:10.1016/j.fct.2011.06.049.
  • Li W, Wang X, Zhi W, Zhang H, He Z, Wang Y, . . . Zhang X. 2017. The gastroprotective effect of nobiletin against ethanol-induced acute gastric lesions in mice: impact on oxidative stress and inflammation. Immunopharmacol Immunotoxicol, 39(6): 354-363. doi:10.1080/08923973.2017.1379088.
  • Li Y, Xu C, Zhang Q, Liu JY, Tan R.X. 2005. In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J Ethnopharmacol, 98(3): 329-333. doi:10.1016/j.jep.2005.01.020.
  • Maheshwari DT, Yogendra Kumar MS, Verma SK, Singh VK, Singh SN. 2011. Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.): leaves. Food Chem Toxicol, 49(9): 2422-2428. doi:10.1016/j.fct.2011.06.061.
  • Mahmoud MF, Nabil M, Abdo W, Abdelfattah MAO, El-Shazly AM, El Kharrassi Y, Sobeh M. 2021. Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-kappaB signaling pathway in rats. Biomed Pharmacother, 139: 111675. doi:10.1016/j.biopha.2021.111675.
  • Pineda-Pena EA, Orona-Ortiz A, Velazquez-Moyado JA, Tavares-Carvalho JC, Chavez-Pina AE, Balderas-Lopez JL, Navarrete A. 2020. Anti-inflammatory antioxidant and gaso-protective mechanism of 3alpha-hydroxymasticadienoic acid and diligustilide combination on indomethacin gastric damage. Naunyn Schmiedebergs Arch Pharmacol, 393(8): 1501-1513. doi:10.1007/s00210-020-01857-7.
  • Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, . . . Bitto A. 2017. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev 2017 8416763. doi:10.1155/2017/8416763.
  • Pundir S, Garg P, Dviwedi A, Ali A, Kapoor V, Kapoor D, . . . Negi P. 2021. Ethnomedicinal uses phytochemistry and dermatological effects of Hippophae rhamnoides L.: A review. J Ethnopharmacology, 26: 113434.
  • Purushothaman J, Suryakumar G, Shukla D, Jayamurthy H, Kasiganesan H, Kumar R Sawhney R. C. 2011. Modulation of Hypoxia-Induced Pulmonary Vascular Leakage in Rats by Seabuckthorn (Hippophae rhamnoides L.). Evid Based Complement Alternat Med, 2011: 574524. doi:10.1093/ecam/nep199.
  • Purushothaman J, Suryakumar G, Shukla D, Malhotra AS, Kasiganesan H, Kumar R, . . . Chami A. 2008. Modulatory effects of seabuckthorn (Hippophae rhamnoides L.): in hypobaric hypoxia induced cerebral vascular injury. Brain Res Bull 77(5): 246-252. doi:10.1016/j.brainresbull.2008.08.026.
  • Ran B, Guo CE, Li W, Li W, Wang Q, Qian J, Li H. 2021. Sea buckthorn (Hippophae rhamnoides L.): fermentation liquid protects against alcoholic liver disease linked to regulation of liver metabolome and the abundance of gut microbiota. J Sci Food Agric, 101(7): 2846-2854. doi:10.1002/jsfa.10915.
  • Saggu S Kumar R. 2008. Effect of seabuckthorn leaf extracts on circulating energy fuels lipid peroxidation and antioxidant parameters in rats during exposure to cold hypoxia and restraint (C-H-R): stress and post stress recovery. Phytomedicine, 15(6-7): 437-446. doi:10.1016/j.phymed.2007.11.002.
  • Sharma B, Arora S, Sahoo D Deswal R. 2020. Comparative fatty acid profiling of Indian seabuckthorn showed altitudinal gradient dependent species-specific variations. Physiol Molec Biol Plants, 26: 41-49.
  • Shivapriya S, Ilango K Dubey G. P. 2015. Evaluation of antioxidant and neuroprotective effect of Hippophae rhamnoides (L.): on oxidative stress induced cytotoxicity in human neural cell line IMR32. Saudi J Biol Sci, 22(5): 645-650. doi:10.1016/j.sjbs.2015.04.011.
  • Suleyman H, Buyukokuroglu M, Koruk M, Akcay F, Kiziltunc A Gepdiremen A. 2001. The effects of Hippophae rhamnoides L. extract on ethanol-induced gastric lesion and gastric tissue glutathione level in rats: a comparative study with melatonin and omeprazole. Indian J Pharmacology, 33(2): 77-81.
  • Suleyman H, Demirezer LO, Buyukokuroglu ME, Akcay MF, Gepdiremen A, Banoglu Z. N Gocer F. 2001. Antiulcerogenic effect of Hippophae rhamnoides L. Phytother Res, 15(7): 625-627. doi:10.1002/ptr.831.
  • Suo H, Zhao X, Qian Y, Sun P, Zhu K, Li J Sun B. 2016. Lactobacillus fermentum Suo Attenuates HCl/Ethanol Induced Gastric Injury in Mice through Its Antioxidant Effects. Nutrients, 8(3): 155. doi:10.3390/nu8030155.
  • Toktay E, Yayla M, Sahin L, Harmankaya A, Ozic C, Aksu Kilicle P, . . . Bayram P. 2022. The effects of dragon fruit (Hylocereus polyrhizus): extract on indomethacin-induced stomach ulcer in rats. J Food Biochem, 46(9): e14274. doi:10.1111/jfbc.14274.
  • Upadhyay NK, Kumar R, Siddiqui MS Gupta A. 2011. Mechanism of Wound-Healing Activity of Hippophae rhamnoides L. Leaf Extract in Experimental Burns. Evid Based Complement Alternat Med, 2011: 659705. doi:10.1093/ecam/nep189.
  • Wang GY, Chen SY, Chen YY, Hong CJ, Hsu YH Yen GC. 2021. Protective effect of rosmarinic acid-rich trichodesma khasianum clarke leaves against ethanol-induced gastric mucosal injury in vitro and in vivo. Phytomedicine, 80: 153382. doi:10.1016/j.phymed.2020.153382.
  • Wang K, Xu Z Liao X. 2022. Bioactive compounds health benefits and functional food products of sea buckthorn: a review. Crit Rev Food Sci Nutr, 62(24): 6761-6782. doi:10.1080/10408398.2021.1905605.
  • Xing J, Yang B, Dong Y, Wang B, Wang J Kallio HP. 2002. Effects of sea buckthorn (Hippophae rhamnoides L.): seed and pulp oils on experimental models of gastric ulcer in rats. Fitoterapia, 73(7-8): 644-650. doi:10.1016/s0367-326x(02):00221-6..
  • Xu X, Xie B, Pan S, Liu L, Wang Y Chen C. 2007. Effects of sea buckthorn procyanidins on healing of acetic acid-induced lesions in the rat stomach. Asia Pac J Clin Nutr, 16(Suppl 1): 234-238.
  • Yoldaş A, Eser N, Yaylalı A, Kökbaş U Bozkurt AS. 2022. Attenuation of senescence-induced oxidative exacerbations in aged rat testis by ferula elaeochytris root extract. European J Therapeutics, 28(4): 306-312.
  • Zakynthinos G, Varzakas T. 2015. Hippophae rhamnoides: safety and nutrition. Current Res Nutri Food Sci J, 3(2): 89-97.
Toplam 48 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık Biyokimyası
Bölüm Araştırma Makalesi
Yazarlar

Lale Duysak 0000-0001-7872-3880

Mine Gülaboğlu 0000-0002-3248-1502

Tuğba Nurcan Yüksel 0000-0001-5092-1674

Zekai Halıcı 0000-0001-6854-6059

Doğukan Canayakın 0009-0006-5974-7880

Galip Mesut Demir 0000-0001-6107-2604

Proje Numarası 2013/58
Erken Görünüm Tarihi 5 Ekim 2023
Yayımlanma Tarihi 15 Ekim 2023
Gönderilme Tarihi 2 Ağustos 2023
Kabul Tarihi 28 Eylül 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 6 Sayı: 4

Kaynak Göster

APA Duysak, L., Gülaboğlu, M., Yüksel, T. N., Halıcı, Z., vd. (2023). Protective Effects of Ethanol Extract from Hippophae rhamnoides L. Leaves against Indomethacin-Induced Gastric Ulcer in Rats. Black Sea Journal of Health Science, 6(4), 697-704. https://doi.org/10.19127/bshealthscience.1336015
AMA Duysak L, Gülaboğlu M, Yüksel TN, Halıcı Z, Canayakın D, Demir GM. Protective Effects of Ethanol Extract from Hippophae rhamnoides L. Leaves against Indomethacin-Induced Gastric Ulcer in Rats. BSJ Health Sci. Ekim 2023;6(4):697-704. doi:10.19127/bshealthscience.1336015
Chicago Duysak, Lale, Mine Gülaboğlu, Tuğba Nurcan Yüksel, Zekai Halıcı, Doğukan Canayakın, ve Galip Mesut Demir. “Protective Effects of Ethanol Extract from Hippophae Rhamnoides L. Leaves Against Indomethacin-Induced Gastric Ulcer in Rats”. Black Sea Journal of Health Science 6, sy. 4 (Ekim 2023): 697-704. https://doi.org/10.19127/bshealthscience.1336015.
EndNote Duysak L, Gülaboğlu M, Yüksel TN, Halıcı Z, Canayakın D, Demir GM (01 Ekim 2023) Protective Effects of Ethanol Extract from Hippophae rhamnoides L. Leaves against Indomethacin-Induced Gastric Ulcer in Rats. Black Sea Journal of Health Science 6 4 697–704.
IEEE L. Duysak, M. Gülaboğlu, T. N. Yüksel, Z. Halıcı, D. Canayakın, ve G. M. Demir, “Protective Effects of Ethanol Extract from Hippophae rhamnoides L. Leaves against Indomethacin-Induced Gastric Ulcer in Rats”, BSJ Health Sci., c. 6, sy. 4, ss. 697–704, 2023, doi: 10.19127/bshealthscience.1336015.
ISNAD Duysak, Lale vd. “Protective Effects of Ethanol Extract from Hippophae Rhamnoides L. Leaves Against Indomethacin-Induced Gastric Ulcer in Rats”. Black Sea Journal of Health Science 6/4 (Ekim 2023), 697-704. https://doi.org/10.19127/bshealthscience.1336015.
JAMA Duysak L, Gülaboğlu M, Yüksel TN, Halıcı Z, Canayakın D, Demir GM. Protective Effects of Ethanol Extract from Hippophae rhamnoides L. Leaves against Indomethacin-Induced Gastric Ulcer in Rats. BSJ Health Sci. 2023;6:697–704.
MLA Duysak, Lale vd. “Protective Effects of Ethanol Extract from Hippophae Rhamnoides L. Leaves Against Indomethacin-Induced Gastric Ulcer in Rats”. Black Sea Journal of Health Science, c. 6, sy. 4, 2023, ss. 697-04, doi:10.19127/bshealthscience.1336015.
Vancouver Duysak L, Gülaboğlu M, Yüksel TN, Halıcı Z, Canayakın D, Demir GM. Protective Effects of Ethanol Extract from Hippophae rhamnoides L. Leaves against Indomethacin-Induced Gastric Ulcer in Rats. BSJ Health Sci. 2023;6(4):697-704.

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