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Bor ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış

Yıl 2017, Cilt: 7 Sayı: 3, 107 - 114, 15.09.2017

Öz

Bor, doğada bileşikleri halinde bulunan ve dünyada en fazla rezervi ülkemizde olan bir elementtir. Bor bileşiklerinin kullanım alanları arasında cam, seramik, temizlik, beyazlatma, kozmetik, metalurji, nükleer, bilgisayar ve uçak sanayi, enerji sektörü, tarım ve sağlık yer almaktadır. Bor başlıca, besinler ve içme suyu ile vücudumuza girmektedir. Son yıllarda yapılan çalışmalarda borun biyolojik önemi ve insan sağlığı üzerinde olumlu etkilerinden söz edilmekte ve borun mineral ve hormon metabolizmasında, kemik gelişiminde, antioksidan savunma sisteminde, yara iyileşmesinde, enerji metabolizmasında ve immün sistemde çok önemli rolü bulunduğu vurgulanmaktadır. Bu derlemede borun beslenmemiz için önemi ve insan sağlığına olan etkileri ele alınmıştır.

Kaynakça

  • 1. Nielsen FH. Boron-an overlooked element of potential nutritional importance. Nutr Today 1988; 23: 4-7. [CrossRef] 2. Yünlü K. Bor. 1st ed. Ankara: Değişim Yayınları; 2016. 3. Ulusal Bor Araştırma Enstitüsü Web Site: http://www.boren.gov.tr/trErişim Tarihi: 29.12.2016. 4. European Food Safety Authority. Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the commission related to the tolerable upper intake level of boron. EFSA J 2004; 2: 1-9. 5. Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987; 1: 394-7. 6. Yenmez N. Stratejik bir maden olarak bor minerallerinin Türkiye için önemi. Coğrafya Dergisi 2009; 19: 59-94. 7. Uçkun Z. Esansiyel bir komponent: bor-borun günlük alımı ve fizyolojik etkileri. J Turkish Sci Rev 2013; 6: 119-23. 8. Demirtaş A. Bor bileşikleri ve tarımda kullanım alanları. Atatürk Üniv Ziraat Fak Derg 2006; 37: 111-5. 9. Çanakkale Onsekiz Mart Üniversitesi Yer Bilimleri Müzesi URL: http:// ybm.comu.edu.tr/v2/mobile/about.php. Erişim Tarihi: 29.12.2016. 10. World Health Organization. Boron in drinking-water report. Geneva, 1998, p. 1-12. 11. Derun EM, Kipcak AS, Ozdemir OD. The determination of the boron amounts of teas that are sold in Turkey by using the ICP boron in human health evidence for dietary recommendations and public policies, Proceedings of the World Congress on Engineering; Londra; 2010. p. 2277-9. 12. Derum EM, Kipcak AS, Ozdemir OD. The determination of the boron amounts of teas that are sold in Turkey by using the ICP-OES technique. Int Rev Chem Eng 2010; 2: 326-8. 13. Ozbek N, Akman S. Determination of boron in Turkish wines by microwave plasma atomic emission spectrometry. J Food Sci 2015; 61: 532-5. [CrossRef] 14. Simsek A, Velioglu S, Coskun AL, Saylı BS. Boron concentrations in selected foods from borate-producing regions in Turkey. J Sci Food Agric 2003; 83: 586-92. [CrossRef] 15. Sungur S, Okur R. Using Azomethine-H method determination of boron contents of various foods consumed in Hatay region in Turkey. Food Chem 2009; 115: 711-4. [CrossRef] 16. Simsek A, Korkmaz D, Velioglu A, Ataman YO. Determination of boron in hazelnut (Corylus avellana L.) varieties by inductively coupled plasma optical emission spectrometry and spectrophotometry. Food Chem 2003; 83: 293-6. [CrossRef] 17. National Institutes of Health. URL: https://dsld.nlm.nih.gov/dsld/ 18. Naghii MR, Wall PM, Samman S. The boron content of selected foods and the estimation of its daily intake among free-living subjects. J Am Coll Nutr 1996; 15: 614-9. [CrossRef] 19. Karadağ M, Türközü D. Diyetle bor alımının sağlık ile etkileşimi. GUSBD 2014; 3: 770-85. 20. Trumbo P, Yates AA, Schlicker S, Poos M. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc 2001; 101: 294-301. [CrossRef] 21. European Food Safety Authority. Scientific Opinion on the re-evaluation of boric acid (E 284) and sodium tetraborate (borax) (E 285) as food additives. EFSA J 2013; 11: 1-52. 22. Dogan G, Sabah E, Erkal T. Borun çevresel etkileri üzerine Türkiye'de yapılan bilimsel araştırmalar. 19. Uluslararası Madencilik Kongresi; 9-12 Haziran 2015; İzmir, s. 425-31. 23. Tosun E. Çeşitli örneklerdeki borun spektrofotometrik tayini. E.Ü. Fen Bilimleri Enstitüsü. Yüksek Lisans Tezi. 2010. 24. Murray FJ. A comparative review of the pharmacokinetics of boric acid in rodents and humans. Biol Trace Elem Res 1998; 66: 331-41. [CrossRef] 25. Park M, Li Q, Shcheynikov N, Muallem S, Zeng W. Borate transport and cell growth and proliferation. Not only in plants. Cell Cycle 2005; 4: 24-6. [CrossRef] 26. Sutherland B, Woodhouse LR, Strong P, King JC. Boron balance in humans. J Trace Elem Exp Med 1999; 12: 271-84. [CrossRef] 27. Naghii MR, Samman S. The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol Trace Elem Res 1997; 56: 273-86. [CrossRef] 28. Ku WW, Chapin RE, Moseman RF, Brink RE, Pierce KD, Adams KY. Tissue disposition of boron in male Fischer rats. Toxicol Appl Pharmacol 1991; 111: 145-51. [CrossRef] 29. Kabu M. Akosman MS. Biological effects of boron. Rev Environ Contam Toxicol 2013; 225: 57-75. [CrossRef] 30. Kucukkurt I, Akbel E, Karabag F, Ince S. The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicol Ind Health 2015; 31: 255-60. [CrossRef] 31. Aysan E, Sahin F, Telci D, Erdem M, Muslumanoglu M, Yardımcı E, Bektasoglu H. Mechanism of body weight reducing effect of oral boric acid intake. Int J Endocrinol 2013; 2013: 1-5. [CrossRef] 32. Ince S, Kucukkurt I, Cigerci IH, Fatih Fidan A, Eryavuz A. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J Trace Elem Med Biol 2010; 24: 161-4. [CrossRef] 33. Kucukkurt I, Ince S, Demirel HH, Turkmen R, Akbel E, Celik Y. The effects of boron on arsenic-induced lipid peroxidation and antioxidant status in male and female rats. J Biochem Mol Toxicol 2015; 29: 564-71. [CrossRef] 34. Coban FK, Ince S, Kucukkurt I, Demirel HH, Hazman O. Boron attenuates malathion-induced oxidative stress and acetylcholinesterase inhibition in rats. Drug Chem Toxicol 2015; 38: 391-9. [CrossRef] 35. Pizzorno L. Nothing boring about boron. Integr Med 2015; 14: 35-48. 36. Demirci S, Doğan A, Karakuş E, Halıcı Z, Topçu A, Demirci E, Sahin F. Boron and poloxamer (F68 and F127) containing hydrogel formulation for burn wound healing. Biol Trace Elem Res 2015; 168: 169-80. [CrossRef] 37. Akgün Z, Yucel S, Kilic U, Aysan E, Sahin F, Musumseroglu M, et al. Protective effect of boron-based gel on radiation induced dermatitis in rats. Int J Radiat Oncol Biol Phys 2015; 93: 514. [CrossRef] 38. Hunt CD, Herbel JL. Effects of dietary boron on calcium and mineral metabolism in the streptozotocin-injected, vitamin D3-deprived rat. Magnes Trace Elem 1991; 10: 387-408. 39. Toker H, Ozdemir H, Yuce HB, Goze F. The effect of boron on alveolar bone loss in osteoporotic rats. J Dent Sci 2016; 20: 1-7. [CrossRef] 40. Hakki SS, Malkoc S, Dundar N, Kayis SA, Hakki EE, Hamurcu M, et al. Dietary boron does not affect tooth strength, micro-hardness and density, but affects tooth mineral composition and alveolar bone mineral density in rabbits fed a high-energy diet. J Trace Elem Med Biol 2015; 29: 208-15. [CrossRef] 41. Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3T3-E1). J Trace Elem Med Biol 2010; 24: 243-50. [CrossRef] 42. Dogan A, Demirci S, Bayir Y, Halici Z, Karakus E, Aydin A, et al. Boron containing poly-(lactide-co-glycolide) (PLGA) scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl 2014; 44: 246-53. [CrossRef] 43. Pan HB, Zhao XL, Zhang X, Zhang KB, Li LC, Li ZY, et al. Strontium borate glass: potential biomaterial for bone regeneration. J R Soc Interface 2010; 7: 1025-31. [CrossRef] 44. Nielsen FH, Mullen LM, Gallagher SK. Effect of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium- low diet. J Trace Elem Exp Med 1990; 3: 45-54. 45. Mogaşanu GD, Bita A, Bejenaru LE, Bejenaru C, Croitoru O, Rau G, et al. Calcium fructoborate for bone and cardiovascular health. Biol Trace Elem Res 2016; 172: 277-81. [CrossRef] 46. Hunt CD. Boron. In: Coates PM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York: Marcel Dekker; 2010, p: 55-65. [CrossRef] 47. Nielsen FH. Update on human health effects of boron. J Trace Elem Med and Biol 2014; 28: 383-7. [CrossRef] 48. Cui Y, Winton MI, Zhang ZF, Rainey C, Marshall J, De Kernion JB, et al. Dietary boron intake and prostrate cancer risk. Oncol Rep 2004; 11: 887-92. 49. Penland JG. Dietary boron, brain function, and cognitive performance. Environ Health Perspect 1994; 102: 65-72. [CrossRef] 50. Nielsen FH, Mullen LM, Nielsen EJ. Dietary boron affects blood cell counts and hemoglobin concentrations in humans. J Trace Elem Exp Med 1991; 4: 211-23.

Boron and a Current Overview of its Effects On Health

Yıl 2017, Cilt: 7 Sayı: 3, 107 - 114, 15.09.2017

Öz

Boron is an element that naturally exists as compounds and has the most reserves in our country. Boron compounds are used in glass, ceramics, cleaning, whitening, cosmetic, metallurgy, nuclear, computer, aircraft, energy, agricultural, and health industries. It enters the body through nutrients and drinking water. Recent studies have focused on the biological importance of boron and its positive effects on human health and have emphasized the importance of its role in mineral and hormone metabolisms, bone development, antioxidant defense system, wound healing, energy metabolism, and immune system. Here we review the importance of boron in our nutrition and its effects on health.

Kaynakça

  • 1. Nielsen FH. Boron-an overlooked element of potential nutritional importance. Nutr Today 1988; 23: 4-7. [CrossRef] 2. Yünlü K. Bor. 1st ed. Ankara: Değişim Yayınları; 2016. 3. Ulusal Bor Araştırma Enstitüsü Web Site: http://www.boren.gov.tr/trErişim Tarihi: 29.12.2016. 4. European Food Safety Authority. Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the commission related to the tolerable upper intake level of boron. EFSA J 2004; 2: 1-9. 5. Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J 1987; 1: 394-7. 6. Yenmez N. Stratejik bir maden olarak bor minerallerinin Türkiye için önemi. Coğrafya Dergisi 2009; 19: 59-94. 7. Uçkun Z. Esansiyel bir komponent: bor-borun günlük alımı ve fizyolojik etkileri. J Turkish Sci Rev 2013; 6: 119-23. 8. Demirtaş A. Bor bileşikleri ve tarımda kullanım alanları. Atatürk Üniv Ziraat Fak Derg 2006; 37: 111-5. 9. Çanakkale Onsekiz Mart Üniversitesi Yer Bilimleri Müzesi URL: http:// ybm.comu.edu.tr/v2/mobile/about.php. Erişim Tarihi: 29.12.2016. 10. World Health Organization. Boron in drinking-water report. Geneva, 1998, p. 1-12. 11. Derun EM, Kipcak AS, Ozdemir OD. The determination of the boron amounts of teas that are sold in Turkey by using the ICP boron in human health evidence for dietary recommendations and public policies, Proceedings of the World Congress on Engineering; Londra; 2010. p. 2277-9. 12. Derum EM, Kipcak AS, Ozdemir OD. The determination of the boron amounts of teas that are sold in Turkey by using the ICP-OES technique. Int Rev Chem Eng 2010; 2: 326-8. 13. Ozbek N, Akman S. Determination of boron in Turkish wines by microwave plasma atomic emission spectrometry. J Food Sci 2015; 61: 532-5. [CrossRef] 14. Simsek A, Velioglu S, Coskun AL, Saylı BS. Boron concentrations in selected foods from borate-producing regions in Turkey. J Sci Food Agric 2003; 83: 586-92. [CrossRef] 15. Sungur S, Okur R. Using Azomethine-H method determination of boron contents of various foods consumed in Hatay region in Turkey. Food Chem 2009; 115: 711-4. [CrossRef] 16. Simsek A, Korkmaz D, Velioglu A, Ataman YO. Determination of boron in hazelnut (Corylus avellana L.) varieties by inductively coupled plasma optical emission spectrometry and spectrophotometry. Food Chem 2003; 83: 293-6. [CrossRef] 17. National Institutes of Health. URL: https://dsld.nlm.nih.gov/dsld/ 18. Naghii MR, Wall PM, Samman S. The boron content of selected foods and the estimation of its daily intake among free-living subjects. J Am Coll Nutr 1996; 15: 614-9. [CrossRef] 19. Karadağ M, Türközü D. Diyetle bor alımının sağlık ile etkileşimi. GUSBD 2014; 3: 770-85. 20. Trumbo P, Yates AA, Schlicker S, Poos M. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc 2001; 101: 294-301. [CrossRef] 21. European Food Safety Authority. Scientific Opinion on the re-evaluation of boric acid (E 284) and sodium tetraborate (borax) (E 285) as food additives. EFSA J 2013; 11: 1-52. 22. Dogan G, Sabah E, Erkal T. Borun çevresel etkileri üzerine Türkiye'de yapılan bilimsel araştırmalar. 19. Uluslararası Madencilik Kongresi; 9-12 Haziran 2015; İzmir, s. 425-31. 23. Tosun E. Çeşitli örneklerdeki borun spektrofotometrik tayini. E.Ü. Fen Bilimleri Enstitüsü. Yüksek Lisans Tezi. 2010. 24. Murray FJ. A comparative review of the pharmacokinetics of boric acid in rodents and humans. Biol Trace Elem Res 1998; 66: 331-41. [CrossRef] 25. Park M, Li Q, Shcheynikov N, Muallem S, Zeng W. Borate transport and cell growth and proliferation. Not only in plants. Cell Cycle 2005; 4: 24-6. [CrossRef] 26. Sutherland B, Woodhouse LR, Strong P, King JC. Boron balance in humans. J Trace Elem Exp Med 1999; 12: 271-84. [CrossRef] 27. Naghii MR, Samman S. The effect of boron supplementation on its urinary excretion and selected cardiovascular risk factors in healthy male subjects. Biol Trace Elem Res 1997; 56: 273-86. [CrossRef] 28. Ku WW, Chapin RE, Moseman RF, Brink RE, Pierce KD, Adams KY. Tissue disposition of boron in male Fischer rats. Toxicol Appl Pharmacol 1991; 111: 145-51. [CrossRef] 29. Kabu M. Akosman MS. Biological effects of boron. Rev Environ Contam Toxicol 2013; 225: 57-75. [CrossRef] 30. Kucukkurt I, Akbel E, Karabag F, Ince S. The effects of dietary boron compounds in supplemented diet on hormonal activity and some biochemical parameters in rats. Toxicol Ind Health 2015; 31: 255-60. [CrossRef] 31. Aysan E, Sahin F, Telci D, Erdem M, Muslumanoglu M, Yardımcı E, Bektasoglu H. Mechanism of body weight reducing effect of oral boric acid intake. Int J Endocrinol 2013; 2013: 1-5. [CrossRef] 32. Ince S, Kucukkurt I, Cigerci IH, Fatih Fidan A, Eryavuz A. The effects of dietary boric acid and borax supplementation on lipid peroxidation, antioxidant activity, and DNA damage in rats. J Trace Elem Med Biol 2010; 24: 161-4. [CrossRef] 33. Kucukkurt I, Ince S, Demirel HH, Turkmen R, Akbel E, Celik Y. The effects of boron on arsenic-induced lipid peroxidation and antioxidant status in male and female rats. J Biochem Mol Toxicol 2015; 29: 564-71. [CrossRef] 34. Coban FK, Ince S, Kucukkurt I, Demirel HH, Hazman O. Boron attenuates malathion-induced oxidative stress and acetylcholinesterase inhibition in rats. Drug Chem Toxicol 2015; 38: 391-9. [CrossRef] 35. Pizzorno L. Nothing boring about boron. Integr Med 2015; 14: 35-48. 36. Demirci S, Doğan A, Karakuş E, Halıcı Z, Topçu A, Demirci E, Sahin F. Boron and poloxamer (F68 and F127) containing hydrogel formulation for burn wound healing. Biol Trace Elem Res 2015; 168: 169-80. [CrossRef] 37. Akgün Z, Yucel S, Kilic U, Aysan E, Sahin F, Musumseroglu M, et al. Protective effect of boron-based gel on radiation induced dermatitis in rats. Int J Radiat Oncol Biol Phys 2015; 93: 514. [CrossRef] 38. Hunt CD, Herbel JL. Effects of dietary boron on calcium and mineral metabolism in the streptozotocin-injected, vitamin D3-deprived rat. Magnes Trace Elem 1991; 10: 387-408. 39. Toker H, Ozdemir H, Yuce HB, Goze F. The effect of boron on alveolar bone loss in osteoporotic rats. J Dent Sci 2016; 20: 1-7. [CrossRef] 40. Hakki SS, Malkoc S, Dundar N, Kayis SA, Hakki EE, Hamurcu M, et al. Dietary boron does not affect tooth strength, micro-hardness and density, but affects tooth mineral composition and alveolar bone mineral density in rabbits fed a high-energy diet. J Trace Elem Med Biol 2015; 29: 208-15. [CrossRef] 41. Hakki SS, Bozkurt BS, Hakki EE. Boron regulates mineralized tissue-associated proteins in osteoblasts (MC3T3-E1). J Trace Elem Med Biol 2010; 24: 243-50. [CrossRef] 42. Dogan A, Demirci S, Bayir Y, Halici Z, Karakus E, Aydin A, et al. Boron containing poly-(lactide-co-glycolide) (PLGA) scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl 2014; 44: 246-53. [CrossRef] 43. Pan HB, Zhao XL, Zhang X, Zhang KB, Li LC, Li ZY, et al. Strontium borate glass: potential biomaterial for bone regeneration. J R Soc Interface 2010; 7: 1025-31. [CrossRef] 44. Nielsen FH, Mullen LM, Gallagher SK. Effect of boron depletion and repletion on blood indicators of calcium status in humans fed a magnesium- low diet. J Trace Elem Exp Med 1990; 3: 45-54. 45. Mogaşanu GD, Bita A, Bejenaru LE, Bejenaru C, Croitoru O, Rau G, et al. Calcium fructoborate for bone and cardiovascular health. Biol Trace Elem Res 2016; 172: 277-81. [CrossRef] 46. Hunt CD. Boron. In: Coates PM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York: Marcel Dekker; 2010, p: 55-65. [CrossRef] 47. Nielsen FH. Update on human health effects of boron. J Trace Elem Med and Biol 2014; 28: 383-7. [CrossRef] 48. Cui Y, Winton MI, Zhang ZF, Rainey C, Marshall J, De Kernion JB, et al. Dietary boron intake and prostrate cancer risk. Oncol Rep 2004; 11: 887-92. 49. Penland JG. Dietary boron, brain function, and cognitive performance. Environ Health Perspect 1994; 102: 65-72. [CrossRef] 50. Nielsen FH, Mullen LM, Nielsen EJ. Dietary boron affects blood cell counts and hemoglobin concentrations in humans. J Trace Elem Exp Med 1991; 4: 211-23.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Articles
Yazarlar

Rüya Kuru Bu kişi benim

Ayşen Yarat

Yayımlanma Tarihi 15 Eylül 2017
Gönderilme Tarihi 18 Ocak 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 7 Sayı: 3

Kaynak Göster

APA Kuru, R., & Yarat, A. (2017). Bor ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış. Clinical and Experimental Health Sciences, 7(3), 107-114.
AMA Kuru R, Yarat A. Bor ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış. Clinical and Experimental Health Sciences. Eylül 2017;7(3):107-114.
Chicago Kuru, Rüya, ve Ayşen Yarat. “Bor Ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış”. Clinical and Experimental Health Sciences 7, sy. 3 (Eylül 2017): 107-14.
EndNote Kuru R, Yarat A (01 Eylül 2017) Bor ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış. Clinical and Experimental Health Sciences 7 3 107–114.
IEEE R. Kuru ve A. Yarat, “Bor ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış”, Clinical and Experimental Health Sciences, c. 7, sy. 3, ss. 107–114, 2017.
ISNAD Kuru, Rüya - Yarat, Ayşen. “Bor Ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış”. Clinical and Experimental Health Sciences 7/3 (Eylül 2017), 107-114.
JAMA Kuru R, Yarat A. Bor ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış. Clinical and Experimental Health Sciences. 2017;7:107–114.
MLA Kuru, Rüya ve Ayşen Yarat. “Bor Ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış”. Clinical and Experimental Health Sciences, c. 7, sy. 3, 2017, ss. 107-14.
Vancouver Kuru R, Yarat A. Bor ve Sağlığımıza Olan Etkilerine Güncel Bir Bakış. Clinical and Experimental Health Sciences. 2017;7(3):107-14.

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