Sepsis ve septik şok patojenezinde endotelin-1’in rolü ve tedavide yeni yaklaşımlar

Demet Sinem Güden; Meryem Temiz; Bahar Tunçtan; Seyhan Şahan Fırat

doi:10.5455/musbed.20150602023809

The role of endothelin-1 and new therapeutic approaches in sepsis and septic shock

Yıl 2015, Cilt: 5 Sayı: 3, 178 - 190, 01.10.2015

Demet Sinem Güden Meryem Temiz Bahar Tunçtan Seyhan Şahan Fırat

Öz

As a systemic inflammatory response to infection, sepsis describes a complex clinical syndrome that results in progressively advance stage, probably evoke septic shock, multiple organ dysfunction syndrome and ultimately cause to death. Sepsis is markedly enhanced by proinflammatory cytokines that can trigger a systemic inflammatory cascade mediated by chemokines, vasoactive amines, complement and coagulation system as well as reactive oxygen species (ROS). In 1988, endothelin (ET)-1 was identified as a vasoactive amine from endothelium which has a 21 amino acid peptide. It has been demonstrated with the experimental and clinical studies that endothelin acts as an important role in sepsis and septic shock pathogenesis. Moreover, endothelin receptor antagonists have been studied as novel therapeutic target for treatment of sepsis and septic shock and according to these studies beneficial results have been obtained . Mitogen-activated protein kinase signal transduction pathway is stimulated by ET-1 which activates a variety of downstream molecules; it is believed that ET-1could play an important role in the development of sepsis, septic shock, and multiple organ dysfunction syndrome by events that can cause increased reactive oxygen species (ROS) production, inflammation, endothelial dysfunction, abnormal vascular tonus, and vascular remodelling.

Anahtar Kelimeler

Endothelin-1, sepsis, septic shock, inflammation

Kaynakça

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Sepsis ve septik şok patojenezinde endotelin-1’in rolü ve tedavide yeni yaklaşımlar

Yıl 2015, Cilt: 5 Sayı: 3, 178 - 190, 01.10.2015

Demet Sinem Güden Meryem Temiz Bahar Tunçtan Seyhan Şahan Fırat

Öz

Vücuda giren patojene karşı gelişen sistemik enflamatuvar yanıt olarak adlandırılan sepsis, septik şok, çoklu organ yetmezliği ve ölümle sonuçlanabilmektedir. Sistemik enflamatuvar yanıtı tetikleyebilen artmış proenflamatuvar sitokin düzeyleriyle birlikte kemokinler, koagülasyon ve kompleman sistemleri ile vazoaktif aminler de sepsis patojenezinde yer almaktadır. Endotelin (ET)-1, 1988 yılında vazoaktif amin olarak damar endotelinden izole edilmiş olup 21 zincirli amino asit zincirine sahip bir peptitdir. (ET)-1’in sepsis ve septik şok gelişimindeki rolü deneysel ve klinik çalışmalarda gösterilmiş olup, reseptör antagonistleri sepsis tedavisinde denenmiş ve yararlı sonuçlar sağlamıştır. ET-1’in mitojenle etkinleştirilen protein kinaz sinyal ileti yolunu uyararak etkinleştirdiği downstream sinyal molekülleri aracılığıyla reaktif oksijen türlerinin üretiminde artış, enflamasyon gelişimi, endotelyal işlevde bozulma, anormal damar gerimi ve damarlarda yeniden modellenme gibi olaylara yol açarak sepsis, septik şok ve çoklu organ yetmezliği gelişiminde önemli rolü olabileceği düşünülmektedir.

Anahtar Kelimeler

Endotelin-1, sepsis, septik şok, enflamasyon

Kaynakça

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Iskit AB, Guc MO. Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia and survival in experimental models of septic shock. Acta Pharmacol Sin. 2003;24:953-957.
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Kavuklu B, Iskit AB, Guc MO, Ilhan M, Sayek I. Aminoguanidine attenuates endotoxin-induced mesenteric vascular hyporeactivity. Br J Surg. 2000;87:448-453.
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Crimi E, Liguori A, Condorelli M, Cioffi M, Astuto M, Bontempo P, Pignalosa O,Vietri MT, Molinari AM, Sica V, Della Corte F, Napoli C. The benefi cial eff ects of antioxidant supplementation in enteral feeding in critically ill patients: A prospective, randomized, double-blind, placebo-controlled trial. Anesth Analg. 2004;99:857-863.
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Loomis ED, Sullivan JC, Osmond DA Pollock DM, Pollock JS. Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta. J Pharmacol Exp Ther. 2005;315:1058-1064.
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Peyton MD, Hinshaw LB, Greenfield LJ, Elkins RC. The effects of coronary vasodilation on cardiac performance during endotoxin shock. Surg Gynecol Obstet. 1976;143:533-538.
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Toplam 118 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Bölüm	Articles
Yazarlar	Demet Sinem Güden Bu kişi benim Meryem Temiz Bu kişi benim Bahar Tunçtan Bu kişi benim Seyhan Şahan Fırat
Yayımlanma Tarihi	1 Ekim 2015
Gönderilme Tarihi	1 Ekim 2015
Yayımlandığı Sayı	Yıl 2015 Cilt: 5 Sayı: 3

Kaynak Göster

APA	Güden, D. S., Temiz, M., Tunçtan, B., Şahan Fırat, S. (2015). Sepsis ve septik şok patojenezinde endotelin-1’in rolü ve tedavide yeni yaklaşımlar. Clinical and Experimental Health Sciences, 5(3), 178-190. https://doi.org/10.5455/musbed.20150602023809
AMA	Güden DS, Temiz M, Tunçtan B, Şahan Fırat S. Sepsis ve septik şok patojenezinde endotelin-1’in rolü ve tedavide yeni yaklaşımlar. Clinical and Experimental Health Sciences. Ekim 2015;5(3):178-190. doi:10.5455/musbed.20150602023809
Chicago	Güden, Demet Sinem, Meryem Temiz, Bahar Tunçtan, ve Seyhan Şahan Fırat. “Sepsis Ve Septik şok Patojenezinde Endotelin-1’in Rolü Ve Tedavide Yeni yaklaşımlar”. Clinical and Experimental Health Sciences 5, sy. 3 (Ekim 2015): 178-90. https://doi.org/10.5455/musbed.20150602023809.
EndNote	Güden DS, Temiz M, Tunçtan B, Şahan Fırat S (01 Ekim 2015) Sepsis ve septik şok patojenezinde endotelin-1’in rolü ve tedavide yeni yaklaşımlar. Clinical and Experimental Health Sciences 5 3 178–190.
IEEE	D. S. Güden, M. Temiz, B. Tunçtan, ve S. Şahan Fırat, “Sepsis ve septik şok patojenezinde endotelin-1’in rolü ve tedavide yeni yaklaşımlar”, Clinical and Experimental Health Sciences, c. 5, sy. 3, ss. 178–190, 2015, doi: 10.5455/musbed.20150602023809.
ISNAD	Güden, Demet Sinem vd. “Sepsis Ve Septik şok Patojenezinde Endotelin-1’in Rolü Ve Tedavide Yeni yaklaşımlar”. Clinical and Experimental Health Sciences 5/3 (Ekim 2015), 178-190. https://doi.org/10.5455/musbed.20150602023809.
JAMA	Güden DS, Temiz M, Tunçtan B, Şahan Fırat S. Sepsis ve septik şok patojenezinde endotelin-1’in rolü ve tedavide yeni yaklaşımlar. Clinical and Experimental Health Sciences. 2015;5:178–190.
MLA	Güden, Demet Sinem vd. “Sepsis Ve Septik şok Patojenezinde Endotelin-1’in Rolü Ve Tedavide Yeni yaklaşımlar”. Clinical and Experimental Health Sciences, c. 5, sy. 3, 2015, ss. 178-90, doi:10.5455/musbed.20150602023809.
Vancouver	Güden DS, Temiz M, Tunçtan B, Şahan Fırat S. Sepsis ve septik şok patojenezinde endotelin-1’in rolü ve tedavide yeni yaklaşımlar. Clinical and Experimental Health Sciences. 2015;5(3):178-90.

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